| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17596522 | Zhang A, Jia Z, Guo X, Yang T: induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31. Epub 2007 Jun 27. Aldo induced phosphorylation of ERK1/2 that was completely blocked by rotenone. |
2(0,0,0,2) | Details |
| 19073841 | Mookerjee I, Hewitson TD, Halls ML, Summers RJ, Mathai ML, Bathgate RA, Tregear GW, Samuel CS: Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 2009 Apr;23(4):1219-29. Epub 2008 Dec 10. H2 relaxin also induced a transient rise in cAMP in the presence of G (i/o) inhibition, and a sustained increase in extracellular signal-regulated kinase (ERK)-1/2 phosphorylation. |
1(0,0,0,1) | Details |
| 17615152 | Cheng J, Zhang C, Shapiro DJ: A functional serine 118 phosphorylation site in estrogen receptor-alpha is required for down-regulation of gene expression by 17beta- and 4-hydroxytamoxifen. Endocrinology. 2007 Oct;148(10):4634-41. Epub 2007 Jul 5. To evaluate the contribution of ERK1/2 phosphorylation of estrogen receptor (ER)-alpha to activation and repression of endogenous genes, we produced stably transfected lines of HeLa cells with functional ERK1/2 pathways that express similar levels of wild-type human ERalpha and ERalpha mutated to inactivate the well-known MAPK site at serine 118 (ERalphaS118A). In contrast, for Sma and mothers against decapentaplegic-3-related, which is down-regulated by E (2) and not OHT, the S118A mutation had little effect. |
1(0,0,0,1) | Details |
| 19614927 | Ishiguro S, Akasaka Y, Kiguchi H, Suzuki T, Imaizumi R, Ishikawa Y, Ito K, Ishii T: Basic fibroblast growth factor induces down-regulation of alpha-smooth muscle actin and reduction of myofibroblast areas in open skin wounds. Wound Repair Regen. 2009 Jul-Aug;17(4):617-25. Along with the inhibition of alpha-SMA expression by bFGF, the RMF and RMFL cells also showed different activated expression of extracellular signal-regulated kinase 1/2, suggesting the involvement of extracellular signal-regulated kinase 1/2 activation in the down-regulation of alpha-SMA expression in myofibroblasts. |
1(0,0,0,1) | Details |
| 19175832 | Lin YL, Wu CF, Huang YT: Effects of rhubarb on migration of rat hepatic stellate cells. J Gastroenterol Hepatol. 2009 Mar;24(3):453-61. Epub 2008 Oct 23. Phosphorylations of Smad2/3 and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) 1/2, p38, and c-jun N-terminal kinase (JNK), were analyzed with Western blotting. |
1(0,0,0,1) | Details |
| 19650157 | Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA: Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep;50(3):929-38. HSCs express the Ang (1-7) receptor Mas and Ang (1-7) inhibited Ang II-induced phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in cultured HSCs. |
1(0,0,0,1) | Details |
| 19011011 | Yadav UC, Ighani-Hosseinabad F, van Kuijk FJ, Srivastava SK, Ramana KV: Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):752-9. Epub 2008 Nov 14. Inhibition of AR also prevented the BFGF-induced activation of ERK1/2, JNK, and NF-kappaB in HLECs. |
1(0,0,0,1) | Details |
| 17884089 | Wakisaka O, Takahashi N, Shinohara T, Ooie T, Nakagawa M, Yonemochi H, Hara M, Shimada T, Saikawa T, Yoshimatsu H: Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72. J Mol Cell Cardiol. 2007 Nov;43(5):616-26. Epub 2007 Aug 16. HT induced the expression of HSP72, which was associated with the attenuation of AII-induced extracellular signal-regulated kinase (ERK1/ERK2) phosphorylation, alpha-smooth muscle actin (alpha-SMA) expression, transforming growth factor-beta (1) secretion, collagen synthesis, and expression of collagen type I and tissue inhibitor of metalloproteinases-1. |
1(0,0,0,1) | Details |
| 19819988 | Chang SF, Chang TK, Peng HH, Yeh YT, Lee DY, Yeh CR, Zhou J, Cheng CK, Chang CA, Chiu JJ: BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol. 2009 Nov;23(11):1827-38. Epub 2009 Oct 9. Using specific small interfering RNA (siRNA), we found that BMP-4-induced G (0)/G (1) arrest, and p21 (CIP1) and p27 (KIP1) expressions were mediated by BMP receptor type IA (BMPRIA)-specific Sma- and Mad-related protein (Smad) 1/5. |
0(0,0,0,0) | Details |
| 18064666 | Okada Y, Tsuzuki Y, Hokari R, Miyazaki J, Matsuzaki K, Mataki N, Komoto S, Watanabe C, Kawaguchi A, Nagao S, Itoh K, Miura S: Pressure loading and exposure differentially modulate rat hepatic stellate cell activation. J Cell Physiol. 2008 May;215(2):472-80. Pressure loading alone induced up-regulation of alpha-SMA via the extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-jun N-terminal kinase (JNK) signaling pathways, prolonged extension of marginal length, and increased production of collagen IV. |
1(0,0,0,1) | Details |
| 18346908 | Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, Sortino MA, Nicoletti F, Copani A, Vancheri C: TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res. 2008 Apr;57(4):274-82. Epub 2008 Feb 9. This study demonstrates that TGF-beta1 induces alpha-SMA expression and collagen production in human lung fibroblasts via ERK1/2 activation, GSK-3beta inhibition and nuclear beta-catenin translocation. |
1(0,0,0,1) | Details |
| 20205597 | Lin Q, Fang LP, Zhou WW, Liu XM: inhibits migration, proliferation, and phenotypic differentiation in cultured human lung fibroblasts. Exp Lung Res. 2010 Mar;36(2):120-8. In addition, RSG incubation reduced the ratio of phospho-extracellular signal-regulated kinases 1/2 (p-ERK1/2) to ERK1/2 expression stimulated by FBS, PDGF-BB, and TGF-beta1. |
1(0,0,0,1) | Details |
| 19723340 | Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT: Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci. 2009 Sep 2;16:78. Arm also suppressed TNF-alpha-induced collagen collagen deposition, NFkappaB activation and MAPK (p38, ERK1/2, and JNK) phosphorylations. |
1(0,0,0,1) | Details |
| 18061165 | Pacheco-Dominguez RL, Palma-Nicolas JP, Lopez E, Lopez-Colome AM: The activation of MEK-ERK1/2 by glutamate receptor-stimulation is involved in the regulation of RPE proliferation and morphologic transformation. Exp Eye Res. 2008 Feb;86(2):207-19. Epub 2007 Oct 30. Activation of metabotropic, AMPA and NMDA receptors by induced the time-and dose-dependent phosphorylation of ERK1/2, assessed by Western blot analysis, in parallel to a significant increase in cell proliferation and a decrease in alpha-sma expression and its recruitment into stress fibers. |
34(0,1,1,4) | Details |
| 19154323 | Xu G, Liu A, Liu X: induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules. Nephrology. 2008 Dec;13(8):694-701. |
5(0,0,0,5) | Details |
| 19926889 | Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL: NAD (P) H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol. 2010 Jan;21(1):93-102. Epub 2009 Nov 19. In addition, TGF-beta1 stimulated phosphorylation of extracellular signal-regulated kinase (ERK1/2), and this was inhibited by blocking TGF-beta1 receptor 1, Smad3, or the Nox oxidases; ERK1/2 activation increased alpha-SMA and Fn-ED-A. |
2(0,0,0,2) | Details |
| 19101622 | Xie XS, Yang M, Liu HC, Zuo C, Li HJ, Fan JM: Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro. J Ethnopharmacol. 2009 Feb 25;122(1):35-41. Epub 2008 Dec 3. In addition, western blot analysis indicated that ginsenoside Rg1 inhibited the expression of P-ERK1/2 in NRK-52E induced by TGF-beta1. |
2(0,0,0,2) | Details |
| 19576044 | Huang HQ, Zhang P, Jiang Z, Chen HZ: [Overexpression of endothelin-1 induces hypertrophy of rat pulmonary arterial microvascular smooth muscle cells via Akt/mTOR pathway]. Zhonghua Jie He He Hu Xi Za Zhi. 2009 Apr;32(4):287-91. Western blotting was used to examine the levels of phosphorylations of protein kinase B/Akt, mTOR, and ERK1/2. |
2(0,0,0,2) | Details |