| Name | GABA receptor (protein family or complex) |
|---|---|
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3027258 | Lummis SC, Chow SC, Holan G, Johnston GA: gamma-Aminobutyric acid receptor ionophore complexes: differential effects of deltamethrin, dichlorodiphenyltrichloroethane, and some novel insecticides in a rat brain membrane preparation. J Neurochem. 1987 Mar;48(3):689-94. |
112(1,2,2,2) | Details |
| 3000377 | Bloomquist JR, Soderlund DM: insecticides inhibit -dependent uptake by mouse brain vesicles. Biochem Biophys Res Commun. 1985 Nov 27;133(1):37-43. The insecticides endrin, dieldrin, aldrin, lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane) and deltamethrin inhibited -dependent 36Cl- uptake by mouse brain vesicles. These results demonstrate the disruption of gamma-aminobutyric acid receptor- ionophore function in mammalian brain by insecticides and provide evidence that this complex is the principal site of cyclodiene action. |
1(0,0,0,1) | Details |
| 18243323 | Meyer DA, Carter JM, Johnstone AF, Shafer TJ: Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture. Neurotoxicology. 2008 Mar;29(2):213-25. Epub 2007 Dec 3. In order to characterize pyrethroid effects on neurotransmitter release and neuronal excitability in glutamatergic networks, we examined the effects of deltamethrin (DM) and permethrin (PM) on neuronal activity in hippocampal neuronal cultures using patch-clamp and microelectrode array (MEA) recordings. In the presence of inhibitors of GABA receptors, spontaneous excitatory post-synaptic currents (sEPSCs) and spontaneous spike rates were reduced in a concentration-dependent manner by both DM and PM. |
2(0,0,0,2) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. The type II pyrethroids deltamethrin and fenvalerate augmented the -activated peak current when applied concurrently with but the effect was diminished as the pyrethroids were applied for long periods of time prior to application. It seems that general anesthetics have a specific affinity for the GABA receptor-channel complex. |
2(0,0,0,2) | Details |
| 6310756 | Lawrence LJ, Casida JE: Stereospecific action of pyrethroid insecticides on the gamma-aminobutyric acid receptor-ionophore complex. Science. 1983 Sep 30;221(4618):1399-401. The potent alpha-cyano-3-phenoxybenzyl pyrethroids, including cypermethrin, deltamethrin, and fenvalerate, act stereospecifically to inhibit binding to rat brain synaptic membranes of -35-labeled t-butylbicyclophosphorothionate, a new radioligand for the picrotoxinin binding site. |
2(0,0,0,2) | Details |
| 2458984 | Ogata N, Vogel SM, Narahashi T: Lindane but not deltamethrin blocks a component of -activated channels. FASEB J. 1988 Oct;2(13):2895-900. Thus, the action of lindane to stimulate the nervous system is partly because of an interaction with the GABA receptor-channel complex. |
1(0,0,0,1) | Details |
| 6314207 | Gammon D, Casida JE: Pyrethroids of the most potent class antagonize action at the crayfish neuromuscular junction. Neurosci Lett. 1983 Sep 30;40(2):163-8. Deltamethrin and three insecticidal cyano analogs causing the Type II pyrethroid syndrome increased the input resistance of crayfish claw opener muscle fibers bathed in Cyanophenoxybenzyl pyrethroids therefore appear to act on the GABA receptor-ionophore complex. |
1(0,0,0,1) | Details |