Protein Information

Name phosphodiesterase 4
Synonyms CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4…

Compound Information

Name benzyladenine
CAS

Reference List

PubMed Abstract RScore(About this table)
10640302 Boichot E, Wallace JL, Germain N, Corbel M, Lugnier C, Lagente V, Bourguignon JJ: Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derived from 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53.

We compared the effects of various compounds derived from 9-benzyladenine with those of the selective PDE4 inhibitor RP 73401 on the inhibition of PDE4 isolated from bovine aorta, arachidonic acid, and tumor necrosis factor-alpha release by mononuclear cells from healthy subjects.
114(1,2,2,4) Details
11606060 Reimund JM, Raboisson P, Pinna G, Lugnier C, Bourguignon JJ, Muller CD: Anti-TNF-alpha properties of new 9-benzyladenine derivatives with selective phosphodiesterase-4- inhibiting properties. Biochem Biophys Res Commun. 2001 Oct 26;288(2):427-34.
114(1,2,2,4) Details
168874 Elliott DC, Murray AW: Evidence against an involvement of cyclic nucleotides in the induction of betacyanin synthesis by cytokinins. Biochem J. 1975 Feb;146(2):333-7.

The induction of pigment by benzyladenine, dibutyryl cyclic AMP or cyclic AMP was not potentiated by aminophylline.
Aminophylline was shown to inhibit Amaranthus cyclic AMP phosphodiesterase activity. 4.
1(0,0,0,1) Details
16659417 Armstrong DJ, Murai N, Taller BJ, Skoog F: Incorporation of Cytokinin N-Benzyladenine into Tobacco Callus Transfer Ribonucleic Acid and Ribosomal Ribonucleic Acid Preparations. Plant Physiol. 1976 Jan;57(1):15-22.

N (6)-benzyladenosine was released from the rRNA preparation by treatment with venom phosphodiesterase and phosphatase, ribonuclease T (2) and phosphatase, or ribonuclease T (2) and a 3'-nucleotidase.
1(0,0,0,1) Details