| ID | 2 |
|---|---|
| Name | gamma aminobutyric acid receptor (protein family or complex) |
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 12770368 | Aydar E, Beadle DJ: The pharmacological profile of GABA receptors on cultured insect neurones. J Insect Physiol. 1999 Mar;45(3):213-219. Neuronal cultures of the cockroach, Periplaneta americana, were used to study the pharmacological profile of GABA receptors using the whole-cell-voltage clamp technique. The results indicated that insect GABA receptors are linked to a chloride channel that can be activated by both (A) and (C) receptor agonists. The receptors are blocked by (A) chloride channel blockers and some insecticides but not by competitive (A) receptor antagonists. The (C) receptor competitive antagonists were either full or partial agonists of the cockroach GABA receptors. The receptors were modulated by the enantiomers of lindane. In conclusion, insect GABA receptors appear to have a distinct pharmacological profile that does not conform to either vertebrate (A) or (C) receptors. |
4(0,0,0,4) |