| Name | CDK5 |
|---|---|
| Synonyms | CDK 5; CDK5; CDK5 protein; Cell division kinase 5; Cell division protein kinase 5; Cyclin dependent kinase 5; PSSALRE; Serine/threonine protein kinase PSSALRE… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18948252 | Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Izumi T, Yamauchi K, Hisanaga S, Pessin JE, Mori M: CDK5-dependent phosphorylation of the Rho family GTPase TC10 (alpha) regulates insulin-stimulated GLUT4 translocation. J Biol Chem. 2008 Dec 19;283(51):35455-63. Epub 2008 Oct 23. |
5(0,0,0,5) | Details |
| 15152189 | Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST: A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J. 2004 Jun 2;23(11):2235-45. Epub 2004 May 20. |
3(0,0,0,3) | Details |
| 9933594 | Fletcher AI, Shuang R, Giovannucci DR, Zhang L, Bittner MA, Stuenkel EL: Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. J Biol Chem. 1999 Feb 12;274(7):4027-35. |
2(0,0,0,2) | Details |
| 11268215 | Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P: Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. 2001 Mar 15;410(6826):376-80. Here we identify cyclin-dependent kinase 5 (Cdk5) as a downstream target gene of DeltaFosB by use of DNA array analysis of striatal material from inducible transgenic mice. |
1(0,0,0,1) | Details |
| 19944738 | Choi HS, Chung SH: Roscovitine increases intracellular release and capacitative entry in PC12 cells. Neurosci Lett. 2010 Jan 18;469(1):141-4. Epub 2009 Nov 26. Cyclin-dependent kinase 5 (Cdk5), which is activated by the non-cyclin regulator p35 or p39, is a -directed serine/threonine kinase that is implicated in many physiological and pathological processes. |
1(0,0,0,1) | Details |
| 10465404 | Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Giocanti N, Sadri R, Favaudon V: Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. Bioorg Med Chem. 1999 Jul;7(7):1281-93. Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts. |
2(0,0,0,2) | Details |
| 11923424 | Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li ST, Takei K, Matsui H: Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci. 2002 Apr 1;22(7):2590-7. Cyclin-dependent kinase 5 (Cdk5) is a -directed serine/threonine kinase with close structural homology to the mitotic Cdks. |
1(0,0,0,1) | Details |
| 15240808 | Li C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T, Nakamura F, Yagi T, Ohshima T, Goshima Y: Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E. J Neurosci. 2004 Jul 7;24(27):6161-70. We found previously that a Src type kinase Fyn and cyclin-dependent kinase 5 (Cdk5) mediate Sema3A-signaling. |
1(0,0,0,1) | Details |
| 10495356 | Gray N, Detivaud L, Doerig C, Meijer L: ATP-site directed inhibitors of cyclin-dependent kinases. . Curr Med Chem. 1999 Sep;6(9):859-75. They also play a role in apoptosis (CDK2), in neuronal cells (CDK5) and in the control of transcription (CDK 7, 8, 9). |
1(0,0,0,1) | Details |
| 17360491 | Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb JA: Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4147-52. Epub 2007 Feb 23. Cyclin-dependent kinase 5 (Cdk5) regulates striatal signaling and is a downstream target gene of the transcription factor DeltaFosB, which accumulates in striatal neurons after chronic cocaine exposure. |
1(0,0,0,1) | Details |
| 14743398 | Sharma MR, Tuszynski GP, Sharma MC: Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem. 2004 Feb 1;91(2):398-409. Cyclin-dependent kinase-5 (cdk5) is expressed in neuronal cells and plays an important role in neurite outgrowth, of neuronal migration and neurogenesis, its functions in non-neuronal cells are unclear. |
1(0,0,0,1) | Details |