Protein Information

Name SP6
Synonyms Epiprofin; KLF14; Krueppel like factor 14; Kruppel like factor 14; SP6; Sp6 transcription factor; Transcription factor Sp6; Sp6 transcription factors…

Compound Information

Name azobenzene
CAS diphenyldiazene

Reference List

PubMed Abstract RScore(About this table)
14510482 Liu M, Asanuma H, Komiyama M: Effective photo-regulation of transcription reaction by SP6 RNA polymerase with modified DNA tethering multiple azobenzenes. Nucleic Acids Res Suppl. 2003;(3):265-6.

With one azobenzene in either TATA or RNAP binding region of the SP6 promoter, photo-regulation activity was very small.
83(1,1,1,3) Details
17150558 Liu M, Asanuma H, Komiyama M: Real time monitoring of the interaction of T7 RNA polymerase with azobenzene-tethered T7 promoter by biosensor. Nucleic Acids Symp Ser. 2004;(48):221-2.

We have already reported that transcription reaction by phage T7 or SP6 RNA polymerase (RNAP) can be reversibly photo-regulated with azobenzene-tethered promoter.
6(0,0,1,1) Details
12903112 Asanuma H, Liu M, Tamaru D, Liang X, Komiyama M: Photo-regulation of transcription by RNA polymerase with azobenzene-tethered promoter. Nucleic Acids Res Suppl. 2002;(2):75-6.

This strategy was also effective for the photo-regulation of SP6-RNA polymerase.
1(0,0,0,1) Details