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Zatsepin EP, Churaev NN, Uspenskaia TA, Tirzit GD, Dubur GIa: [Action of antioxidants on membrane-toxic effects of anticholinesterase agents]. Biull Eksp Biol Med. 1990 Dec;110(12):623-4. It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate. Thus, antioxidants are pathogenetic drugs for treatment of poisonings with cholinesterase inhibitors. |
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