Protein Information

Name monoamine oxidase
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name deltamethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
6539110 Pham Huu Chanh, Navarro-Delmasure C, Pham Huu Chanh, Cheav SL, Ziade F, Samaha F: Pharmacological effects of deltamethrin on the central nervous system. . Arzneimittelforschung. 1984;34(2):175-81.

Deltamethrin reveals the latent toxicity of tryptamine used in the non-toxic dose range; this predicts that deltamethrin might have an IMAO (inhibitor of monoamine oxidase) activity.
81(1,1,1,1) Details
8090688 Husain R, Malaviya M, Seth PK, Husain R: Effect of deltamethrin on regional brain polyamines and behaviour in young rats. Pharmacol Toxicol. 1994 Apr-May;74(4-5):211-5.

A significant increase in the activities of mitochondrial monoamine oxidase and microsomal acetylcholinesterase without any effect on microsomal Na+, K (+)-ATPase activity was observed in the brain of experimental animals.
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8751838 Husain R, Husain R, Adhami VM, Seth PK: Behavioral, neurochemical, and neuromorphological effects of deltamethrin in adult rats. J Toxicol Environ Health. 1996 Aug 9;48(5):515-26.

A significant increase in the activity of monoamine oxidase was observed in frontal cortex, hippocampus, and cerebellum, and acetylcholinesterase activity was markedly increased in frontal cortex, corpus striatum, hippocampus, cerebellum, and pons medulla.
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16310970 Tsai SJ: Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent. Med Hypotheses. 2006;66(3):605-8. Epub 2005 Nov 28.

Antidepressants, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and serotonin-noradrenalin reuptake inhibitors, are the main biological treatment for major depression.
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