| ID | 25 |
|---|---|
| Name | phospholipase C |
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 7536436 | Senar S, Puente JC, Lopez-Aparicio P, Recio MN, Perez-Albarsanz MA: Increased intracellular glycerophosphoinositol and are biochemical markers for lindane toxicity. Cell Signal. 1994 Nov;6(8):915-21. Lindane stimulates the release of both glycerophosphoinositol and from phospholipids in rat renal proximal tubular cell cultures. When lindane was added to the culture medium, a correlation between the time-course profiles of glycerophosphoinositol and release was found. This suggests a pathway in which phosphatidylinositol is not directly broken down by phospholipase C, but can instead be broken down to glycerophosphoinositol and by phospholipase A enzymes. Therefore, a mechanism of action of lindane is through its effect on glycerophosphoinositol and arachidonic acid metabolism. |
0(0,0,0,0) |