| 10754214 |
Manubay P, van Lunteren E: Effects on dystrophic (dy/dy) limb muscle of the K+ channel blocker tetraethylammonium. Neurosci Lett. 2000 Apr 14;283(3):169-72.
K (+) channel blockers, such as tetraethylammonium (TEA) and 4-aminopyridine, increase force of normal skeletal muscle. To determine whether they also increase force of diseased muscle, effects of TEA were examined on limb muscles of dy/dy dystrophic mice in vitro. TEA significantly increased isometric twitch force of normal and dystrophic soleus muscle by 29.9+/-5.8 and 30.0+/-5.0%, respectively, and significantly increased force of normal and dystrophic extensor digitorum longus muscle by 18.3+/-1.9 and 34. 9+/-10.4%, respectively. Force increases could be attributed only partially to a prolongation of contraction time. These data indicate that TEA augments force of overtly diseased (dystrophic) limb muscle to an extent comparable with that of normal limb muscle. |
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