Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name anthraquinone
CAS 9,10-anthracenedione

Reference List

PubMed Abstract RScore(About this table)
18822374 Brunauer G, Muggia L, Stocker-Worgotter E, Grube M: A transcribed polyketide synthase gene from Xanthoria elegans. Mycol Res. 2009 Jan;113(Pt 1):82-92. Epub 2008 Sep 6.

The hypothetical protein is phylogenetically related to genes that are basal to a clade of dihydroxynaphthalene synthases (non-reducing clade II) and anthraquinone type synthases of non-lichenized fungi (non-reducing clade I).
31(0,1,1,1) Details
12356333 Lloyd JR, Leang C, Hodges Myerson AL, Coppi MV, Cuifo S, Methe B, Sandler SJ, Lovley DR: Biochemical and genetic characterization of PpcA, a periplasmic c-type cytochrome in Geobacter sulfurreducens. Biochem J. 2003 Jan 1;369(Pt 1):153-61.

The purified protein is basic (pI 9.5), contains three haems and has an N-terminal amino acid sequence closely related to those of the previously described trihaem c (7) cytochromes of Geobacter metallireducens and Desulfuromonas acetoxidans.
The transfer of electrons from acetate to anthraquinone 2,6-disulphonate (AQDS; a humic acid analogue) and to U (VI) was also compromised in the mutant, but acetate-dependent reduction of fumarate was not altered.
1(0,0,0,1) Details
16730806 Ho TY, Wu SL, Chen JC, Li CC, Hsiang CY: Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74(2):92-101. Epub 2006 May 15.

SARS-CoV spike (S) protein, a type I membrane-bound protein, is essential for the viral attachment to the host cell receptor angiotensin-converting enzyme 2 (ACE2).
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner.
1(0,0,0,1) Details
822126 Harvey AM, Batt RD, Pritchard GG: Inhibition of RNA synthesis in Chlorella pyrenoidosa and Bacillus megaterium by the pine-blight toxin, dothistromin. J Gen Microbiol. 1976 Aug;96(2):268-76.

Dosthistromin, an anthraquinone derivative produced by the pine-blight fungus, Dothistroma pini, inhibits the growth of Chlorella pyrenoidosa and Bacillus megaterium.
With B. megaterium, marked inhibition of [3H] uridine incorporation is apparent within 5 min of addition of dothistromin, but only a slight inhibition of [3H] thymidine incorporation into the DNA-containing fraction or of [14C] leucine incorporation into protein is detectable after 10 min.
1(0,0,0,1) Details