Protein Information

Name retinal S antigen
Synonyms 48 kDa protein; SAG; ARRESTIN; Retinal S antigen; Rod photoreceptor arrestin; S AG; S Antigen; S Arrestin…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
8258322 Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B: TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur J Immunol. 1993 Dec;23(12):3096-103.

Mercuric chloride (HgCl2) injections protect (Lewis x Brown-Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S-Ag); in contrast HgCl2-injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S-Ag alone.
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1424735 Saoudi A, Bellon B, de Kozak Y, Druet P: Adoptive transfer of experimental autoimmune uveoretinitis in HgCl2 injected rats. Curr Eye Res. 1992;11 Suppl:101-5.

We previously demonstrated that mercuric chloride (HgCl2) injected-(Lewis x Brown-Norway) F1 rats are protected against experimental autoimmune uveoretinitis (EAU) induced by active immunization with the retinal S-antigen (S-Ag).
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2384007 Saoudi A, Bellon B, de Kozak Y, Vial MC, Thillaye B, Druet P: Inhibition of experimental autoimmune uveoretinitis by mercuric chloride injections in (Lewis x Brown Norway) F1 hybrid rats. Curr Eye Res. 1990;9 Suppl:135-8.

Experimental autoimmune uveoretinitis (EAU), induced in (LEW X BN) F1 rats by immunization with S antigen (S-Ag) is T cell and antibody (ab) mediated and anti-S-Ag IgE ab have been involved in the occurrence of ocular lesions. (LEW X BN) F1 rats repeatedly injected with HgCl2 develop an autoimmune disease characterized by numerous auto-ab and a high increase of serum IgE level.
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1748484 Saoudi A, Bellon B, de Kozak Y, Kuhn J, Vial MC, Thillaye B, Druet P: Prevention of experimental autoimmune uveoretinitis and experimental autoimmune pinealitis in (Lewis x Brown-Norway) F1 rats by HgCl2 injections. Immunology. 1991 Oct;74(2):348-54.

Mercuric chloride (HgCl2) induces in Brown-Norway (BN) and (Lewis x Brown-Norway) F1 hybrid rats a transient autoimmune disease characterized by the production of various antibodies to self and non-self antigens and by a dramatic increase of serum IgE.
Experimental autoimmune uveoretinitis (EAU) can be induced in Lewis (LEW) and (LEW x BN) F1 hybrid rats by a single immunization with retinal S-antigen (S-Ag).
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