Protein Information

ID 283
Name P13
Synonyms 3' 5' exoribonuclease CSL4 homolog; 3' 5' exoribonuclease CSL4 homolog; CGI 108; CGI108; CSL 4; CSL4; Csl4p; EXOSC 1…

Compound Information

ID 336
Name strychnine
CAS strychnidin-10-one

Reference

PubMed Abstract RScore(About this table)
10627581 Iwasaki S, Momiyama A, Uchitel OD, Takahashi T: Developmental changes in calcium channel types mediating central synaptic transmission. J Neurosci. 2000 Jan 1;20(1):59-65.
Multiple types of high-voltage-activated Ca (2+) channels trigger neurotransmitter release at the mammalian central synapse. Among them, the omega-conotoxin GVIA-sensitive N-type channels and the omega-Aga-IVA-sensitive P/Q-type channels mediate fast synaptic transmission. However, at most central synapses, it is not known whether the contributions of different Ca (2+) channel types to synaptic transmission remain stable throughout postnatal development. We have addressed this question by testing type-specific Ca (2+) channel blockers at developing central synapses. Our results indicate that N-type channels contribute to thalamic and cerebellar IPSCs only transiently during early postnatal period and P/Q-type channels predominantly mediate mature synaptic transmission, as we reported previously at the brainstem auditory synapse formed by the calyx of Held. In fact, Ca (2+) currents directly recorded from the auditory calyceal presynaptic terminal were identified as N-, P/Q-, and R-types at postnatal day 7 (P7) to P10 but became predominantly P/Q-type at P13. In contrast to thalamic and cerebellar IPSCs and brainstem auditory EPSCs, N-type Ca (2+) channels persistently contribute to cerebral cortical EPSCs and spinal IPSCs throughout postnatal months. Thus, in adult animals, synaptic transmission is predominantly mediated by P/Q-type channels at a subset of synapses and mediated synergistically by multiple types of Ca (2+) channels at other synapses.
1(0,0,0,1)