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alpha-endosulfan

Identification (Source:EPA,EU)

ID	1478
Name	alpha-endosulfan
CAS	959-98-8
IUPAC
Inchi	InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2/t3-,4+,7-,8+,19?
CIPAC	89
EPA Code
Formula	C9H6Cl6O3S
SMILES	Cl\C1=C(/Cl)C3(Cl)C(Cl)(Cl)C1(Cl)C2C3COS(=O)OC2
Status	Not Available

Classification

Mode of Action	Non-systemic with contact and stomach action, acts as a non-competitive GABA antagonist
Pesticide Type	Insecticide, Acaricide
Chemical Group	Organochlorine
Classification	cyclodiene insecticides

Properties (Source:PubChem)

Molecular Weight	406.93
Physical State	Brown crystals
AlogP	2.641
H-Bond Donor	0
H-Bond Acceptor	3
Surface Area	304.29
Polar Surface Area	54.74

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	2.15 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.24 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.44 mg l-1
Birds	Acute		LD50	111 mg kg-1
Earthworms	Acute	14 day	LD50	14 mg kg-1
Fish	Acute	96 hour	LC50	0.002 mg l-1
Honeybees	Acute	48 hour	LD50	7.81 μg bee-1
Mammals	Acute oral		LD50	38 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.1 mg l-1
	Bio-concentration factor		BCF	2755
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
GABA receptor (protein family or complex)	97(1,1,1,17)	Details
glycine receptor (protein family or complex)	88(1,1,1,8)	Details
CS5	88(1,1,1,8)	Details
CYP3A	84(1,1,1,4)	Details
CYP2B6	83(1,1,1,3)	Details
CYP3A5	82(1,1,1,2)	Details
beta is	81(1,1,1,1)	Details
GABA at	81(1,1,1,1)	Details
ATPase	34(0,1,1,4)	Details

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