| 10430508 |
Li P, Yang XL: Zn2+ differentially modulates glycine receptors versus GABA receptors in isolated carp retinal third-order neurons. Neurosci Lett. 1999 Jul 9;269(2):75-8.
It was previously reported that strychnine-sensitive glycine receptors and GABAA receptors co-existed on carp retinal third-order neurons (amacrine/ganglion cells) (Li, P. and Yang, X.-L., Strong synergism between GABAA and glycine receptors on isolated carp third-order neurons. NeuroReport, 9 (1998) 2785-2789.). In this study, the effects of the divalent cation Zn2+ on these two receptors were studied in amacrine/ganglion cells acutely isolated from carp, with the use of the whole-cell patch clamp recording technique. The glycine-induced currents were steadily potentiated by Zn2+ of lower concentrations (0.1-10 microM), while being dose-dependently inhibited by Zn2+ of higher concentrations ( > 100 microM). Both the effects involved changes in apparent glycine affinity of the glycine receptor. In contrast, Zn2+ consistently suppressed the GABA (A) mediated currents of these cells, and did not show similar dual effect. The differential modulation by Zn2+ of glycine receptors versus GABA (A) receptors provides a versatility for regulating inhibitory glycinergic and GABAergic inputs converging on most amacrine/ganglion cells. |
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