| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | heptachlor |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8900138 | Guzov VM, Houston HL, Murataliev MB, Walker FA, Feyereisen R: Molecular cloning, overexpression in Escherichia coli, structural and functional characterization of house fly cytochrome b5. J Biol Chem. 1996 Oct 25;271(43):26637-45. The cytochrome b5 is reduced by house fly cytochrome P450 reductase in a reconstituted system at a high rate (5.5 s-1), and it stimulates heptachlor epoxidation when reconstituted with house fly cytochrome P450 reductase, cytochrome P450 6A1, phospholipid, and detergent. |
38(0,1,2,3) | Details |
| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. Oral administration of sumithion, dursban, chlordane, methoxychlore, and heptachlor epoxide as repeated doses decreased: (i) the hepatic content of cytochrome P450 by 36, 37, 47, 37, and 67%, respectively, (ii) AHH activity by 28, 29, 70, 31, and 79%, respectively, (iii) NDMA-dI activity by 43, 44, 32, 27, and 31, respectively. |
9(0,0,1,4) | Details |
| 11595308 | Snyder MJ, Mulder EP: Environmental endocrine disruption in decapod crustacean larvae: hormone titers, cytochrome P450, and stress protein responses to heptachlor exposure. Aquat Toxicol. 2001 Nov 12;55(3-4):177-90. |
7(0,0,1,2) | Details |
| 824158 | Wade AE, Norred WP: Effect of dietary lipid on drug-metabolizing enzymes. Fed Proc. 1976 Nov;35(13):2475-9. Male rats fed diet containing 3% corn oil for 3 weeks metabolized hexobarbital, and heptachlor significantly faster than those fed fat-free diet. Associated with the increased drug metabolism in corn oil-fed rats were increases in concentration of cytochrome P-450 in male and female rats, decreased sleeping time in male rats, and decreased glucose 6-phosphate dehydrogenase activity of male and female rats. |
3(0,0,0,3) | Details |
| 9784239 | Snyder MJ: Identification of a new cytochrome P450 family, CYP45, from the lobster, Homarus americanus, and expression following hormone and xenobiotic exposures. Arch Biochem Biophys. 1998 Oct 15;358(2):271-6. Induction of CYP45 expression occurred following phenobarbital and heptachlor administration, but not by beta-naphthoflavone. |
2(0,0,0,2) | Details |
| 9407006 | Dunkov BC, Guzov VM, Mocelin G, Shotkoski F, Brun A, Amichot M, Ffrench-Constant RH, Feyereisen R: The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. DNA Cell Biol. 1997 Nov;16(11):1345-56. The CYP6A2 protein produced in this system metabolized aldrin and heptachlor to their epoxides and metabolized the insecticide diazinon by desulfuration to diazoxon and by oxidative ester cleavage to 2-isopropyl-4-methyl-6-hydroxypyrimidine. |
2(0,0,0,2) | Details |
| 9456078 | Khan MA, Jovanovich LV, Martin LT, Qadri SY, Podowski AA: Effects of photoisomers of cyclodiene insecticides on liver and microsomal cytochrome P450 in rats. Arch Toxicol. 1998;72(2):74-83. |
2(0,0,0,2) | Details |
| 18930820 | Murataliev MB, Guzov VM, Walker FA, Feyereisen R: P450 reductase and cytochrome b5 interactions with cytochrome P450: effects on house fly CYP6A1 catalysis. Insect Biochem Mol Biol. 2008 Nov;38(11):1008-15. Epub 2008 Sep 27. Both holo- and apo-b5 stimulated CYP6A1 heptachlor epoxidase and steroid hydroxylase activities and influenced the regioselectivity of hydroxylation. |
2(0,0,0,2) | Details |
| 3569844 | Haake J, Kelley M, Keys B, Safe S: The effects of organochlorine pesticides as inducers of and benzo [a] pyrene hydroxylases. Gen Pharmacol. 1987;18(2):165-9. p,p'-DDE, phenobarbital, dieldrin heptachlor, chlordane and toxaphene induced rat liver microsomes exhibited increased formation of the 4,5-dihydrodiol, 3,6- 9- and 3-hydroxymetabolites of benzo [a] pyrene and the latter three compounds also induced an increase in the rate of formation of the 9,10-dihydrodiol metabolite. Using a battery of monooxygenase enzyme assays it was evident that there were significant differences between PB and several organochlorine pesticides as inducers of rat hepatic cytochrome P-450-dependent monooxygenases. |
1(0,0,0,1) | Details |
| 8117673 | Andersen JF, Utermohlen JG, Feyereisen R: Expression of house fly CYP6A1 and NADPH-cytochrome P450 reductase in Escherichia coli and reconstitution of an insecticide-metabolizing P450 system. Biochemistry. 1994 Mar 1;33(8):2171-7. The house fly (Musca domestica) cytochrome P450 gene CYP6A1 was expressed in Escherichia coli. The reconstituted system was effective in the epoxidation of the cyclodiene insecticides aldrin and heptachlor, with turnover rates of 12 and 34 min-1, respectively. |
1(0,0,0,1) | Details |
| 6618147 | Campbell MA, Gyorkos J, Leece B, Homonko K, Safe S: The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Gen Pharmacol. 1983;14(4):445-54. The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat have been determined, this group includes four isomeric hexachlorocyclohexanes, technical chlordane, alpha-chlordane, gamma-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. |
1(0,0,0,1) | Details |
| 2372869 | Ruch RJ, Fransson R, Flodstrom S, Warngard L, Klaunig JE: Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor. Carcinogenesis. 1990 Jul;11(7):1097-101. |
0(0,0,0,0) | Details |