Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
19324396 Sarma K, Pal AK, Sahu NP, Ayyappan S, Baruah K: Dietary high protein and vitamin C mitigates endosulfan toxicity in the spotted murrel, Channa punctatus (Bloch, 1793). Sci Total Environ. 2009 Jun 1;407(12):3668-73. Epub 2009 Mar 26.

Results indicated significant reduction in the growth performance, survival, and activities of lactate dehydrogenase (liver and muscle), malate dehydrogenase (liver and muscle), enzymes of protein metabolism (aspartate amino transferase in liver and alanine amino transferase in liver and muscle), acetyl choline esterase (brain), alkaline phosphatase activity (liver), and ATPase (gill) enzymes of group fed control diet and exposed to endosulfan.
31(0,1,1,1) Details
6180524 Wali RK, Singh R, Dudeja PK, Mahmood A: Effect of a single oral dose of endosulfan on intestinal uptake of nutrients and on brush-border enzymes in rats. Toxicol Lett. 1982 Jun;12(1):7-12.

The activities of brush-border sucrase and alkaline phosphatase were considerably increased while the activity of Na+ K+ ATPase was reduced in endosulfan-exposed animals.
31(0,1,1,1) Details
2328352 Sharma RM: Effect of endosulfan on acid and alkaline phosphatase activity in liver, kidney, and muscles of Channa gachua. Bull Environ Contam Toxicol. 1990 Mar;44(3):443-8.
6(0,0,1,1) Details
15259607 Choudhary N, Sharma M, Verma P, Joshi SC: Hepato and nephrotoxicity in rat exposed to endosulfan. . J Environ Biol. 2003 Jul;24(3):305-8.

Aspartate amino transferase, alanine amino transferase, acid phosphatase, alkaline phosphatase, bilirubin urea and creatinine were increased which clearly showed the hepato and nephrotoxic effect of endosulfan.
6(0,0,1,1) Details
3388749 Dikshith TS, Raizada RB, Kumar SN, Srivastava MK, Kaushal RA, Singh RP, Gupta KP: Effect of repeated dermal application of endosulfan to rats. Vet Hum Toxicol. 1988 Jun;30(3):219-24.

However, a significant decrease in liver GOT and GPT and serum GPT activities and a significant rise in serum alkaline phosphatase and total protein were recorded in the endosulfan-treated animals.
6(0,0,1,1) Details
11883509 Labana S, Bansal RC, Mahmood A: Effects of endosulfan on intestinal functions in protein-malnourished rats. Indian J Exp Biol. 2001 Oct;39(10):1017-21.

However, in protein malnourished rats (fed 8% protein) exposed to endosulfan, brush border sucrase and peptidase activities were enhanced, while alkaline phosphatase activity was decreased compared to untreated malnourished animals.
6(0,0,1,1) Details
7444972 Shaffi SA: Thiodon toxicity: non-specific phosphomonoesterases in nine freshwater teleosts. Toxicol Lett. 1980 Oct;6(6):339-47.


Sublethal doses (5 and 10 ppm) of thiodon increased alkaline phosphatase in liver, muscle, kidney and brain, while lethal doses (15 and 20 ppm) decreased it.
2(0,0,0,2) Details
20020928 Hatipoglu FS, Gulay MS, Balic A, Yildiz-Gulay O, Volkan S: Subacute oral toxicity of endosulfan in male new zealand white rabbits. Toxicol Mech Methods. 2008 Jan;18(9):705-10.

Serum alkaline phosphatase (ALP) and aspartate aminotransferase (AST) levels were significantly elevated in the 3 mg/kg dose group.
1(0,0,0,1) Details
6277045 Verma SR, Rani S, Dalela RC: Pesticide-induced physiological alterations in certain tissues of a fish, Mystus vittatus. Toxicol Lett. 1981 Dec;9(4):327-32.


Maximum (62.79%) inhibition of alkaline phosphatase in gills after thiotox (0.00013 mg/l) treatment have been observed.
2(0,0,0,2) Details
11225895 Chitra KC, Latchoumycandane C, Mathur PP: Chronic effect of endosulfan on the testicular functions of rat. Asian J Androl. 1999 Dec;1(4):203-6.

The lysosomal enzyme acid phosphatase and brush-border enzyme alkaline phosphatase activities were also decreased in the testis of treated rats.
1(0,0,0,1) Details
7900959 Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61.

It also decreased significantly Na+, K+ and Mg (2+) ATPases, plasma calcium level and alkaline phosphatase in the intestinal epithelium. 6.
1(0,0,0,1) Details
15204980 Garg UK, Pal AK, Jha GJ, Jadhao SB: Pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides on bone health of broiler chicks. Toxicol Pathol. 2004 May-Jun;32(3):364-9.

This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks.
However, increase an (p < 0.01) in serum alkaline phosphatase activity was noted and serum total protein decreased (p < 0.01) in all treated groups.
1(0,0,0,1) Details