| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | thiram |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6520339 | Dalvi RR, Robbins TJ, Williams MK, Deoras DP, Donastorg F, Banks C: Thiram-induced toxic liver injury in male Sprague-Dawley rats. J Environ Sci Health B. 1984 Nov-Dec;19(8-9):703-12. Additional evidence for thiram-induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N-demethylase with a concomitant decrease in the concentration of cytochrome P-450, an important component of the mixed-function oxidase system. |
81(1,1,1,1) | Details |
| 3953292 | Dalvi RR, Deoras DP: Metabolism of a dithiocarbamate fungicide thiram to carbon disulfide in the rat and its hepatotoxic implications. Acta Pharmacol Toxicol. 1986 Jan;58(1):38-42. Furthermore, measurement of the activities of hepatic microsomal and serum enzymes at 5 hrs and 24 hrs following thiram treatment indicated that thiram caused significant loss of cytochrome P-450 and benzphetamine N-demethylase activity only at 24 hrs interval whereas there was significant elevation of sorbitol dehydrogenase (SDH) and serum glutamic oxalacetic transaminase (SGOT) activity at 5 and 24 hrs after treatment. |
6(0,0,1,1) | Details |
| 8382714 | Gupta M, Amma MK: Alterations in hepatic biochemistry of mice intoxicated with MIC, carbaryl and thiram. J Appl Toxicol. 1993 Jan-Feb;13(1):33-7. The activities of drug-metabolizing enzymes (aminopyrine demethylase-- and -linked--and hydroxylase) were found to increase with all three compounds in general. |
1(0,0,0,1) | Details |