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difenoconazole

Identification (Source:EPA,EU)

ID	529
Name	difenoconazole
CAS	119446-68-3
IUPAC
Inchi	InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3
CIPAC	687
EPA Code
Formula	C19H17Cl2N3O3
SMILES	Clc4ccc(Oc1ccc(c(Cl)c1)C2(OCC(O2)C)Cn3ncnc3)cc4
Status	Approved

Classification

Mode of Action	Systemic with preventative and curative action. Disrupts membrane function.
Pesticide Type	Fungicide
Chemical Group	Triazole
Classification	conazole fungicides (triazoles)

Properties (Source:PubChem)

Molecular Weight	406.26
Physical State	White crystals
AlogP	4.38
H-Bond Donor	0
H-Bond Acceptor	5
Surface Area	362.43
Polar Surface Area	58.4

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	0.87 mg l-1
Algae	Acute	72 hour	EC50, growth	1.2 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.15 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.0056 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.77 mg l-1
Birds	Short term dietary		LC50/LD50	> 5000 ppm
Birds	Acute		LD50	> 2150 mg kg-1
Earthworms	Acute	14 day	LD50	> 610 mg kg-1
Fish	Acute	96 hour	LC50	1.1 mg l-1
Fish	Chronic	21 day	NOEC	0.023 mg l-1
Honeybees	Acute	48 hour	LD50	> 100 μg bee-1
Mammals	Acute oral		LD50	1453 mg kg-1
Mammals	Short term dietary		NOEL	20 mg kg-1
Mammals	Short term dietary		NOEL	40 ppm diet
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.015 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	10.0 mg kg-1
	Bio-concentration factor		BCF	320
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
TMPRSS2	7(0,0,1,2)	Details
CYP19	2(0,0,0,2)	Details
SPMD	2(0,0,0,2)	Details

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