| 1488063 |
Wu CM, Matsuoka T, Takemitsu M, Goto Y, Nonaka I: An experimental model of mitochondrial myopathy: germanium-induced myopathy and coenzyme Q10 administration. Muscle Nerve. 1992 Nov;15(11):1258-64.
In skeletal muscles from rats treated with germanium for 23 weeks, there were numerous ragged-red fibers and cytochrome-c oxidase (COX)-deficient fibers. Biochemically, germanium reduced the enzyme activities in the mitochondrial respiratory chain. Rotenone-sensitive NADH-cytochrome-c reductase as well as COX activities were markedly reduced, while succinate-cytochrome-c reductase was less severely, but significantly, affected. The histopathological findings in these muscles were similar to those seen in patients with mitochondrial encephalomyopathy, suggesting that germanium-induced myopathy may be a useful experimental model. Coenzyme Q10 administration appeared to be ineffective in preventing this experimental myopathy. |
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