| Name | melanoma associated antigen |
|---|---|
| Synonyms | CLL associated antigen KW 1; CLL associated antigen KW 1 splice variant 1; CLL associated antigen KW 1 splice variant 2; Melanoma associated antigen; CLL associated antigen KW 1 splice variant 1s; CLL associated antigen KW 1 splice variant 2s; Melanoma associated antigens |
| Name | MAA |
|---|---|
| CAS | methylarsonic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18829565 | Maciag PC, Seavey MM, Pan ZK, Ferrone S, Paterson Y: Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature. Cancer Res. 2008 Oct 1;68(19):8066-75. |
2(0,0,0,2) | Details |
| 9466650 | Cormier JN, Hijazi YM, Abati A, Fetsch P, Bettinotti M, Steinberg SM, Rosenberg SA, Marincola FM: Heterogeneous expression of melanoma-associated antigens and HLA-A2 in metastatic melanoma in vivo. Int J Cancer. 1998 Feb 9;75(4):517-24. |
2(0,0,0,2) | Details |
| 3900230 | Natali P, Bigotti A, Cavalieri R, Wakabayaski S, Taniguchi M, Ferrone S: Distribution of a cross-species melanoma-associated antigen in normal and neoplastic human tissues. J Invest Dermatol. 1985 Oct;85(4):340-6. |
2(0,0,0,2) | Details |
| 8416734 | Chen ZJ, Yang H, Liu CC, Hirai S, Ferrone S: Modulation by adjuvants and carriers of the immunogenicity in xenogeneic hosts of mouse anti-idiotypic monoclonal antibody MK2-23, an internal image of human high molecular weight-melanoma associated antigen. Cancer Res. 1993 Jan 1;53(1):112-9. |
2(0,0,0,2) | Details |
| 15305155 | Murer K, Urosevic M, Willers J, Selvam P, Laine E, Burg G, Dummer R: Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients. Melanoma Res. 2004 Aug;14(4):257-62. The lack of melanoma-associated antigen (MAA) expression has been associated with the reduced overall survival in melanoma patients. |
1(0,0,0,1) | Details |
| 9456433 | Cormier JN, Abati A, Fetsch P, Hijazi YM, Rosenberg SA, Marincola FM, Topalian SL: Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: implications for immunotherapy. J Immunother. 1998 Jan;21(1):27-31. A variety of human melanoma-associated antigens (MAA) have been identified that can be recognized by T lymphocytes in a major histocompatibility complex-restricted fashion. |
1(0,0,0,1) | Details |
| 8311486 | Kageshita T, Hirai S, Ono T: [Clinical trial of anti-idiotypic monoclonal antibodies in advanced melanoma]. Gan To Kagaku Ryoho. 1994 Feb;21(2):163-9. In this study, first the background of idiotype network and characterization of high molecular weight-melanoma associated antigen (HMW-MAA) was reviewed. |
1(0,0,0,1) | Details |
| 10752477 | Tordsson JM, Ohlsson LG, Abrahmsen LB, Karlstrom PJ, Lando PA, Brodin TN: Phage-selected primate antibodies fused to superantigens for immunotherapy of malignant melanoma. Cancer Immunol Immunother. 2000 Mar;48(12):691-702. The high-molecular-weight melanoma-associated antigen, HMW-MAA, has been demonstrated to be of potential interest for diagnosis and treatment of malignant melanoma. |
1(0,0,0,1) | Details |
| 3135310 | Graf LH Jr, Rosenberg CD, Mancino V, Ferrone S: Transfer and co-amplification of a gene encoding a 96-kDa immune IFN-inducible human melanoma-associated antigen. J Immunol. 1988 Aug 1;141(3):1054-60. Use of a selective co-amplification procedure led to transfectant cells' increased expression of 96-kDa MAA and to commensurate increases in their content of presumed 96-kDa MAA gene-associated h-alu. |
1(0,0,0,1) | Details |
| 9579583 | Li M, Xu F, Muller J, Hearing VJ, Gorelik E: Ecotropic C-type retrovirus of B16 melanoma and malignant transformation of normal melanocytes. Int J Cancer. 1998 May 4;76(3):430-6. We reported previously that B16,JB/RH and JB/MS melanomas of C57BL/6 mice express the common melanoma-associated antigen (MAA) recognized by MM2-9B6 monoclonal antibody (MAb). |
1(0,0,0,1) | Details |
| 19386352 | Meije CB, Swart GW, Lepoole C, Das PK, Van den Oord JJ: Antigenic profiles of individual-matched pairs of primary and melanoma metastases. Hum Pathol. 2009 Oct;40(10):1399-407. Epub 2009 Apr 22. A unique collection of individual-matched pairs of primary and melanoma metastases were studied immunohistochemically with a panel of 6 monoclonal antibodies directed to gp-100, pigmentation-associated antigen, tyrosinase-related protein, human leukocyte antigen DR, MAA-1, and MAA-2 (high molecular weight melanoma-associated antigens). |
2(0,0,0,2) | Details |
| 8275478 | Mittelman A, Chen ZJ, Liu CC, Hirai S, Ferrone S: Kinetics of the immune response and regression of metastatic lesions following development of humoral anti-high molecular weight-melanoma associated antigen immunity in three patients with advanced malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23. Cancer Res. 1994 Jan 15;54(2):415-21. |
2(0,0,0,2) | Details |
| 15623750 | van Dinten LC, Pul N, van Nieuwpoort AF, Out CJ, Jager MJ, van den Elsen PJ: Uveal and cutaneous melanoma: shared expression characteristics of melanoma-associated antigens. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):24-30. |
2(0,0,0,2) | Details |
| 10048982 | Cormier JN, Panelli MC, Hackett JA, Bettinotti MP, Mixon A, Wunderlich J, Parker LL, Restifo NP, Ferrone S, Marincola FM: Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model. Int J Cancer. 1999 Mar 1;80(5):781-90. Increasing attention has been devoted to elucidating the mechanism of lost or decreased expression of MHC or melanoma-associated antigens (MAAs), which may lead to tumor escape from immune recognition. |
1(0,0,0,1) | Details |
| 9764850 | Huang SK, Okamoto T, Morton DL, Hoon DS: Antibody responses to melanoma/melanocyte autoantigens in melanoma patients. J Invest Dermatol. 1998 Oct;111(4):662-7. Identification of highly expressed melanoma-associated antigens (MAA) that are immunogenic in humans will provide potential targets for cancer vaccines. |
1(0,0,0,1) | Details |
| 9176405 | Chi DD, Merchant RE, Rand R, Conrad AJ, Garrison D, Turner R, Morton DL, Hoon DS: Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas. Am J Pathol. 1997 Jun;150(6):2143-52. Using an established reverse transcriptase polymerase chain reaction plus Southern blot assay, we compared the mRNA expression of melanoma-associated antigens (MAAs) of melanomas to brain tumors primarily derived from glial cells. |
1(0,0,0,1) | Details |
| 3100635 | Tsujisaki M, Igarashi M, Sakaguchi K, Eisinger M, Herlyn M, Ferrone S: Immunochemical and functional analysis of HLA class II antigens induced by recombinant immune interferon on normal epidermal melanocytes. J Immunol. 1987 Feb 15;138(4):1310-6. The effect of recombinant immune interferon (IFN-gamma) on the expression and shedding of HLA antigens and of melanoma-associated antigens (MAA) by epidermal melanocytes was investigated by using serologic and immunochemical techniques. |
1(0,0,0,1) | Details |
| 16455987 | Peng L, Ko E, Luo W, Wang X, Shrikant PA, Ferrone S: CD4-dependent potentiation of a high molecular weight-melanoma-associated antigen-specific CTL response elicited in HLA-A2/Kb transgenic mice. J Immunol. 2006 Feb 15;176(4):2307-15. |
1(0,0,0,1) | Details |
| 2432832 | Giacomini P, Gambari R, Barbieri R, Nistico P, Tecce R, Pestka S, Gustafsson K, Natali PG, Fisher PB: Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons. Anticancer Res. 1986 Sep-Oct;6(5):877-84. IFN-alpha and -beta induced similar changes in the synthesis, expression and shedding of two TAAs, a HMW-MAA and a Cyt-MAA, in the established melanoma cell line Colo 38, whereas IFN-gamma exerted a differential effect on these melanoma associated antigens. |
1(0,0,0,1) | Details |
| 16407841 | Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S: Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. Oncogene. 2006 May 11;25(20):2873-84. |
32(0,1,1,2) | Details |
| 6760354 | Wilson BS, Giacomini P, Imai K, Natali PG, Nakanishi T, Ruberto G, Ferrone S: Human melanoma-associated antigens identified with monoclonal antibodies. Ric Clin Lab. 1982 Oct-Dec;12(4):517-38. The tissue distribution, the immunological profile and the structural properties of these melanoma associated antigens (MAA) are described. |
7(0,0,1,2) | Details |
| 19951123 | Stell AJ, Dobson JM, Scase TJ, Catchpole B: Evaluation of variants of melanoma-associated antigen genes and mRNA transcripts in melanomas of dogs. Am J Vet Res. 2009 Dec;70(12):1512-20. |
2(0,0,0,2) | Details |
| 1643429 | Vlock DR, Toporowicz A, Arnold B: Modulation by interferon alpha and gamma of the expression of a melanoma-associated antigen detected by autologous antibody. Melanoma Res. 1992 Jul;2(2):105-14. |
2(0,0,0,2) | Details |
| 18519770 | Goto Y, Ferrone S, Arigami T, Kitago M, Tanemura A, Sunami E, Nguyen SL, Turner RR, Morton DL, Hoon DS: Human high molecular weight-melanoma-associated antigen: utility for detection of metastatic melanoma in sentinel lymph nodes. Clin Cancer Res. 2008 Jun 1;14(11):3401-7. |
2(0,0,0,2) | Details |
| 8081557 | Kim TS, Cohen EP: Immunization of mice with allogeneic fibroblasts genetically modified for interleukin-2-secretion and expression of melanoma-associated antigens stimulate predetermined classes of anti-melanoma effector cells. J Immunother Emphasis Tumor Immunol. 1994 Jul;16(1):24-35. |
2(0,0,0,2) | Details |
| 6582312 | Morgan AC Jr, Crane MM, Rossen RD: Measurement of a monoclonal antibody-defined, melanoma-associated antigen in human sera: correlation of circulating antigen levels with tumor burden. J Natl Cancer Inst. 1984 Feb;72(2):243-9. |
2(0,0,0,2) | Details |
| 8568901 | Ban N, Day J, Wang X, Ferrone S, McPherson A: Crystal structure of an anti-anti-idiotype shows it to be self-complementary. J Mol Biol. 1996 Feb 2;255(4):617-27. The structure of the Fab fragment of the mouse anti-anti-idiotypic monoclonal antibody (mAb) GH1002 was solved by X-ray crystallography. mAb GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined by anti-human high molecular weight-melanoma associated antigen (HMW-MAA) mAb 763.74. |
1(0,0,0,1) | Details |
| 11779404 | Metharom P, Ellem KA, Schmidt C, Wei MQ: Lentiviral vector-mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma. Hum Gene Ther. 2001 Dec 10;12(18):2203-13. The transgene, murine tyrosinase-related protein 2 (mTRP-2), encodes a clinically relevant melanoma-associated antigen (MAA), which has been found to be a tumor rejection antigen for B16 melanoma. |
1(0,0,0,1) | Details |
| 7829240 | Kageshita T, Hirai S, Ono T, Ferrone S: Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic MAb MK2-23. Int J Cancer. 1995 Jan 27;60(3):334-40. |
1(0,0,0,1) | Details |
| 2798319 | Tamat SR, Moore DE, Patwardhan A, Hersey P: Boronated monoclonal antibody 225.28S for potential use in neutron capture therapy of malignant melanoma. Pigment Cell Res. 1989 Jul-Aug;2(4):278-80. The present report describes the conjugation of dicesium-mercapto-undecahydrododecaborate (Cs2B12H11SH) to 225.28S monoclonal antibody directed against high molecular weight melanoma-associated antigens (HMW-MAA), using poly-L- as a "bridge" to increase the carrying capacity of the antibody and to minimize change in the conformational structure of antibody. |
1(0,0,0,1) | Details |
| 18628468 | Molenkamp BG, Sluijter BJ, van Leeuwen PA, Santegoets SJ, Meijer S, Wijnands PG, Haanen JB, van den Eertwegh AJ, Scheper RJ, de Gruijl TD: Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients. Clin Cancer Res. 2008 Jul 15;14(14):4532-42. CD8 (+) T cells from SLN and peripheral blood were tested for reactivity by IFN-gamma ELISPOT assay against several HLA-A1/A2/A3-restricted epitopes derived from various melanoma-associated antigens (MAA) in 21 of 24 enrolled patients. |
1(0,0,0,1) | Details |
| 18652234 | Moiseenko VM, Danilova AB, Danilov AO, Turkevich EA, Baldueva IA, Matsko DE: [An immunocytochemical investigation of antigen expression by skin melanoma cells cultured for vaccine production]. Vopr Onkol. 2008;54(3):303-14. As of now, several varieties of melanoma-associated antigens (MAA) have been identified: MART1/melan A, tyrosinase, MITF, gp100, members of MAGE family, S100, CD63 and CD146. |
1(0,0,0,1) | Details |
| 2273574 | Nakamura T, Kageshita T, Arao T, Yamazaki N, Ishihara K: [Analysis of anti HMW.MAA antibodies in sera of melanoma patients using antiidiotypic monoclonal antibodies]. Nippon Hifuka Gakkai Zasshi. 1990 Oct;100(11):1121-6. The immunogenicity in patients with melanoma of three high molecular weight melanoma associated antigens (HMW.MAA) defined by murine monoclonal antibodies (MoAb) was investigated. |
1(0,0,0,1) | Details |
| 3889169 | Ernstoff MS, Duray P, Stenn K, Kirkwood JM: Antigenic phenotype of pigment cell lesions: a study of melanoma, its precursor lesions and heterogeneity in metastatic melanoma. J Invest Dermatol. 1985 May;84(5):430-2. We have demonstrated expression of HLA-DR, beta 2-microglobulin, and 2 melanoma-associated antigens (MAA) in a range of benign and malignant lesion, and have confirmed the close association of HLA-DR and MAA on malignant lesions. |
6(0,0,1,1) | Details |
| 2203468 | Schaling DF, van der Pol JP, Jager MJ, van Kroonenburgh MJ, Oosterhuis JA, Ruiter DJ: Radioimmunoscintigraphy and immunohistochemistry with melanoma-associated monoclonal antibodies in choroidal melanoma: a comparison of the clinical and immunohistochemical results. Br J Ophthalmol. 1990 Sep;74(9):538-41. Radioimmunoscintigraphy with monoclonal antibodies (MoAbs) to melanoma associated antigens is a new technique that can be used as an additional test to detect ocular melanomas in clinically difficult cases. |
2(0,0,0,2) | Details |
| 15588226 | Campoli MR, Chang CC, Kageshita T, Wang X, McCarthy JB, Ferrone S: Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance. Crit Rev Immunol. 2004;24(4):267-96. |
2(0,0,0,2) | Details |
| 6344987 | Giacomini P, Ng AK, Kantor RR, Natali PG, Ferrone S: Double determinant immunoassay to measure a human high-molecular-weight melanoma-associated antigen. Cancer Res. 1983 Aug;43(8):3586-90. |
2(0,0,0,2) | Details |
| 15650259 | Chang CC, Campoli M, Luo W, Zhao W, Zaenker KS, Ferrone S: Immunotherapy of melanoma targeting human high molecular weight melanoma-associated antigen: potential role of nonimmunological mechanisms. Ann N Y Acad Sci. 2004 Dec;1028:340-50. |
2(0,0,0,2) | Details |
| 8111189 | Kim M, Herberman R, Gorelik E: Evidence for indirect involvement of the H-2Kb gene in the regulation of natural killer sensitivity of BL6 melanoma cells. Nat Immun. 1994 Jan-Feb;13(1):1-14. We have previously demonstrated that transfection of BL6-8 melanoma cells with the H-2Kb gene increased their sensitivity to natural killer (NK)- and natural cytotoxic (NC) cell-mediated cytotoxicity, and resulted in alterations of various cell characteristics such as the loss of melanoma-associated antigen (MAA), and the appearance of Griffonia simplicifolia 1B4 (GS1B4)- and soybean agglutinin (SBA)-lectin-binding sites. |
1(0,0,0,1) | Details |
| 15846144 | Hafner C, Wagner S, Allwardt D, Riemer AB, Scheiner O, Pehamberger H, Breiteneder H: Cross-reactivity of mimotopes with a monoclonal antibody against the high molecular weight melanoma-associated antigen (HMW-MAA) does not predict cross-reactive immunogenicity. Melanoma Res. 2005 Apr;15(2):111-7. The high molecular weight melanoma-associated antigen (HMW-MAA) is highly expressed in advanced primary and metastatic melanoma. |
1(0,0,0,1) | Details |
| 15578703 | Hafner C, Breiteneder H, Ferrone S, Thallinger C, Wagner S, Schmidt WM, Jasinska J, Kundi M, Wolff K, Zielinski CC, Scheiner O, Wiedermann U, Pehamberger H: Suppression of human melanoma tumor growth in SCID mice by a human high molecular weight-melanoma associated antigen (HMW-MAA) specific monoclonal antibody. Int J Cancer. 2005 Apr 10;114(3):426-32. |
1(0,0,0,1) | Details |
| 2506138 | Maio M, Gulwani B, Morgano A, Ferrone S: Differential modulation by tumor necrosis factor and immune interferon of HLA class-II antigens expressed by melanoma cells. Int J Cancer. 1989 Sep 15;44(3):554-9. Tumor necrosis factor (TNF-alpha) was compared to immune interferon (IFN-gamma) for its ability to modulate the expression and shedding of HLA antigens, of intercellular adhesion molecule I (ICAM I) and of high-molecular-weight melanoma-associated antigen (HMW MAA) by a panel of melanoma cell lines. |
1(0,0,0,1) | Details |
| 12861477 | Sivanandham M, Kim EM, Wallack MK: Experimental melanoma vaccines. IDrugs. 2002 Feb;5(2):159-70. Vaccines such as melanoma cell and cell-lysate preparations, chemically characterized and pure melanoma associated antigens (MAA), anti-idiotypic antibodies mimicking MAA, and vectors encoding the genes of MAA have been tested in early and advanced clinical trials. |
6(0,0,1,1) | Details |
| 6731148 | Bumol TF, Harper JR, Chee DO, Reisfeld RA: Antigenic expression of human melanoma cells in serum-free medium. Adv Exp Med Biol. 1984;172:455-70. A human melanoma cell line, M14 , adapted to grow in serum free synthetic media was examined for its expression and secretion of several serologically defined melanoma associated antigens (MAA) previously described in this laboratory. |
4(0,0,0,4) | Details |
| 8813142 | Li M, Muller J, Xu F, Hearing VJ, Gorelik E: Inhibition of melanoma-associated antigen expression and ecotropic retrovirus production in B16BL6 melanoma cells transfected with major histocompatibility complex class I genes. Cancer Res. 1996 Oct 1;56(19):4464-74. |
2(0,0,0,2) | Details |
| 7049355 | Burchiel SW, Martin JC, Imai K, Ferrone S, Warner NL: Heterogeneity of HLA-A,B, Ia-like, and melanoma-associated antigen expression by human melanoma cell lines analyzed with monoclonal antibodies and flow cytometry. Cancer Res. 1982 Oct;42(10):4110-5. |
2(0,0,0,2) | Details |
| 15577316 | Kovalcsik E, John J, Turner M, Birchall L, Sage D, Whittle R, Dalgleish A, Pandha H: Differential expression of melanoma-associated antigens and molecules involved in antigen processing and presentation in three cell lines established from a single patient. Melanoma Res. 2004 Dec;14(6):463-71. |
2(0,0,0,2) | Details |
| 2582052 | Giacomini P, Natali P, Ferrone S: Analysis of the interaction between a human high molecular weight melanoma-associated antigen and the monoclonal antibodies to three distinct antigenic determinants. J Immunol. 1985 Jul;135(1):696-702. |
2(0,0,0,2) | Details |
| 1373670 | Temponi M, Gold AM, Ferrone S: Binding parameters and idiotypic profile of the whole immunoglobulin and Fab' fragments of murine monoclonal antibody to distinct determinants of the human high molecular weight-melanoma associated antigen. Cancer Res. 1992 May 1;52(9):2497-503. |
2(0,0,0,2) | Details |
| 12777979 | Dissemond J, Gotte P, Mors J, Lindeke A, Goos M, Ferrone S, Wagner SN: Association of TAP1 downregulation in human primary melanoma lesions with lack of spontaneous regression. Melanoma Res. 2003 Jun;13(3):253-8. Spontaneous regression of primary melanoma lesions is regarded as the result of the recognition of melanoma-associated antigen (MAA)-derived peptides by cytotoxic T-lymphocytes and destruction of melanoma cells. |
1(0,0,0,1) | Details |
| 8314324 | Kageshita T, Kimura T, Yoshi A, Hirai S, Ono T, Ferrone S: Antigenic profile of mucosal melanoma lesions. Int J Cancer. 1994 Feb 1;56(3):370-4. The latter included MAbs recognizing membrane-bound and cytoplasmic-melanoma-associated antigens, adhesion molecules and their receptors, and HLA Class-I and Class-II antigens. |
1(0,0,0,1) | Details |
| 2624919 | Guarini L, Temponi M, Edwalds GM, Vita JR, Fisher PB, Ferrone S: In vitro differentiation and antigenic changes in human melanoma cell lines. Cancer Immunol Immunother. 1989;30(5):262-8. Incubation of the three melanoma cell lines with interferon beta, TPA or their combination resulted in a differential modulation of the expression of membrane-bound high-molecular-mass melanoma-associated antigen, 115-kDa MAA, 100-kDa MAA, intercellular adhesion molecule 1, HLA class I antigens and gene products of the HLA-D region. |
1(0,0,0,1) | Details |
| 15373771 | Mittelman A, Tiwari R, Lucchese G, Willers J, Dummer R, Kanduc D: Identification of monoclonal anti-HMW-MAA antibody linear peptide epitope by proteomic database mining. J Invest Dermatol. 2004 Oct;123(4):670-5. The proteomic analysis of the antigenic peptide repertoire is described and demonstrated by using high-molecular weight melanoma-associated antigen. |
1(0,0,0,1) | Details |
| 2584721 | Kusama M, Kageshita T, Chen ZJ, Ferrone S: Characterization of syngeneic antiidiotypic monoclonal antibodies to murine anti-human high molecular weight melanoma-associated antigen monoclonal antibodies. J Immunol. 1989 Dec 1;143(11):3844-52. |
1(0,0,0,1) | Details |
| 10203062 | Chan MC, Murphy RM: Kinetics of cellular trafficking and cytotoxicity of 9.2.27-gelonin immunotoxins targeted against the high-molecular-weight melanoma-associated antigen. Cancer Immunol Immunother. 1999 Feb;47(6):321-9. |
1(0,0,0,1) | Details |
| 1671829 | Kageshita T, Nakamura T, Yamada M, Kuriya N, Arao T, Ferrone S: Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. Cancer Res. 1991 Mar 15;51(6):1726-32. |
3(0,0,0,3) | Details |
| 2428476 | Kantor RR, Albino AP, Ng AK, Ferrone S: Biosynthesis and intracellular processing of four human melanoma associated antigens. Cancer Res. 1986 Oct;46(10):5223-8. |
3(0,0,0,3) | Details |
| 15289358 | Murray JL, Gillogly M, Kawano K, Efferson CL, Lee JE, Ross M, Wang X, Ferrone S, Ioannides CG: Fine specificity of high molecular weight-melanoma-associated antigen-specific cytotoxic T lymphocytes elicited by anti-idiotypic monoclonal antibodies in patients with melanoma. Cancer Res. 2004 Aug 1;64(15):5481-8. |
3(0,0,0,3) | Details |
| 7688577 | Toporowicz A, Gersten DM, Hearing VJ, Brown WE, Vlock DR: Cross-reactivity between murine melanoma antigen B700 and a human melanoma-associated antigen (M-66) recognized by autologous antibody: evidence suggesting shared epitopes. Biochim Biophys Acta. 1993 Aug 4;1182(1):51-6. |
3(0,0,0,3) | Details |
| 15086240 | Hjortland GO, Garman-Vik SS, Juell S, Olsen OE, Hirschberg H, Fodstad O, Engebraaten O: Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiforme. J Neurosurg. 2004 Feb;100(2):320-7. |
2(0,0,0,2) | Details |
| 2456315 | Paul E, Cochran AJ, Wen DR: Immunohistochemical demonstration of S-100 protein and melanoma-associated antigens in melanocytic nevi. J Cutan Pathol. 1988 Jun;15(3):161-5. |
2(0,0,0,2) | Details |
| 6188530 | Wilson BS, Ruberto G, Ferrone S: Immunochemical characterization of a human high molecular weight--melanoma associated antigen identified with monoclonal antibodies. Cancer Immunol Immunother. 1983;14(3):196-201. |
2(0,0,0,2) | Details |
| 11156253 | Kang N, Hamilton S, Odili J, Wilson G, Kupsch J: In vivo targeting of malignant melanoma by 125Iodine- and 99mTechnetium-labeled single-chain Fv fragments against high molecular weight melanoma-associated antigen. Clin Cancer Res. 2000 Dec;6(12):4921-31. |
2(0,0,0,2) | Details |
| 16117794 | Vergilis IJ, Szarek M, Ferrone S, Reynolds SR: Presence and prognostic significance of melanoma-associated antigens CYT-MAA and HMW-MAA in serum of patients with melanoma. J Invest Dermatol. 2005 Sep;125(3):526-31. |
2(0,0,0,2) | Details |
| 2435792 | Perosa F, Tsujisaki M, Ferrone S: Syngeneic anti-idiotypic antisera to murine monoclonal antibodies to monomorphic and polymorphic determinants of HLA class I antigens. J Immunol. 1987 Apr 1;138(7):2202-7. Cross-blocking studies with a panel of anti-HLA class I, anti-HLA class II, and anti-human melanoma-associated antigen (MAA) MoAb showed that the anti-MoAb CR10-215 and anti-MoAb CR11-115 antisera contain only antibodies to private idiotopes, whereas the anti-HLA MoAb CR11-351 and anti-MoAb Q6/64 antisera also contain antibodies to public idiotopes. |
1(0,0,0,1) | Details |
| 3135332 | Matsui M, Nakanishi T, Noguchi T, Ferrone S: Synergistic in vitro and in vivo anti-tumor effect of daunomycin-anti-96-kDa melanoma-associated antigen monoclonal antibody CL 207 conjugate and recombinant IFN-gamma. J Immunol. 1988 Aug 15;141(4):1410-7. |
1(0,0,0,1) | Details |
| 9918881 | Li M, Xu F, Muller J, Huang X, Hearing VJ, Gorelik E: Loss of retrovirus production in JB/RH melanoma cells transfected with H-2Kb and TAP-1 genes. Virology. 1999 Jan 20;253(2):230-40. JB/RH1 melanoma cells, as well as other melanomas of C57BL/6 mice (B16 and JB/MS), express a common melanoma-associated antigen (MAA) encoded by an ecotropic melanoma-associated retrovirus (MelARV). |
1(0,0,0,1) | Details |
| 9220317 | Kim CJ, Prevette T, Cormier J, Overwijk W, Roden M, Restifo NP, Rosenberg SA, Marincola FM: Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro. J Immunother. 1997 Jul;20(4):276-86. In this report, we show that human DC are (a) capable of infection by recombinant poxviruses encoding melanoma-associated antigen (MAA) genes and (b) capable of efficiently processing and presenting these MAA to cytotoxic T cells. |
1(0,0,0,1) | Details |
| 9118024 | Fishman P, Merimski O, Baharav E, Shoenfeld Y: Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo. . Cancer. 1997 Apr 15;79(8):1461-4. The titer of antityrosinase antibodies in patients with metastatic melanoma treated by vaccination with antiidiotypic antibodies mimicking the high molecular weight melanoma-associated antigen (HMW MAA) initially increased after the vaccination and then decreased. |
1(0,0,0,1) | Details |
| 9816036 | Mittelman A, Chen GZ, Wong GY, Liu C, Hirai S, Ferrone S: Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: modulation of the immunogenicity in patients with malignant melanoma. Clin Cancer Res. 1995 Jul;1(7):705-13. |
2(0,0,0,2) | Details |
| 3928760 | Giacomini P, Imberti L, Aguzzi A, Fisher PB, Trinchieri G, Ferrone S: Immunochemical analysis of the modulation of human melanoma-associated antigens by DNA recombinant immune interferon. J Immunol. 1985 Oct;135(4):2887-94. |
2(0,0,0,2) | Details |
| 11023194 | Fujii S, Huang S, Fong TC, Ando D, Burrows F, Jolly DJ, Nemunaitis J, Hoon DS: Induction of melanoma-associated antigen systemic immunity upon intratumoral delivery of interferon-gamma retroviral vector in melanoma patients. Cancer Gene Ther. 2000 Sep;7(9):1220-30. |
2(0,0,0,2) | Details |
| 6692408 | Giacomini P, Veglia F, Cordiali Fei P, Rehle T, Natali PG, Ferrone S: Level of a membrane-bound high-molecular-weight melanoma-associated antigen and a cytoplasmic melanoma-associated antigen in surgically removed tissues and in sera from patients with melanoma. Cancer Res. 1984 Mar;44(3):1281-7. |
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| 1933867 | Chattopadhyay P, Kaveri SV, Byars N, Starkey J, Ferrone S, Raychaudhuri S: Human high molecular weight-melanoma associated antigen mimicry by an anti-idiotypic antibody: characterization of the immunogenicity and the immune response to the mouse monoclonal antibody IMel-1. Cancer Res. 1991 Nov 15;51(22):6045-51. |
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| 19088033 | Wagner S, Krepler C, Allwardt D, Latzka J, Strommer S, Scheiner O, Pehamberger H, Wiedermann U, Hafner C, Breiteneder H: Reduction of human melanoma tumor growth in severe combined immunodeficient mice by passive transfer of antibodies induced by a high molecular weight melanoma-associated antigen mimotope vaccine. Clin Cancer Res. 2008 Dec 15;14(24):8178-83. |
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| 1913644 | Gorelik E, Jay G, Kim M, Hearing VJ, DeLeo A, McCoy JP Jr: Effects of H-2Kb gene on expression of melanoma-associated antigen and lectin-binding sites on BL6 melanoma cells. Cancer Res. 1991 Oct 1;51(19):5212-8. |
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| 10661765 | Kang NV, Hamilton S, Sanders R, Wilson GD, Kupsch JM: Efficient in vivo targeting of malignant melanoma by single-chain Fv antibody fragments. Melanoma Res. 1999 Dec;9(6):545-56. LHM2 is specific for the high molecular weight proteoglycan melanoma-associated antigen (HMW-MAA), while B4 scFv binds a novel melanoma-specific antigen. |
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| 8227707 | Ferrone S, Kageshita T, Hirai S: Active specific immunotherapy of malignant melanoma with anti-idiotypic monoclonal antibodies. J Dermatol. 1993 Sep;20(9):533-9. In this study, we have utilized the human high molecular weight-melanoma associated antigen (HMW-MAA) as a target for active specific immunotherapy with mouse anti-idiotypic (anti-id) monoclonal antibodies (mAb) in patients with malignant melanoma. |
1(0,0,0,1) | Details |
| 1861071 | Chen ZJ, Yang H, Ferrone S: Human high molecular weight melanoma-associated antigen mimicry by mouse antiidiotypic monoclonal antibody MK2-23. J Immunol. 1991 Aug 1;147(3):1082-90. |
1(0,0,0,1) | Details |
| 1409413 | Chen ZJ, Yang H, Liu CC, Mittelman A, Ferrone S: Association between induction of anti high molecular weight-melanoma associated antigen (HMW-MAA) immunity with mouse antiidiotypic monoclonal antibody (MoAb) MK2-23 and prolongation of survival in patients with melanoma. Pigment Cell Res. 1992;Suppl 2:113-22. |
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| 1409414 | Kageshita T, Yamada M, Arao T, Ferrone S: Expression of high molecular weight-melanoma associated antigen (HMW-MAA) in primary ALM lesions is associated with a poor prognosis. Pigment Cell Res. 1992;Suppl 2:132-5. |
1(0,0,0,1) | Details |
| 3157450 | Natali P, Bigotti A, Cavaliere R, Liao SK, Taniguchi M, Matsui M, Ferrone S: Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma. Cancer Res. 1985 Jun;45(6):2883-9. |
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| 7904182 | Kim TS, Collins MK, Cohen EP: Independent cell types are involved in the induction of antimelanoma responses in C57BL/6 mice immunized with interleukin-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens. J Immunother Emphasis Tumor Immunol. 1993 Nov;14(4):298-304. |
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| 8504426 | Kageshita T, Kuriya N, Ono T, Horikoshi T, Takahashi M, Wong GY, Ferrone S: Association of high molecular weight melanoma-associated antigen expression in primary acral lentiginous melanoma lesions with poor prognosis. Cancer Res. 1993 Jun 15;53(12):2830-3. |
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| 8811494 | Marincola FM, Hijazi YM, Fetsch P, Salgaller ML, Rivoltini L, Cormier J, Simonis TB, Duray PH, Herlyn M, Kawakami Y, Rosenberg SA: Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ lesions. J Immunother Emphasis Tumor Immunol. 1996 May;19(3):192-205. |
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| 18641983 | Schwab JH, Boland PJ, Agaram NP, Socci ND, Guo T, O'Toole GC, Wang X, Ostroumov E, Hunter CJ, Block JA, Doty S, Ferrone S, Healey JH, Antonescu CR: Chordoma and chondrosarcoma gene profile: implications for immunotherapy. Cancer Immunol Immunother. 2009 Mar;58(3):339-49. Epub 2008 Jul 19. They shared overexpression of many extracellular matrix genes including aggrecan, type II & X collagen, fibronectin, matrillin 3, high molecular weight-melanoma associated antigen (HMW-MAA), matrix metalloproteinase MMP-9, and MMP-19. |
1(0,0,0,1) | Details |
| 12755292 | Catchpole B, Gould SM, Kellett-Gregory LM, Dobson JM: Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs. Am J Vet Res. 2003 May;64(5):544-9. OBJECTIVE: To develop a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect canine melanoma-associated antigens (MAAs) and to use this technique to screen aspirates of lymph nodes (LNs) for evidence of metastatic spread of oral malignant melanoma. |
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| 9085125 | Hamby CV, Chinol M, Manzo C, Ferrone S: Purification by affinity chromatography with anti-idiotypic monoclonal antibodies of immunoreactive monoclonal antibodies following labeling with 188Re. Hybridoma. 1997 Feb;16(1):27-31. Utilizing the anti-high-molecular-weight melanoma-associated antigen (HMW-MAA) mAb 763.74 as a model system, we found that the immunoreactivity of mAb 763.74 labeled with 188Re to a specific activity of 1 mCi/mg increased from about 50% to at least 80% following passage over columns of immobilized anti-id mAb. |
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| 1861072 | Hayashibe K, Mishima Y, Ferrone S: Cloning and in vitro expression of a melanoma-associated antigen immunogenic in patients with melanoma. J Immunol. 1991 Aug 1;147(3):1098-104. |
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| 9456431 | Kim CJ, Parkinson DR, Marincola F: Immunodominance across HLA polymorphism: implications for cancer immunotherapy. J Immunother. 1998 Jan;21(1):1-16. For this reason, peptide-based or whole protein vaccination protocols against melanoma-associated antigens (MAA) are ongoing in several institutions, with the goal of inducing tumor regression by enhancing in vivo specific antitumor CTL reactivity. |
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| 1756533 | Kim YS, Slomski R, Cohen EP: Immunity to melanoma in mice immunized with transfected allogeneic mouse fibroblasts expressing melanoma-associated antigens. Cancer Immunol Immunother. 1991;34(3):163-8. |
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| 16470181 | Ulmer A, Fierlbeck G: Circulating tumor cells and detection of the melanoma-associated antigen HMW-MAA in the serum of melanoma patients. J Invest Dermatol. 2006 Apr;126(4):914-5; author reply 915-6. |
1(0,0,0,1) | Details |
| 3920101 | Matsui M, Nakanishi T, Noguchi T, Imai K, Yachi A, Ferrone S: Suppression of human melanoma growth in nude mice injected with anti high-molecular-weight melanoma-associated antigen monoclonal antibody 225.28S conjugated to purothionin. Jpn J Cancer Res. 1985 Feb;76(2):119-23. |
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| 2254463 | Mittelman A, Chen ZJ, Kageshita T, Yang H, Yamada M, Baskind P, Goldberg N, Puccio C, Ahmed T, Arlin Z, et al.: Active specific immunotherapy in patients with melanoma. J Clin Invest. 1990 Dec;86(6):2136-44. A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti-high-molecular-weight-melanoma-associated antigen monoclonal antibodies.. |
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| 6747299 | Giacomini P, Aguzzi A, Pestka S, Fisher PB, Ferrone S: Modulation by recombinant DNA leukocyte (alpha) and fibroblast (beta) interferons of the expression and shedding of HLA- and tumor-associated antigens by human melanoma cells. J Immunol. 1984 Sep;133(3):1649-55. With a panel of monoclonal antibodies, the effect of recombinant human leukocyte interferons (i.e., IFN-alpha A, IFN-alpha D), of a hybrid leukocyte IFN (i.e., IFN-alpha A/D (Bg1)), and of recombinant fibroblast (beta) IFN on the expression and shedding of four types of melanoma-associated antigens (MAA) and of HLA antigens by the cultured melanoma cell line Colo 38 was investigated. |
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| 3989605 | Fawwaz RA, Wang TS, Estabrook A, Rosen JM, Hardy MA, Alderson PO, Srivastava SC, Richards P, Ferrone S: Immunoreactivity and biodistribution of indium-111-labeled monoclonal antibody to a human high molecular weight-melanoma associated antigen. J Nucl Med. 1985 May;26(5):488-92. |
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| 3129542 | Murray JL, Stuckey SE, Pillow JK, Rosenblum MG, Gutterman JU: Differential in vitro effects of recombinant alpha-interferon and recombinant gamma-interferon alone or in combination on the expression of melanoma-associated surface antigens. J Biol Response Mod. 1988 Apr;7(2):152-61. These data demonstrate that the effects of each interferon (IFN) on the expression of melanoma-associated antigens (MAA) are heterogeneous and depend on IFN type and concentration, exposure time, and characteristics of the antigen studied. |
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| 8368768 | Chen ZJ, Ferrone S: Comparison of the binding parameters to melanoma cells of antihuman high molecular weight-melanoma associated antigen (HMW-MAA) monoclonal antibodies (mAb) and syngeneic anti-anti-idiotypic (anti-anti-id) mAb. Ann N Y Acad Sci. 1993 Aug 12;690:398-401. |
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| 6376904 | Natali PG, Bigotti A, Cavaliere R, Nicotra MR, Ferrone S: Phenotyping of lesions of melanocyte origin with monoclonal antibodies to melanoma-associated antigens and to HLA antigens. J Natl Cancer Inst. 1984 Jul;73(1):13-24. |
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| 16670313 | Luo W, Ko E, Hsu JC, Wang X, Ferrone S: Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects. J Immunol. 2006 May 15;176(10):6046-54. |
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| 7686858 | Yang H, Chen ZJ, Kageshita T, Yamada M, Ferrone S: Idiotypic cascade in the human high molecular weight melanoma-associated antigen system: fine specificity and idiotypic profile of anti-anti-idiotypic monoclonal antibodies. Eur J Immunol. 1993 Jul;23(7):1671-7. |
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| 8244584 | Kim TS, Russell SJ, Collins MK, Cohen EP: Immunization with interleukin-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens prolongs the survival of mice with melanoma. Int J Cancer. 1993 Nov 11;55(5):865-72. |
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| 2490510 | Graf LH Jr, Ferrone S: Human melanoma-associated antigens. . Immunol Ser. 1989;43:643-79. |
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| 3114385 | Matsui M, Temponi M, Ferrone S: Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon. J Immunol. 1987 Sep 15;139(6):2088-95. |
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| 12543800 | Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS: Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res. 2003 Jan 15;63(2):441-8. |
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| 11092050 | Ferrone S, Wang X: Active specific immunotherapy of malignant melanoma and peptide mimics of the human high-molecular-weight melanoma-associated antigen. Recent Results Cancer Res. 2001;158:231-5. |
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| 15905554 | Luo W, Hsu JC, Tsao CY, Ko E, Wang X, Ferrone S: Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities. J Immunol. 2005 Jun 1;174(11):7104-10. |
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| 3860479 | Brocker EB, Suter L, Bruggen J, Ruiter DJ, Macher E, Sorg C: Phenotypic dynamics of tumor progression in human malignant melanoma. . Int J Cancer. 1985 Jul 15;36(1):29-35. The phenotypic changes in human melanoma cells during the course of tumor progression were studied with monoclonal antibodies (MAbs) against the melanoma-associated antigens (MAA) M.2.2.4, H.2.8.10, K.1.2, A.1.43, and A.10.33, and HLA-(A,B,C and D). |
1(0,0,0,1) | Details |
| 20363194 | Conteduca G, Ferrera F, Pastorino L, Fenoglio D, Negrini S, Sormani MP, Indiveri F, Scarra GB, Filaci G: The role of AIRE polymorphisms in melanoma. . Clin Immunol. 2010 Apr 1. Polymorphisms of AIRE, a transcription factor that up-regulates intrathymic expression of tissue-specific antigens including melanoma-associated antigens (MAAs), may variably affect the selection of MAAs-specific thymocytes, generating T-cell repertoires protecting or predisposing individuals to melanoma. |
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| 10323448 | Rajkumar VS, Sundberg C, Abraham DJ, Rubin K, Black CM: Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. Arthritis Rheum. 1999 May;42(5):930-41. METHODS: Monoclonal antibodies against PDGFbeta receptors, PDGF-AB/BB, and high molecular weight-melanoma-associated antigen (HMW-MAA), a marker for activated pericytes, were used to immunohistochemically analyze serial sections of skin biopsy tissue from patients with RP and from scleroderma patients. |
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| 3040633 | Wang TS, NG AK, Alsedairy S, Fawwaz RA, Hardy MA, Alderson PO: A method for direct quantification of the amount of DTPA in 111In monoclonal antibody preparations. Int J Rad Appl Instrum A. 1987;38(4):315-9. The bicyclic anhydride of DTPA-1-14C (BADTPA-1-14C) was synthesized and reacted with an antibody to human melanoma associated antigen (MAA) and with one to human class II major histocompatibility complex antigen (HLA-DR). |
1(0,0,0,1) | Details |
| 9797138 | Hamby CV, Chinol M, Palestro CJ, Manzo C, Ferrone S: Improved tumor targeting of rhenium-186-labeled anti-human high-m.w. melanoma-associated antigen monoclonal antibody 763.74 following purification with anti-idiotypic monoclonal antibody MK2-23. Int J Cancer. 1998 Nov 9;78(4):486-90. |
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| 14679014 | Prins RM, Odesa SK, Liau LM: Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model. Cancer Res. 2003 Dec 1;63(23):8487-91. |
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| 6656776 | Morgan AC Jr, McIntyre RF: Monoclonal antibody defined-human melanoma-associated antigens: molecular and phylogenetic studies in normal serum. Mol Immunol. 1983 Dec;20(12):1293-9. |
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| 3497718 | Giacomini P, Viora M, Tecce R, Knowles DM, Natali PG, Ferrone S: A cytoplasmic human melanoma associated antigen as a marker of activation in lymphoid cells. Cancer Res. 1987 Oct 1;47(19):5175-80. |
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| 11863419 | Tanaka M, Kaneda Y, Fujii S, Yamano T, Hashimoto K, Huang SK, Hoon DS: Induction of a systemic immune response by a polyvalent melanoma-associated antigen DNA vaccine for prevention and treatment of malignant melanoma. Mol Ther. 2002 Mar;5(3):291-9. |
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| 3476198 | Liao SK, Smith JW, Kwong PC, Natali PG, Kusama M, Hamby CV, Ferrone S: Cross-reactivity of murine anti-human high molecular weight-melanoma associated antigen monoclonal antibodies with guinea pig melanoma cells. Cancer Res. 1987 Sep 15;47(18):4835-41. |
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| 7939169 | Merimsky O, Shoenfeld Y, Chaitchik S, Yecheskel G, Fishman P: Antigens and antibodies in malignant melanoma. . Tumour Biol. 1994;15(4):188-202. Certain melanoma-associated antigens (MAA) such as epidermal growth factor receptor and adhesium molecules can be modulated by cytokines. |
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| 2302716 | Rosenberg CD, Ferrone S, Hamby CV, Mancino V, Graf LH Jr: Interspecific DNA-mediated transfer and amplification of a gene specifying a Mr 100,000 human melanoma-associated cell surface glycoprotein. Cancer Res. 1990 Mar 1;50(5):1559-65. The gene that encodes the membrane-bound Mr 100,000 human melanoma-associated antigen (MAA) defined by mouse mAb 376.96, a leukocyte and fibroblast interferon-modulated glycoprotein having preferential distribution on melanoma and carcinoma cells, has been transfected into the mouse melanoma cell line B78H1 as a step toward molecular cloning and characterization of the MAA. Primary, secondary, and tertiary B78H1 transfectants expressing the Mr 100,000 MAA gene were generated by treatment with coprecipitated DNA from Mr 100,000 MAA+ human or transfectant mouse cells and they were detected by an indirect RBC rosetting assay. |
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| 3093392 | Anichini A, Mortarini R, Fossati G, Parmiani G: Phenotypic profile of clones from early cultures of human metastatic melanomas and its modulation by recombinant interferon gamma. Int J Cancer. 1986 Oct 15;38(4):505-11. Fifty-six tumor clones isolated by cloning in soft agar from early cultures (before the 10th in vitro passage) of two different human metastatic melanomas (Me9229 and Me28) were characterized by FACS analysis for surface expression of class-I and class-II HLA antigens and of melanoma-associated antigens (MAA) with a panel of 15 monoclonal antibodies (MAbs). |
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| 9810766 | Zeuthen J, Dzhandzhugazyan K, Hansen MR, Kirkin AF: The immunogenic properties of human melanomas and melanoma-associated antigens recognized by cytotoxic T lymphocytes. Bratisl Lek Listy. 1998 Aug-Sep;99(8-9):426-34. |
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| 2076895 | Shockley TR, Mandeville JT, Tompkins RG, Yarmush ML: Equilibrium binding characteristics of monoclonal antibodies recognizing melanoma cell surface antigens. Hybridoma. 1990 Dec;9(6):527-44. The equilibrium binding characteristics of a panel of six monoclonal antibodies (MAb) recognizing melanoma cell surface antigens (125 kdal cell surface melanoma associated glycoprotein antigen, 125kD-MAA; high molecular weight melanoma associated antigen, HMW-MAA; and a non-protein melanoma associated antigen, NP-MAA) were investigated using the cell lines SK-MEL-2, SK-MEL-5, and M21. |
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| 2118485 | Giacomini P, Fraioli R, Nistico P, Tecce R, Nicotra MR, Di Filippo F, Fisher PB, Natali PG: Modulation of the antigenic phenotype of early-passage human melanoma cells derived from multiple autologous metastases by recombinant human leukocyte, fibroblast and immune interferon. Int J Cancer. 1990 Sep 15;46(3):539-45. We have investigated the relationship between in vitro cultivation of autologous melanoma metastases derived from different patients and their levels of expression of class-I and -II major histocompatibility complex (MHC) antigens and melanoma-associated antigens (MAAs). |
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| 16061683 | Wang X, Ko EC, Peng L, Gillies SD, Ferrone S: Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2. Cancer Res. 2005 Aug 1;65(15):6976-83. |
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| 11449353 | Benlalam H, Labarriere N, Linard B, Derre L, Diez E, Pandolfino MC, Bonneville M, Jotereau F: Comprehensive analysis of the frequency of recognition of melanoma-associated antigen (MAA) by CD8 melanoma infiltrating lymphocytes (TIL): implications for immunotherapy. Eur J Immunol. 2001 Jul;31(7):2007-15. |
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| 7042082 | Heaney-Kieras J, Bystryn JC: Identification and purification of a Mr 75,000 cell surface human melanoma-associated antigen. Cancer Res. 1982 Jun;42(6):2310-6. |
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| 1716513 | Chen ZJ, Yang H, Kageshita T, Ferrone S: Human high-molecular-weight melanoma-associated antigen mimicry by mouse antiidiotypic monoclonal antibody TK7-371. Cancer Res. 1991 Sep 15;51(18):4790-7. |
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| 17198085 | Wesa A, Kalinski P, Kirkwood JM, Tatsumi T, Storkus WJ: Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient TH1-type antimelanoma CD4+ T cell responses in vitro. J Immunother. 2007 Jan;30(1):75-82. We confirmed our own earlier observations that patient CD4+ T cell reactivity against melanoma-associated antigens (MAA) was weaker and less Type-1-polarized than their corresponding antiviral responses. |
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| 15565329 | Riemer AB, Hantusch B, Sponer B, Kraml G, Hafner C, Zielinski CC, Scheiner O, Pehamberger H, Jensen-Jarolim E: High-molecular-weight melanoma-associated antigen mimotope immunizations induce antibodies recognizing melanoma cells. Cancer Immunol Immunother. 2005 Jul;54(7):677-84. Epub 2004 Nov 24. |
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| 11396186 | Dell'Erba L, Calo-Gabrieli G, Caruso ML, Thomas R, Cortino G, Valentini AM, Muto P, Albrizio M, Pastena MI, Lastoria S: Immunohistochemical reactivity of anti-melanoma monoclonal antibody 225.28S in human breast cancer biopsies. Anticancer Res. 2001 Mar-Apr;21(2A):925-30. The high molecular weight melanoma-associated antigen, defined by murine monoclonal antibody (IgG1) 225.28S is largely expressed by melanoma cells and weakly expressed by other human tumors originating from neural crest. |
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| 10432284 | Wang Z, Marincola FM, Rivoltini L, Parmiani G, Ferrone S: Selective histocompatibility leukocyte antigen (HLA)-A2 loss caused by aberrant pre-mRNA splicing in 624MEL28 melanoma cells. J Exp Med. 1999 Jul 19;190(2):205-15. Histocompatibility leukocyte antigen (HLA)-A2 is used as a restricting element to present several melanoma-associated antigen (MAA)-derived peptides to cytotoxic T lymphocytes (CTLs). |
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| 3079589 | Taramelli D, Fossati G, Mazzocchi A, Delia D, Ferrone S, Parmiani G: Classes I and II HLA and melanoma-associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions. Cancer Res. 1986 Jan;46(1):433-9. |
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| 17912445 | Ulasov IV, Rivera AA, Nettelbeck DM, Rivera LB, Mathis JM, Sonabend AM, Tyler M, Wang M, Douglas JT, Lesniak MS: An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy. Int J Oncol. 2007 Nov;31(5):1177-85. In this context, melanoma associated antigens (MAAs) are usually over-expressed in brain tumors in comparison to normal brain tissue. |
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| 3276385 | Henzen-Logmans SC, Meijer CJ, Ruiter DJ, Mullink H, Balm AJ, Snow GB: Diagnostic application of panels of antibodies in mucosal melanomas of the head and neck. Cancer. 1988 Feb 15;61(4):702-11. Staining with antivimentin and the melanoma-associated antigen, moAb NKI/C-3, was found to occur in all cases. |
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| 8361995 | Ferrone S, Chen ZJ, Liu CC, Hirai S, Kageshita T, Mittelman A: Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibodies MK2-23. Pharmacol Ther. 1993 Feb-Mar;57(2-3):259-90. |
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| 3115563 | Hamby CV, Liao SK, Kanamaru T, Ferrone S: Immunogenicity of human melanoma-associated antigens defined by murine monoclonal antibodies in allogeneic and xenogeneic hosts. Cancer Res. 1987 Oct 15;47(20):5284-9. |
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| 9430197 | Mutz M, Hawthorne T, Ferrone S, Pluschke G: Titration calorimetry study of an anti-idiotypic antibody cascade in a human melanoma-associated antigen system. Mol Immunol. 1997 Jul;34(10):695-707. |
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| 3552215 | Ziai MR, Imberti L, Nicotra MR, Badaracco G, Segatto O, Natali PG, Ferrone S: Analysis with monoclonal antibodies of the molecular and cellular heterogeneity of human high molecular weight melanoma associated antigen. Cancer Res. 1987 May 1;47(9):2474-80. |
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| 2475487 | Neville DM Jr, Srinivasachar K, Stone R, Scharff J: Enhancement of immunotoxin efficacy by acid-cleavable cross-linking agents utilizing diphtheria toxin and toxin mutants. J Biol Chem. 1989 Sep 5;264(25):14653-61. The potency of conjugates made from diphtheria toxin and the anti-high molecular weight melanoma-associated antigen (HMW-MAA) is enhanced 3-10-fold by a cleavable cross-linker. |
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| 18677475 | Drake AS, Brady MT, Wang XH, Sait SJ, Earp JC, Ghoshal Gupta S, Ferrone S, Wang ES, Wetzler M: Targeting 11q23 positive acute leukemia cells with high molecular weight-melanoma associated antigen-specific monoclonal antibodies. Cancer Immunol Immunother. 2009 Mar;58(3):415-27. Epub 2008 Aug 2. |
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| 9924695 | Coral S, Sigalotti L, Gasparollo A, Cattarossi I, Visintin A, Cattelan A, Altomonte M, Maio M: Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'- (5-AZA-CdR). J Immunother. 1999 Jan;22(1):16-24. The immunogenic potential of melanoma cells and their recognition by the host's cytotoxic cells depends on the presence and on the level of expression of human leukocyte antigen (HLA) class I antigens, costimulatory molecules and melanoma-associated antigens (MAA), on neoplastic cells. |
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| 19350633 | Risberg K, Fodstad O, Andersson Y: The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. Int J Cancer. 2009 Jul 1;125(1):23-33. We have studied the effects of a chemical conjugate of pseudomonas exotoxin A (PE) and the antibody 9.2.27, which recognizes the high molecular weight melanoma associated antigen (HMW-MAA) expressed in most malignant melanomas and melanoma cell lines. |
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| 12471624 | Losch FO, Muller R, Mutschler B, Neri D, Natali PG, Reth M, Carsetti R: Activation of T cells via tumor antigen specific chimeric receptors: the role of the intracellular signaling domain. Int J Cancer. 2003 Jan 20;103(3):399-407. The antigen binding domain of the receptors was a single-chain fragment of a monoclonal antibody, which recognize a High Molecular Weight Melanoma-Associated Antigen with high affinity. |
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| 8780163 | Sundberg C, Ivarsson M, Gerdin B, Rubin K: Pericytes as collagen-producing cells in excessive dermal scarring. Lab Invest. 1996 Feb;74(2):452-66. Double immunofluorescence stainings using combinations of monoclonal antibodies specific for activated pericytes in vivo (high molecular weight-melanoma associated antigen (HMW-MAA)), P-4-H, smooth muscle alpha-actin (SMA), endothelial cells (PAL-E), platelet-derived growth factor (PDGF) beta-receptor, and the integrin alpha 5 subunit were performed. |
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| 10653598 | Castelli C, Rivoltini L, Andreola G, Carrabba M, Renkvist N, Parmiani G: T-cell recognition of melanoma-associated antigens. . J Cell Physiol. 2000 Mar;182(3):323-31. |
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| 1760821 | Ghose T, Ferrone S, Blair AH, Kralovec Y, Temponi M, Singh M, Mammen M: Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen. Cancer Immunol Immunother. 1991;34(2):90-6. |
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| 11188931 | Wang X, Luo W, Ferrone S: Immunotherapy of melanoma: peptide mimics of a human high molecular weight-melanoma associated antigen. Medicina (B Aires). 2000;60 Suppl 2:48-50. |
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| 15946236 | Urosevic M, Braun B, Willers J, Burg G, Dummer R: Expression of melanoma-associated antigens in melanoma cell cultures. Exp Dermatol. 2005 Jul;14(7):491-7. |
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| 9622083 | Desai SA, Wang X, Noronha EJ, Kageshita T, Ferrone S: Characterization of human anti-high molecular weight-melanoma-associated antigen single-chain Fv fragments isolated from a phage display antibody library. Cancer Res. 1998 Jun 1;58(11):2417-25. |
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| 2427767 | Heaney-Kieras J, Bystryn JC: Identification and purification of 115- and 125-kilodalton cell surface human melanoma-associated antigens. J Natl Cancer Inst. 1986 Sep;77(3):643-8. |
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| 7074593 | Boctor AM, Bystryn JC: Degradation of tumor-associated antigens shed by human melanoma cells in culture. Cancer Res. 1982 Jun;42(6):2121-5. Both melanoma-associated antigens (MAAs), quantitated by specific immunoprecipitation, and unrelated surface macromolecules were degraded or inactivated by normal and malignant cells including the melanoma cells themselves. |
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| 8941875 | Player MA, Barracchini KC, Simonis TB, Rivoltini L, Arienti F, Castelli C, Mazzocchi A, Belli F, Parmiani G, Marincola FM: Differences in frequency distribution of HLA-A2 subtypes between North American and Italian white melanoma patients: relevance for epitope specific vaccination protocols. J Immunother Emphasis Tumor Immunol. 1996 Sep;19(5):357-63. Multiple HLA-A*0201 restricted peptides derived from melanoma associated antigens (MAA) have been described, and peptide-based vaccination protocols against melanoma are being developed worldwide for the treatment of HLA-A2 melanoma patients based on the assumption that most serologically typed HLA-A2+ individuals will be suitable for such vaccinations. |
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| 7506284 | Gasparini M, Zampino MG, Maffioli L, De Braud F, Bombardieri E, Buraggi GL: Enhancement of in vivo monoclonal antibody targeting with recombinant interferon and cytokines. Int J Biol Markers. 1993 Jul-Sep;8(3):160-5. Some authors reported that alpha-IFN enhances the expression of a melanoma-associated antigen (MAA), recognized by conventional antiserum. |
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| 6886437 | Natali PG, Segatto O, Zupi G, Cavaliere R, Giacomini P, Ferrone S: Isolation of viable melanoma cells from surgically removed lesions using dishes coated with monoclonal antibody to a high molecular weight melanoma associated antigen. J Immunol Methods. 1983 Sep 16;62(3):337-46. |
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| 3622556 | Cerny T, Owens SE, Mackenzie SA, Nuttall PM, Gosh AK, Smith DB, Thatcher N: Immunoscintigraphy with 99mTc labelled F (ab') 2 fragments of an anti melanoma monoclonal antibody (225.28S) in patients with metastatic malignant melanoma. Eur J Nucl Med. 1987;13(3):130-3. In 11 cases, tissue samples of metastatic lesions were investigated for the expression of melanoma associated antigens by immunohistochemical techniques. |
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| 1603113 | Mittelman A, Puccio C, Chun H, Ahmed T: Humoral antimelanoma immunity: induction by mouse antiidiotypic mAb, MK2-23 and association with survival of patients with advanced melanoma. Mt Sinai J Med. 1992 May;59(3):234-7. Furthermore, the induction of an immune response to a well-defined melanoma-associated antigen has been shown to be associated with a favorable clinical response. |
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| 11092052 | Abken H, Hombach A, Heuser C, Reinhold U: A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T cells with tumor specificity. Recent Results Cancer Res. 2001;158:249-64. This trend reflects, at least in part, the disappointing results of conventional chemotherapy, the identification of melanoma-associated antigens suitable to be used as targets for immunotherapy, and the significant progress in our understanding of molecular processes involved in the development of an immune response. |
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| 9102226 | Sarantou T, Chi DD, Garrison DA, Conrad AJ, Schmid P, Morton DL, Hoon DS: Melanoma-associated antigens as messenger RNA detection markers for melanoma. Cancer Res. 1997 Apr 1;57(7):1371-6. |
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| 19233913 | Kitago M, Koyanagi K, Nakamura T, Goto Y, Faries M, O'Day SJ, Morton DL, Ferrone S, Hoon DS: mRNA expression and BRAF mutation in circulating melanoma cells isolated from peripheral blood with high molecular weight melanoma-associated antigen-specific monoclonal antibody beads. Clin Chem. 2009 Apr;55(4):757-64. Epub 2009 Feb 20. |
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| 1533203 | Kim TS, Russell SJ, Collins MK, Cohen EP: Immunity to B16 melanoma in mice immunized with IL-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens. Int J Cancer. 1992 May 8;51(2):283-9. |
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| 1917164 | Temponi M, Fawwaz RA, Kekish U, Wang TS, Ferrone S: Improvement by affinity chromatography on antiidiotypic monoclonal antibodies (MAbs) of immunoreactivity and in vivo targeting of radiolabelled anti-HMW-MAA MAb TP61.5 in nude mice bearing human melanoma lesions. Int J Cancer. 1991 Oct 21;49(4):624-30. The human high-molecular-weight melanoma-associated antigen (HMW-MAA) represents a useful marker for immunoscintigraphy in patients with melanoma. |
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| 10501852 | thor Straten P, Becker JC, Guldberg P, Zeuthen J: In situ T cells in melanoma. . Cancer Immunol Immunother. 1999 Oct;48(7):386-95. Several melanoma-associated antigens (MAA) recognized by T cells have been characterized, and a number of HLA class I- and class II-restricted peptides have been identified. |
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| 8791267 | Muller J, Khan AS, Li M, Rao V, Hearing VJ, Gorelik E: Phenotypic changes and loss of melanoma-specific endogenous C-type retroviruses in BL6 melanoma cells transfected with the H-2Kb gene. Melanoma Res. 1996 Apr;6(2):101-11. In clones derived from the B16F10BL6 subline, expression of the transfected or endogenous H-2Kb gene resulted in alterations of various phenotypic properties of these melanoma cells, among which was the loss of melanoma-associated antigen (MAA) expression. |
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| 8541724 | Baharav E, Merimsky O, Altomonte M, Shoenfeld Y, Pavlovic M, Maio M, Ferrone S, Fishman P: Anti-tyrosinase antibodies participate in the immune response to vaccination with anti-idiotypic antibodies mimicking the high-molecular-weight melanoma-associated antigen. Melanoma Res. 1995 Oct;5(5):337-43. |
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| 16227204 | Chang CC, Hernandez-Guzman FG, Luo W, Wang X, Ferrone S, Ghosh D: Structural basis of antigen mimicry in a clinically relevant melanoma antigen system. J Biol Chem. 2005 Dec 16;280(50):41546-52. Epub 2005 Oct 14. Therefore, in this study we have characterized the structural basis of the human high molecular weight-melanoma-associated antigen (HMW-MAA) mimicry by the mouse anti-idiotypic (anti-id) monoclonal antibody (mAb) MK2-23. |
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| 10400790 | Martin F, Neil S, Kupsch J, Maurice M, Cosset F, Collins M: Retrovirus targeting by tropism restriction to melanoma cells. J Virol. 1999 Aug;73(8):6923-9. To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope. |
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| 16450373 | Reynolds SR, Vergilis IJ, Szarek M, Ferrone S, Bystryn JC: Cytoplasmic melanoma-associated antigen (CYT-MAA) serum level in patients with melanoma: a potential marker of response to immunotherapy?. Int J Cancer. 2006 Jul 1;119(1):157-61. |
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| 2944474 | Fisher PB, Hermo H Jr, Solowey WE, Dietrich MC, Edwalds GM, Weinstein IB, Langer JA, Pestka S, Giacomini P, Kusama M, et al.: Effect of recombinant human fibroblast interferon and mezerein on growth, differentiation, immune interferon binding and tumor associated antigen expression in human melanoma cells. Anticancer Res. 1986 Jul-Aug;6(4):765-74. In the present study we have further analyzed this synergistic interaction and have also evaluated the effect of IFN-delta and MEZ, alone and in combination, on recombinant human gamma interferon (IFN-gamma) binding and Class I HLA and melanoma associated antigen (MAA) expression in the HO-1 human melanoma cell line. |
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| 1694058 | Schlingemann RO, Rietveld FJ, de Waal RM, Ferrone S, Ruiter DJ: Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds. Am J Pathol. 1990 Jun;136(6):1393-405. |
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| 1612780 | Safi N, Kantor RR, Atkinson B, Moratz C, Wilt AR, Pancake S, Reba R, Mathieson BJ, Desgrez A: Two antigens detected on human ocular melanomas with the mouse monoclonal antibodies 2/10SN and 10/12SN. Int J Cancer. 1992 Jul 9;51(5):718-26. These melanoma-associated antigens (MAA) are detected at high concentrations in the cytoplasm of ocular melanoma cells. |
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| 9828818 | Hatta N, Takata M, Takehara K, Ohara K: Polymerase chain reaction and immunohistochemistry frequently detect occult melanoma cells in regional lymph nodes of melanoma patients. J Clin Pathol. 1998 Aug;51(8):597-601. AIMS: To evaluate immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR) for melanoma associated antigens (MAA) in detecting occult melanoma cells in lymph nodes which were missed on routine pathology. |
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| 4005860 | Buraggi GL, Callegaro L, Mariani G, Turrin A, Cascinelli N, Attili A, Bombardieri E, Terno G, Plassio G, Dovis M, et al.: Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F (ab') 2 fragments. Cancer Res. 1985 Jul;45(7):3378-87. |
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| 2962476 | Salinas FA, Wee KH: Prognostic and pathogenetic implications of immune complexes in human cancer. Adv Immun Cancer Ther. 1986;2:189-209. In view of the phenotypic heterogeneity of antigen expression in malignant melanoma, we have extracted, purified, and utilized melanoma-associated antigens (MAA) from CIC, and human oncofetal antigens (HOFA) from fetal liver cells, and reacted them with patients' sera in an in vitro model that simulates tumor burden changes. |
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| 1728407 | Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML: A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels. Cancer Res. 1992 Jan 15;52(2):357-66. MAb 436 recognizes a Mr 125,000 cell surface melanoma-associated glycoprotein antigen (125 kDa-MAA); MAbs IND1 and 9.2.27 recognize a high molecular weight melanoma-associated antigen, but with equilibrium association constants differing by 2 orders of magnitude (10 (8)-10 (10) M-1). |
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| 15634921 | Wagner S, Hafner C, Allwardt D, Jasinska J, Ferrone S, Zielinski CC, Scheiner O, Wiedermann U, Pehamberger H, Breiteneder H: Vaccination with a human high molecular weight melanoma-associated antigen mimotope induces a humoral response inhibiting melanoma cell growth in vitro. J Immunol. 2005 Jan 15;174(2):976-82. |
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| 1731316 | Mittelman A, Chen ZJ, Yang H, Wong GY, Ferrone S: Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):466-70. |
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| 7496156 | Kim TS, Xu WS, Sun T, Cohen EP: Immunization with interleukin-2/interferon-gamma double cytokine-secreting allogeneic fibroblasts prolongs the survival of mice with melanoma. Melanoma Res. 1995 Aug;5(4):217-27. LM mouse fibroblasts (H-2k) were modified for the expression of (antibody-defined) melanoma-associated antigens (MAA) and the secretion of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) (RLBA-IL-2/IFN-gamma cells). |
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