| Name | thrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12540482 | Berry LR, Klement P, Andrew M, Chan AK: Effect of covalent serpin-heparinoid complexes on plasma thrombin generation on fetal distal lung epithelium. Am J Respir Cell Mol Biol. 2003 Feb;28(2):150-8. |
10(0,0,0,10) | Details |
| 1377731 | Joseph P, Viswanatha S, Krishnakumari MK: Role of in the haematotoxicity of hexachlorocyclohexane (HCH) in the rat. J Environ Sci Health B. 1992 Jun;27(3):269-80. Assessment of HCH-induced haematotoxicity at the end of the 7 weeks feeding period was done on the basis of haemoglobin content, total count of red blood cells and white blood cells and the differential counts of the white blood cells as well as by parameters such as packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin content, prothrombin time and clotting time. |
2(0,0,0,2) | Details |
| 11783323 | Yu W, Shen F, Ma Z: [Observation of therapeutic effect of Salviae miltiorrhiza and - injection on patients with hypertensive cerebral hemorrhage]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Feb;20(2):94-6. METHODS: Fifty-one cases (age 50-78 years, 61.2 years on average) of HCH were randomly divided into three groups (SM + - (CDP-C) group and para-aminomethyl (PAMBA) + CDP-C group as treated group, CDP-C group as control group) to observe the outcome of the clinical treatment, hematoma absorbability and changes of ADP-platelet agglutination rate (Pag), prothrombin time (PT) and function of the liver and kidney. |
1(0,0,0,1) | Details |
| 6163731 | Brassow HL, Baumann K, Lehnert G: Occupational exposure to hexachlorocyclohexane. Int Arch Occup Environ Health. 1981;48(1):81-7. However, the following significant differences in clinical-chemical blood tests were ascertained: higher polymorphonuclear leukocyte count, lower lymphocyte count, higher reticulocyte count, lower prothrombin (Quick's) test, and lower blood concentrations of and |
1(0,0,0,1) | Details |
| 10480230 | Saenko E, Sarafanov A, Greco N, Shima M, Loster K, Schwinn H, Josic D: Use of surface plasmon resonance for studies of protein-protein and protein-phospholipid membrane interactions. J Chromatogr A. 1999 Aug 6;852(1):59-71. It was demonstrated that the loss of the LCh acidic region upon thrombin cleavage leads to an 11 and 160-fold increase in the dissociation rate constant (k (off) value) and a 165 and 1500-fold increase in the Kd value of the binding of fVIII fragment A3-C1-C2 to vWf compared to that of LCh and fVIII, respectively. The finding that Kd of LCh binding to vWf (3.8 nM) is 9.5 times higher than that of fVIII (0.4 nM), indicates that the heavy chain (HCh) is required for the maximal affinity of fVIII for vWf. |
1(0,0,0,1) | Details |