2007.09 ~ 2011.06 B.E., School of Pharmacy, major in Pharmaceutical engineering and
minor in English, East China University of Science and Technology;
2011.09 ~ 2016.06 Ph.D., School of Pharmacy, East China University of Science and
2016.06 ~ present Post Doctor, School of Pharmacy, East China University of Science and Technology.
1. Homology modeling, virtual screening, lead discoverying and target prediction;
2. Network pharmacology research and application;
3. Free energy landscape of ligand-receptor interaction construction;
4. Binding kinetics prediction and it's application in drug discovery;
5. Study of polypharmacology based on 3D Drug binding site similarity.
Shiliang li, Yi Zhou, Weiqiang Lu, Ye Zhong, Jin Huang*, zhenjiang zhao, Xiaofeng Liu*, Yufang Xu, Honglin Li. Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-based Virtual Screening with the Inhibitor-constrained Refined Homology Model. J. Chem. Inf. Model., 2011, 51(11), 2939–2947.
Shiliang Li*, Guoqin Luan*, Xiaoli Ren*, Wenlin Song, Liuxin Xu, Minghao Xu, Junsheng Zhu, Dong Dong, Yanyan Diao, Xiaofeng Liu, Lili Zhu, Rui Wang, Zhenjiang Zhao, Yufang Xu, Honglin Li. Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity. Sci. Rep., 2015. 5 : 14836.
Shiliang Li, Xiaojuan Yu, Chuanxin Zou, Jiayu Gong, Xiaofeng Liu, Honglin Li. Are Topological Properties of Drug Targets Based on Protein-Protein Interaction Network Ready to Predict Potential Drug Targets?. Comb. Chem. High Throughput Screen., 2016. 2 : 109-120.
Shiliang Li, Yuwei Song, Xiaofeng Liu, Honglin Li. A Rapid Python-Based Methodology for Target-Focused Combinatorial Library Design. Comb. Chem. High Throughput Screen., 2016. 1 : 25-35.
Wei Zhou*, Shiliang Li*, Weiqiang Lu*, Jun Yuan, Yufang Xu, Honglin Li, Jin Huang, Zhenjiang Zhao. Isoindole-1,3-dione Derivatives as RSK2 Inhibitors: Synthesis, Molecular Docking Simulation and SAR Analysis. Med. Chem. Commun., 2016. 7 : 292-296.
Wenlin Song*, Shiliang Li*, Yi Tong*, Jiawei Wang, Lina Quan, Zhuo Chen, Zhenjiang Zhao, Yufang Xu, Lili Zhu, Xuhong Qian, Honglin Li. Structure-based Design of Potent Human Dihydroorotate Dehydrogenase Inhibitors as Anticancer Agents. Med. Chem. Commun.. DOI: 10.1039/C6MD00179C.
Jun Yuan*, Ye Zhong*, Shiliang Li, Xue Zhao, Guoqin Luan, Zhenjiang Zhao, Jin Huang, Honglin Li, Yufang Xu. Triazole and Benzotrizaole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis. Chin. J. Chem., 2013. 31(9) : 1192-1198.
Jiawei Wang, Yanyan Diao, Junsheng Zhu, Shiliang Li, Zhenjiang Zhao, Honglin Li, Lili Zhu. Biological Evaluation of Quinoline Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase. Med. Chem. Commun., 2016, DOI: 10.1039/C6MD00024J.
Junsheng Zhu*, Le Han*, Yanyan Diao*, Xiaoli Ren, Minghao Xu, Liuxin Xu, Shiliang Li, Qiang Li, Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang zhao, Rui Wang, Lili Zhu,* Yufang Xu, Xuhong Qian, Honglin Li. Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole-Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem., 2015. 58 : 1123-1139.
Honglin Li's Lab Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Sci. & Tech. Room 527, Building 18, 130 Meilong Road, Shanghai, 200237, P. R. China Tel: (86) 21 6425 0213
Prof. Honglin Li email@example.com