Acetylcholinesterases

General Information (Source: NCBI Gene,UniProt)

Text mining Term Acetylcholinesterases
UniProt ID ACES_DROME
Name Acetylcholinesterase 55 kDa subunit
AChE
Acetylcholinesterase
Acetylcholinesterase 16 kDa subunit
Gene Names Ace
Taxonomy Drosophila melanogaster

General annotation

Function Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.
Subcellular location Cell junction, synapse. Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.

Gene Ontology

GO:0042331 phototaxis BP
GO:0042426 choline catabolic process BP
GO:0001507 acetylcholine catabolic process in synaptic cleft BP
GO:0005737 cytoplasm CC
GO:0031225 anchored to membrane CC
GO:0003990 acetylcholinesterase activity MF
GO:0005886 plasma membrane CC
GO:0030054 cell junction CC
GO:0042803 protein homodimerization activity MF
GO:0004091 carboxylesterase activity MF

Sequence

>gi|113036|sp|P07140.1|ACES_DROME RecName: Full=Acetylcholinesterase; Short=AChE; Contains: RecName: Full=Acetylcholinesterase 16 kDa subunit; Contains: RecName: Full=Acetylcholinesterase 55 kDa subunit; Flags: Precursor
MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGI
PYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPA
KARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGN
VIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS
SVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVD
AKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDK
DDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALA
ERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP
AQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSASISPRLQL
LGIAALIYICAALRTKRVF

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.1179
PDB 1QON
1DX4
1QO9
RefSeq NP_001163600.1
NP_476953.1
Pfam PF00135