Protein Information

Name gamma aminobutyric acid receptor (protein family or complex)
Synonyms GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors

Compound Information

Name aldicarb
CAS

Reference List

PubMed Abstract RScore(About this table)
19066504 Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G: Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants. J Vis Exp. 2008 Aug 18;(18). pii: 837. doi: 10.3791/837.

In this video, we describe how two complementary neural stimulants, an acetylcholinesterase inhibitor, called aldicarb, and a gamma-aminobutyric acid (GABA) receptor antagonist, called pentylenetetrazole (PTZ), may be employed to specifically characterize signaling at C. elegans neuromuscular junctions (NMJs) and facilitate our understanding of antagonistic neural circuits.
31(0,1,1,1) Details
19545405 Whittaker AJ, Sternberg PW: Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior. BMC Biol. 2009 Jun 22;7:33.


Gamma-aminobutyric acid activity is required for both dorsal and ventral acetylcholine-induced curling of the male tail and an inhibitory gamma-aminobutyric acid receptor, UNC-49, prevents over-curling of the male tail during mating, suggesting that cross-inhibition of muscle groups helps maintain proper tail posture.
1(0,0,0,1) Details