F12

General Information (Source: NCBI Gene,UniProt)

Text mining Term F12
UniProt ID Q2YGF1_9GAST
Name Cytochrome c oxidase subunit 1
Gene Names COI
Taxonomy Theodoxus fluviatilis

General annotation

Function Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
Subcellular location Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0005743 mitochondrial inner membrane CC
GO:0016021 integral to membrane CC
GO:0009060 aerobic respiration BP
GO:0022900 electron transport chain BP
GO:0009055 electron carrier activity MF
GO:0004129 cytochrome-c oxidase activity MF
GO:0070469 respiratory chain CC
GO:0020037 heme binding MF

Sequence

>gi|59859018|gb|AAX09295.1| cytochrome oxidase subunit I [Theodoxus fluviatilis]
VWSGLVGTALSLLIRAELGQPGALLGDDQLYNVIVTAHAFVMIFFLVMPMMIGGFGNWLVPLMLGAPDMA
FPRLNNMSFWLLPPSLTLLLASSAVESGVGTGWTVYPPLSGNLAHAGGSVDLAIFSLHLAGVSSILGAVN
FITTIINMRWQGMQFERLPLFVWSVKITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPA

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00115