| 18929557 |
Shigemi K, Tsuneyoshi Y, Hamasu K, Han L, Hayamizu K, Denbow DM, Furuse M: l-Serine induces sedative and hypnotic effects acting at GABA (A) receptors in neonatal chicks. Eur J Pharmacol. 2008 Dec 3;599(1-3):86-90. Epub 2008 Sep 30.
Intracerebroventricular injection of l-serine has been shown to have sedative and hypnotic effects on neonatal chicks exposed to acute stressful conditions. However, the mechanism by which l-serine induces these effects is unclear. The present study was conducted to clarify the mechanism by l-serine. The involvement of gamma-aminobutyric acid (GABA)(A) receptors on the effect of l-serine was investigated using the GABA (A) receptor antagonist picrotoxin. Co-administration of picrotoxin attenuated the sedative and hypnotic effect of l-serine. Further, we also investigated the involvement of glycine receptors since l-serine is suggested to act as the alpha-homomeric glycine receptor agonist. Glycine similarly induced sedative and hypnotic effects in chicks, but its effect was attenuated by the glycine receptor antagonist strychnine. Therefore, whether the effect of l-serine was mediated through the glycine receptor was investigated using l-serine and strychnine. The effect of l-serine was inhibited by picrotoxin, but not strychnine. It appears that l-serine induces sedative and hypnotic effects by enhancing inhibitory neurotransmission via GABA (A) receptors. |
1(0,0,0,1) |