Protein Information

Name MDM2
Synonyms Double minute 2 protein; HDM 2; HDM2; HDM2 HD1 protein; HDM2 HD2 protein; HDM2 HD3 protein; HDM2 HD4 protein; HDM2 HD5 protein…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
18045764 Lee MH, Kim YA, Na TY, Kim SH, Shin YK, Lee BH, Shin HS, Lee MO: Identification of formaldehyde-responsive genes by suppression subtractive hybridization. Toxicology. 2008 Jan 14;243(1-2):224-35. Epub 2007 Oct 22.

We identified 27 different formaldehyde-inducible genes, including those coding for the major histocompatibility complex, class IA, calcyclin, glutathione S-transferase pi, mouse double minute 2 (MDM2), platelet-derived growth factor receptor alpha, and which are known to be associated with cell proliferation and differentiation, immunity and inflammation, and detoxification.
87(1,1,2,2) Details
19193609 Bousquet-Dubouch MP, Baudelet E, Guerin F, Matondo M, Uttenweiler-Joseph S, Burlet-Schiltz O, Monsarrat B: Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. Mol Cell Proteomics. 2009 May;8(5):1150-64. Epub 2009 Feb 3.

The benefit of in vivo formaldehyde cross-linking as a stabilizer of protein-protein interactions was studied by comparing the status of purified proteasomes and the identified proteins in both protocols (with or without formaldehyde cross-linking).
One of them, the ubiquitin-specific protease USP7, also known as HAUSP, is an important player in the p53-HDM2 pathway.
1(0,0,0,1) Details