| Name | sodium channel (protein family or complex) |
|---|---|
| Synonyms | Sodium channel |
| Name | indoxacarb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12974351 | Tsurubuchi Y, Kono Y: Modulation of channels by the oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite in rat dorsal root ganglion neurons. Pest Manag Sci. 2003 Sep;59(9):999-1006. Based on these results, it was concluded that indoxacarb and DCJW potently blocked the TTX-R sodium channel in rat DRG neurons with hyperpolarizing shifts of the steady-state inactivation curves, suggesting preferential association of the insecticides to the inactivated state of channels. |
81(1,1,1,1) | Details |
| 19443036 | Silver KS, Nomura Y, Salgado VL, Dong K: Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. Neurotoxicology. 2009 Jul;30(4):613-21. Epub 2009 Apr 8. Sodium channel blocker insecticides (SCBIs), such as indoxacarb and metaflumizone, are a new class of insecticides with a mechanism of action different from those of other insecticides that target channels. |
33(0,1,1,3) | Details |
| 16487558 | Silver KS, Soderlund DM: Differential sensitivity of rat voltage-sensitive sodium channel isoforms to pyrazoline-type insecticides. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):209-17. Epub 2006 Feb 17. This study employed the Xenopus oocyte expression system to examine the relative sensitivity of rat Na (v) 1.2a, Na (v) 1.4, Na (v) 1.5, and Na (v) 1.8 sodium channel alpha subunit isoforms to the pyrazoline-type insecticides indoxacarb, DCJW, and RH 3421. |
9(0,0,1,4) | Details |
| 17089332 | Yu SJ, McCord E Jr: Lack of cross-resistance to indoxacarb in insecticide-resistant Spodoptera frugiperda (Lepidoptera: Noctuidae) and Plutella xylostella (Lepidoptera: Yponomeutidae). Pest Manag Sci. 2007 Jan;63(1):63-7. The lack of cross-resistance between indoxacarb and permethrin in P. xylostella further supports the notion that the mode of action of these insecticides on the insect sodium channel is different. |
6(0,0,1,1) | Details |
| 11455646 | McCann SF, Annis GD, Shapiro R, Piotrowski DW, Lahm GP, Long JK, Lee KC, Hughes MM, Myers BJ, Griswold SM, Reeves BM, March RW, Sharpe PL, Lowder P, Barnette WE, Wing KD: The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides. Pest Manag Sci. 2001 Feb;57(2):153-64. The evolution of the insecticidal pyrazoline moiety that was originally discovered in 1972 has led to the discovery of a new crop insecticide, indoxacarb, which is the first commercialized pyrazoline-type sodium-channel blocker. |
6(0,0,1,1) | Details |
| 15935211 | Silver K, Soderlund DM: State-dependent block of rat Nav1.4 channels expressed in xenopus oocytes by pyrazoline-type insecticides. Neurotoxicology. 2005 Jun;26(3):397-406. Studies on the effects of pyrazoline insecticides on mammalian channels have been limited to experimentation on the tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium channel populations of rat dorsal root ganglion (DRG) neurons. In this study, we examined the effects of the insecticidal pyrazolines indoxacarb, the N-decarbomethoxyllated metabolite of indoxacarb (DCJW), and RH 3421 on rat Na (v) 1.4 channels expressed in Xenopus laevis oocytes using the two-electrode voltage clamp technique. |
3(0,0,0,3) | Details |
| 17367864 | Silver KS, Soderlund DM: Point mutations at the local anesthetic receptor site modulate the state-dependent block of rat Na v1.4 channels by pyrazoline-type insecticides. Neurotoxicology. 2007 May;28(3):655-63. Epub 2007 Feb 11. Pyrazoline-type insecticides (PTIs) selectively block channels at membrane potentials that promote slow sodium channel inactivation and are proposed to interact with a site that overlaps the local anesthetic (LA) receptor site. To test the hypothesis that PTIs bind to the LA receptor, we constructed mutated Na (v) 1.4/F1579A and Na (v) 1.4/Y1586A cDNAs, expressed native and mutated channels in Xenopus oocytes, and examined the effects of these mutations on channel block by three PTIs (indoxacarb, its bioactivation product DCJW, and RH3421) by two-electrode voltage clamp. |
2(0,0,0,2) | Details |
| 16325912 | Song W, Liu Z, Dong K: Molecular basis of differential sensitivity of insect channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. Neurotoxicology. 2006 Mar;27(2):237-44. Epub 2005 Dec 2. In this study, we identified two cockroach sodium channel variants, BgNa (v) 1-1 and BgNa (v) 1-4, which differ in voltage dependence of fast and slow inactivation, and channel sensitivity to DCJW. |
2(0,0,0,2) | Details |
| 12564385 | Zhao X, Ikeda T, Yeh JZ, Narahashi T: Voltage-dependent block of channels in mammalian neurons by the oxadiazine insecticide indoxacarb and its metabolite DCJW. Neurotoxicology. 2003 Jan;24(1):83-96. |
0(0,0,0,0) | Details |