| Name | thyroid hormone receptor (protein family or complex) |
|---|---|
| Synonyms | Thyroid hormone receptor; Thyroid hormone receptors |
| Name | nitrofen |
|---|---|
| CAS | 2,4-dichloro-1-(4-nitrophenoxy)benzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7947941 | Brandsma AE, Tibboel D, Vulto IM, de Vijlder JJ, Ten Have-Opbroek AA, Wiersinga WM: Inhibition of T3-receptor binding by Nitrofen. . Biochim Biophys Acta. 1994 Nov 11;1201(2):266-70. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. |
81(1,1,1,1) | Details |
| 11685700 | Teramoto H, Guarino N, Puri P: Altered gene level expression of thyroid hormone receptors alpha-1 and beta-1 in the lung of nitrofen-induced diaphragmatic hernia. J Pediatr Surg. 2001 Nov;36(11):1675-8. |
6(0,0,1,1) | Details |
| 15585367 | Yamada-Okabe T, Sakai H, Kashima Y, Yamada-Okabe H: Modulation at a cellular level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4'-diiodobiphenyl (DIB), and nitrofen (NIP). Toxicol Lett. 2005 Jan 15;155(1):127-33. By screening 38 chemical agents, it was found that 4,4'-diiodobiphenyl (DIB), markedly, and 1,2,5,6,9,10-hexabromocyclododecane (HBCD) and nitrofen (NIP), to a much lesser extent but significantly, enhanced the expression of the luciferase gene at concentrations that did not affect the growth of HeLaTR cells. |
2(0,0,0,2) | Details |
| 9859898 | Causak RA, Zgleszewski SE, Zhang L, Cilley RE, Krummel TM, Chinoy MR: Differential gene expression at gestational days 14 and 16 in normal and -induced hypoplastic murine fetal lungs with coexistent diaphragmatic hernia. Pediatr Pulmonol. 1998 Nov;26(5):301-11. This sequence also had similarity to lipid-binding proteins. 2) On Gd 16, hypoplastic lungs had one cDNA sequence with reduced expression which had 82% similarity with thyroid hormone receptor gene exon 1 and two other cDNA sequences with enhanced expressions. The purpose of this study was to identify differentially expressed genes in normal and nitrofen-induced hypoplastic lungs in fetal mice. |
2(0,0,0,2) | Details |
| 19853750 | Doi T, Sugimoto K, Puri P: Prenatal up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia. J Pediatr Surg. 2009 Oct;44(10):1933-7. Chicken ovalbumin upstream promoter-transcription (COUP-TFII) is a transcription factor in the steroid/thyroid hormone receptor superfamily, and targeted ablation of COUP-TFII causes CDH and associated lung hypoplasia in mice. MATERIALS AND METHODS: Pregnant rats were exposed to either olive oil or 100 mg nitrofen on day 9 of gestation (D9). 5 mg/kg of RA was given intraperitoneally on days D18, D19, and D20. |
1(0,0,0,1) | Details |
| 11477730 | Chinoy MR, Chi X, Cilley RE: Down-regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: altered mesenchymal-epithelial interactions. Pediatr Pulmonol. 2001 Aug;32(2):129-41. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastrically on gestational day 8 [Gd8]), as published earlier. Further, the nuclear transcription factors thyroid transcription factor-1 (TITF-1) and glucocorticoid receptor (GR) were reduced, and thyroid hormone receptor (TR) and receptors (RARs) were inhibited in severely hypoplastic lungs compared to normal lungs of equivalent gestational stage, except in neonatal lungs, where signals for RARs were seen. |
1(0,0,0,1) | Details |
| 17065567 | Rajatapiti P, Keijzer R, Blommaart PE, Lamers WH, DE Krijger RR, Visser TJ, Tibboel D, Rottier R: Spatial and temporal expression of glucocorticoid, retinoid, and thyroid hormone receptors is not altered in lungs of congenital diaphragmatic hernia. Pediatr Res. 2006 Dec;60(6):693-8. Epub 2006 Oct 25. To determine their therapeutic potential in hypoplastic lungs of CDH patients, the temporal and spatial expression of glucocorticoid receptor, thyroid hormone receptors, receptors, and retinoid X receptors were evaluated in lungs of CDH patients, hypoplastic lungs from other causes, and normal lungs. As a series of supportive experiments, the expressions of these receptors were analyzed in lungs of nitrofen-induced CDH rats. |
1(0,0,0,1) | Details |