Protein Information

Name Lactoferrin
Synonyms GIG12; Growth inhibiting protein 12; HLF 2; HLF2; LF; LTF; Lactoferrin; Lactotransferrin…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9746616 Jarosik GP, Land CB, Duhon P, Chandler R Jr, Mercer T: Acquisition of iron by Gardnerella vaginalis. Infect Immun. 1998 Oct;66(10):5041-7.


In a plate bioassay, all six strains acquired iron from ferrous chloride, ferric chloride, ferrous sulfate, ferric ammonium citrate, ferrous ammonium sulfate, bovine and equine hemin, bovine catalase, and equine, bovine, rabbit, and human hemoglobin.
0(0,0,0,0) Details
16469988 Lonnerdal B, Bryant A: Absorption of iron from recombinant human lactoferrin in young US women. Am J Clin Nutr. 2006 Feb;83(2):305-9.

Serum ferritin and iron absorption were inversely correlated in subjects when they received either lactoferrin or ferrous sulfate, which suggested that iron is absorbed from the 2 sources by a similar mechanism.
54(0,1,4,9) Details
19639462 Nappi C, Tommaselli GA, Morra I, Massaro M, Formisano C, Di Carlo C: Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. Acta Obstet Gynecol Scand. 2009;88(9):1031-5.
30(0,0,5,5) Details
8708108 Kume S, Tanabe S: Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves. J Dairy Sci. 1996 Mar;79(3):459-64.

7(0,0,0,7) Details
6469273 Amouric M, Marvaldi J, Pichon J, Bellot F, Figarella C: Effect of lactoferrin on the growth of a human colon adenocarcinoma cell line--comparison with transferrin. In Vitro. 1984 Jul;20(7):543-8.

Lactoferrin was examined for its effect on the growth of a human colon adenocarcinoma cell line (HT 29) in culture and its action was compared to that produced by transferrin and two different iron solutions (ferrous sulfate and ferric chloride).
9(0,0,1,4) Details
16936810 Paesano R, Torcia F, Berlutti F, Pacifici E, Ebano V, Moscarini M, Valenti P: Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women. Biochem Cell Biol. 2006 Jun;84(3):377-80.

In our study, 300 women at different trimesters of pregnancy were enrolled in a trial of oral administration of ferrous sulfate (520 mg once a day) or 30% iron-saturated bovine lactoferrin (bLf) (100 mg twice a day).
8(0,0,1,3) Details
2314947 Davidson LA, Litov RE, Lonnerdal B: Iron retention from lactoferrin-supplemented formulas in infant rhesus monkeys. Pediatr Res. 1990 Feb;27(2):176-80.

In our study, iron retention from human milk, milk-based infant formula (IF) with and without supplemental ferrous sulfate, and IF supplemented with either human or bovine lactoferrin (Lf) was evaluated in infant rhesus monkeys.
7(0,0,1,2) Details
16887629 Daniel C, Bissinger MC, Courcol RJ: Effects of host iron transport compounds on growth kinetics and outer-membrane protein expression of Bilophila wadsworthia. Anaerobe. 1998 Apr;4(2):103-9.

Since the environmental iron concentration has emerged as an important attribute in the expression of bacterial virulence, the purpose of this study was to determine the effects of transferrin, lactoferrin, heme compounds, and inorganic iron sources (ferric and ferrous sulfate) on the growth of Bilophila wadsworthia and to study its outer membrane composition when grown under these different simulated in vivo conditions.
7(0,0,1,2) Details
8025391 Lonnerdal B, Hernell O: Iron, zinc, copper and selenium status of breast-fed infants and infants fed trace element fortified milk-based infant formula. Acta Paediatr. 1994 Apr;83(4):367-73.

One formula with 4 mg of iron/l contained iron as ferrous sulfate, in another, part of the iron was provided as bovine lactoferrin.
6(0,0,1,1) Details
7553361 Salamah AA, al-Obaidi AS: In vivo and in vitro effects of lactoferrin on Yersinia pseudotuberculosis. New Microbiol. 1995 Jul;18(3):267-74.

4(0,0,0,4) Details
1309510 Agiato LA, Dyer DW: Siderophore production and membrane alterations by Bordetella pertussis in response to iron starvation. Infect Immun. 1992 Jan;60(1):117-23.


Lactoferrin and transferrin supported growth of B. pertussis even when the protein was sequestered inside dialysis tubing.
2(0,0,0,2) Details
2963123 Richie ER, Hilliard JK, Gilmore R, Gillespie DJ: Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. J Reprod Immunol. 1987 Oct;12(2):137-48.

2(0,0,0,2) Details
6233906 Fligiel SE, Ward PA, Johnson KJ, Till GO: Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis. Am J Pathol. 1984 Jun;115(3):375-82.


Iron-saturated lactoferrin is devoid of protective effects.
1(0,0,0,1) Details