B12

General Information (Source: NCBI Gene,UniProt)

Text mining Term B12
UniProt ID HEM3_PEA
Name Pre-uroporphyrinogen synthase
HMBS
Hydroxymethylbilane synthase
PBG
Porphobilinogen deaminase, chloroplastic
Gene Names HEMC
Taxonomy Pisum sativum

General annotation

Function Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Subcellular location Plastid, chloroplast.

Gene Ontology

GO:0004418 hydroxymethylbilane synthase activity MF
GO:0009507 chloroplast CC
GO:0018160 peptidyl-pyrromethane cofactor linkage BP
GO:0015995 chlorophyll biosynthetic process BP

Sequence

>gi|2495180|sp|Q43082.1|HEM3_PEA RecName: Full=Porphobilinogen deaminase, chloroplastic; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase; Flags: Precursor
MEMTLYSSSSFSLPSAPSNPSLSLFTSSFRFSSFKTSPFSKCRIRASLAVEQQTQQNKTALIRIGTRGSP
LALAQAHETRDKLMASHTELAEEGAIQIVIIKTTGDKILSQPLADIGGKGLFTKEIDEALINGDIDIAVH
SMKDVPTYLPEETILPCNLPREDVRDAFISLSAASLADLPAGSVIGTASLRRKSQILHRYPSLTVQDNFR
GNVQTRLRKLSEGVVKATLLALAGLKRLNMTENVTSTLSIDDMLPAVAQGAIGIACRSNDDKMAEYLASL
NHEETRLAISCERAFLTTLDGSCRTPIAGYASRDKDGNCLFRGLVASPDGTRVLETSRIGSYTYEDMMKI
GKDAGEELLSRAGPGFFNS

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF03900
PF01379