| ID | 2 |
|---|---|
| Name | gamma aminobutyric acid receptor (protein family or complex) |
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 7534833 | Pomes A, Frandsen A, Sunol C, Sanfeliu C, Rodriguez-Farre E, Schousboe A: Lindane cytotoxicity in cultured neocortical neurons is ameliorated by and flunitrazepam. J Neurosci Res. 1994 Dec 15;39(6):663-8. The effect of lindane (gamma-hexachlorocyclohexane) on [35S] t-butylbicyclophosphorothionate ([35S] TBPS) binding and -stimulated 36Cl- influx was investigated in cultured cerebral cortical neurons. In addition, the cytotoxic action of lindane as well as a protection by and flunitrazepam were studied together with the ability of lindane to increase the intracellular concentration of free Ca2+. Lindane was found to be toxic to the neurons, an effect that could be completely prevented by the simultaneous presence of (0.1 microM) and flunitrazepam (100 microM) and reduced by alone. An interaction with the GABA receptor-gated chloride channel was demonstrated by an inhibitory action of lindane on [35S] TBPS binding (IC50 188 +/- 51 nM) and on -stimulated 36Cl- influx in the neurons. Lindane only marginally increased the intracellular Ca2+ concentration in the neurons. It is concluded that the cytotoxic action of lindane is mediated through interaction with GABA receptors in a manner essentially independent of changes in intracellular Ca2+ homeostasis. |
112(1,2,2,2) |