Protein Information

Name dopamine transporter
Synonyms DA transporter; DAT1; DAT; DAT 1; Dopamine transporter; SLC6A3; Sodium dependent dopamine transporter; Dopamine transporters…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
16005927 Elwan MA, Richardson JR, Guillot TS, Caudle WM, Miller GW: Pyrethroid pesticide-induced alterations in dopamine transporter function. . Toxicol Appl Pharmacol. 2006 Mar 15;211(3):188-97. Epub 2005 Jul 11.

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12428726 Bloomquist JR, Barlow RL, Gillette JS, Li W, Kirby ML: Selective effects of insecticides on nigrostriatal dopaminergic nerve pathways. Neurotoxicology. 2002 Oct;23(4-5):537-44.


Western blot analysis confirmed increased levels of dopamine transporter (DAT) protein in the striatum of mice treated with heptachlor and permethrin.
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19748499 Tayebati SK, Di Tullio MA, Ricci A, Amenta F: Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry. Brain Res. 2009 Dec 8;1301:180-8. Epub 2009 Sep 11.


These findings indicate that dermal exposure to the pyrethroid insecticide deltamethrin using an administration module mimicking a possible long-lasting occupational skin contact is accompanied by cerebrocortical injury and loss of hippocampal and striatal dopamine and dopamine transporter.
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