| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17222583 | Xu S, Wu A, Chen H, Xie Y, Xu Y, Zhang L, Li J, Zhang D: Production of a novel recombinant Drosophila melanogaster acetylcholinesterase for detection of organophosphate and insecticide residues. Biomol Eng. 2007 Jun;24(2):253-61. Epub 2006 Dec 22. The bimolecular rate constants of R-DmAChE to dichlorvos, aldicarb and carbaryl were ranging from three to six times higher than of native DmAChE. |
4(0,0,0,4) | Details |
| 12018594 | Parveen M, Kumar S: Effect of DDVP on the histology and AChE kinetics of heart muscles of Rattus norvegicus. J Environ Biol. 2001 Oct;22(4):257-61. |
3(0,0,0,3) | Details |
| 17157343 | Dekundy A, Kaminski RM, Zielinska E, Turski WA: antagonists exert distinct effects in experimental organophosphate or poisoning in mice. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):114-21. Epub 2006 Nov 6. Organophosphate (OP) and acetylcholinesterase (AChE) inhibitors produce seizures and lethality in mammals. In the present study, the effects of dizocilpine (MK-801, 1 mg/kg) or 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP, 10 mg/kg), alone or combined with muscarinic antagonist atropine (1.8 mg/kg), on convulsant and lethal properties of an OP pesticide dichlorvos or a drug physostigmine, were studied in mice. |
3(0,0,0,3) | Details |
| 3421541 | Khan AA, Coppock RW, Schuler MM, Lillie LE: In vitro and in vivo effects of dichlorvos on blood cholinesterase activities of cattle. Am J Vet Res. 1988 Jul;49(7):1184-7. Treatment in vitro of erythrocytes and plasma with DDVP resulted in concentration- and time-dependent inhibition of erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (ChE) activities. |
3(0,0,0,3) | Details |
| 8585661 | Sarasola P, McKellar QA: Pharmacokinetics of bacampicillin in equids. Am J Vet Res. 1995 Nov;56(11):1486-92. Plasma pseudocholinesterase and erythrocyte acetylcholinesterase activities were reduced to < 5% of reference (predichlorvos) values after dichlorvos administration. |
81(1,1,1,1) | Details |
| 11842237 | Boublik Y, Saint-Aguet P, Lougarre A, Arnaud M, Villatte F, Estrada-Mondaca S, Fournier D: Acetylcholinesterase engineering for detection of insecticide residues. Protein Eng. 2002 Jan;15(1):43-50. The greatest improvement was for the sensitivity to dichlorvos for which a mutant was 300-fold more sensitive than the Drosophila wild-type enzyme and 288 000-fold more sensitive than the electric eel enzyme, the enzyme commonly used to detect organophosphate and |
3(0,0,0,3) | Details |
| 6255749 | Owczarczyk H, Gajewski D, Kisielinski T: Effect of preceding physostigmine administration on neuromuscular transmission disturbances in rats caused by dichlorphos and phospholine. Acta Physiol Pol. 1980 Jul-Aug;31(4):431-8. Physostigmine effect on the blockade of tetanic muscular contractions was studied after administration of these organophosphate inhibitors of acetylcholinesterase. |
3(0,0,0,3) | Details |
| 2340983 | Ikeda T, Kojima T, Yoshida M, Takahashi H, Tsuda S, Shirasu Y: Pretreatment of rats with an organophosphorus insecticide, chlorfenvinphos, protects against subsequent challenge with the same compound. Fundam Appl Toxicol. 1990 Apr;14(3):560-7. The CVP pretreatment did not appreciably change the toxicities of the cholinergic agonists, carbachol and oxotremorine, but significantly increased the toxicity of another organophosphate, dichlorvos. Oral treatment of rats with CVP (15 mg/kg) inhibited brain acetylcholinesterase (AChE) activity. |
3(0,0,0,3) | Details |
| 3113033 | Nistiarova A, Nistiar F, Bajgar J: [Use of sheep erythrocytes and plasma for the determination of neuroparalytic substances in vitro]. Vet Med. 1987 Jun;32(6):365-9. Dichlorvos administered at the rate of 94.64 ng per litre induced 50% inhibition of acetylcholinesterase in the erythrocytes; administration of dichlorvos at the rate of 243.82 ng per litre caused a 50% inhibition of butyrylcholinesterase in the plasma. |
81(1,1,1,1) | Details |
| 12389909 | Sanchez-Hernandez JC, Sanchez BM: Lizard cholinesterases as biomarkers of pesticide exposure: enzymological characterization. Environ Toxicol Chem. 2002 Nov;21(11):2319-25. Serum and brain tissue of the lizard Gallotia galloti were used as ChE sources and in vitro assays were performed to identify acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Serum was incubated with different doses of the organophosphorus (OP) compounds dichlorvos and paraoxon and subsequently incubated in the presence of two concentrations of 2-PAM (2 x 10 (-2) or 2 x 10 (-4) M). |
3(0,0,0,3) | Details |
| 10365643 | Dingemanse J, Halabi A, Kleinbloesem CH, Heinig R, Blume H: Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor metrifonate in patients with renal impairment. Ther Drug Monit. 1999 Jun;21(3):310-6. Blood and urine samples were collected for 24 hours and concentrations of metrifonate and its metabolites dichlorvos, dichloroacetic acid, and M3 were determined. |
3(0,0,0,3) | Details |
| 7234437 | Gajewski D: Acetylcholinesterase activity in several rat liver cell fractions after repeated poisoning with some organophosphates. Acta Physiol Pol. 1980 Sep-Oct;31(5):575-80. |
3(0,0,0,3) | Details |
| 19379766 | Olmos C, Sandoval R, Rozas C, Navarro S, Wyneken U, Zeise M, Morales B, Pancetti F: Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: involvement of acylpeptide hydrolase and alpha (7) nicotinic receptors. Toxicol Appl Pharmacol. 2009 Jul 1;238(1):37-46. Epub 2009 Apr 18. A few years ago it was reported that dichlorvos inhibits the enzyme acylpeptide hydrolase at lower doses than those necessary to inhibit acetylcholinesterase to the same extent. |
63(0,2,2,3) | Details |
| 7233448 | Rath S, Misra BN: Toxicological effects of dichlorvos (DDVP) on brain and liver acetylcholinesterase (AChE) activity of Tilapia mossambica, Peters. Toxicology. 1981;19(3):239-45. Acetylcholinesterase (AChE) activity of T. mossambica in relation to the interacting effects of aging and sub-lethal concentrations of Dichlorvos was studied. |
41(0,1,2,6) | Details |
| 19680907 | Chen C, Li Y, Chen M, Chen Z, Qian Y: Organophosphorus pesticide residues in milled rice (Oryza sativa) on the Chinese market and dietary risk assessment. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Mar;26(3):340-7. The present study investigates the occurrence of acetylcholinesterase (AChE)-inhibiting organophosphorus (OP) pesticide residues in milled rice samples obtained form local markets in China during the period 2004-2006 and estimates their cumulative exposure. The results showed that 9.3% of the samples contained detectable residues of at least one of the seven target OP pesticides (chlorpyrifos, dichlorvos, omethoate, methamidophos, parathion-methyl, parathion and triazophos) mainly used for agriculture in China, with concentrations ranging 0.011-1.756 mg kg (-1). |
3(0,0,0,3) | Details |
| 9515941 | Ehrich M, Correll L: Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters. J Toxicol Environ Health A. 1998 Mar 13;53(5):385-99. CbxE are thought to protect the critical enzyme acetylcholinesterase (AChE) from OP inhibition in animals. Therefore, this study examined concentration-related OP-induced inhibition of CbxE in human SH-SY5Y and mouse NB41A3 neuroblastoma cells with 11 active esterase inhibitors: paraoxon, malaoxon, chlorpyrifos-oxon, tolyl saligenin (TSP), phenyl saligenin (PSP), diisopropyl phosphorofluoridate (DFP), mipafox, dichlorvos, trichlorfon, dibutyryl dichlorovinyl (DBVP), and dioctyl dichlorovinyl (DOVP). |
3(0,0,0,3) | Details |
| 9397501 | Mohammad FK, Faris GA, al-Kassim NA: A modified electrometric method for measurement of erythrocyte acetylcholinesterase activity in sheep. Vet Hum Toxicol. 1997 Dec;39(6):337-9. The method was used to demonstrate in vitro inhibition of sheep EChE activity by the organophosphorus and insecticides dichlorvos and methomyl, respectively. |
2(0,0,0,2) | Details |
| 9268605 | Ehrich M, Correll L, Veronesi B: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63. Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). |
37(0,1,1,7) | Details |
| 15556357 | Vakurov A, Simpson CE, Daly CL, Gibson TD, Millner PA: Acetylcholinesterase-based biosensor electrodes for organophosphate pesticide detection. Biosens Bioelectron. 2004 Dec 15;20(6):1118-25. The detection limit of the biosensors produced by non-covalent immobilization of acetylcholinesterase onto polyethyleneimine modified carbon electrodes was found to be about 10 (-10) M for the organophosphate pesticide dichlorvos. |
35(0,1,1,5) | Details |
| 2640774 | Horsberg TE, Hoy T, Nafstad I: Organophosphate poisoning of Atlantic salmon in connection with treatment against salmon lice. Acta Vet Scand. 1989;30(4):385-90. The strongest inhibition of brain AChE was found in association with the highest dichlorvos residues. |
33(0,1,1,3) | Details |
| 12884618 | Wang XG, Zhen TM, Tan WB, Wang HW, Gong MQ, Sun CH, Zhao YQ: [The correlation between DDVP resistance of Culex pipiens pallens and esterase activity]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21(2):90-2. The AChE average inhibition rate decreased with the extended generation and increased resistance, and the individual frequency of those with inhibition rate less than 30% became strengthened with the extension of generations, showing a positive correlation. |
2(0,0,0,2) | Details |
| 11526466 | Racchi M, Sironi M, Caprera A, Konig G, Govoni S: Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein. Mol Psychiatry. 2001 Sep;6(5):520-8. We have investigated the acute and chronic effect of metrifonate (MTF) and dichlorvos (DDVP), respectively the prodrug and active acetylcholinesterase inhibitor, on the secretory processing of the amyloid precursor protein (APP) in SH-SY5Y neuroblastoma cells. |
33(0,1,1,3) | Details |
| 2301824 | Khan AA, Coppock RW, Schuler MM, Lillie LE: Effects of dichlorvos on blood cholinesterase activities of cattle. Am J Vet Res. 1990 Jan;51(1):79-82. Inhibitory effects of dichlorvos (2,2-dichlorovinyl dimethyl DDVP) [corrected] on erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (ChE) activities of steers were characterized after treatments in vitro and in vivo (cutaneous application). |
32(0,1,1,2) | Details |
| 8083479 | Kobayashi H, Sato I, Akatsu Y, Fujii S, Suzuki T, Matsusaka N, Yuyama A: Effects of single or repeated administration of a propoxur, and an organophosphate, DDVP, on jejunal cholinergic activities and contractile responses in rats. J Appl Toxicol. 1994 May-Jun;14(3):185-90. Wistar rats were injected once or repeatedly for 10 days with dichlorvos (DDVP, 5 mg kg-1), propoxur (10 mg kg-1), oxotremorine (0.1 mg kg-1) or atropine (5 mg kg-1). Single treatments: while DDVP and propoxur decreased acetylcholinesterase (AChE) activity, oxotremorine and atropine did not. |
2(0,0,0,2) | Details |
| 11053541 | Hamers T, Molin KR, Koeman JH, Murk AJ: A small-volume bioassay for quantification of the esterase inhibiting potency of mixtures of organophosphate and insecticides in rainwater: development and optimization. Toxicol Sci. 2000 Nov;58(1):60-7. Purified acetylcholinesterase (AChE) from electric eel (Electrophorus electricus) and carboxylesterases from a homogenate of honeybee heads (Apis mellifera) were used as esterases, each having different affinities for the substrates S-acetylthiocholine-iodide (ATC) and N-methylindoxylacetate (MIA). This dose-dependent instant inhibition can be quantified with kinetics for competitive inhibition at dichlorvos concentrations < 16 nM. |
2(0,0,0,2) | Details |
| 18423506 | Sultatos LG, Kaushik R: Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):390-6. Epub 2008 Mar 15. |
164(2,2,2,4) | Details |
| 3216102 | Dambska M, Maslinska D: Morphological changes after acetylcholinesterase (AChE) inhibition by dichlorvos (DDVP) in young rabbit brain. J Hirnforsch. 1988;29(5):569-71. |
164(2,2,2,4) | Details |
| 119426 | Maslinski S, Ciurzynska G, Maslinska D: Dichlorvos intoxication and gastric secretion. . Acta Physiol Pol. 1979 Sep-Dec;30(5-6):657-60. Gastric acid secretion, pepsin concentration in gastric juice and acetylcholinesterase and histidine decarboxylase activities in gastric mucosa of rats treated with dichlorvos (DDVP) were investigated. |
32(0,1,1,2) | Details |
| 7344417 | Johnson MK: Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?. Acta Pharmacol Toxicol. 1981;49 Suppl 5:87-98. In vitro the inhibitory power of dichlorvos against neurotoxic esterase of hen brain is 0.02 x the power against acetylcholinesterase. |
31(0,1,1,1) | Details |
| 718420 | Nordgren I, Bergstrom M, Holmstedt B, Sandoz M: Transformation and action of metrifonate. Arch Toxicol. 1978 Oct 13;41(1):31-41. The effect of metrifonate and dichlorvos on levels, acetylcholinesterase activity and synthesis rate of in mouse brain was also studied. |
31(0,1,1,1) | Details |
| 17017223 | Cui F, Raymond M, Berthomieu A, Alout H, Weill M, Qiao CL: Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae). J Med Entomol. 2006 Sep;43(5):878-83. Bioassays performed with a purified G119S strain indicated that this substitution was associated with high levels of resistance to chlorpyrifos, fenitrothion, malathion, and parathion, but low levels of resistance to dichlorvos, trichlorfon, and fenthion. |
2(0,0,0,2) | Details |
| 8714762 | Hai DQ, Varga IS, Matkovics B: Effects of an organophosphate on the antioxidant systems of fish tissues. Acta Biol Hung. 1995;46(1):39-50. The effect of a Hungarian made and applied insecticide, organophosphate (Dichlorvos) on antioxidant enzymes and other oxidative and redox parameters of two different fish species, carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) was studied. From antioxidant enzymes, changes in superoxide dismutase, catalase, peroxidase and, in the case of carp, acetylcholinesterase activities were studied in tissue homogenates. |
2(0,0,0,2) | Details |
| 20026515 | Dwivedi N, Bhutia YD, Kumar V, Yadav P, Kushwaha P, Swarnkar H, Flora SJ: Effects of combined exposure to dichlorvos and monocrotophos on blood and brain biochemical variables in rats. Hum Exp Toxicol. 2010 Feb;29(2):121-9. Epub 2009 Dec 21. We studied the effect of concomitant exposure to DDVP and MC on selected biochemical variables suggestive of liver damage, changes in whole brain biogenic amines levels, acetylcholinesterase (AchE) and monoamine oxidase (MAO) activities in rats. |
2(0,0,0,2) | Details |
| 4656609 | Bueding E, Liu CL, Rogers SH: Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes. Br J Pharmacol. 1972 Nov;46(3):480-7. Administration of a possible metabolite of metrifonate, dichlorvos, to hamsters resulted in a greater inhibition of AChE and ChE activities of S. haematobium than those of S. mansoni. |
162(2,2,2,2) | Details |
| 15033007 | Dai XF, Zhou ZJ, Gu XA, Sun YG, Zheng G, Zheng J: [Protective effect of memantine on N-methyl-D-aspartate receptor in dichlorvos-poisoned rat brain]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):11-4. The activity of acetylcholinesterase (AChE) and binding capacity of NMDA receptor with [(3) H] MK-801 were determined 16 h after dichlorvos injection. |
162(2,2,2,2) | Details |
| 19101586 | Verma SK, Kumar V, Gill KD: An acetylcholinesterase-independent mechanism for neurobehavioral impairments after chronic low level exposure to dichlorvos in rats. Pharmacol Biochem Behav. 2009 Mar;92(1):173-81. Epub 2008 Dec 3. |
162(2,2,2,2) | Details |
| 15622723 | Hasan M, Ali SF: Organophosphate pesticide dichlorvos-induced increase in the rate of lipid peroxidation in the different regions of the rat brain: supporting ultrastructural findings. Neurotoxicology. 1981 Jan;2(1):43-52. Using dose-dependent inhibition of acetylcholinesterase activity as an index of its neurotoxicity, effects of three different doses of dichlorvos (0.6 mg, 1.5 mg, and 3.0 mg/kg body weight i.p. daily for 10 days) have been observed on the rate of lipid-peroxidation in the cerebrum, cerebellum and brain stem of albino rats. |
31(0,1,1,1) | Details |
| 15741058 | Law KA, Higson SP: Sonochemically fabricated acetylcholinesterase micro-electrode arrays within a flow injection analyser for the determination of organophosphate pesticides. Biosens Bioelectron. 2005 Apr 15;20(10):1914-24. The enzymatic response of the sensors is inhibited upon incubation with the pesticide, and we have shown that Dichlorvos, Parathion and Azinphos may be determined down to concentrations of approximately 1 x 10 (-17) M, approximately 1 x 10 (-16) M and approximately 1 x 10 (-16) M, respectively. |
2(0,0,0,2) | Details |
| 9474819 | Rippeth JJ, Gibson TD, Hart JP, Hartley IC, Nelson G: Flow-injection detector incorporating a screen-printed disposable amperometric biosensor for monitoring organophosphate pesticides. Analyst. 1997 Nov;122(11):1425-9. This system was initially employed in studies to stabilise the enzyme acetylcholinesterase (AChE), which was immobilised on a phthalocyanine screen-printed carbon electrode to form a biosensor. Flow-injection and biosensor conditions were optimised, then the system was evaluated by monitoring the model organophosphate pesticides (OP) dichlorvos and paraoxon. |
2(0,0,0,2) | Details |
| 17171303 | Bolton-Warberg M, Coen LD, Weinstein JE: Acute toxicity and acetylcholinesterase inhibition in grass shrimp (Palaemonetes pugio) and oysters (Crassostrea virginica) exposed to the organophosphate dichlorvos: laboratory and field studies. Arch Environ Contam Toxicol. 2007 Feb;52(2):207-16. |
124(1,2,4,4) | Details |
| 16023296 | Gupta SC, Siddique HR, Saxena DK, Chowdhuri DK: Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Biochim Biophys Acta. 2005 Aug 30;1725(1):81-92. |
113(1,2,2,3) | Details |
| 17665685 | Assis CR, Amaral IP, Castro PF, Carvalho LB, Bezerra RS: Effect of dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) brain. Environ Toxicol Chem. 2007 Jul;26(7):1451-3. Dichlorvos is an acutely toxic organophosphorous pesticide that is known as a classical acetylcholinesterase (AChE; EC 3.1.1.7) inhibitor. |
107(0,3,5,7) | Details |
| 7713347 | Ehrich M, Jortner BS, Padilla S: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam Appl Toxicol. 1995 Jan;24(1):94-101. Inhibition of neuropathy target esterase (NTE, neurotoxic esterase) and acetylcholinesterase (AChE) activities was compared in brain and spinal cords of adult While Leghorn hens and adult male Long Evan rats 4-48 hr after administration of triortho-tolyl (TOTP po, 50-500 mg/kg to hens; 300-1000 mg/kg to rats), phenyl saligenin (PSP im 0.1-2.5 mg/kg to hens; 5-24 mg/kg to rats), mipafox (3-30 mg/kg ip to hens and rats), diisopropyl phosphorofluoridate (DFP sc, 0.25-1.0 mg/kg to hens; 1-3 mg/kg to rats), dichlorvos (5-60 mg/kg ip to hens; 600-2000 mg/kg to rats), and carbaryl (300-560 mg/kg ip to hens; 30-170 mg/kg to rats). |
95(0,3,3,5) | Details |
| 16449251 | Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE: Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicol Sci. 2006 May;91(1):166-72. Epub 2006 Jan 31. In an overview, inhibition of 28 serine hydrolases (including lipases) by eight OPs (chlorpyrifos oxon, diazoxon, paraoxon, dichlorvos, and four nonpesticides) showed that brain acetylcholinesterase is usually less sensitive than butyrylcholinesterase, liver esterase, cholesterol esterase, and KIAA1363. |
31(0,1,1,1) | Details |
| 1587340 | Julka D, Pal R, Gill KD: Neurotoxicity of dichlorvos: effect on antioxidant defense system in the rat central nervous system. Exp Mol Pathol. 1992 Apr;56(2):144-52. In the present paper an inhibition of acetylcholinesterase activity was used as an index of dichlorvos neurotoxicity. |
31(0,1,1,1) | Details |
| 2619560 | Moretto A, Lotti M, Spencer PS: In vivo and in vitro regional differential sensitivity of neuropathy target esterase to di-n-butyl-2,2-dichlorovinyl Arch Toxicol. 1989;63(6):469-73. With doses up to 4.0 mg/kg s.c., acetylcholinesterase (AChE) inhibition was similar throughout the nervous system. |
2(0,0,0,2) | Details |
| 7218377 | Kobayashi H, Yuyama A, Imajo S, Matsusaka N: Effects of acute and chronic administration of DDVP (dichlorvos) on distribution of brain in rats. J Toxicol Sci. 1980 Nov;5(4):311-9. In acutely treated animals (4 mg/kg, singly), cholinergic signs were evident and accompanied with a 100, 146, 113, and 61 per cent increase in total, free, labile-bound and stable-bound content of the brain, respectively, and a 66 per cent decrease in acetylcholinesterase (AChE) activity 20 min after injection. |
2(0,0,0,2) | Details |
| 17533655 | Lin YW, Wu G, Miyata T: Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. Pest Manag Sci. 2007 Sep;63(9):841-50. The average AChE activity inhibition by methamidophos and dichlorvos in 34-60 adults of the two parasitoids that emerged from the treatments (15.1% and 31.8% respectively for C. plutellae, and 21.1% and 26.9% for D. rapae) was also significantly lower than those of the controls (55.4% and 48.3% respectively for C. plutellae, and 42.9% and 51.7% for D. rapae). |
94(1,1,3,4) | Details |
| 18970653 | Wong FC, Ahmad M, Heng LY, Peng LB: An optical biosensor for dichlovos using stacked sol-gel films containing acetylcholinesterase and a lipophilic chromoionophore. Talanta. 2006 Jun 15;69(4):888-93. Epub 2006 Jan 4. Based on the optimum incubation time of 15min, a linear calibration curve of dichlorvos against the percentage inhibition of AChE was obtained from 0.5 to 7mg/L of dichlorvos (17-85% inhibition, R (2)=0.991, n=9). |
90(1,1,2,5) | Details |
| 15861238 | Wang JJ, Cheng WX, Ding W, Zhao ZM: The effect of the insecticide dichlorvos on esterase activity extracted from the psocids, Liposcelis bostrychophila and L. entomophila. J Insect Sci. 2004;4:23. Epub 2004 Jul 14. The inhibition kinetics of dichlorvos on carboxylesterase and acetylcholinesterase (AChE) activity extracted from Liposcelis bostrychophila and L. entomophila (Psocoptera: Liposcelididae) were compared. |
88(1,1,2,3) | Details |
| 1143525 | Schmidt G, Schmidt M, Nenner M: Proceedings: Inhibition of acetylcholinesterase in the bronchial system of rats caused by inhalation of dichlorvos. Naunyn Schmiedebergs Arch Pharmacol. 1975;287 Suppl:R97. |
31(0,1,1,1) | Details |
| 15568361 | Wu G, Jiang S, Miyata T: Seasonal changes of methamidophos susceptibility and biochemical properties in Plutella xylostella (Lepidoptera: Yponomeutidae) and its parasitoid Cotesia plutellae (Hymenoptera: Braconidae). J Econ Entomol. 2004 Oct;97(5):1689-98. Methamidophos resistance and acetylcholinesterase (AChE) insensitivity to methamidophos, dichlorvos, and carbofuran were determined in the field populations of Plutella xylostella (L.) (Lepidoptera: Yponomeutidae) and its parasitoid Cotesia plutellae Kurdjumov (Hymenoptera: Braconidae) collected from the corresponding hosts between October 1998 and December 2003 in Fuzhou and Minhou, Fijian, China. |
23(0,0,3,8) | Details |
| 18663432 | Valdes-Ramirez G, Cortina M, Ramirez-Silva MT, Marty JL: Acetylcholinesterase-based biosensors for quantification of carbofuran, carbaryl, methylparaoxon, and dichlorvos in 5% acetonitrile. Anal Bioanal Chem. 2008 Oct;392(4):699-707. Epub 2008 Jul 29. |
19(0,0,3,4) | Details |
| 15525694 | Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3. The classical laboratory tests for exposure to organophosphorus toxicants (OP) are inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in blood. In vitro experiments with human plasma showed that chlorpyrifos oxon, echothiophate, malaoxon, paraoxon, methyl paraoxon, diazoxon, diisopropylfluorophosphate, and dichlorvos competed with FP- for binding to human albumin. |
2(0,0,0,2) | Details |
| 19145051 | Kavalci C, Durukan P, Ozer M, Cevik Y, Kavalci G: Organophosphate poisoning due to a wheat bagel. Intern Med. 2009;48(2):85-8. Epub 2009 Jan 15. Organophosphate compounds cause poisoning, inhibiting acetylcholinesterase at the cholinergic synapses. |
2(0,0,0,2) | Details |
| 8231460 | Moriearty PL, Thornton SL, Becker RE: Transdermal patch delivery of acetylcholinesterase inhibitors. . Methods Find Exp Clin Pharmacol. 1993 Jul-Aug;15(6):407-12. |
2(0,0,0,2) | Details |
| 8783813 | Worek F, Kirchner T, Backer M, Szinicz L: Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503. For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. |
84(1,1,1,4) | Details |
| 18970436 | Shi M, Xu J, Zhang S, Liu B, Kong J: A mediator-free screen-printed amperometric biosensor for screening of organophosphorus pesticides with flow-injection analysis (FIA) system. Talanta. 2006 Feb 15;68(4):1089-95. Epub 2005 Aug 16. A wide linear inhibition response for dichlorvos, typical OP, is observed in the range of 0.1-80muM, corresponding to 7.91-84.94% inhibition for AChE. |
84(1,1,1,4) | Details |
| 16786864 | Del Carlo M, Pepe A, De Gregorio M, Mascini M, Marty JL, Fournier D, Visconti A, Compagnone D: An electrochemical bioassay for dichlorvos analysis in durum wheat samples. J Food Prot. 2006 Jun;69(6):1406-11. The use of an acetylcholinesterase inhibition assay for the detection of dichlorvos in durum wheat samples by a simplified extraction procedure is reported. |
83(1,1,1,3) | Details |
| 19449386 | Anguiano GA, Amador A, Moreno-Legorreta M, Arcos-Ortega F, Vazquez-Boucard C: Effects of exposure to oxamyl, carbofuran, dichlorvos, and lindane on acetylcholinesterase activity in the gills of the Pacific oyster Crassostrea gigas. Environ Toxicol. 2009 May 15. |
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| 475593 | Schmidt G, Schmidt M, Nenner M, Vetterlein F: Effects of dichlorvos (DDVP) inhalation on the activity of acetylcholinesterase in the bronchial tissue of rats. Arch Toxicol. 1979 Jul 11;42(3):191-8. |
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| 15797338 | Sotiropoulou S, Fournier D, Chaniotakis NA: Genetically engineered acetylcholinesterase-based biosensor for attomolar detection of dichlorvos. Biosens Bioelectron. 2005 May 15;20(11):2347-52. |
15(0,0,2,5) | Details |
| 10421489 | Richards P, Johnson M, Ray D, Walker C: Novel protein targets for organophosphorus compounds. Chem Biol Interact. 1999 May 14;119-120:503-11. The 30 kDa band was found to be more sensitive to paraoxon, dichlorvos and diazoxon than acetylcholinesterase. |
13(0,0,2,3) | Details |
| 10975133 | Mason HJ: The recovery of plasma cholinesterase and erythrocyte acetylcholinesterase activity in workers after over-exposure to dichlorvos. Occup Med. 2000 Jul;50(5):343-7. |
9(0,0,1,4) | Details |
| 9206589 | Hai DQ, Varga SI, Matkovics B: Organophosphate effects on antioxidant system of carp (Cyprinus carpio) and catfish (Ictalurus nebulosus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 May;117(1):83-8. The effect of the organophosphate insecticide Dichlorvos on antioxidant enzymes and other oxidative and redox parameters of carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) were studied. Changes in superoxide dismutase, catalase, peroxidase, and in the case of carp acetylcholinesterase activities were studied in tissue homogenates. |
2(0,0,0,2) | Details |
| 3945941 | Kobayashi H, Yuyama A, Chiba K: Cholinergic system of brain tissue in rats poisoned with the organophosphate, 0,0-dimethyl 0-(2,2-dichlorovinyl) Toxicol Appl Pharmacol. 1986 Jan;82(1):32-9. Acetylcholinesterase (AChE) activity decreased to between 12 and 43% of the control over a period of 5 to 180 min and recovered almost completely within 24 hr after injection. |
2(0,0,0,2) | Details |
| 10421444 | Radic Z, Taylor P: The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. Chem Biol Interact. 1999 May 14;119-120:111-7. |
2(0,0,0,2) | Details |
| 9504975 | Tripathi AM, Agarwal RA: Molluscicidal and anti-AChE activity of tertiary mixtures of pesticides . Arch Environ Contam Toxicol. 1998 Apr;34(3):271-4. We studied the toxicity and in vivo inhibition of acetylcholinesterase (AChE) by the organophosphate Nuvan (dichlorvos); Nuvan mixed with a mixed function oxidase inhibitor, piperonyl butoxide (PB); Nuvan with a pyrethroid Decis (deltamethrin); and a tertiary mixture of Nuvan, PB, and Decis in the snail Lymnaea acuminata. |
83(1,1,1,3) | Details |
| 18569613 | Rajini PS, Melstrom P, Williams PL: A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides. J Toxicol Environ Health A. 2008;71(15):1043-50. The toxicity of 10 organophophorus (OP) insecticides-acephate, dimethoate, dichlorvos, dicrotophos, monocrotophos, methamidophos, phosphamidon, omethoate, phosdrin, and trichlorfon-was evaluated in Caenorhabditis elegans using lethality, movement, and acetylcholinesterase (AChE) activity as the endpoints after a 4-hr- exposure period. |
9(0,0,1,4) | Details |
| 17723708 | Dondoi MP, Bucur B, Danet AF, Toader CN, Barthelmebs L, Marty JL: Organophosphorus insecticides extraction and heterogeneous oxidation on column for analysis with an acetylcholinesterase (AChE) biosensor. Anal Chim Acta. 2006 Sep 25;578(2):162-9. Epub 2006 Jul 8. The LODs of the AChE biosensor without sample preconcentration were 8 x 10 (-8) M for paraoxon and 1 x 10 (-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10 (-8) M for paraoxon and 2.5 x 10 (-8) M for dichlorvos. |
9(0,0,1,4) | Details |
| 13677510 | Pena-Llopis S, Ferrando MD, Pena JB: Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with Dis Aquat Organ. 2003 Aug 4;55(3):237-45. |
8(0,0,1,3) | Details |
| 10826201 | Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71. Assays of acetylcholinesterase sensitivity to inhibition by methiocarb, dichlorvos, and eserine suggested insensitive acetylcholinesterase in two of the resistant populations. |
82(1,1,1,2) | Details |
| 18371703 | Valdes-Ramirez G, Fournier D, Ramirez-Silva MT, Marty JL: Sensitive amperometric biosensor for dichlorovos quantification: Application to detection of residues on apple skin. Talanta. 2008 Jan 15;74(4):741-6. Epub 2007 Jul 10. This paper presents the construction of an amperometric biosensor for the highly sensitive detection of the organophosphorus insecticide dichlorvos, based on the inhibition of acetylcholinesterase (AChE). |
82(1,1,1,2) | Details |
| 15679473 | Antonijevic B, Bokonjic D, Stojiljkovic MP, Kilibarda V, Milovanovic ZA, Nedeljkovic M, Maksimovic M: Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. Basic Clin Pharmacol Toxicol. 2005 Feb;96(2):111-7. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. |
82(1,1,1,2) | Details |
| 8359835 | Purshottam T, Kaveeshwar U: Comparative efficacy of exogenous acetylcholinesterase administration on soman and dichlorvos toxicity in rats. Indian J Exp Biol. 1993 Apr;31(4):365-8. |
8(0,0,1,3) | Details |
| 19830865 | Li SG: [Differences of acetylcholinesterase level in variety classes and strains of Culex pipiens pallens]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Sep;38(5):511-4. |
8(0,0,0,8) | Details |
| 11246494 | Chuiko GM: Comparative study of acetylcholinesterase and butyrylcholinesterase in brain and serum of several freshwater fish: specific activities and in vitro inhibition by DDVP, an organophosphorus pesticide. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Dec;127(3):233-42. |
8(0,0,0,8) | Details |
| 3927568 | Nistiar F, Hrusovsky J, Mojzis J: [The effect of dichlorvos and metathion on selected enzymes of the amoeba Tetrahymena pyriformis]. Vet Med. 1985 Jul;30(7):443-7. The effect of dichlorvos and metathion was studied as exerted on acetylcholinesterase activity in the protozoan Tetrahymena pyriformis. |
7(0,0,1,2) | Details |
| 18049927 | Pancetti F, Olmos C, Dagnino-Subiabre A, Rozas C, Morales B: Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):623-30. This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer's disease. |
7(0,0,1,2) | Details |
| 10953051 | Richards PG, Johnson MK, Ray DE: Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol Pharmacol. 2000 Sep;58(3):577-83. We show that, in vivo, acylpeptide hydrolase is significantly more sensitive than AChE to inhibition by dichlorvos and that the inhibition is more prolonged after a single dose of inhibitor. |
82(1,1,1,2) | Details |
| 6849937 | Das YT, Brown HD, Chattopadhyay SK: Microcalorimetric determination of binding sites of acetylcholinesterase. . Biochim Biophys Acta. 1983 May 30;745(1):107-10. Acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7), phosphorylated with dichlorvos, showed relatively more reactivity toward the substrate indophenyl than the enzyme that was carbamylated with carbaryl. |
82(1,1,1,2) | Details |
| 19202558 | Jadhav KB, Rajini PS: Evaluation of sublethal effects of dichlorvos upon Caenorhabditis elegans based on a set of end points of toxicity. J Biochem Mol Toxicol. 2009 Jan;23(1):9-17. The primary objective of this study was to examine a possible correlation among the three endpoints of toxicity, namely, stress gene expression (hsp16), feeding, and acetylcholinesterase (AChE) activity in transgenic C. elegans (hsp16-lacZ) exposed to sublethal concentrations of dichlorvos, an organophosphorus insecticide. |
7(0,0,1,2) | Details |
| 600389 | Gadamski R, Szumanska G: [Effect of Dichlorvos intoxication (DDVP) on acetylcholinesterase activity of rat brain] Neuropatol Pol. 1977 Oct-Dec;15(4):537-44. |
6(0,0,1,1) | Details |
| 10472753 | Sweeney RE, Maxwell DM: A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning. Math Biosci. 1999 Sep;160(2):175-90. A system of coupled non-linear differential equations describing interactions between organophosphorus compounds (OPs), OP hydrolase, acetylcholinesterase (AChE), and carboxylesterase (CaE) in a single compartment was derived incorporating irreversible combination of OP with AChE, hydrolytic breakdown of OP, and irreversible combination of OP with CaE. |
6(0,0,0,6) | Details |
| 18775593 | Laguerre C, Sanchez-Hernandez JC, Kohler HR, Triebskorn R, Capowiez Y, Rault M, Mazzia C: B-type esterases in the snail Xeropicta derbentina: an enzymological analysis to evaluate their use as biomarkers of pesticide exposure. Environ Pollut. 2009 Jan;157(1):199-207. Epub 2008 Sep 4. Acetylcholinesterase activity was concentration-dependently inhibited by chlorpyrifos-oxon, dichlorvos, carbaryl and carbofuran (IC50=1.35x10 (-5)-3.80x10 (-8) M). |
82(1,1,1,2) | Details |
| 14568351 | Pena-Llopis S, Ferrando MD, Pena JB: Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by Aquat Toxicol. 2003 Dec 10;65(4):337-60. The present work studied the effects of the antioxidant and pro-drug N-acetyl- (NAC) on the survival of a natural population of A. anguilla exposed to a lethal concentration of dichlorvos, focusing on the glutathione metabolism and the enzyme activities of acetylcholinesterase (AChE) and caspase-3 as biomarkers of neurotoxicity and induction of apoptosis, respectively. |
6(0,0,1,1) | Details |
| 9586870 | Sarin S, Gill KD: Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure. Pharmacol Biochem Behav. 1998 Apr;59(4):1081-6. The acetylcholinesterase activity was also appreciably decreased following dichlorvos exposure. |
6(0,0,1,1) | Details |
| 4017989 | Omkar, Shukla GS: Nature of dichlorvos intoxication in a freshwater prawn, Macrobrachium lamarrei (H. Environ Res. 1985 Aug;37(2):349-54. Milne Edwards) to a lethal dose (96-hr LC50;0.78 mg/l) of dichlorvos for 24, 48, 72, and 96 hr induced inhibition in acetylcholinesterase and alkaline phosphatase activities and enhanced acid phosphatase activity. |
81(1,1,1,1) | Details |
| 1609424 | Maxwell DM: The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds. Toxicol Appl Pharmacol. 1992 Jun;114(2):306-12. Endogenous CaE provided significant protection against the in vivo toxicity of soman, sarin, tabun, and paraoxon, but not against dichlorvos, diisopropyl fluorophosphate, or ethoxymethyl-S-[2-(diisopropylamino) ethyl] thiophosphonate (VX). The relationship between the in vivo CaE protection against OP compounds and their relative reactivities with CaE and acetylcholinesterase (AChE) was evaluated by measuring the in vitro bimolecular rate constants (ki) for inhibition of plasma CaE and brain AChE. |
5(0,0,0,5) | Details |
| 1494302 | Moriearty PL, Becker RE: Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). Methods Find Exp Clin Pharmacol. 1992 Oct;14(8):615-21. |
5(0,0,0,5) | Details |
| 16598855 | Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P: Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. Biochem Biophys Res Commun. 2006 Apr 14;342(3):973-8. |
4(0,0,0,4) | Details |
| 19100812 | Verma SK, Raheja G, Gill KD: Role of muscarinic signal transduction and CREB phosphorylation in dichlorvos-induced memory deficits in rats: an independent mechanism. Toxicology. 2009 Feb 27;256(3):175-82. Epub 2008 Dec 3. The present study was designed to explore the alternative mechanism (other than AChE inhibition) for chronic, low-level exposure to dichlorvos, an organophosphate, in vivo. |
81(1,1,1,1) | Details |
| 1609489 | Raina R, Srivastava AK, Malik JK: The influence of monoxime on dichlorvos-induced enzymatic changes in buffalo calves. Vet Hum Toxicol. 1992 Jun;34(3):218-20. Dichlorvos given po at 160 mg/kg body weight produced pronounced inhibition of erythrocyte acetylcholinesterase (AChE) and elevation in serum aminotransferases and phosphatases within 30 min. 2,3-BM administered alone or in conjunction with atropine to dichlorvos-exposed calves significantly reactivated erythrocyte AChE activity whereas atropine was ineffective. |
81(1,1,1,1) | Details |
| 15578596 | Fallang A, Ramsay JM, Sevatdal S, Burka JF, Jewess P, Hammell KL, Horsberg TE: Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Kroyer). Pest Manag Sci. 2004 Dec;60(12):1163-70. From the mid-1990s the organophosphates dichlorvos and azamethiphos were seriously compromised by the development of resistance. |
4(0,0,0,4) | Details |
| 17188317 | Kobayashi H, Suzuki T, Sakamoto M, Hashimoto W, Kashiwada K, Sato I, Akahori F, Satoh T: Brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):151-61. Epub 2006 Nov 11. |
4(0,0,0,4) | Details |
| 6636207 | Kobayashi H, Yuyama A, Kudo M, Matsusaka N: Effects of organophosphorus compounds, O,O-dimethyl O-(2,2-dichlorovinyl) (DDVP) and O,O-dimethyl O-(3-methyl phosphorothioate (fenitrothion), on brain content and acetylcholinesterase activity in Japanese quail. Toxicology. 1983;28(3):219-27. |
4(0,0,0,4) | Details |
| 1363306 | Pavlov DD, Chuiko GM, Gerassimov YV, Tonkopiy VD: Feeding behavior and brain acetylcholinesterase activity in bream (Abramis brama L.) as affected by DDVP, an organophosphorus insecticide. Comp Biochem Physiol C. 1992 Nov;103(3):563-8. |
4(0,0,0,4) | Details |
| 12660363 | Dekundy A, Kaminski RM, Turski WA: Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice. Toxicol Sci. 2003 Apr;72(2):289-95. Coinjection of MEC (at both doses studied) and MK-801 completely prevented seizures produced by both acetylcholinesterase (AChE) inhibitors. Mice were administered anticholinesterase pesticides dichlorvos (DDVP) or methomyl (MET). |
1(0,0,0,1) | Details |
| 2537085 | Traverso R, Moretto A, Lotti M: Human serum "A"-esterases. Biochem Pharmacol. 1989 Feb 15;38(4):671-6. When incubated with human serum, DDVP was losing its inhibitory power toward acetylcholinesterase (AChE). |
1(0,0,0,1) | Details |
| 8723267 | Wirth MC, Georghiou GP: Organophosphate resistance in Culex pipiens from Cyprus. J Am Mosq Control Assoc. 1996 Mar;12(1):112-8. All population samples generally revealed organophosphate resistance to malathion, temephos, chlorpyrifos, fenthion, dichlorvos, and pirimiphos methyl, in decreasing order of magnitude. Resistance was associated with the presence of 5 different overproduced esterases (esterases A1, A2, A5, B2, and B5) as well as an insensitive form of acetylcholinesterase. |
1(0,0,0,1) | Details |
| 6685446 | Mohammad FK, St Omer VE: Interaction of dichlorvos-crotoxyphos insecticide with phenothiazine anthelmintic in sheep with or without Haemonchus and Trichostrongylus infections. Am J Vet Res. 1983 Oct;44(10):1949-53. Onset of clinical signs of toxicosis, lethality, and erythrocyte acetylcholinesterase (EACE) activity were monitored. |
1(0,0,0,1) | Details |
| 18368617 | Taylor JT, Davis E, Dabisch P, Horsmon M, Matson K, Crouse C, Mioduszewski R: Acute toxic effects of inhaled dichlorvos vapor on respiratory mechanics and blood cholinesterase activity in guinea pigs. Inhal Toxicol. 2008 Mar;20(5):465-72. An analysis of whole-blood cholinesterase activity revealed significantly decreased activity for both acetylcholinesterase (AChE) and butyl-cholinesterase (BChE). |
1(0,0,0,1) | Details |
| 8784247 | Bassant MH, Jazat-Poindessous F, Lamour Y: Effects of metrifonate, a cholinesterase inhibitor, on local cerebral utilization in young and aged rats. J Cereb Blood Flow Metab. 1996 Sep;16(5):1014-25. The effects of the centrally acting anti-cholinesterase metrifonate (MFT) and its metabolite dichlorvos (2,2-dichlorovinyl dimethyl DDVP) on local cerebral utilization (LCGU) have been studied in 3- and 27-month-old rats, using the autoradiographic [14C] deoxyglucose technique. Regional distributions of MFT- and DDVP-induced increases in LCGU were similar and overlapped the distribution of the acetylcholinesterase activity. |
1(0,0,0,1) | Details |
| 4139992 | Karnak RE, Collins WJ: The susceptibility to selected insecticides and acetylcholinesterase activity in a laboratory colony of midge larvae, Chironomus tentans (diptera: chironomidae). Bull Environ Contam Toxicol. 1974 Jul;12(1):62-9. |
1(0,0,0,1) | Details |
| 8424827 | Kaltner H, Andrae S, Wittmann J: Activity of cholinesterases in the Japanese quail embryo. Biochem Pharmacol. 1993 Jan 7;45(1):87-92. By using BW284c51 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one and ISO-OMPA tetraisoprophylpyrophosphoramide as inhibitors, it was found that the enzyme in the embryo is predominantly acetylcholinesterase (EC 3.1.1.7), whereas that in the yolk and subembryonic liquid is butyrylcholinesterase (EC 3.1.1.8). |
1(0,0,0,1) | Details |
| 16302752 | Longobardi F, Solfrizzo M, Compagnone D, Del Carlo M, Visconti A: Use of electrochemical biosensor and gas chromatography for determination of dichlorvos in wheat. J Agric Food Chem. 2005 Nov 30;53(24):9389-94. The electrochemical assay was based on the detection of the acetylcholinesterase product, via a oxidase biosensor. |
1(0,0,0,1) | Details |
| 15824473 | Zhou Z, Dai X, Gu X, Sun Y, Zheng G, Zheng J: Memantine alleviates toxicity induced by dichlorvos in rats. J Occup Health. 2005 Mar;47(2):96-101. The binding capacity of NMDA receptor and acetylcholinesterase activity were determined at 4 h, 8 h, 16 h, 24 h and 48 h after treatment. |
1(0,0,0,1) | Details |
| 3666870 | Naidu KA, Viswanatha S, Krishnakumari MK: Cardiotoxic effects of dichlorvos (DDVP) in albino rats. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):19-24. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. |
1(0,0,0,1) | Details |
| 19779279 | Okamura A, Kamijima M, Ohtani K, Yamanoshita O, Nakamura D, Ito Y, Miyata M, Ueyama J, Suzuki T, Imai R, Takagi K, Nakajima T: Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophosphorus pesticides in rats. J Occup Health. 2009;51(6):478-87. Epub 2009 Sep 25. METHODS: Ten-week-old Wistar rats were divided into 4 groups (n=10) and orally administered corn oil, dichlorvos (DDVP; 5, 10 mg/kg) or diazinon (DZN; 3 mg/kg) 6 days a week for 9 wk. |
0(0,0,0,0) | Details |
| 17615116 | Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53. We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo. |
0(0,0,0,0) | Details |
| 16036766 | Petroianu GA, Schmitt A, Arafat K, Hasan MY: Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride. Int J Toxicol. 2005 Mar-Apr;24(2):79-86. Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood and butyrylcholinesterase (BChE) activities in human plasma were measured photometrically in the presence of different DDVP and TIA concentrations and IC50 was calculated. |
1(0,0,0,1) | Details |
| 1439591 | Kassa J: [The therapeutic effect of diazepam in dichlorvos poisoning] . Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1992;35(1):59-72. There was smaller decrease in activity of acetylcholinesterase in CNS and diaphragm compared with untreated intoxication. |
1(0,0,0,1) | Details |
| 12143930 | Varo I, Navarro JC, Amat F, Guilhermino L: Characterisation of cholinesterases and evaluation of the inhibitory potential of chlorpyrifos and dichlorvos to Artemia salina and Artemia parthenogenetica. Chemosphere. 2002 Aug;48(6):563-9. |
0(0,0,0,0) | Details |
| 1914997 | Dunier M, Siwicki AK, Demael A: Effects of organophosphorus insecticides: effects of trichlorfon and dichlorvos on the immune response of carp (Cyprinus carpio). Ecotoxicol Environ Saf. 1991 Aug;22(1):79-87. |
0(0,0,0,0) | Details |
| 4035678 | Volpe LS, Biagioni TM, Marquis JK: In vitro modulation of bovine caudate muscarinic receptor number by organophosphates and carbamates. Toxicol Appl Pharmacol. 1985 Apr;78(2):226-34. Diethyl-p-nitrophenyl (paraoxon; PX), dichlorvos (DDVP), and tetraethyl (TEPP) were demonstrated to be weak noncompetitive receptor inactivators. |
0(0,0,0,0) | Details |
| 6939284 | Maslinska D, Lewandowska I, Prokopczyk J: Effect of prolonged acetylcholinesterase inhibition on postnatal brain development in rabbit. Acta Neuropathol Suppl. 1981;7:52-5. Studies were performed on young rabbits treated with dichlorvos (organophosphorus pesticide) 9 mg/kg/day by oral gavage. |
1(0,0,0,1) | Details |
| 17223333 | Vamvakaki V, Chaniotakis NA: Pesticide detection with a liposome-based nano-biosensor. Biosens Bioelectron. 2007 Jun 15;22(12):2848-53. Epub 2007 Jan 16. Monitoring of the organophosphorus pesticides dichlorvos and paraoxon at very low levels has been achieved with liposome-based nano-biosensors. The enzyme acetylcholinesterase was effectively stabilized within the internal nano-environment of the liposomes. |
1(0,0,0,1) | Details |
| 7344413 | Sterri SH: Factors modifying the toxicity of organophosphorus compounds including dichlorvos. Acta Pharmacol Toxicol. 1981;49 Suppl 5:67-71. |
0(0,0,0,0) | Details |
| 2026213 | O'Leary KA, Tracy JW: Schistosoma mansoni: glutathione S-transferase-catalyzed detoxication of dichlorvos. Exp Parasitol. 1991 May;72(4):355-61. |
0(0,0,0,0) | Details |
| 7351088 | Eriksson H, Faijersson Y: A reliable way of estimating cholinesterases from whole blood in the presence of anti-cholinesterases. Clin Chim Acta. 1980 Jan 15;100(2):165-71. The cholinesterases in blood samples, which were dried on filter papers, could be eluted with water (plasma cholinesterase) and with 1% Triton X-100 (erythrocyte acetylcholinesterase) with complete recovery of the enzyme activity. |
1(0,0,0,1) | Details |
| 8740539 | Jokanovic M, Kosanovic M, Maksimovic M: Interaction of organophosphorus compounds with carboxylesterases in the rat. Arch Toxicol. 1996;70(7):444-50. Carboxylesterases (CarbE) are involved in detoxication of organophosphorus compounds (OPC) through two mechanisms: hydrolysis of ester bonds in OPC which contain them and binding of OPC at the active site of CarbE which reduces the amount of OPC available for acetylcholinesterase inhibition. This study of the interaction of rat plasma and liver CarbE with dichlorvos, soman and sarin in vitro and in vivo was undertaken in order to contribute to better understanding of the role of CarbE in detoxication of OPC. |
1(0,0,0,1) | Details |
| 8579882 | Schulz H, Nagymajtenyi L, Desi I: Life-time exposure to dichlorvos affects behaviour of mature rats. Hum Exp Toxicol. 1995 Sep;14(9):721-6. AChE activity in the brain and in blood at sacrifice was roughly 40% to 65% of control, again reflecting the doses administered. |
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| 11219744 | Neufeld T, Eshkenazi I, Cohen E, Rishpon J: A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosens Bioelectron. 2000 Aug;15(5-6):323-9. The system traces very small quantities of OP by monitoring the enzymatic reaction of acetylcholine esterase (AChE) and its inhibition. |
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| 10509429 | Abdelsalam EB: potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2. The potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens. All compounds were administered at high single oral doses and the NTE and acetylcholinesterase (AchE) activities were measured at 24 h and 6 w later. |
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| 1276991 | Ecobichon DJ: Species differences in the reactivation of organophosphate-inhibited plasma esterases by diacetylmonoxime. Can J Physiol Pharmacol. 1976 Apr;54(2):86-92. In contrast, DAM protected the rabbit against a lethal dose of DFP but only reactivation of the erythrocyte acetylcholinesterase was observed. |
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| 1877982 | Reddy MS, Rao KV: Phosphamidon, methylparathion and dichlorvos impact on tissue oxidative metabolism in penaeid prawn, Metapenaeus monoceros. Biochem Int. 1991 Feb;23(3):439-47. The OPI are found to inhibit the activity levels of acetylcholinesterase, succinate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase, lactate dehydrogenase and cytochrome-c-oxidase and cause accumulation of in the hepatopancreas and muscle tissues. |
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| 17722737 | Raheja G, Gill KD: Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain. Toxicol Ind Health. 2007 Feb;23(1):25-37. Activity of the synthesizing enzyme of ie, choline acetyltransferase, was found to be significantly increased and the activity of hydrolyzing enzyme, acetyl cholinesterase (AChE), was inhibited in all the three brain regions studied. |
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| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. The ratio of inhibitory powers for acetylcholinesterase and NTE represents the crucial guideline for the aetiological attribution of OP-induced peripheral neuropathy. In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates. |
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| 744539 | Maslinska D, Zalewska Z: Effect of dichlorvos, administered to the pregnant rabbits, on the colinesterases activity in the progeny. Folia Histochem Cytochem. 1978;16(4):335-41. The decrease of acetylcholinesterase activity in the brain tissue and the increase of cholinesterase activity in the blood plasma were observed. |
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| 12325258 | Chuiko GM, Podgornaia VA, Lavrikova IV: [Phosphororganic compound O,O-dimethyl-O-(2,2-dichlorovinyl) as a selective inhibitor for separate analysis of the roach Rutilus rutilus acetylcholinesterase and butylcholinesterase activities ] Zh Evol Biokhim Fiziol. 2002 May-Jun;38(3):203-7. |
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| 18433895 | Varo I, Amat F, Navarro JC: Acute toxicity of dichlorvos to Aphanius iberus (Cuvier & Valenciennes, 1846) and its anti-cholinesterase effects on this species. Aquat Toxicol. 2008 Jun 2;88(1):53-61. Epub 2008 Mar 14. These results indicate that in the head and muscle the predominant ChE form is acetylcholinesterase (AChE) for both sexes. |
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| 2904862 | Price NR: Insecticide-insensitive acetylcholinesterase from a laboratory selected and a field strain of housefly (Musca domestica) (L.). Comp Biochem Physiol C. 1988;90(1):221-4. The enzyme from resistant insects was also more tolerant to malaoxon, dichlorvos and bomyl but not to azamethiphos. 3. |
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| 617949 | Simon G, Lengyel A, Szucs A: Erythrocyte acetylcholinesterase activity is not affected by adenovirus-induced haemagglutination. Haematologia. 1977;11(3-4):265-8. The haemagglutination titre of the adenoviruses did not decrease when RBCs with AChE inhibited by dichlorvos or eserine were used. The AChE inactivating effect of substances such as tannic acid and glutaraldehyde, among others, might be due to a non-specific damage of the RBC membrane. |
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| 12190811 | Sener EB, Ustun E, Kocamanoglu S, Tur A: Prolonged apnea following succinylcholine administration in undiagnosed acute organophosphate poisoning. Acta Anaesthesiol Scand. 2002 Sep;46(8):1046-8. Organophosphates (OP) are irreversibly bound to cholinesterase, causing deactivation of acetylcholinesterase. |
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| 4024446 | Mohammad FK, St Omer VV: Toxicity and interaction of topical organophosphate insecticide dichlorvoscrotoxyphos and phenothiazine anthelmintic in sheep previously exposed to both drugs. Vet Hum Toxicol. 1985 Jun;27(3):181-4. The erythrocyte acetylcholinesterase (EACE) activities of the D-C exposed groups were significantly (P less than 0.05) depressed on post-treatment days (PTD) 1 and 3 regardless of the PTZ treatment. |
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| 3672530 | Pauluhn J, Machemer L, Kimmerle G: Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct 30;46(2):177-90. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the propoxur. |
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| 18644713 | Valdes-Ramirez G, Gutierrez M, Del Valle M, Ramirez-Silva MT, Fournier D, Marty JL: Automated resolution of dichlorvos and methylparaoxon pesticide mixtures employing a Flow Injection system with an inhibition electronic tongue. Biosens Bioelectron. 2009 Jan 1;24(5):1103-8. Epub 2008 Jun 21. The sensors used were three screen-printed amperometric biosensors that incorporated three different acetylcholinesterase enzymes: the wild type from Electric eel and two different genetically modified enzymes, B1 and B394 mutants, from Drosophila melanogaster. |
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| 17698511 | Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O: Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci. 2007 Nov;100(1):136-45. Epub 2007 Aug 13. Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P (O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). Our work utilized matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry to study the aging mechanism of human BChE inhibited by dichlorvos, echothiophate, diisopropylfluorophosphate (DFP), isomalathion, soman, sarin, cyclohexyl sarin, VX, and VR. |
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| 15793557 | Isoda H, Talorete TP, Han J, Oka S, Abe Y, Inamori Y: Effects of organophosphorous pesticides used in china on various mammalian cells. Environ Sci. 2005;12(1):9-19. Five organophosphorous pesticides, monocrotophos, omethoate, parathion-methyl, phoxim and dichlorvos, were examined for their effects on mammalian cell lines to determine their potential impact on physiological functions in vivo. The different pesticides reduced the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 in a dose-dependent manner up to 100 microM. |
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| 2339420 | Silveira CL, Eldefrawi AT, Eldefrawi ME: Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases. Toxicol Appl Pharmacol. 1990 May;103(3):474-81. Acetylcholinesterases are the primary targets for these OP compounds because of the irreversible nature of their inhibition, which results in building of concentrations that activate muscarinic and nicotinic receptors and desensitize them, thereby inhibiting respiration. Other OP insecticides had lower potencies, inhibiting less than 50% of 5 nM [3H] CD binding by 1 microM of EPN, coumaphos, dioxathion, dichlorvos, or chlorpyriphos. |
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| 16193528 | Petroianu GA, Hasan MY, Arafat K, Nurulain SM, Schmitt A: Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. J Appl Toxicol. 2005 Nov-Dec;25(6):562-7. Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood and butyrylcholinesterase (BChE) activities in human plasma were measured photometrically in the presence of different POX and TIA concentrations and the IC (50) was calculated. The purpose of the study was to quantify in vitro the extent that TIA conferred protection, using paraoxon (POX) as an inhibitor, and to compare the results with existing data obtained using TIA as a protective agent against dichlorvos (DDVP). |
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| 15811534 | Bentley GN, Jones AK, Agnew A: Expression and comparative functional characterisation of recombinant acetylcholinesterase from three species of Schistosoma. Mol Biochem Parasitol. 2005 May;141(1):119-23. |
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| 4006839 | Omkar, Shukla GS: Dichlorvos intoxication in a freshwater prawn, Macrobrachium lamarrei (H. Ecotoxicol Environ Saf. 1985 Jun;9(3):392-6. Inhibition in acetylcholinesterase and alkaline phosphatase activities with an elevation in acid phosphatase activity were recorded in a freshwater prawn, Macrobrachium lamarrei (H. |
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| 235931 | Reiner E, Krauthacker B, Simeon V, Skrinjaric-Spoljar M: Mechanism of inhibition in vitro of mammalian acetylcholinesterase and cholinesterase in solutions of 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethyl phosphonate (Trichlorphon). Biochem Pharmacol. 1975 Mar 15;24(6):717-22. |
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| 15888665 | Quistad GB, Klintenberg R, Casida JE: Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Toxicol Sci. 2005 Aug;86(2):291-9. Epub 2005 May 11. The most potent in vitro inhibitors for human erythrocyte and mouse brain APH are DFP (IC (50) 11-17 nM), chlorpyrifos oxon (IC (50) 21-71 nM), dichlorvos (IC (50) 230-560 nM), naled (IC (50) 370-870 nM), and their analogs with modified alkyl substituents. (3) H-diisopropyl fluorophosphate is a potent inhibitor of mouse blood and brain APH in vivo (ED (50) 0.09-0.2 mg/kg and 0.02-0.03 mg/l for ip and vapor exposure, respectively). Sarin administered ip at a lethal dose to guinea pigs inhibits blood acetylcholinesterase and BChE completely but erythrocyte APH only partially. |
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| 6933967 | Brzezinski J, Wysocka-Paruszewska B: Neurochemical alterations in rat brain as a test for studying the neurotoxicity of organophosphorus insecticides. Arch Toxicol Suppl. 1980;4:475-8. Male Wistar rats were acutely and chronically intoxicated with organophosphorus insecticides (OPI)-chlorfenvinphos, dichlorvos and fenitrothion. The effects on brain acetylcholine esterase activity (AChE) and (NE) level were determined. |
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