Protein Information

Name phosphatidylinositol specific
Synonyms PLC beta 3; Phosphoinositide phospholipase C; PLCB 3; PLCB3; Phosphatidylinositol specific; Phospholipase C beta 3; Phosphatidylinositol specifics; Phospholipase C beta 3s

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
20045694 Almeida-Amaral EE, Cardoso VC, Francioli FG, Meyer-Fernandes JR: Leishmania amazonensis: heme stimulates (Na (+)+K (+)) ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways. Exp Parasitol. 2010 Apr;124(4):436-41. Epub 2010 Jan 4.

2(0,0,0,2) Details
10938438 Narita M, Ohsawa M, Mizoguchi H, Aoki T, Suzuki T, Tseng LF: Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord. Neuroscience. 2000;99(2):327-31.

2(0,0,0,2) Details
18191462 Schmolke M, Fabian J, Lehr M: High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C. Anal Biochem. 2008 Apr 15;375(2):291-8. Epub 2007 Dec 25.

2(0,0,0,2) Details
11557588 Sano A, Zhu X, Sano H, Munoz NM, Boetticher E, Leff AR: Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA (2). Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L844-51.

1(0,0,0,1) Details
12140177 Wang CT, Loch-Caruso R: Phospholipase-mediated inhibition of spontaneous oscillatory uterine contractions by lindane in vitro. Toxicol Appl Pharmacol. 2002 Jul 15;182(2):136-47.


Pretreatment with 20-50 microM of the phosphatidylinositol-specific phospholipase C inhibitor 1-O-octadecyl-2-O-methyl-sn-glycerol-3-phosphorylcholine (ET-18-OCH (3)) reversed lindane-induced inhibition of spontaneous uterine contractions.
1(0,0,0,1) Details
17363325 Lukinovic-Skudar V, Matkovic K, Banfic H, Visnjic D: Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G (1) phase of the cell cycle. Biochim Biophys Acta. 2007 Apr;1771(4):514-21. Epub 2007 Feb 13.


Phosphatidylinositol-specific phospholipase C (PI-PLC) is activated in cell nuclei during the cell cycle progression.
1(0,0,0,1) Details