| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | precocene II |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8847709 | Hammond AH, Garle MJ, Fry JR: Mechanism of toxicity of precocene II in rat hepatocyte cultures. J Biochem Toxicol. 1995 Oct;10(5):265-273. Inhibition of cytochrome P-450 prevented the toxicity, and partially protected against the loss of membrane potential and in 24 hour cultures but was ineffective in 72 hour cultures. |
1(0,0,0,1) | Details |
| 3653573 | Duddy SK, Hsia MT: Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity. Fundam Appl Toxicol. 1987 Aug;9(2):304-13. These results indicate that the level of activity of various forms of cytochrome P-450 significantly influences the severity of hepatic necrosis induced by precocene II. |
6(0,0,1,1) | Details |
| 8284801 | Hammond AH, Fry JR: Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. Toxicol Lett. 1994 Feb 15;70(3):337-42. Omission of serum from culture medium markedly increased the toxicity of the cytochrome P450-activated toxin precocene II in 24-h cultures of rat hepatocytes. |
112(1,2,2,2) | Details |
| 1796613 | Fentem JH, Hammond AH, Fry JR: Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures. Xenobiotica. 1991 Oct;21(10):1363-70. The toxicity of precocene I and precocene II to gerbil hepatocyte cultures was dose-dependent. |
4(0,0,0,4) | Details |
| 2495263 | Trower MK, Sariaslani FS, O'Keefe DP: Purification and characterization of a soybean flour-induced cytochrome P-450 from Streptomyces griseus. J Bacteriol. 1989 Apr;171(4):1781-7. When reconstituted with spinach ferredoxin and spinach ferredoxin:NADP+ oxidoreductase, purified cytochrome P-450soy catalyzed the -dependent oxidation of the xenobiotic substrates precocene II and 7-ethoxycoumarin. |
4(0,0,0,4) | Details |
| 3144975 | Trower MK, Sariaslani FS, Kitson FG: Xenobiotic oxidation by cytochrome P-450-enriched extracts of Streptomyces griseus. Biochem Biophys Res Commun. 1988 Dec 30;157(3):1417-22. |
3(0,0,0,3) | Details |
| 1417966 | Hammond AH, Fry JR: Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. Biochem Pharmacol. 1992 Oct 6;44(7):1461-4. The toxicities of precocene I and precocene II to 24 hr hepatocyte cultures, determined as decreased survival, were also shown to be increased in serum-free medium. |
2(0,0,0,2) | Details |
| 10418968 | Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM: Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem Biol Interact. 1999 Jun 1;121(1):17-35. Drug-metabolizing enzyme activities of the cryopreserved hepatocytes (mean of ten donors) as percentages of the freshly isolated cells were: 97%, for cytochrome P450 isoform (CYP) 1A2, 78% for CYP2A6, 96% for CYP2C9. 86% for CYP2Cl9, 90% for CYP2D6, 164% for CYP3A4, 76% for UDP-glucuronidase, and 88% for umbelliferone sulfotransferase. Dose-dependent cytotoxicity, measured using MTT metabolism as an endpoint, was observed for the known hepatotoxic chemicals tamoxifen, clozapine, cadmium diclofenac, amiodarone, tranylcypromine, precocene II, but not for 2-thiouracil. |
1(0,0,0,1) | Details |