| Name | prothrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | difenacoum |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2883288 | Winn MJ, Clegg JA, Park BK: An investigation of sex-linked differences to the toxic and to the pharmacological actions of difenacoum: studies in mice and rats. J Pharm Pharmacol. 1987 Mar;39(3):219-22. |
0(0,0,0,0) | Details |
| 9088970 | McCarthy PT, Cox AD, Harrington DJ, Evely RS, Hampton E, al-Sabah AI, Massey E, Jackson H, Ferguson T: Covert poisoning with difenacoum: clinical and toxicological observations. Hum Exp Toxicol. 1997 Mar;16(3):166-70. Intermittent and unexpected increases in plasma concentrations of difenacoum and descarboxypro-thrombin suggested that covert, repeated ingestion of the anticoagulant was the most likely cause of the poisoning. |
6(0,0,1,1) | Details |
| 19752778 | Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50. RESULTS AND CONCLUSION: In this manuscript we report the prothrombin times measured in the F7 generation after exposure to chlorophacinone, bromadiolone, difenacoum and difethialone. |
6(0,0,1,1) | Details |
| 2771552 | Smolinske SC, Scherger DL, Kearns PS, Wruk KM, Kulig KW, Rumack BH: Superwarfarin poisoning in children: a prospective study. Pediatrics. 1989 Sep;84(3):490-4. This prospective study was undertaken to determine the incidence, severity, time of onset, and duration of coagulopathy in children following accidental ingestion of long-acting anticoagulant rodenticides, often called "superwarfarins." Of 110 children, who ingested superwarfarins and in whom one or more prothrombin time values were obtained, 8 had a prothrombin time ratio (patient to control) of greater than or equal to 1.2, indicative of anticoagulation. |
3(0,0,0,3) | Details |
| 3964529 | Park BK, Choonara IA, Haynes BP, Breckenridge AM, Malia RG, Preston FE: Abnormal metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins. Br J Clin Pharmacol. 1986 Mar;21(3):289-93. The case histories of two patients exposed to the novel anticoagulants brodifacoum and difenacoum are reported. There was a marked prolongation of prothrombin time (greater than 50 s) in both cases, at the time of exposure. |
2(0,0,0,2) | Details |
| 1361149 | Butcher GP, Shearer MJ, MacNicoll AD, Kelly MJ, Ind PW: Difenacoum poisoning as a cause of haematuria. Hum Exp Toxicol. 1992 Nov;11(6):553-4. A man presented with frank haematuria and a grossly prolonged prothrombin time. |
1(0,0,0,1) | Details |
| 7181945 | Park BK, Leck JB: A comparison of antagonism by difenacoum and brodifacoum in the rabbit. Biochem Pharmacol. 1982 Nov 15;31(22):3635-9. The pharmacological response to vitamin K1 in anticoagulated (prothrombin complex activity less than 30%) New Zealand white rabbits was determined by measuring prothrombin complex activity (P.C.A.) in peripheral plasma. |
1(0,0,0,1) | Details |
| 9477532 | Robben JH, Kuijpers EA, Mout HC: Plasma superwarfarin levels and vitamin K1 treatment in dogs with anticoagulant rodenticide poisoning. Vet Q. 1998 Jan;20(1):24-7. The dose of vitamin K1 was reduced in a stepwise manner as long as the prothrombin time remained within physiological limits. Brodifacoum, difethialone, and difenacoum were detected by high-performance liquid chromatography (HPLC) in the plasma of 13, 3, and 2 dogs, respectively. |
1(0,0,0,1) | Details |
| 3978316 | Breckenridge AM, Cholerton S, Hart JA, Park BK, Scott AK: A study of the relationship between the pharmacokinetics and the pharmacodynamics of the anticoagulants difenacoum and brodifacoum in the rabbit. Br J Pharmacol. 1985 Jan;84(1):81-91. The pharmacological response to the anticoagulants was measured as changes in prothrombin complex activity, from which the rate of clotting factor synthesis was determined. |
1(0,0,0,1) | Details |
| 2330467 | Nighoghossian N, Ruel JH, Ffrench P, Froment JC, Trouillas P: [Cervicodorsal subdural hematoma caused by coumarinic rodenticide poisoning]. Rev Neurol. 1990;146(3):221-3. Prothrombin complex activity was low. |
1(0,0,0,1) | Details |
| 1056964 | Hadler MR, Redfern R, Rowe FP: Laboratory evaluation of difenacoum as a rodenticide. J Hyg. 1975 Jun;74(3):441-8. Prothrombin assays indicated that the compound had as marked an activity with -resistant common rats as coumatetralyl had with non-resistant animals. |
1(0,0,0,1) | Details |
| 16499407 | Watt BE, Proudfoot AT, Bradberry SM, Vale JA: Anticoagulant rodenticides. Toxicol Rev. 2005;24(4):259-69. This group includes the second generation 4-hydroxycoumarins brodifacoum, bromadiolone, difenacoum, flocoumafen and the indanedione derivatives chlorophacinone and diphacinone. |
0(0,0,0,0) | Details |