| Name | acetylcholine receptors (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19434058 | Xi ZX, Spiller K, Gardner EL: Mechanism-based medication development for the treatment of nicotine dependence. Auton Autacoid Pharmacol. 2010 Jan 19. Nicotine binds to alpha4beta2 and alpha7 nicotinic acetylcholine receptors (nAChRs) located on dopaminergic, glutamatergic and GABAergic neurons in the mesolimbic (DA) system, which causes an increase in extracellular DA in the nucleus accumbens (NAc). |
81(1,1,1,1) | Details |
| 19212318 | Brunzell DH, Mineur YS, Neve RL, Picciotto MR: Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. J Neurochem. 2009 Mar;108(6):1507-14. Epub 2009 Feb 16. The ability of nicotine to alter firing of neurons is the first step leading to nicotine reward, but activation of intracellular signaling pathways downstream of nicotinic acetylcholine receptors is likely to be critical for longer-term consequences of nicotine exposure, including conditioned reward. |
81(1,1,1,1) | Details |
| 20060465 | Eppolito AK, Bachus SE, McDonald CG, Meador-Woodruff JH, Smith RF: Late emerging effects of prenatal and early postnatal nicotine exposure on the cholinergic system and anxiety-like behavior. J Neurosci. 2008 Dec 17;28(51):13985-94. Analysis of mRNA for the alpha4, alpha7, and beta2 subunits of nicotinic acetylcholine receptors revealed lower expression of these subunits in the adult hippocampus and medial prefrontal cortex following pre- and postnatal nicotine exposure, suggesting that nicotine altered the developmental trajectory of the brain. |
6(0,0,1,1) | Details |
| 20170672 | Berrendero F, Robledo P, Trigo JM, Martin-Garcia E, Maldonado R: Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system. Physiol Rev. 2009 Jan;89(1):73-120. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. |
6(0,0,1,1) | Details |
| 19494136 | Buttigieg J, Brown S, Holloway AC, Nurse CA: Chronic nicotine blunts hypoxic sensitivity in perinatal rat chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha. J Neurosci. 2009 Jun 3;29(22):7137-47. |
6(0,0,1,1) | Details |
| 19077054 | Noh MY, Koh SH, Kim Y, Kim HY, Cho GW, Kim SH: Neuroprotective effects of through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. Int J Cancer. 2009 Mar 1;124(5):1090-6. The neuroprotective effects of were blocked by LY294002 (10 microM), a phosphoinositide 3 kinase inhibitor, but only partially by mecamylamine (10 microM), a blocker of nicotinic acetylcholine receptors. |
2(0,0,0,2) | Details |
| 20038125 | Carroll FI, Ma W, Deng L, Navarro HA, Damaj MI, Martin BR: Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl) epibatidine analogues. J Thorac Oncol. 2010 Mar 15. Epibatidine's unique structure and its potent nicotinic agonist activity have had a tremendous impact on nicotine receptor research. |
2(0,0,0,2) | Details |
| 19416779 | Hirschburger M, Zakrzewicz A, Kummer W, Padberg W, Grau V: Nicotine attenuates macrophage infiltration in rat lung allografts. Psychopharmacology. 2010 Jan 14. has been shown to exert anti-inflammatory effects on these cells via nicotinic acetylcholine receptors. |
2(0,0,0,2) | Details |
| 19040571 | Paleari L, Catassi A, Ciarlo M, Cavalieri Z, Bruzzo C, Servent D, Cesario A, Chessa L, Cilli M, Piccardi F, Granone P, Russo P: Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation. Eur J Pharmacol. 2009 May 1;609(1-3):100-4. Epub 2009 Mar 12. Nicotine, an active component of cigarettes, can induce cell proliferation, angiogenesis and apoptosis resistance. |
2(0,0,0,2) | Details |
| 19499400 | Junhui Z, Xiaojing H, Binquan Z, Xudong X, Junzhu C, Guosheng F: Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway. Eur J Neurosci. 2009 Feb;29(3):539-50. Epub 2009 Jan 28. In addition, mecamylamine, a non-selective antagonist of nicotinic acetylcholine receptors (nAchR), abrogated the effects of nicotine on EPC. |
1(0,0,0,1) | Details |
| 19576181 | Kox M, van Velzen JF, Pompe JC, Hoedemaekers CW, van der Hoeven JG, Pickkers P: GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation. Biochem Pharmacol. 2009 Oct 1;78(7):863-72. Epub 2009 Jul 1. The vagus nerve can limit inflammation via the alpha7 nicotinic acetylcholine receptor (alpha7nAChR). We determined the anti-inflammatory potential of GTS-21, an alpha7nAChR-selective partial agonist, on primary human leukocytes and compared it with nicotine, the nAChR agonist widely used for research into the anti-inflammatory effects of alpha7nAChR stimulation. |
1(0,0,0,1) | Details |
| 19614864 | Lecea B, Martinez E, Auli M, Opazo A, Clave P: Selective stimulation of intrinsic excitatory and inhibitory motor pathways in porcine lower oesophageal sphincter. Eur J Neurosci. 2009 Sep;30(6):1011-22. Epub 2009 Sep 4. The aim of this study was to assess the effect of selective stimulation of inhibitory and excitatory MNs in porcine LOS through nicotinic acetylcholine receptors (nAChRs), 5-HT (3) and P2X receptors. We compared the effects of stimulation of MNs by electrical field stimulation (26 V, 0.3-20 Hz); nicotine (1-300 micromol L (-1)); and 2-Me- (1 nmol (-1)-30 micromol L (-1)); and alpha,beta-methylene ATP (alpha,beta-meATP 1-100 micromol L (-1)); in standard Krebs solution; a non-adrenergic non-nitrergic non-purinergic (NANNNP) solution; and a non-adrenergic non-cholinergic (NANC) solution. |
1(0,0,0,1) | Details |
| 19387337 | Al-Wadei HA, Al-Wadei MH, Schuller HM: Prevention of pancreatic cancer by the beta-blocker . Anticancer Drugs. 2009 Jul;20(6):477-82. We have previously reported that beta-adrenergic receptors (beta-ARs) stimulate the proliferation and migration of human PDAC cells in vitro by cAMP-dependent signaling and that the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) activates this pathway directly in vitro while additionally stimulating the release of / by binding to alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) in hamsters. |
81(1,1,1,1) | Details |
| 20223446 | Mimura K, Tomimatsu T, Sharentuya N, Tskitishvili E, Kinugasa-Taniguchi Y, Kanagawa T, Kimura T: Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia. Neuropsychopharmacology. 2010 Feb 10. |
62(0,2,2,2) | Details |
| 19483072 | Kawasaki H, Eguchi S, Miyashita S, Chan S, Hirai K, Hobara N, Yokomizo A, Fujiwara H, Zamami Y, Koyama T, Jin X, Kitamura Y: acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery. Neuropsychopharmacology. 2010 Feb;35(3):665-73. Epub 2009 Nov 4. Nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter (s) that activate transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerves, resulting in vasodilation. |
62(0,2,2,2) | Details |
| 19772864 | Hall BJ, Pearson LS, Buccafusco JJ: Effect of administration of the nicotinic acetylcholine receptor antagonist BTMPS, during nicotine self-administration, on lever responding induced by context long after withdrawal. Rev Med Chir Soc Med Nat Iasi. 2009 Jul-Sep;113(3):832-7. |
62(0,2,2,2) | Details |
| 19171179 | Delbro D, Westerlund A, Bjorklund U, Hansson E: In inflammatory reactive astrocytes co-cultured with brain endothelial cells nicotine-evoked Ca (2+) transients are attenuated due to interleukin-1beta release and rearrangement of actin filaments. Neuroscience. 2009 Mar 17;159(2):770-9. Epub 2009 Jan 9. The aim of this study was to investigate whether nicotine acetylcholine receptors (nAChRs) are expressed in a more pronounced way in astrocytes co-cultured with microvascular endothelial cells from adult rat brain, compared with monocultured astrocytes, as a sign of a more developed signal transduction system. |
6(0,0,1,1) | Details |
| 20007754 | Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE, Kellar KJ: Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. Cell Calcium. 2009 Feb;45(2):198-207. Epub 2008 Nov 26. In addition to activating nicotinic acetylcholine receptors, nicotine also desensitizes them. |
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| 19082523 | Severance EG, Dickerson FB, Stallings CR, Origoni AE, Sullens A, Monson ET, Yolken RH: Differentiating nicotine- versus schizophrenia-associated decreases of the alpha7 nicotinic acetylcholine receptor transcript, CHRFAM7A, in peripheral blood lymphocytes. Behav Pharmacol. 2009 Sep 5. |
6(0,0,1,1) | Details |
| 19735287 | Griguoli M, Scuri R, Ragozzino D, Cherubini E: Activation of nicotinic acetylcholine receptors enhances a slow -dependent conductance and reduces the firing of stratum oriens interneurons. Med Hypotheses. 2009 Oct;73(4):604-5. Epub 2009 Jul 21. Unexpectedly, activation of nAChRs by nicotine or endogenously released strongly enhanced spike frequency adaptation. |
2(0,0,0,2) | Details |
| 19498419 | Dougherty JJ, Nichols RA: Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals. J Neurosci. 2008 Nov 19;28(47):12465-76. AIM: Substantial colocalization of functionally independent alpha4 nicotinic acetylcholine receptors and 5-HT (3) serotonin receptors on presynaptic terminals has been observed in brain. Presynaptic nerve endings that had not responded to m-chlorophenylbiguanide, indicating that 5-HT (3) receptors were not present, displayed typical responses to nicotine. |
2(0,0,0,2) | Details |
| 19290018 | Breitling LP, Dahmen N, Mittelstrass K, Rujescu D, Gallinat J, Fehr C, Giegling I, Lamina C, Illig T, Muller H, Raum E, Rothenbacher D, Wichmann HE, Brenner H, Winterer G: Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. Brain Res. 2010 Feb 11. |
2(0,0,0,2) | Details |
| 19569163 | Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, He R, Caldarone B, Manzano M, Yuen PW, Lukas RJ: Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy) pyridin-3-yl] hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. Biochem Pharmacol. 2009 Oct 1;78(7):756-65. Epub 2009 Jun 18. The net action of prolonged exposure to AMOP-H-OH or its analogues, as for nicotine, seems to be a selective decrease in alpha4beta2-nAChR function. AMOP-H-OH (sazetidine-A; 6-[5-(azetidin-2-ylmethoxy) pyridin-3-yl] hex-5-yn-1-ol) and some -bearing analogues were tested for their activities in vitro against human alpha4beta2-, alpha4beta4-, alpha3beta4*- and alpha1*-nicotinic acetylcholine receptors (nAChRs). |
1(0,0,0,1) | Details |
| 19741505 | Camarasa J, Rates SG, Pubill D, Escubedo E: The involvement of nicotinic receptor subtypes in the locomotor activity and analgesia induced by methamphetamine in mice. Acta Pharmacol Sin. 2009 Jun;30(6):740-51. We have previously reported that methamphetamine (METH) interacts with nicotinic acetylcholine receptor (nAChR) subtypes. Chronic, but not acute, nicotine pretreatment potentiated METH-induced hyperlocomotion. |
1(0,0,0,1) | Details |
| 19481063 | Gotti C, Clementi F, Fornari A, Gaimarri A, Guiducci S, Manfredi I, Moretti M, Pedrazzi P, Pucci L, Zoli M: Structural and functional diversity of native brain neuronal nicotinic receptors. J Psychopharmacol. 2009 Feb 27. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes. nAChRs are involved in many physiological functions in the central and peripheral nervous systems, and are the targets of the widely used drug of abuse nicotine. |
1(0,0,0,1) | Details |
| 19236866 | Bernal JA, Mulet J, Castillo M, Criado M, Sala F, Sala S: Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor. FEBS Lett. 2009 Mar 18;583(6):1045-51. Epub 2009 Feb 21. We have studied the role of the highly conserved residue alphaLysine145 in the early steps of activation by of the nicotinic acetylcholine receptor (nAChR). |
1(0,0,0,1) | Details |
| 19453497 | Breivik T, Gundersen Y, Gjermo P, von Horsten S, Opstad PK: Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. J Periodontal Res. 2009 Jun;44(3):297-304. The animals were either given daily intraperitoneal injections of the nicotinic acetylcholine receptor antagonist mecamylamine (1 mg/kg) 45 min before subcutaneous injections in the neck skin of nicotine (0.8 mg/kg), or treated with the same amount of saline intraperitoneally and nicotine subcutaneously, or treated with mecamylamine and saline. |
37(0,1,2,2) | Details |
| 19032090 | Tantama M, Licht S: Use of calculated cation-pi binding energies to predict relative strengths of nicotinic acetylcholine receptor agonists. Eur J Pharmacol. 2009 Jan 14;602(2-3):395-8. Epub 2008 Nov 25. Agonists and antagonists of the nicotinic acetylcholine receptor (nAChR) are used to treat nicotine addiction, neuromuscular disorders, and neurological diseases. |
33(0,1,1,3) | Details |
| 19389046 | Cheng W, Yin Q, Zeng YM, Wang S, Chen HS, Feng T: Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain. Addict Behav. 2009 Sep;34(9):772-5. Epub 2009 May 22. After having established the mice model of analgesia by intraperitoneally injecting (i.p.) appropriate doses of isoflurane, nicotine, a neuronal nicotinic acetylcholine receptor agonist was intrathecally injected. |
33(0,1,1,3) | Details |
| 19921817 | Shih YL, Liu HC, Chen CS, Hsu CH, Pan MH, Chang HW, Chang CH, Chen FC, Ho CT, Yang YY, Ho YS: Combination treatment with and enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors. J Agric Food Chem. 2010 Jan 13;58(1):235-41. |
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| 19142197 | Chang L, Rapoport SI, Nguyen HN, Greenstein D, Chen M, Basselin M: Acute nicotine reduces brain signaling in unanesthetized rats. CNS Neurol Disord Drug Targets. 2010 Mar 1;9(1):60-76. Nicotine exerts its central effects by activating pre- and postsynaptic nicotinic acetylcholine receptors (nAChRs). |
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| 19259974 | Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ: Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. J Cereb Blood Flow Metab. 2009 Sep;29(9):1601-8. Epub 2009 Jun 3. To detect and characterize the influence of genetic variation on vulnerability to nicotine dependence, we analyzed 226 SNPs covering the complete family of 16 CHRN genes, which encode the nicotinic acetylcholine receptor (nAChR) subunits, in a sample of 1,050 nicotine-dependent cases and 879 non-dependent controls of European descent. |
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| 19059502 | Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, Tzartos SJ: Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties. Bioorg Med Chem. 2009 Jul 1;17(13):4477-85. Epub 2009 May 8. This mutant displayed a significantly improved (125) I-alpha-bungarotoxin-binding affinity (K (d)=24 nM) compared to the wild-type-ECD (K (d)=70 nM), the binding being inhibited by unlabelled alpha-bungarotoxin, d-tubocurarine or nicotine (K (i) of 21.5 nM, 127 microM and 17.5 mM, respectively). |
2(0,0,0,2) | Details |
| 19619852 | Li DJ, Tang Q, Shen FM, Su DF, Duan JL, Xi T: Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells. Biochim Biophys Acta. 2009 Feb;1794(2):355-66. Epub 2008 Nov 19. No changes were found between NIH3T3-pIRES2-EGFP and NIH3T3-pIRES2-EGFP-alpha7nAChR culture supernatant under LPS challenge, however under nicotine pre-stimulation, pro-inflammatory cytokine release was significantly attenuated in alpha7nAChR transfected cell line. |
2(0,0,0,2) | Details |
| 19815701 | Roman J, Koval M: Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin. Eur J Pharmacol. 2009 Jan 28;603(1-3):1-11. Epub 2008 Dec 16. |
2(0,0,0,2) | Details |
| 19379770 | Coolon RA, Cain ME: Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats. Psychopharmacology. 2009 Jul;204(4):563-72. Epub 2009 Feb 27. These findings suggest that environmental enrichment may alter nicotinic acetylcholine receptors during development and may be a protective factor in the initiation and relapse of smoking behavior. |
1(0,0,0,1) | Details |
| 19846875 | Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T: Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. Pharmacol Biochem Behav. 2009 Jul;93(1):59-66. Epub 2009 Apr 18. The alpha7 nicotinic acetylcholine receptor (nAChR) was recently described as an anti-inflammatory target in both macrophages and T cells. |
1(0,0,0,1) | Details |
| 19121331 | Thomas LT, Welsh L, Galvez F, Svoboda KR: Acute nicotine exposure and modulation of a spinal motor circuit in embryonic zebrafish. Am J Obstet Gynecol. 2010 Mar 10. Taken together, these results indicate the presence of nicotinic acetylcholine receptors (nAChRs) associated with embryonic spinal motor circuits early in embryogenesis. |
1(0,0,0,1) | Details |
| 19498413 | Wu J: Understanding of nicotinic acetylcholine receptors. Eur Neuropsychopharmacol. 2009 Sep;19(9):670-81. Epub 2009 Apr 29. |
1(0,0,0,1) | Details |
| 20173312 | Takada-Takatori Y, Kume T, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A: Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of in cortical neurons. Neurogastroenterol Motil. 2009 Dec;21(12):1342-e130. Epub 2009 Jul 3. We have previously shown that chronic treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of |
1(0,0,0,1) | Details |
| 20167427 | Gao B, Hierl M, Clarkin K, Juan T, Nguyen H, Valk M, Deng H, Guo W, Lehto SG, Matson D, McDermott JS, Knop J, Gaida K, Cao L, Waldon D, Albrecht BK, Boezio AA, Copeland KW, Harmange JC, Springer SK, Malmberg AB, McDonough SI: Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain. Pain. 2010 Apr;149(1):33-49. Epub 2010 Feb 18. Electrophysiological recordings from spinal cord slice showed a strong nicotine-induced increase in inhibitory synaptic transmission that was mediated partially by alpha4beta2 and only minimally by alpha7 subtypes. |
1(0,0,0,1) | Details |
| 19047205 | Yang K, Hu J, Lucero L, Liu Q, Zheng C, Zhen X, Jin G, Lukas RJ, Wu J: Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol. 2009 Jan 15;587(Pt 2):345-61. Epub 2008 Dec 1. |
1(0,0,0,1) | Details |
| 19789337 | Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M: Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. Clin Neurophysiol. 2009 Aug;120(8):1610-5. Epub 2009 Jul 28. Recent genome-wide association studies have linked the chromosome 15q24-25.1 locus to nicotine addiction and lung cancer susceptibility. We identified two distinct subregions, hapL (P = 3.20 x 10 (-6)) and hapN (P = 1.51 x 10 (-6)), which were significantly associated with familial lung cancer. hapL encompasses IREB2, LOC123688, and PSMA4, and hapN encompasses the three nicotinic acetylcholine receptor subunit genes CHRNA5, CHRNA3, and CHRNB4. |
1(0,0,0,1) | Details |
| 19139119 | Sun X, Ritzenthaler JD, Zheng Y, Roman J, Han S: inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Am J Pathol. 2009 Nov;175(5):1799-801. Epub 2009 Oct 8. We and others have shown previously that nicotine, a major component of tobacco, stimulates non-small cell lung carcinoma (NSCLC) proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. |
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| 19223664 | Papke RL, Kem WR, Soti F, Lopez-Hernandez GY, Horenstein NA: Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. J Pharmacol Exp Ther. 2009 May;329(2):791-807. Epub 2009 Feb 17. |
32(0,1,1,2) | Details |
| 19623583 | Wu JC, Chruscinski A, De Jesus Perez VA, Singh H, Pitsiouni M, Rabinovitch M, Utz PJ, Cooke JP: Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. J Cell Biochem. 2009 Oct 1;108(2):433-46. Nicotine acts on endothelial nicotinic acetylcholine receptors (nAChRs) to activate endothelial cells and to augment pathological angiogenesis. |
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| 20234319 | Niu X, Chen Z, Shen S, Liu Y, Zhou D, Zhang J, Li Z, Yu Y, Liao M, Lu S, He L: Association of the CHRNA3 Locus with Lung Cancer Risk and Prognosis in Chinese Han Population. J Cereb Blood Flow Metab. 2009 Mar;29(3):648-58. Epub 2009 Jan 14. INTRODUCTION:: Recent genome-wide association studies in Caucasians revealed association with lung cancer risk of single nucleotide polymorphisms (SNPs) in the locus containing two nicotine acetylcholine receptor CHRNA genes. |
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| 19896492 | Oloris SC, Frazer-Abel AA, Jubala CM, Fosmire SP, Helm KM, Robinson SR, Korpela DM, Duckett MM, Baksh S, Modiano JF: Nicotine-mediated signals modulate cell death and survival of T lymphocytes. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):299-309. Epub 2009 Nov 4. The capacity of nicotine to affect the behavior of non-neuronal cells through neuronal nicotinic acetylcholine receptors (nAChRs) has been the subject of considerable recent attention. |
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| 19896527 | Browne CJ, Sharma N, Waters KA, Machaalani R: The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem. Int J Dev Neurosci. 2010 Feb;28(1):1-7. Epub 2009 Nov 5. We tested the hypothesis that nicotine increases expression of the nicotinic acetylcholine receptor (nAChR) subunits alpha7 and beta2 in a piglet model. |
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| 19672724 | Papke RL: Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization. Dev Dyn. 2009 Apr;238(4):980-92. In the case of ligand-gated ion channels, such as nicotinic acetylcholine receptors (nAChRs), it is also important to consider the nature of the dynamic changes in the chemical stimulus required for activation. The amplitude and time course of the agonist pulse provided to nAChR at a fast synapse will be vastly different from those of the stimulus presented to presynaptic receptors in the brain and neither of these physiological processes will resemble the stimuli presented by nicotine self-administration or with systemic delivery of a therapeutic agent. |
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| 19940180 | Hruska M, Keefe J, Wert D, Tekinay AB, Hulce JJ, Ibanez-Tallon I, Nishi R: Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. Am J Respir Crit Care Med. 2010 Mar 1;181(5):486-93. Epub 2009 Dec 10. PSCA is highly expressed in chicken and mouse telencephalon and peripheral ganglia and correlates with expression of alpha7-containing nicotinic acetylcholine receptors (alpha7-nAChRs). Misexpressing PSCA before cell death in the ciliary ganglion blocks alpha7-nAChR activation by nicotine and rescues the choroid subpopulation from dying. |
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| 19625996 | Ishibashi M, Leonard CS, Kohlmeier KA: Nicotinic activation of laterodorsal tegmental neurons: implications for addiction to nicotine. Acta Pharmacol Sin. 2009 Jun;30(6):653-5. Utilization of nicotinic acetylcholine receptors (nAChR) subunit antagonists revealed that presynaptic, inhibitory terminals on cholinergic neurons were activated by receptors containing alpha 7, beta2, and non-alpha 7 subunits, whereas, presynaptic glutamatergic terminals were activated by nAChRs that comprised non-alpha 7 subunits. |
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| 19690163 | Zhang G, Kernan KA, Thomas A, Collins S, Song Y, Li L, Zhu W, Leboeuf RC, Eddy AA: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. Toxicol Appl Pharmacol. 2009 Aug 15;239(1):1-12. Epub 2008 Dec 14. The nicotinic acetylcholine receptor alpha1 (nAChRalpha1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an alternative urokinase (urokinase plasminogen activator; uPA) receptor in addition to the classical receptor uPAR. Pre-exposure of uPA to the fibroblasts inhibited [(3) H] nicotine binding. |
1(0,0,0,1) | Details |
| 19778953 | Konishi H, Wu J, Cooke JP: Chronic exposure to nicotine impairs cholinergic angiogenesis. Vasc Med. 2010 Feb;15(1):47-54. Epub 2009 Sep 24. Cholinergic angiogenesis is mediated by an endothelial nicotinic acetylcholine receptor (EC nAChR). |
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| 19164465 | Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gundisch D, Picciotto MR: Cytisine-based nicotinic partial agonists as novel antidepressant compounds. J Pharmacol Sci. 2010 Mar 19;112(3):265-72. Epub 2010 Feb 20. Nicotine and other nicotinic agents are thought to regulate mood in human subjects and have antidepressant-like properties in animal models. Recent studies have demonstrated that blockade of nicotinic acetylcholine receptors (nAChRs) including those containing the beta2 subunit (beta2 (*)), results in antidepressant-like effects. |
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| 19166510 | Grilli M, Zappettini S, Zoli M, Marchi M: Pre-synaptic nicotinic and D receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens. Pharmacogenomics J. 2009 Aug;9(4):219-24. Epub 2009 Mar 17. The aim of the present work was to investigate whether acetylcholine receptors (nAChRs) and (DA) autoreceptors, which are both able to modulate DA release, functionally interact on the same nerve endings. Both the inhibitory effect of quinpirole and the stimulatory effect of (-) nicotine did not change when the nAChRs or the DA receptors were desensitized. (-) Nicotine and 4-AP were able to stimulate [(3) H] DA overflow also in mouse synaptosomes and this overflow was partially inhibited by quinpirole. |
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| 19404193 | Andreasen JT, Redrobe JP: Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. J Immunol. 2009 Nov 15;183(10):6681-8. Epub 2009 Oct 21. In humans, both nicotine and the nonselective nicotinic acetylcholine receptor antagonist mecamylamine ameliorate depressive symptoms. |
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| 20004675 | Lagostena L, Danober L, Challal S, Lestage P, Mocaer E, Trocme-Thibierge C, Cherubini E: Modulatory effects of S 38232, a non alpha-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus. J Pharmacol Exp Ther. 2009 Feb;328(2):364-70. Epub 2008 Nov 20. |
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| 19889792 | Paulson JR, Yang T, Selvaraj PK, Mdzinarishvili A, Van der Schyf CJ, Klein J, Bickel U, Abbruscato TJ: Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions. AAPS J. 2009 Mar;11(1):167-77. Epub 2009 Mar 12. Furthermore, long-term 1-week administration of nicotine increased water content in hippocampal slices that could be attenuated with nicotine acetylcholine receptor (nAChR) antagonists, suggesting nicotine increase edema during OGD via nAChRs. |
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| 20171986 | Loomis S, Gilmour G: urinalysis and nicotinic receptor modulation in rats. Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):926-33. The pharmacological specificity of this effect was confirmed as the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (0.05-0.5mg/kg sc) dose-dependently reversed the effects of nicotine (0.5mg/kg sc) on urinary CORT. |
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| 19077117 | Mineur YS, Brunzell DH, Grady SR, Lindstrom JM, McIntosh JM, Marks MJ, King SL, Picciotto MR: Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. PLoS One. 2010 Jan 7;5(1):e8616. High-affinity, beta2-subunit-containing (beta2*) nicotinic acetylcholine receptors (nAChRs) are essential for nicotine reinforcement; however, these nAChRs are found on both and dopaminergic (DA) neurons in the ventral tegmental area (VTA) and also on terminals of glutamatergic and cholinergic neurons projecting from the pedunculopontine tegmental area and the laterodorsal tegmental nucleus. |
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| 19151195 | Paleari L, Negri E, Catassi A, Cilli M, Servent D, D'Angelillo R, Cesario A, Russo P, Fini M: Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment. J Bone Miner Metab. 2009;27(5):555-61. Epub 2009 May 13. RATIONALE: Studies strongly suggest that the nicotinic acetylcholine receptors for nicotine (nAChRs) play a significant role in lung cancer predisposition and natural history. |
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| 19278836 | Davis JA, Gould TJ: Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2608-12. Epub 2009 Sep 15. The role of hippocampal nicotinic acetylcholine receptors (nAChRs) in the effects of acute, chronic and withdrawal from chronic nicotine on learning was assessed via intrahippocampal drug infusion in mice. |
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| 19936715 | Small E, Shah HP, Davenport JJ, Geier JE, Yavarovich KR, Yamada H, Sabarinath SN, Derendorf H, Pauly JR, Gold MS, Bruijnzeel AW: Tobacco smoke exposure induces nicotine dependence in rats. Psychopharmacology. 2010 Jan;208(1):143-58. Epub 2009 Nov 21. RATIONALE: Tobacco smoke contains nicotine and many other compounds that act in concert on the brain reward system. Nicotinic receptor autoradiography was used to investigate if exposure to tobacco smoke affects central alpha7 nicotinic acetylcholine receptor (nAChR) and non-alpha7 nAChR levels (primarily alpha4beta2 nAChRs). |
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| 19715382 | Annemans L, Nackaerts K, Bartsch P, Prignot J, Marbaix S: Cost effectiveness of varenicline in Belgium, compared with nicotine replacement therapy, brief counselling and unaided smoking cessation: a BENESCO Markov cost-effectiveness analysis. Acc Chem Res. 2009 Feb 17;42(2):260-9. BACKGROUND AND OBJECTIVE: Varenicline is a nicotinic acetylcholine receptor partial agonist that is approved for use as an aid to smoking cessation. |
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| 19632243 | De Rosa MJ, Dionisio L, Agriello E, Bouzat C, Esandi Mdel C: Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation. . J Neurosci. 2009 Nov 25;29(47):14847-54. By measuring the increase of intracellular in response to nicotine we determine that alpha7 receptors in lymphocytes are functional. |
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| 19436041 | Baker TB, Weiss RB, Bolt D, von Niederhausern A, Fiore MC, Dunn DM, Piper ME, Matsunami N, Smith SS, Coon H, McMahon WM, Scholand MB, Singh N, Hoidal JR, Kim SY, Leppert MF, Cannon DS: Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Innate Immun. 2010 Feb;16(1):3-13. Epub 2009 Jul 8. |
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| 20337855 | Bruchfeld A, Goldstein RS, Chavan S, Patel NB, Rosas-Ballina M, Kohn N, Qureshi AR, Tracey KJ: Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis. Behav Pharmacol. 2009 May;20(3):286-95. Addition of cholinergic agonists (nicotine and GTS-21) to the stimulated whole blood cultures however significantly suppressed cytokine production to a similar extent in patients and healthy controls. The central nervous system regulates innate immunity in part via the cholinergic anti-inflammatory pathway, a neural circuit that transmits signals in the vagus nerve that suppress pro-inflammatory cytokine production by an alpha-7 nicotinic acetylcholine receptors (alpha7nAChR) dependent mechanism. |
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| 20203212 | Parikh V, Ji J, Decker MW, Sarter M: Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1682-5. Epub 2009 Feb 4. Nicotine and, more robustly, selective agonists at alpha4beta2* nicotinic acetylcholine receptors (nAChRs) enhance cue detection and attentional performance by augmenting prefrontal cholinergic activity. |
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| 19491921 | Kas A, Bottlaender M, Gallezot JD, Vidailhet M, Villafane G, Gregoire MC, Coulon C, Valette H, Dolle F, Ribeiro MJ, Hantraye P, Remy P: Decrease of nicotinic receptors in the nigrostriatal system in Parkinson's disease. J Neurosci. 2010 Mar 3;30(9):3518-30. Smoking is associated with a lower incidence of Parkinson's disease (PD), which might be related to a neuroprotective action of nicotine. Postmortem studies have shown a decrease of cerebral nicotinic acetylcholine receptors (nAChRs) in PD. |
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| 19252273 | Shimohama S: Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Acta Pharmacol Sin. 2009 Jun;30(6):723-39. Epub 2009 May 11. This review article presents evidence for nicotinic acetylcholine receptor (nAChR)-mediated protection and the signal transduction involved in this mechanism. Nicotine-induced protection was blocked by an alpha7 nAChR antagonist, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and an Src inhibitor. |
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| 19140167 | Brasic JR, Zhou Y, Musachio JL, Hilton J, Fan H, Crabb A, Endres CJ, Reinhardt MJ, Dogan AS, Alexander M, Rousset O, Maris MA, Galecki J, Nandi A, Wong DF: Single photon emission computed tomography experience with (S)-5-[(123) I] iodo-3-(2-azetidinylmethoxy) in the living human brain of smokers and nonsmokers. Synapse. 2009 Apr;63(4):339-58. (S)-5-[(123) I] iodo-3-(2-azetidinylmethoxy) (5-[(123) I] IA), a novel potent radioligand for high-affinity alpha4beta2* neuronal nicotinic acetylcholine receptors (nAChRs), provides a means to evaluate the density and the distribution of nAChRs in the living human brain. High plasma-nicotine level was significantly associated with low 5-[(123) I] IA binding in: (1) the caudate head, the cerebellum, the cortex, and the putamen, utilizing both the Sign and Mann-Whitney U-tests; (2) the fusiform gyrus, the hippocampus, the parahippocampus, and the pons utilizing the Mann-Whitney U-test; and (3) the thalamus utilizing the Sign test. |
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| 19209239 | Mabley JG, Pacher P, Szabo C: Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice. Zhonghua Yi Xue Za Zhi. 2009 Aug 18;89(31):2206-9. Activation of the cholinergic antiinflammatory pathway, specifically through the alpha7 nicotinic acetylcholine receptor (either indirectly through vagus nerve stimulation or directly through nicotine treatment) reduces proinflammatory gene expression. |
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| 19594327 | Singh S, Singh K, Patel DK, Singh C, Nath C, Singh VK, Singh RK, Singh MP: The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation Res. 2009 Jun;12(3):185-97. Tyrosine hydroxylase (TH)-immunoreactivity in the substantia nigra, the expression of nicotinic acetylcholine receptors (nAChRs) alpha6 and alpha4, content, and 1-methyl-4-phenylpyridinium ion (MPP (+)) level in the striatum were measured to confirm the MPTP-induced PD phenotype and nicotine-mediated neuroprotection. |
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| 19540212 | Govind AP, Vezina P, Green WN: Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Exp Parasitol. 2010 Jan 20. In this commentary, we review how nicotinic acetylcholine receptors (nAChRs) are upregulated by nicotine exposure, the potential posttranslational events that appear to cause it and how upregulation is linked to nicotine addiction. |
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| 20085573 | Anuvarbekova A, Fincan GS, Vural IM, Ozger SI, Ercan ZS, Utkan T, Sarioglu Y: Investigation of enhancement effects of nicotine on cholinergic neurotransmission in isolated rabbit gastric fundus: role of antioxidants. Pharmacol Biochem Behav. 2009 Dec;94(2):319-28. Epub 2009 Sep 22. Nicotine having influence on the neuronal acetylcholine receptors (nAChRs) increases release of most certain neurotransmitters from the nerve endings. |
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| 19652217 | Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dolle F, Bottlaender M: 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. ACS Chem Biol. 2008 Nov 21;3(11):693-702. Displacement by nicotine or unlabeled ZW-104 demonstrated a lower nonspecific binding than that of 2-F-A-85380. |
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| 19586999 | Tyagi E, Agrawal R, Nath C, Shukla R: Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation. J Biosci Bioeng. 2009 Aug;108(2):85-91. Nicotine (0.2, 0.4 and 0.8 mg/kg, i.p.) or oxotremorine (0.2, 0.4 and 0.8 mg/kg, i.p.) were administered 2 h prior to sacrifice. |
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| 19427310 | van der Zanden EP, Snoek SA, Heinsbroek SE, Stanisor OI, Verseijden C, Boeckxstaens GE, Peppelenbosch MP, Greaves DR, Gordon S, De Jonge WJ: Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2. Gastroenterology. 2009 Sep;137(3):1029-39 |
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| 19236119 | Cahill K, Stead L, Lancaster T: A preliminary benefit-risk assessment of varenicline in smoking cessation. 1039.e1-4. Epub 2009 May 7. It is a selective nicotinic acetylcholine receptor partial agonist, and is designed to reduce withdrawal symptoms and to lessen the rewards of continued smoking. Eight of the trials compared varenicline with placebo for cessation, two compared it with nicotine replacement therapy and one tested extended use for relapse prevention. |
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| 19132693 | Chen X, Chen J, Williamson VS, An SS, Hettema JM, Aggen SH, Neale MC, Kendler KS: Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. Clin Drug Investig. 2009;29(10):655-65. doi: 10.2165/11317730-000000000-00000. Nicotinic acetylcholine receptors bind to nicotine and initiate the physiological and pharmacological responses to tobacco smoking. |
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| 19319967 | Zouridakis M, Zisimopoulou P, Poulas K, Tzartos SJ: Recent advances in understanding the structure of nicotinic acetylcholine receptors. IUBMB Life. 2009 Apr;61(4):407-23. Nicotinic acetylcholine receptors (nAChRs), members of the Cys-loop ligand-gated ion channels (LGICs) superfamily, are involved in signal transduction upon binding of the neurotransmitter or exogenous ligands, such as nicotine. nAChRs are pentameric assemblies of homologous subunits surrounding a central pore that gates cation flux, and are expressed at the neuromuscular junction and in the nervous system and several nonneuronal cell types. |
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| 20211194 | Gustafsson H, Runesson J, Lundqvist J, Lindegren H, Axelsson V, Forsby A: Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicol Appl Pharmacol. 2010 Mar 6. We studied cell membrane potential (CMP), (NA) uptake, acetylcholine esterase (AChE) activity, acetylcholine receptor (AChR) signalling and voltage-operated calcium channel (VOCC) function in human neuroblastoma SH-SY5Y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. The CMP assay was the most sensitive assay, identifying eight chemicals as alerts and improving the LC50 correlation for nicotine, lindane, atropine and methadone. |
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| 20058601 | Feng CS, Wang Y, Ma HC, Yue Y: [Role of central neuronal nicotinic receptor in the inhibitory effect of isoflurane on synaptic long-term potentiation in hippocampal slices of rats]. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):684-90. CONCLUSION: The inhibition of LTP induction may contribute to isoflurane-induced deficits in memory, and the underlying mechanism is involved in the inhibition of nicotinic acetylcholine receptor activation in hippocampus of rats. Seventy-seven slices were randomly divided into 11 equal groups (n = 7 each): group LTP; group isoflurane 0.125; group isoflurane 0.25; group isoflurane 0.5; group nicotine 0.1; group nicotine 1.0; group nicotine 10.0; group nicotine 1.0 + isoflurane 0.25; group nicotine 10.0 + isoflurane 0.25; group mecamylamine; group mecamylamine + isoflurane 0.125. |
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| 19383498 | Hoda JC, Wanischeck M, Bertrand D, Steinlein OK: Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene. Eur J Neurosci. 2009 Jan;29(2):377-87. Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) can be caused by mutations in the neuronal nicotinic acetylcholine receptor (nAChR) subunit genes CHRNA4 and CHRNB2. We demonstrate here that alpha2-I279N can be co-expressed with the major structural subunit CHRNB2. alpha2-I279N causes a marked gain-of-function effect and displays a distinct biopharmacological profile, including markedly reduced inhibition by carbamazepine and increased nicotine sensitivity. |
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| 19859904 | Li MD, Xu Q, Lou XY, Payne TJ, Niu T, Ma JZ: Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Nicotine Tob Res. 2009 Jul;11(7):785-96. Epub 2009 May 12. Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. |
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| 19785998 | Gaede AH, Lung MS, Pilowsky PM: Catestatin attenuates the effects of intrathecal nicotine and isoproterenol. Eur J Pharmacol. 2009 Jan 14;602(2-3):288-93. Epub 2008 Nov 30. The results indicate that Cts antagonizes both central nicotinic acetylcholine receptors and beta-adrenoceptors that are involved in cardiovascular regulation in vivo. |
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| 19452140 | Andreasen JT, Nielsen EO, Redrobe JP: Chronic oral nicotine increases brain [3H] epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test. J Biomol Struct Dyn. 2009 Apr;26(5):535-47. Finally, the effects on the brain expression levels of high- and low-affinity nicotinic acetylcholine receptors (nAChRs) and the transporters for (SERT) and (NET) were assessed using [(3) H] epibatidine, [(3) H] alpha-bungarotoxin, [(3) H] and [(3) H] nisoxetine binding, respectively. |
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| 19616570 | Zielinska E, Kuc D, Zgrajka W, Turski WA, Dekundy A: Long-term exposure to nicotine markedly reduces in rat brain--in vitro and ex vivo evidence. Toxicol Appl Pharmacol. 2009 Oct 15;240(2):174-9. Epub 2009 Jul 17. Recent studies show that KYNA strongly blocks alpha7 subtype of nicotinic acetylcholine receptors (nAChRs). |
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| 19429911 | Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT: A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Mol Psychiatry. 2009 Oct;14(10):912-45. Epub 2009 Jun 30. A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence. |
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| 20007924 | Lambrechts D, Buysschaert I, Zanen P, Coolen J, Lays N, Cuppens H, Groen HJ, Dewever W, van Klaveren RJ, Verschakelen J, Wijmenga C, Postma DS, Decramer M, Janssens W: The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. Neuropharmacology. 2010 Jan 28. RATIONALE: Genome-wide association studies have identified genetic variants in the nicotinic acetylcholine receptor (nAChR) on chromosome 15q24/25 as a risk for nicotine dependence, lung cancer, and chronic obstructive pulmonary disease (COPD). |
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| 20147892 | Ray R, Mitra N, Baldwin D, Guo M, Patterson F, Heitjan DF, Jepson C, Wileyto EP, Wei J, Payne T, Ma JZ, Li MD, Lerman C: Convergent Evidence that Choline Acetyltransferase Gene Variation is Associated with Prospective Smoking Cessation and Nicotine Dependence. Neuropsychopharmacology. 2009 Jul;34(8):1993-2001. Epub 2009 Feb 11. We conducted a systems-based genetic association analysis in a sample of 472 treatment-seeking smokers of European ancestry after 8 weeks of transdermal nicotine therapy for smoking cessation. The genotyping panel included 169 single-nucleotide polymorphisms (SNPs) in 7 nicotinic acetylcholine receptor subunit genes and 4 genes in the endogenous cholinergic system. |
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| 19494806 | Bergen AW, Conti DV, Van Den Berg D, Lee W, Liu J, Li D, Guo N, Mi H, Thomas PD, Lessov-Schlaggar CN, Krasnow R, He Y, Nishita D, Jiang R, McClure JB, Tildesley E, Hops H, Tyndale RF, Benowitz NL, Lerman C, Swan GE: genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology. 2009 Sep;34(10):2252-64. Epub 2009 Jun 3. A total of 1123 SNPs at 55 autosomal candidate genes, nicotinic acetylcholine receptors and genes involved in dopaminergic function, were tested for association to baseline FTND scores adjusted for age, depression, education, sex, and study site. |
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| 19417169 | Ingram JR: Nicotine: does it have a role in the treatment of skin disease? . Postgrad Med J. 2009 Apr;85(1002):196-201. There has been renewed interest in nicotinic acetylcholine receptor agonists, such as nicotine, after the discovery of a "nicotinic anti-inflammatory pathway". |
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| 19698703 | Landgren S, Engel JA, Andersson ME, Gonzalez-Quintela A, Campos J, Nilsson S, Zetterberg H, Blennow K, Jerlhag E: Association of nAChR gene haplotypes with heavy alcohol use and body mass. J Pharmacol Exp Ther. 2010 Feb;332(2):371-9. Epub 2009 Nov 4. Certain subtypes of the nicotinic acetylcholine receptors in the ventral tegmental area (a reward node) have preclinically been shown to be important for reward. Therefore the aim was to investigate nicotine receptor subunit genes in a haplotype study of use. |
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| 19095047 | Garza A, Huang LZ, Son JH, Winzer-Serhan UH: Expression of nicotinic acetylcholine receptors and subunit messenger RNAs in the enteric nervous system of the neonatal rat. Drug Saf. 2009;32(2):119-35. doi: 10.2165/00002018-200932020-00005. The results showed strong nicotine sensitive binding of (125) I-epibatidine around the stomach, and small and large intestines. |
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| 19877417 | Omel'chenko DM, Kalashnyk OM, Koval' LM, Skok MV, Komisarenko SV: [Analysis of signaling pathways activated by nicotinic acetylcholine receptors in B-lymphocyte-derived cells]. Brain Res. 2009 Dec 11;1305 Suppl:S72-9. Epub 2009 Aug 19. DT40 cells were shown to express at least alpha7-containing nAChRs; their amount increased upon incubation with 10 microM nicotine. |
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| 19285092 | Vazquez-Gomez E, Garcia-Colunga J: Neuronal nicotinic acetylcholine receptors are modulated by zinc. Neuropharmacology. 2009 May-Jun;56(6-7):1035-40. Epub 2009 Mar 11. Here, we studied the effects of zinc on neuronal alpha4beta4 nAChRs, expressed in Xenopus oocytes and activated by nicotine. |
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| 19232953 | Cooke JP, Ghebremariam YT: Endothelial nicotinic acetylcholine receptors and angiogenesis. Trends Cardiovasc Med. 2008 Oct;18(7):247-53. The receptors may be stimulated by endogenous agonists such as or exogenous chemicals such as nicotine, to activate physiologic angiogenesis (such as in wound healing) or pathologic angiogenesis (such as retinal neovascularization or tumor angiogenesis). |
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| 20008879 | Boezen HM: Genome-wide association studies: what do they teach us about asthma and chronic obstructive pulmonary disease?. Neurobiol Dis. 2009 Jul;35(1):24-31. Epub 2009 Mar 31. The first GWA study on chronic obstructive pulmonary disease (COPD) identified two single nucleotide polymorphisms at the alpha-nicotinic acetylcholine receptor (CHRNA 3/5) locus, identified earlier as risk factor for both lung cancer and nicotine dependence, to be associated with COPD. |
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| 19170184 | Velez-Fort M, Audinat E, Angulo MC: Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. Proc Am Thorac Soc. 2009 Dec;6(8):701-3. Here, we used patch-clamp recordings, immunostaining, imaging, and intracellular labeling to test for the presence of ionotropic nicotinic acetylcholine receptors (nAChRs) in NG2-cells identified in acute hippocampal slices of mice. In addition, nanomolar concentrations of nicotine, which did not induce any response in these cells, largely desensitized nAChR-mediated currents. |
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| 19393839 | Garrison GD, Dugan SE: Varenicline: a first-line treatment option for smoking cessation. Neuropsychopharmacology. 2010 Feb 10. BACKGROUND: Varenicline acts as a partial agonist/antagonist with affinity and selectivity for alpha (4) beta (2) nicotinic acetylcholine receptors. This activity at the nicotine-receptor level may help patients achieve smoking cessation by reducing cravings/withdrawal symptoms and smoking satisfaction. |
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| 19459717 | Kasliwal R, Wilton LV, Shakir SA: Safety and drug utilization profile of varenicline as used in general practice in England: interim results from a prescription-event monitoring study. Drug Saf. 2009;32(6):499-507. doi: 10.2165/00002018-200932060-00006. Varenicline is a highly selective partial agonist of the alpha (4) beta (2) nicotinic acetylcholine receptor (alpha (4) beta (2) receptor). The partial agonistic binding leads to alleviation of symptoms of craving and withdrawal, and simultaneously prevents nicotine from binding to the alpha (4) beta (2) receptor thereby causing reduction in the rewarding and reinforcing effects of smoking. |
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| 19063881 | Ohnishi M, Katsuki H, Takagi M, Kume T, Akaike A: Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures. Breast Cancer Res Treat. 2010 Mar 13. Based on emerging evidence that stimulation of nicotinic acetylcholine receptors provides neuroprotective effects and also suppresses cytotoxic properties of activated microglia, we investigated the effect of nicotine on thrombin-induced pathological changes in cortico-striatal slice cultures. |
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| 19368843 | Decamp E, Schneider JS: Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model. Brain Res. 2009 Mar 25;1262:109-14. Epub 2009 Feb 7. The present study evaluated the effects of nicotine and the nicotinic acetylcholine receptor agonist SIB-1553A alone and in combination on cognition in a non-human primate model of early PD. |
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| 19344760 | Nicolussi EM, Huck S, Lassmann H, Bradl M: The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation. Neuropsychopharmacology. 2009 Nov;34(12):2529-47. Epub 2009 Jul 22. Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRalpha7) by nicotine or initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation. |
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| 19338581 | Arias HR, Xing H, Macdougall K, Blanton MP, Soti F, Kem WR: Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. Drug Discov Today. 2009 Sep;14(17-18):822-36. Epub 2009 Jul 16. Although DMXBA failed to activate human fetal muscle nAChRs, 4OH-DMXBA was found to be a partial agonist. [(3) H] Nicotine competition-binding experiments confirmed that 4OH-DMXBA has higher affinity than DMXBA for the agonist sites, and that DMXBA is also a competitive antagonist. |
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| 19178568 | Kamens HM, McKinnon CS, Li N, Helms ML, Belknap JK, Phillips TJ: The alpha3 Subunit of the Nicotinic Acetylcholine Receptor is a Candidate Gene for Stimulation. Eur J Neurosci. 2009 Apr;29(8):1588-603. and nicotine are co-abused, and preclinical and clinical data suggest that common genes may influence responses to both drugs. |
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| 19187266 | Livingstone PD, Srinivasan J, Kew JN, Dawson LA, Gotti C, Moretti M, Shoaib M, Wonnacott S: alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate release in vitro and in vivo in the rat prefrontal cortex. CNS Neurol Disord Drug Targets. 2008 Nov;7(5):422-41. Nicotine enhances attentional and working memory aspects of executive function in the prefrontal cortex (PFC) where plays a major role. |
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| 19063868 | Marrero MB, Bencherif M: Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):745-56. Our laboratories have previously identified the alpha7 nAChR-JAK2 pathway as playing a central role in nicotine-induced neuroprotection. |
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| 19844757 | Lee LY, Gu Q, Lin YS: Effect of smoking on cough reflex sensitivity: basic and preclinical studies. J Neurosci Methods. 2010 Feb 19. Application of nicotine evoked an inward current and triggered depolarization and action potentials in a concentration-dependent manner in a subset of isolated vagal pulmonary sensory neurons. Taken together, these studies showed that activation of the nicotinic acetylcholine receptors expressed on airway sensory nerves is mainly responsible for the acute airway irritation and cough reflex elicited by inhaled cigarette smoke. |
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| 19641473 | Schwartz AG, Cote ML, Wenzlaff AS, Land S, Amos CI: Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. J Neurosci. 2009 Oct 7;29(40):12428-39. INTRODUCTION: Three genome-wide association studies identified a region on chromosome 15q25.1 associated with lung cancer and measures of nicotine addiction. This region includes nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5. |
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| 20109141 | Radek RJ, Kohlhaas KL, Rueter LE, Mohler EG: Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists. Genes Brain Behav. 2009 Jun;8(4):398-406. Epub 2009 Feb 11. Considerable tobacco use in schizophrenic patients, genetic linkage, and receptor binding studies suggest the involvement of nicotinic acetylcholine receptors (nAChRs) in schizophrenia. The non-selective nAChR agonist nicotine has been shown to improve CDS in several human clinical studies, and recent trials have been undertaken to evaluate the efficacy of more alpha4beta2 selective compounds. |
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| 19812239 | Aracri P, Consonni S, Morini R, Perrella M, Rodighiero S, Amadeo A, Becchetti A: Tonic Modulation of Release by Nicotinic Acetylcholine Receptors in Layer V of the Murine Prefrontal Cortex. Cereb Cortex. 2009 Oct 7. Tonically applied nicotine (1-100 muM) increased the frequency of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) on pyramidal neurons in PFC layer V. |
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| 19321668 | Matsuda K, Kanaoka S, Akamatsu M, Sattelle DB: Diverse actions and target-site selectivity of neonicotinoids: structural insights. Curr Pharm Des. 2010;16(3):309-22. The nicotinic acetylcholine receptors (nAChRs) are targets for human and veterinary medicines as well as insecticides. |
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| 19065831 | Kravtsova VV, Drabkina TM, Prokof'ev AV, Kubasov IV, Vasil'ev AN, Krivoi II: [Effect of nicotine on electrogenic contribution of the Na,K-ATPase isoforms and contractile characteristics of the rat skeletal muscle]. Ross Fiziol Zh Im I M Sechenova. 2008 Oct;94(10):1181-90. |
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| 19057014 | Lin HW, Liu CZ, Cao D, Chen PY, Chen MF, Lin SZ, Mozayan M, Chen AF, Premkumar LS, Torry DS, Lee TJ: Endogenous methyl modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. FEBS Lett. 2009 May 19;583(10):1599-604. Epub 2009 Apr 19. By using a similar technique with rat superior cervical ganglion (SCG) as donor tissue and rabbit endothelium-denuded aortic ring as detector tissue, we report here that a vasodilator, which is more potent than NO, is released in the SCG upon field electrical stimulation (FES) or addition of nicotine. |
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| 19091987 | Melis M, Pillolla G, Luchicchi A, Muntoni AL, Yasar S, Goldberg SR, Pistis M: Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic neurons through nuclear receptors. Mol Med. 2009 May-Jun;15(5-6):166-72. Epub 2009 Feb 5. |
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| 19878666 | Ozturk Fincan GS, Vural IM, Ercan ZS, Sarioglu Y: Enhancement effects of nicotine on neurogenic relaxation responses in the corpus cavernosum in rabbits: the role of nicotinic acetylcholine receptor subtypes. Genes Brain Behav. 2008 Oct 21. Nicotine acts as an agonist of nicotinic acetylcholine receptors, which belong to a superfamily of neurotransmitter-gated ion channels. |
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| 19049804 | Vural IM, Ozturk Fincan GS, Bozkurt NB, Ercan ZS, Sarioglu Y: Role of nicotinic acetylcholine receptor subtypes on nicotine-induced neurogenic contractile response alternation in the rabbit gastric fundus. Clin Ther. 2009 Mar;31(3):463-91. Nicotine is a nonspecific agonist of nicotinic acetylcholine receptors. |
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| 19564872 | Greenbaum L, Lerer B: Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. J Intern Med. 2010 Feb 18. Brain nicotinic acetylcholine receptor (nAChR)-encoding genes are among the most prominent candidate genes studied in the context of ND, because of their biological relevance as binding sites for nicotine. |
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| 20074615 | Ohyama K, Sogawa C, Sogawa N, Morita K, Dohi T, Kitayama S: Nicotine stimulates transcriptional activity of the human dopamine transporter gene. Neurosci Lett. 2010 Feb 26;471(1):34-7. Epub 2010 Jan 13. Hexamethonium, a neuronal (ganglionic) nicotinic acetylcholine receptor antagonist, blocked the action of nicotine. |
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| 19767248 | Kuo JS, Leung YM, Lin NN, Lee TJ, Gong CL: Nicotine stimulation of the medulla increases blood flow of the common carotid artery in cats. Auton Neurosci. 2010 Jan 15;152(1-2):49-54. Epub 2009 Sep 19. Microinjections of nicotine [a non-selective nicotinic acetylcholine receptor (nAChR) agonist], (a selective alpha7-nAChR agonist), or KCl induced a modest increase in CCA blood flow. |
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| 20093112 | Portillo R, Bruges G, Delgado D, Betancourt M, Mijares A: Trypanosoma evansi: Pharmacological evidence of a nicotinic acetylcholine receptor. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Although a dose-dependent response to muscarine could not be demonstrated, nicotine could promote an incremental dose-dependent response. |
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| 19448648 | Xiao Y, Abdrakhmanova GR, Baydyuk M, Hernandez S, Kellar KJ: Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function. J Clin Psychiatry. 2009 Jul;70(7):1026-31. Epub 2009 Mar 24. Using whole-cell current recording, the homomeric alpha7 nAChRs expressed in the cells were activated by and (-)-nicotine with EC (50) values of 280+/-19 micromol/L and 180+/-40 micromol/L, respectively. |
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| 19038445 | Gilbert D, Lecchi M, Arnaudeau S, Bertrand D, Demaurex N: Local and global signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors. Cytotherapy. 2009;11(4):485-91. Application of nicotine (50 microM) consistently evoked transient (30s), stereotyped Ca (2+) responses that were inhibited by the selective alpha7-nAChRs antagonists methyllycaconitine (MLA) and alpha-bungarotoxin, and greatly increased and prolonged by the allosteric modulator PNU-120596 (1 microM). |
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| 19812319 | Xiao C, Nashmi R, McKinney S, Cai H, McIntosh JM, Lester HA: Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. Brain Res. 2009 Feb 23;1256:1-7. Epub 2008 Nov 27. Recordings were made in wild-type and alpha4 nicotinic acetylcholine receptor (nAChR) subunit knock-out mice. |
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| 20211606 | Gubbins EJ, Gopalakrishnan M, Li J: alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. Neuroscience. 2009 Feb 18;158(4):1521-9. Epub 2008 Nov 21. The alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) plays a fundamental role in Ca (2+)-dependent activation of signaling pathways that can modulate intracellular events involved in learning and memory. Robust concentration-dependent increase in ERK1/2 phosphorylation was triggered by structurally diverse alpha7 nAChR agonists such as nicotine, GTS-21, SSR-180711A and PNU-282987 in the presence of the positive allosteric modulator (PAM) PNU-120596. |
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| 19385992 | Jia Y, Yamazaki Y, Nakauchi S, Sumikawa K: Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits. PLoS One. 2008;3(12):e3945. Epub 2008 Dec 16. Rapid activation of nicotinic acetylcholine receptors (nAChRs) at various anatomical and cellular locations in the hippocampus differentially modulates the operation of hippocampal circuits. |
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| 19298235 | Yan S, Dai TJ, Zeng YM: Nicotinic acetylcholine receptors mediate the hypnotic and analgesic effects of emulsified inhalation anesthetics. Arch Gen Psychiatry. 2009 Jun;66(6):666-76. This study was designed to investigate the role of nicotinic acetylcholine receptors (nAChRs) in hypnosis and analgesia induced by emulsified inhalation anesthetics. After having established the mice model of hypnosis and analgesia by intraperitoneal injections of appropriate doses of enflurane, isoflurane or sevoflurane, we intracerebroventricularly or intrathecally injected different doses of nicotine and then observed the effects on the sleeping time using awaken test and the pain threshold in hot-plate test (HPPT) using hot-plate test. |
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| 19070647 | Weiser T, Just S: Hyoscine butylbromide potently blocks human nicotinic acetylcholine receptors in SH-SY5Y cells. Fundam Clin Pharmacol. 2009 Apr;23(2):235-40. Epub 2009 Mar 9. and nicotine application-induced comparable membrane currents with EC (50) values of 25.9+/-0.6 and 40.1+/-0.4microM, respectively. |
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| 19693492 | Sofuoglu M, Herman AI, Mooney M, Waters AJ: Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans. Glia. 2009 Aug 1;57(10):1104-14. RATIONALE: Varenicline, a partial nicotinic acetylcholine receptor (nAChR) agonist, is approved for smoking cessation. |
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| 20146581 | Schuller HM, Al-Wadei HA: Neurotransmitter receptors as central regulators of pancreatic cancer. . Neurosci Lett. 2009 Feb 6;450(3):258-61. Epub 2008 Dec 6. Experimental evidence indicates that the alpha (7)-nicotinic acetylcholine receptor (alpha (7) nAChR) stimulates PDAC via stress neurotransmitter-mediated activation of beta-adrenergic signaling while the alpha (4) beta (2) nAChR inhibits PDAC via -mediated inhibition of adenylyl cyclase activation. In analogy to molecular mechanisms that govern nicotine addiction, chronic exposure to nicotine or its nitrosated derivative nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- render the stimulatory alpha (7) nAChR hyperactive while desensitizing the inhibitory alpha (4) beta (2) nAChR. |
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| 19555668 | Anderson DJ, Malysz J, Gronlien JH, El Kouhen R, Hakerud M, Wetterstrand C, Briggs CA, Gopalakrishnan M: Stimulation of release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination. J Thorac Oncol. 2009 Oct;4(10):1195-201. Binding affinities (pK (i)) and potency (pEC (50)) values for [(3) H]- release closely correlated with a rank order: varenicline>(-)-nicotine> AZD3480> dianicline congruent with ABT-089. |
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| 19706643 | Maritz GS: Are nicotine replacement therapy, varenicline or options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring. Ther Adv Respir Dis. 2009 Aug;3(4):193-210. Epub 2009 Aug 25. |
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| 19374878 | Cui R, Suemaru K, Li B, Kohnomi S, Araki H: Tropisetron attenuates naloxone-induced place aversion in single-dose morphine-treated rats: role of alpha7 nicotinic receptors. Eur J Pharmacol. 2009 May 1;609(1-3):74-7. Epub 2009 Jan 17. We have previously reported that acute dependence can occur when naloxone is administered 24 h after even a single dose of morphine, and that nicotine attenuates this naloxone-precipitated withdrawal syndrome. |
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| 19916927 | Lyukmanova EN, Shulepko MA, Tikhonov RV, Shenkarev ZO, Paramonov AS, Wulfson AN, Kasheverov IE, Ustich TL, Utkin YN, Arseniev AS, Tsetlin VI, Dolgikh DA, Kirpichnikov MP: Bacterial production and refolding from inclusion bodies of a "weak" toxin, a disulfide rich protein. Biochemistry. 2009 Oct;74(10):1142-9. The gene for the "weak" toxin of Naja kaouthia venom was expressed in Escherichia coli. "Weak" toxin is a specific inhibitor of nicotine acetylcholine receptor, but mechanisms of interaction of similar neurotoxins with receptors are still unknown. |
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| 20079464 | Zhou Y, Wang ZX, Tang MP, Yao CJ, Xu WJ, Wang LY, Qiao ZD: Nicotine induces cyclooxygenase-2 and (2) expression in human umbilical vein endothelial cells. Ukr Biokhim Zh. 2009 Jan-Feb;81(1):59-66. Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression. |
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| 19079602 | Kawakita A, Sato K, Makino H, Ikegami H, Takayama S, Toyama Y, Umezawa A: Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. Brain Res. 2010 Mar 6. In the last decade, localization of neuronal nicotinic acetylcholine receptor (nAChR), a specific receptor of nicotine, has been widely detected in non-excitable cells. |
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| 19654299 | Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S: Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. J Heart Lung Transplant. 2009 May;28(5):493-500. We previously showed that nicotine stimulates non-small cell lung carcinoma (NSCLC) cell proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. |
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| 19692619 | Tu B, Gu Z, Shen JX, Lamb PW, Yakel JL: Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. J Neurosci. 2009 Aug 19;29(33):10436-48. The entorhinal cortex (EC) is a part of the hippocampal complex that is essential to learning and memory, and nicotine affects memory by activating nicotinic acetylcholine receptors (nAChRs) in the hippocampal complex. |
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| 19020092 | Boulin T, Gielen M, Richmond JE, Williams DC, Paoletti P, Bessereau JL: Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18590-5. Epub 2008 Nov 19. Pharmacological analysis reveals that the prototypical cholinergic agonist nicotine is unable to activate L-AChRs but rather acts as a potent allosteric inhibitor. |
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| 19247637 | Hendrickson LM, Zhao-Shea R, Tapper AR: Modulation of drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice. J Pharmacol Exp Ther. 2010 Mar;332(3):933-9. Epub 2009 Dec 10. Nicotinic agonists including cytisine and nicotine were also evaluated. |
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| 19403274 | Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D, Zimmer A: Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6. ChemMedChem. 2009 Aug;4(8):1279-91. Lypd6 overexpressed in trigeminal ganglia neurons selectively enhanced the Ca2+-component of nicotine-evoked currents through nAChRs, as evidenced by comparative whole-cell patch clamp recordings and Ca2+-imaging in wildtype and transgenic mice overexpressing Lypd6. |
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| 20231857 | Rigbi A, Yakir A, Sarner-Kanyas K, Pollak Y, Lerer B: Why do young women smoke? VI. Pharmacogenomics J. 2010 Mar 16. A controlled study of nicotine effects on attention: pharmacogenetic interactions.. In prior studies we found that young, female smokers manifest poorer performance than non-smokers on attention-related tasks and that these findings can be moderated by variation in nicotinic acetylcholine receptor (nAChR) genes. |
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| 19778187 | Schep LJ, Slaughter RJ, Beasley DM: Nicotinic plant poisoning. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19526-31. Epub 2008 Dec 4. The nicotinic-type acetylcholine receptor can vary both in its subunit composition and in its distribution within the body (the central and autonomic nervous systems, the neuromuscular junctions, and the adrenal medulla). Plants containing nicotine and nicotine-like alkaloids that have been reported to be poisonous to humans include Conium maculatum, Nicotiana glauca and Nicotiana tabacum, Laburnum anagyroides, and Caulophyllum thalictroides. |
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| 19540210 | Millar NS: A review of experimental techniques used for the heterologous expression of nicotinic acetylcholine receptors. Clin Toxicol. 2009 Sep;47(8):771-81. |
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| 19616116 | Paleari L, Cesario A, Fini M, Russo P: alpha7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma?. Biochem Pharmacol. 2009 Oct 1;78(7):766-76. Epub 2009 Jun 18. Recently, new evidence suggested that nicotinic Acetylcholine Receptors (nAChRs) play a significant role in lung cancer predisposition and natural history. The background and rationale of this approach are based on the experimental observations that: (a) NSCLC and MPM cells express nAChRs and (b) the activation of these receptors by agonists, namely nicotine, inhibits apoptosis, whereas receptor antagonists have a pro-apoptotic effect. |
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| 19192221 | Wang C, Xiao D, Chan KP, Pothirat C, Garza D, Davies S: Varenicline for smoking cessation: a placebo-controlled, randomized study. Respirology. 2009 Apr;14(3):384-92. Epub 2009 Feb 20. BACKGROUND AND OBJECTIVE: Varenicline tartrate, a novel, selective, nicotinic acetylcholine receptor partial agonist, has been developed specifically as a smoking cessation drug. The primary study end-point was the 4-week continuous abstinence rate defined as the proportion of subjects who reported total abstinence from smoking and other nicotine products from weeks 9-12. |
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| 20060845 | Dehkordi O, Rose JE, Balan KV, Millis RM, Bhatti B, Jayam-Trouth A: Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways. Future Oncol. 2010 Feb;6(2):221-8. AIMS: The ability to sense the bitter taste of nicotine is an important component of addiction to, and withdrawal from, cigarette smoking. alpha-Gustducin and phospholipase C-beta2 (PLC-beta2), molecules involved in the taste transduction pathway, have been identified in airway epithelial solitary chemosensory cells (SCCs). Airway epithelial cells also express multiple nicotinic acetylcholine receptors (nAChRs). |
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| 19749751 | Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T: Nicotine activates the chemosensory cation channel TRPA1. . J Neurosci. 2008 Nov 19;28(47):12318-27. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. |
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| 19669732 | Engelmann JM, Radke AK, Gewirtz JC: Potentiated startle as a measure of the negative affective consequences of repeated exposure to nicotine in rats. Psychopharmacology. 2009 Nov;207(1):13-25. Epub 2009 Aug 11. |
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| 19147120 | Nakao S, Ogata Y, Sugiya H: Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. J Pharmacol Exp Ther. 2009 Sep;330(3):745-55. Epub 2009 May 29. |
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| 19279237 | Salas R, Sturm R, Boulter J, De Biasi M: Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice. J Neurosci. 2009 Mar 11;29(10):3014-8. We precipitated withdrawal by systemically injecting the nicotinic antagonist mecamylamine in mice chronically treated with nicotine. |
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| 19188251 | Good CH, Lupica CR: Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulation in vitro. Toxicol Sci. 2010 Jan 27. This was seen as a reduction of PPN-evoked, and not VTA-evoked, synaptic currents by the alpha7-nAChR antagonist methyllycaconitine (MLA) and the agonist nicotine. |
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| 20201817 | Chatterjee S, Bartlett SE: Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of use disorders. Psychopharmacology. 2009 Aug;205(3):517-28. Epub 2009 May 12. As nicotine interacts specifically with the neuronal nicotinic acetylcholine receptor (nAChR) system, this suggests that nAChRs play an important role in the behavioral effects of |
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| 20053173 | Chatterjee S, Bartlett SE: Neuronal Nicotinic Acetylcholine Receptors as Pharmacotherapeutic Targets for the Treatment of Use Disorders. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):453-66. As nicotine interacts specifically with the neuronal nicotinic acetylcholine receptor (nAChR) system, this suggests that nAChRs play an important role in the behavioral effects of |
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| 19063919 | Egleton RD, Brown KC, Dasgupta P: Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases. Pharmacol Ther. 2009 Feb;121(2):205-23. Epub 2008 Nov 14. The pro-angiogenic activity of nicotine is mediated by nicotinic acetylcholine receptors, which have been found to be expressed on several types of cells in the vasculature like endothelial cells, smooth muscle cells and immune cells. |
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| 19164511 | Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan TH, Mummalaneni S, Melone P, Desimone JA, Nicolelis MA, Simon SA: Nicotine activates TRPM5-dependent and independent taste pathways. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1596-601. Epub 2009 Jan 21. Here, rats and mice were used to determine whether nicotine activates peripheral and central taste pathways via TRPM5-dependent mechanisms, which are essential for responses to other bitter tastants such as quinine, and/or via nicotinic acetylcholine receptors (nAChRs). |
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| 20062537 | Wang LP, Li F, Shen X, Tsien JZ: Conditional knockout of NMDA receptors in neurons prevents nicotine-conditioned place preference. Curr Drug Abuse Rev. 2008 Jun;1(2):124-34. It is known that nicotine triggers tobacco addiction by activating nicotine acetylcholine receptors (nAChRs) in the midbrain dopaminergic reward system, primarily via the ventral tegmental area. |
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| 19436947 | Rothem DE, Rothem L, Soudry M, Dahan A, Eliakim R: Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. Auton Neurosci. 2009 Jun 15;148(1-2):97-100. Epub 2009 Apr 5. The inhibition of these effects by D: -tubocurarine suggests that nicotine acts via the nicotinic acetylcholine receptor (nAChR). |
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| 19183258 | Zheng C, Wang MY, Liu Q, Wakui M, Whiteaker P, Lukas RJ, Wu J: U18666A, a -inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line. Acta Pharmacol Sin. 2009 Jun;30(6):842-50. Epub 2009 May 18. U18666A suppresses both peak and steady state components of whole-cell currents mediated by human alpha4beta2-nAChRs in response to nicotine. |
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| 19023041 | Buccafusco JJ, Beach JW, Terry AV Jr: Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Neural Transm. 2009 Feb;116(2):213-20. Epub 2008 Dec 11. Brain concentrations of nicotine rarely increase to the low-mid micromolar concentrations that have been reported to evoke direct agonist-like responses, such as influx or neurotransmitter release. |
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| 19609360 | Williamson SM, Robertson AP, Brown L, Williams T, Woods DJ, Martin RJ, Sattelle DB, Wolstenholme AJ: The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. PLoS Pathog. 2009 Jul;5(7):e1000517. Epub 2009 Jul 17. The subunits are very similar in sequence to C. elegans UNC-29 and UNC-38, are expressed on muscle cells and can be expressed robustly in Xenopus oocytes to form -, nicotine-, levamisole- and pyrantel-sensitive channels. |
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| 19126755 | Albuquerque EX, Pereira EF, Alkondon M, Rogers SW: Mammalian nicotinic acetylcholine receptors: from structure to function. . Semin Cell Dev Biol. 2009 Jun;20(4):418-31. Epub 2009 Jan 20. The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of a "receptor" came to light. |
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| 19651248 | Pilarski JQ, Fregosi RF: Prenatal nicotine exposure alters medullary nicotinic and AMPA-mediated control of respiratory frequency in vitro. Respir Physiol Neurobiol. 2009 Oct 31;169(1):1-10. Epub 2009 Aug 3. Despite evidence that this relationship results from alterations in nicotinic acetylcholine receptors (nAChRs), the mechanisms are poorly understood. |
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| 19358273 | Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA: Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 2009 Jul 15;125(2):276-85. The OPN mRNA induction was inhibited by the nicotinic acetylcholine receptor antagonist, mechamylamine. |
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| 19720621 | Zhao-Shea R, Cohen BN, Just H, McClure-Begley T, Whiteaker P, Grady SR, Salminen O, Gardner PD, Lester HA, Tapper AR: Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB J. 2010 Jan;24(1):49-57. Epub 2009 Aug 31. Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing alpha4 and beta2 subunits (alpha4beta2*) functionally interact with G-protein-coupled (DA) D (2) receptors in basal ganglia. Highlighting the importance of the cholinergic system in this mouse model, inhibiting the effects of by blocking muscarinic receptors, or by selectively activating hypersensitive nAChRs with nicotine, rescued motor symptoms. |
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| 20331614 | Rollema H, Shrikhande A, Ward KM, Tingley Iii FD, Coe JW, O'Neill BT, Tseng E, Wang EQ, Mather RJ, Hurst RS, Williams KE, de Vries M, Cremers T, Bertrand S, Bertrand D: Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Arthritis Rheum. 2009 Jan;60(1):114-22. Background and purpose: Smoking cessation trials with three high-affinity partial agonists of alpha4beta2 neuronal nicotinic acetylcholine receptors (nAChRs) have demonstrated differences in their clinical efficacy. Key results: A comparison of predicted human brain concentrations following therapeutic doses demonstrated that varenicline and nicotine, but not dianicline and cytisine, can extensively desensitize and, to a lesser extent, activate alpha4beta2 nAChRs. |
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| 19628475 | Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I, Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A, Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A, Tonali P, Neri G, Zollino M: Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis. Nat Neurosci. 2009 Oct;12(10):1293-9. Epub 2009 Sep 13. NAChRs formed by mutant alpha3 and alpha4 and wild-type (WT) beta4 subunits exhibited altered affinity for nicotine (Nic), reduced use-dependent rundown of Nic-activated currents (I (Nic)) and reduced desensitization leading to sustained intracellular Ca (2+) concentration, in comparison with WT-nAChR. |
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| 19101536 | Paterson NE: Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: recent preclinical and clinical insights. Biol Pharm Bull. 2009 Mar;32(3):332-6. Third, it is suggested that the unique mixed pharmacological profile of provides (1) attenuation of the multiple negative consequences of withdrawal via blockade of and reuptake; (2) replacement of the reward-facilitating and subjective effects of nicotine via blockade of dopaminergic reuptake; (3) attenuation of the rewarding effects of acute nicotine by nicotinic acetylcholine receptor blockade. |
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| 19285493 | Uchida S, Hotta H, Kawashima K: Long-term nicotine treatment reduces cerebral cortical vasodilation mediated by alpha4beta2-like nicotinic acetylcholine receptors in rats. Neuropharmacology. 2010 Feb;58(2):429-35. Epub 2009 Sep 20. |
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| 19955489 | Takahashi HK, Liu K, Wake H, Mori S, Zhang J, Liu R, Yoshino T, Nishibori M: Effect of nicotine on advanced glycation end product-induced immune response in human monocytes. J Nucl Med. 2009 Aug;50(8):1349-55. Nicotine is reported to inhibit the activation of monocytes via nicotinic acetylcholine receptor alpha7 subunit (alpha7-nAChR). |
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| 19053239 | Tomizawa M, Casida JE: Molecular recognition of neonicotinoid insecticides: the determinants of life or death. Mol Cancer Ther. 2009 Jan;8(1):110-8. The search for unusual structures and optimization revealed a new class of potent insecticides, known as neonicotinoids, which are similar to nicotine in their structure and action as agonists of the nicotinic acetylcholine receptor (nAChR). |
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| 19560048 | Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Int Immunopharmacol. 2010 Apr;10(4):461-6. Epub 2010 Jan 14. The addictive activity of nicotine is due to potent interactions with nicotinic acetylcholine receptors (nAChRs) on neurons in the reinforcement and reward circuits of the brain. |
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| 19778551 | Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA: Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Genes Brain Behav. 2009 Apr;8(3):257-66. Epub 2008 Dec 11. The present work investigated the potential role nicotinic acetylcholine receptors play in the CS effects of nicotine (0.4mg/kg) using antagonists with differential selectivity for beta2*, alpha7*, alpha6beta2*, and alpha3beta4* receptors. |
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| 19398468 | Shan H, Zhang Y, Lu Y, Zhang Y, Pan Z, Cai B, Wang N, Li X, Feng T, Hong Y, Yang B: Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res. 2009 Aug 1;83(3):465-72. Epub 2009 Apr 27. The effects of nicotine were prevented by an alpha7 nicotinic acetylcholine receptor antagonist. |
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| 19477134 | Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA: QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked release from dopaminergic nerve terminals in rat striatum. Eur Neuropsychopharmacol. 2009 Aug;19(8):551-61. Epub 2009 Mar 10. This report represents the first QSAR study on a set of 66 mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating nicotine-evoked release, conducted using multi-linear regression (MLR) and neural network (NN) analysis with the maximal inhibition (I (max)) values of the antagonists as target values. |
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| 19232492 | Sippy KB, Anderson DJ, Bunnelle WH, Hutchins CW, Schrimpf MR: Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. J Neurochem. 2009 Mar;108(6):1526-38. Epub 2009 Feb 16. Nevertheless, some (1a, 1b) possessed (partial) agonist potencies comparable to nicotine at the alpha4beta2 subtype, but with greatly improved selectivity relative to the alpha3beta4* nAChR. |
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| 19401144 | Arias HR, Richards VE, Ng D, Ghafoori ME, Le V, Mousa SA: Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. J Biol Chem. 2009 Oct 16;284(42):29050-64. Epub 2009 Aug 18. Non-selective cholinergic agonists such as nicotine have been shown to induce angiogenesis, enhancing tumor progression. |
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| 19413797 | Grosshans M, Mutschler J, Hermann D, Mann K, Diehl A: Reduced affective symptoms during tobacco dependence treatment with varenicline. Addiction. 2009 May;104(5):859-61. BACKGROUND: The nicotinic acetylcholine receptor partial agonist varenicline has been shown to be effective in the treatment of tobacco dependence, but has been reported to induce exacerbations of psychiatric symptoms in subjects with pre-existing psychiatric disorders. CASE DESCRIPTION: We report a tobacco-dependent patient who developed depression and suicidal tendencies during several cessation attempts, but was finally able to stay nicotine-abstinent by taking varenicline. |
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| 20072781 | Kamens HM, Andersen J, Picciotto MR: Modulation of consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. J Nat Prod. 2010 Mar 26;73(3):306-12. RATIONALE: and nicotine are commonly co-abused. |
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| 20174655 | Alves NC, Bailey CD, Nashmi R, Lambe EK: Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats. Br J Pharmacol. 2010 Mar 22. In male rats, nicotinic acetylcholine receptors excite corticothalamic neurons in layer VI, which are thought to play an important role in attention by gating the sensitivity of thalamic neurons to incoming stimuli. These differences were apparent with three agonists: carbachol, and nicotine. |
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| 20191841 | Ciobica A, Hritcu L, Artenie V, Padurariu M: [The effects of some cholinergic drugs on cognitive processes and oxidative stress in rat]. PLoS One. 2010 Feb 17;5(2):e9261. In the present study, we examined whether oxidative stress contributes to the memory deficits induced by muscarinic acetylcholine receptors (mAchRS) blocked by In our previous studies, we have shown the facilitatory role of nicotine and cholinergic system in learning and memory processes. |
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| 19560047 | Penton RE, Lester RA: Cellular events in nicotine addiction. Lung. 2010 Jan;188 Suppl 1:S23-7. Epub 2009 Oct 21. In the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been a major effort to link alterations in nicotinic acetylcholine receptors (nAChRs) to nicotine-induced behaviors that drive the addiction to tobacco products. |
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| 19755656 | Perkins KA, Lerman C, Mercincavage M, Fonte CA, Briski JL: Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. J Biol Chem. 2009 Aug 28;284(35):23251-9. Epub 2009 Jun 30. Genes coding for nicotinic acetylcholine receptors may influence response to nicotine replacement therapy for smoking cessation. |
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| 19644963 | Mobascher A, Rujescu D, Mittelstrass K, Giegling I, Lamina C, Nitz B, Brenner H, Fehr C, Breitling LP, Gallinat J, Rothenbacher D, Raum E, Muller H, Ruppert A, Hartmann AM, Moller HJ, Gal A, Gieger Ch, Wichmann HE, Illig T, Dahmen N, Winterer G: Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. J Pharmacol Exp Ther. 2010 Mar;332(3):1013-21. Epub 2009 Dec 2. |
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| 20113344 | Jia Y, Yamazaki Y, Nakauchi S, Ito K, Sumikawa K: Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-alpha7 nicotinic acetylcholine receptors. Neuropharmacology. 2010 Mar-Apr;58(4-5):806-15. Epub 2009 Dec 24. |
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| 19005185 | Shiraishi K, Kohno T, Kunitoh H, Watanabe S, Goto K, Nishiwaki Y, Shimada Y, Hirose H, Saito I, Kuchiba A, Yamamoto S, Yokota J: Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis. 2009 Jan;30(1):65-70. Epub 2008 Nov 12. |
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| 19020025 | Pons S, Fattore L, Cossu G, Tolu S, Porcu E, McIntosh JM, Changeux JP, Maskos U, Fratta W: Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. Life Sci. 2010 Feb 13;86(7-8):281-8. Epub 2010 Jan 10. |
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| 19628476 | Keskitalo K, Broms U, Heliovaara M, Ripatti S, Surakka I, Perola M, Pitkaniemi J, Peltonen L, Aromaa A, Kaprio J: Association of serum level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Eur J Neurosci. 2010 Feb;31(3):463-76. Epub 2010 Jan 26. The aim of this study was to clarify whether the variation at this locus regulates nicotine intake among smokers by using the level of a metabolite of nicotine, as an outcome. |
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| 19236104 | Parthiban M, Rajasekaran MB, Ramakumar S, Shanmughavel P: Molecular modeling of human pentameric alpha (7) neuronal nicotinic acetylcholine receptor and its interaction with its agonist and competitive antagonist. Int J Biochem Cell Biol. 2009 Jul;41(7):1441-51. Epub 2009 Jan 29. Agonists such as nicotine, which are used in a diverse array of biological activities, such as enhancements of cognitive performances, were also docked with the theoretical model of human alpha (7) nAChR. |
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| 20055696 | Changeux JP: Allosteric receptors: from electric organ to cognition. Annu Rev Pharmacol Toxicol. 2010;50:1-38. It continues with the identification of the nicotinic acetylcholine receptor, the discovery of its molecular organization, the structure of the -binding site and of the ion channel, and the demonstration of its allosteric transitions. The knowledge acquired with the nicotinic receptor is further exploited to reach higher levels of brain organization, and the contribution of nicotinic receptors to the action of nicotine on reward and cognition is explored, in particular, using a novel experimental strategy that combines nicotinic receptor genes knock-out and stereotaxic gene re-expression. |
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| 19128201 | Rahman S, Lopez-Hernandez GY, Corrigall WA, Papke RL: Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction. Cell Tissue Res. 2010 Mar 23. Nicotine addiction and other forms of drug addiction continue to be significant public health problems in the United States and the rest of the world. Accumulated evidence indicates that brain nicotinic acetylcholine receptors (nAChRs) are a heterogenous family of ion channels expressed in the various parts of the brain. |
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| 19010884 | Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H: Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. CNS Neurol Disord Drug Targets. 2009 Oct 7. A locus at 15q24/15q25.1, which includes the nicotinic acetylcholine receptor A subunits 3 and 5 (CHRNA3 and CHRNA5) genes, has recently been associated with lung cancer risk, self-reported number of cigarettes smoked per day, and a nicotine dependence scale. |
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| 19077124 | Welsby PJ, Rowan MJ, Anwyl R: Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. Hum Mol Genet. 2009 Oct 15;18(20):3997-4006. Epub 2009 Jul 23. We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of alpha7 nAChR. Chronic nicotine enhancement of LTP was found to be dependent on PKA, ERK and Src kinases. |
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| 19583978 | Thany SH: Agonist actions of clothianidin on synaptic and extrasynaptic nicotinic acetylcholine receptors expressed on cockroach sixth abdominal ganglion. Cancer Res. 2009 Aug 15;69(16):6445-53. Epub 2009 Aug 4. Clothianidin is new neonicotinoid insecticide acting selectively on insect nicotinic acetylcholine receptors (nAChRs). |
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| 20124469 | Improgo MR, Schlichting NA, Cortes RY, Zhao-Shea R, Tapper AR, Gardner PD: ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res. 2010 Feb;8(2):194-203. Epub 2010 Feb 2. Nicotine addiction begins with the binding of nicotine to its cognate receptor, the nicotinic acetylcholine receptor (nAChR). |
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| 20147893 | Howe WM, Ji J, Parikh V, Williams S, Mocaer E, Trocme-Thibierge C, Sarter M: Enhancement of Attentional Performance by Selective Stimulation of alpha4beta2 (*) nAChRs: Underlying Cholinergic Mechanisms. Br J Pharmacol. 2009 May;157(2):320-30. Epub 2009 Mar 26. Using an operant sustained attention task (SAT), including a distractor condition (dSAT), we assessed the putative pro-attentional effects of the selective alpha4beta2 (*) nicotinic acetylcholine receptor (nAChR) agonist S 38232 in comparison with the non-selective agonist nicotine. |
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| 19268529 | Eddins D, Cerutti D, Williams P, Linney E, Levin ED: Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to deficits. Neurotoxicol Teratol. 2010 Jan-Feb;32(1):99-108. Epub 2009 Mar 4. To elucidate the contributions of nicotinic and muscarinic acetylcholine receptors to developmental CPF-mediated effects, the effects of developmental nicotine and pilocarpine exposure throughout the first five days after fertilization were determined. |
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| 19890263 | Brunzell DH, Boschen KE, Hendrick ES, Beardsley PM, McIntosh JM: alpha-Conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. Cancer Res. 2008 Nov 15;68(22):9137-40. |
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| 19644040 | Jackson KJ, McIntosh JM, Brunzell DH, Sanjakdar SS, Damaj MI: The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal. Biochem Pharmacol. 2009 Oct 1;78(7):852-62. Epub 2009 Jul 3. |
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| 19633471 | Thunnissen FB: Acetylcholine receptor pathway and lung cancer. . J Thorac Oncol. 2009 Aug;4(8):943-6. The 15q24-25 region encompasses the nicotinic acetylcholine receptor subunit genes (nAchR alpha3, alpha5, and beta4) that play a role in nicotine addiction. |
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| 19301390 | Ackerman KM, Nakkula R, Zirger JM, Beattie CE, Boyd RT: Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs. Cancer Res. 2009 Oct 1;69(19):7844-50. Epub 2009 Sep 29. We are developing zebrafish (Danio rerio) as a model system to study the role of specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes in development and the effects of nicotine on the developing vertebrate nervous system. |
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| 19280351 | Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC: Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. J Mol Neurosci. 2010 Jan;40(1-2):77-86. Epub 2009 Aug 12. |
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| 19959340 | Crunelle CL, Miller ML, Booij J, van den Brink W: The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review. Hum Mol Genet. 2009 Oct 15;18(20):4007-12. Epub 2009 Jul 23. Varenicline, an alpha4beta2 nAChR partial agonist and an alpha7 nAChR full agonist registered for the treatment of nicotine dependence, significantly reduces nicotine craving and prevents relapse. |
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| 19050173 | Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, Gilbert A, Comery TA, Larocque J, Soloveva V, Brown J, Roncarati R: Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the (2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo [1,2-b:4,5-b'] di pyrrole-1 (2H)-carboxamide). J Pharmacol Exp Ther. 2009 Mar;328(3):766-76. Epub 2008 Dec 2. In a Ca2+ flux fluorometric imaging plate reader assay, SB-206553 (3,5-dihydro-5-methyl -N-3-pyridinylbenzo [1, 2-b:4,5 -b']-di pyrrole-1 (2H)-carboxamide), a compound known as a (2B/2C) receptor antagonist, produced an 8-fold potentiation of the evoked signal in the presence of an EC (20) concentration of nicotine and a corresponding EC (50) of 1.5 muM for potentiation of EC (20) nicotine responses in GH4C1 cells expressing the alpha7 receptor. |
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| 19274673 | Al-Wadei HA, Schuller HM: Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. Eur J Pharmacol. 2010 Feb 10;627(1-3):281-4. Epub 2009 Oct 27. The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK) is a potent mutagen and the most powerful tobacco carcinogen. NNK is also an agonist for nicotinic acetylcholine receptors (nAChRs). |
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| 19498417 | Yang KC, Jin GZ, Wu J: Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology. PLoS One. 2009 Sep 15;4(9):e7040. Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling. By modulating DA release in the nucleus accumbens (NAc) and modulating release onto DAergic neurons in the ventral tegmental area (VTA), alpha6*-nAChRs may play important roles in the mediation of nicotine reward and addiction. |
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| 19577545 | Buccafusco JJ, Terry AV Jr: A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2009 Aug;330(2):541-9. Epub 2009 May 12. The nicotine metabolite is a cognitive-enhancer, and active in models predictive of antipsychotic activity. |
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| 19593403 | Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M, Yang L, Valdes-Ferrer SI, Patel NB, Chavan S, Al-Abed Y, Yang H, Tracey KJ: The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med. 2009 Jul-Aug;15(7-8):195-202. Epub 2009 Apr 27. The cholinergic antiinflammatory pathway modulates inflammatory cytokine production through a mechanism dependent on the vagus nerve and the alpha7 subunit of the nicotinic acetylcholine receptor. The suppressive effect of GTS-21 was more potent than nicotine in whole blood and monocytes. |
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| 19625132 | Wang Y, Ge X, Xu XF, Wang XJ: Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Neuroscience. 2009 Sep 15;162(4):1174-86. Epub 2009 May 22. These components include choline acetyltransferase, acetylcholinesterase (AChE) and nicotinic acetylcholine receptors. |
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| 19095220 | Le Foll B, Chefer SI, Kimes AS, Shumway D, Stein EA, Mukhin AG, Goldberg SR: Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. Biol Psychiatry. 2009 Apr 15;65(8):714-6. Epub 2008 Dec 18. The midbrain alpha4beta2* subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediation of the reinforcing effects of nicotine responsible for dependence. |
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| 19371581 | Hernandez-Morales M, Garcia-Colunga J: Effects of nicotine on K+ currents and nicotinic receptors in astrocytes of the hippocampal CA1 region. Mol Pharmacol. 2009 Jul;76(1):1-10. Epub 2009 Mar 25. Nicotine, the main addictive substance in tobacco, interacts with muscle and neuronal nicotinic acetylcholine receptors (nAChRs) that are also localized in astrocytes. |
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| 19435931 | Jackson KJ, Walters CL, Damaj MI: Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. J Muscle Res Cell Motil. 2009;30(1-2):73-83. Epub 2009 Apr 29. Thus, understanding the nicotinic acetylcholine receptor (nAChR) subtypes and subsequent molecular cascades activated after nicotine exposure is of the utmost importance in understanding the progression of nicotine dependence. |
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| 19200240 | Raybuck JD, Gould TJ: Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors. Life Sci. 2009 Sep 9;85(11-12):444-9. Epub 2009 Jul 24. The present study used trace fear conditioning in C57BL/6 mice to investigate the effects of acute nicotine, chronic nicotine and withdrawal of chronic nicotine on processes active during acquisition and recall 24 h later and to examine the nicotinic acetylcholine receptor subtypes (nAChRs) involved in withdrawal deficits in trace fear conditioning. |
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| 20309583 | Wang XJ, Liu YF, Wang QY, Tsuruoka M, Ohta K, Wu SX, Yakushiji M, Inoue T: Functional expression of alpha7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues. Biochem Pharmacol. 2009 Oct 1;78(7):844-51. Epub 2009 Jun 23. Recent reports proposed that nicotine plays an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nAChRs) expressed by non-neuronal cells. |
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| 20229177 | Chen CS, Lee CH, Hsieh CD, Ho CT, Pan MH, Huang CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Yang YY, Wu CH, Ho YS: Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Biochem Pharmacol. 2009 Oct 1;78(7):703-11. Epub 2009 May 27. Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression. |
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| 19874251 | Bacher I, Wu B, Shytle DR, George TP: Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21. However, more recent clinical studies suggest that mecamylamine is effective at much lower doses for blocking the central and peripheral effects of nicotine. |
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| 19220484 | Gangitano D, Salas R, Teng Y, Perez E, De Biasi M: modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle. Eur Neuropsychopharmacol. 2010 Feb;20(2):69-79. Epub 2009 Dec 3. In addition, stress-related disorders such as anxiety, post-traumatic stress syndrome and depression are often associated with chronic nicotine use. To study the role of the alpha5 nicotinic acetylcholine receptor subunit in anxiety-related responses, control and alpha5 subunit null mice (alpha5 (-/-)) were subjected to the open field activity (OFA), light-dark box (LDB) and elevated plus maze (EPM) tests. |
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| 19626424 | Kondo Y, Tachikawa E, Ohtake S, Kudo K, Mizuma K, Kashimoto T, Irie Y, Taira E: Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation. Brain Res. 2009 Dec 11;1305:86-95. Epub 2009 Sep 26. Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. |
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| 19753305 | Yu J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Lee A, Robbins RC, Cooke JP, Wu JC: nAChRs mediate human embryonic stem cell-derived endothelial cells: proliferation, apoptosis, and angiogenesis. Neurotoxicol Teratol. 2010 Jan 7. Finally, in vitro mechanistic analysis suggests activation of the MAPK and Akt pathways following activation of nicotinic acetylcholine receptors (nAChRs). We tested the effect of nicotine (a key component of cigarette smoking) on the therapeutic effects of human embryonic stem cell-derived endothelial cells (hESC-ECs). |
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| 20132834 | Garcia-Rates S, Camarasa J, Sanchez-Garcia AI, Gandia L, Escubedo E, Pubill D: The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: Intracellular increase, calpain/caspase 3 activation, and functional upregulation. J Pathol. 2009 Aug;218(4):437-45. Previous work by our group demonstrated that homomeric alpha7 nicotinic acetylcholine receptors (nAChR) play a role in the neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA), as well as the binding affinity of this drug to these receptors. It also concentration-dependently inhibited the response induced by nicotine, and the specific alpha7 agonist PNU 282987 with IC (50) values in the low micromolar range. |
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| 19694730 | Freysoldt A, Fleckenstein J, Lang PM, Irnich D, Grafe P, Carr RW: Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve. Br J Pharmacol. 2009 Oct;158(3):797-805. Epub 2009 Aug 19. Amitriptyline is known to inhibit voltage-dependent ion channels and also to act as an antagonist at ligand-gated ion channels, such as nicotinic acetylcholine receptors (nAChRs). KEY RESULTS: Amitriptyline (EC (50) 2.6 microM) reduced the nicotine-induced increase in C-fibre excitability but only slightly altered the amplitude and latency to onset of the compound action potential. |
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| 19346165 | Pettersson A, Nylund G, Khorram-Manesh A, Nordgren S, Delbro DS: Nicotine induced modulation of SLURP-1 expression in human colon cancer cells. Basic Clin Pharmacol Toxicol. 2009 Aug;105(2):120-5. Epub 2009 Mar 16. The secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is an endogenous ligand at the alpha 7 subunit of the nicotinic acetylcholine receptor (nAChR). |
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| 19567877 | Cheng SB, Amici SA, Ren XQ, McKay SB, Treuil MW, Lindstrom JM, Rao J, Anand R: Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. Am J Respir Cell Mol Biol. 2009 Jul;41(1):93-9. Epub 2008 Dec 18. |
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| 19184650 | Barik J, Wonnacott S: Molecular and cellular mechanisms of action of nicotine in the CNS. J Neurochem. 2009 Mar;108(5):1116-25. Epub 2009 Jan 23. Nicotine achieves its psychopharmacological effects by interacting with nicotinic acetylcholine receptors (nAChRs) in the brain. |
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| 19465085 | Ribeiro-Carvalho A, Lima CS, Medeiros AH, Siqueira NR, Filgueiras CC, Manhaes AC, Abreu-Villaca Y: Combined exposure to nicotine and in adolescent mice: effects on the central cholinergic systems during short and long term withdrawal. Neurotoxicology. 2009 Nov;30(6):1045-52. Epub 2009 Jul 5. Since nicotine is a cholinergic agonist and it has been shown that interferes with nicotinic acetylcholine receptors (nAChRs), the current study focused on the effects of drug withdrawal on the central cholinergic system. |
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| 19760281 | Palmatier MI, Levin ME, Mays KL, Donny EC, Caggiula AR, Sved AF: and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats. Psychopharmacology. 2009 Dec;207(3):381-90. Epub 2009 Sep 17. However, the reinforcement enhancing effects of nicotine are mediated by nicotinic acetylcholine receptors, whereas the reinforcement enhancing effects of were mediated by alpha noradrenergic receptors. |
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| 19097990 | Fu XW, Lindstrom J, Spindel ER: Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Cell Prolif. 2008 Dec;41(6):936-59. |
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| 19155522 | Shi FD, Piao WH, Kuo YP, Campagnolo DI, Vollmer TL, Lukas RJ: Nicotinic attenuation of central nervous system inflammation and autoimmunity. J Immunol. 2009 Feb 1;182(3):1730-9. The expression of nicotinic acetylcholine receptors by neurons, microglia, and astrocytes suggests possibly diverse mechanisms by which natural nicotinic cholinergic signaling and exposure to nicotine could modulate immune responses within the CNS. |
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| 20114055 | Grady SR, Drenan RM, Breining SR, Yohannes D, Wageman CR, Fedorov NB, McKinney S, Whiteaker P, Bencherif M, Lester HA, Marks MJ: Structural differences determine the relative selectivity of nicotinic compounds for native alpha4beta2*-, alpha6beta2*-, alpha3beta4*- and alpha7-nicotine acetylcholine receptors. J Physiol. 2009 Mar 15;587(Pt 6):1233-47. Epub 2009 Feb 2. |
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| 19733931 | Carcereny E, Ramirez JL, Sanchez-Ronco M, Isla D, Cobo M, Moran T, de Aguirre I, Okamoto T, Wei J, Provencio M, Lopez-Vivanco G, Camps C, Domine M, Alberola V, Sanchez JM, Massuti B, Mendez P, Taron M, Rosell R: Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. Lung Cancer. 2009 Sep 4. Nicotine acetylcholine receptors (nAChRs) are associated with resistance to gemcitabine, cisplatin and paclitaxel in non-small-cell lung cancer (NSCLC) cell lines. |
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| 19962246 | Ortells MO, Barrantes GE: Tobacco addiction: A biochemical model of nicotine dependence. . Med Hypotheses. 2009 Dec 2. Nicotine is the main psychoactive substance present in tobacco, targeting in the CNS the nicotinic acetylcholine receptors (nAChR). |
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| 19487632 | Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK: beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Hum Mol Genet. 2009 Aug 1;18(15):2922-7. Epub 2009 May 9. |
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| 19116908 | van Maanen MA, Lebre MC, van der Poll T, LaRosa GJ, Elbaum D, Vervoordeldonk MJ, Tak PP: Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Mol Cell Biochem. 2010 Jan;333(1-2):57-64. Epub 2009 Jul 22. In a separate study, nicotine was added to the drinking water of mice with collagen-induced arthritis (CIA). |
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| 19048619 | Calleja-Macias IE, Kalantari M, Bernard HU: Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis?. Neuropharmacology. 2009 May-Jun;56(6-7):975-83. Epub 2009 Feb 8. We also measured that the proliferation of SiHa and HeLa cells is stimulated by nicotine. |
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| 19404753 | Cannata DJ, Finkelstein DI, Gantois I, Teper Y, Drago J, West JM: Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor. Psychopharmacology. 2009 Nov;207(1):153-62. Epub 2009 Aug 20. Mutant mice demonstrate brief nicotine induced dystonia that resembles the clinical events seen in patients with the same mutation. |
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| 19323966 | Philip NS, Carpenter LL, Tyrka AR, Whiteley LB, Price LH: Varenicline augmentation in depressed smokers: an 8-week, open-label study. J Mol Neurosci. 2010 Jan;40(1-2):211-6. BACKGROUND: Varenicline is a nicotinic acetylcholine receptor alpha4beta2 partial agonist and alpha7 full agonist approved for smoking cessation. |
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| 19714494 | Akaike A, Takada-Takatori Y, Kume T, Izumi Y: Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Neurosci Biobehav Rev. 2010 Feb 16. We examined the roles of nicotinic acetylcholine receptors (nAChRs) in survival of CNS neurons during excitotoxic events. |
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| 19251827 | Brennan K, Lea R, Fitzmaurice P, Truman P: Nicotinic receptors and stages of nicotine dependence. . Toxicol Appl Pharmacol. 2010 Feb 2. AbstractSmoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. The focus of this review was on nicotinic acetylcholine receptor neuroadaptations that occur during the development of nicotine dependence. |
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| 19492010 | Schlaepfer IR, Hoft NR, Ehringer MA: The genetic components of and nicotine co-addiction: from genes to behavior. Handb Exp Pharmacol. 2009;(192):173-207. Recent work from human genetics studies has provided evidence that neuronal nicotinic acetylcholine receptors (nAChR) genes may have a role in mediating early behaviors that are risk factors for and nicotine dependence, such as age of initiation and early subjective responses to the drugs. |
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| 19020039 | Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S: Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. Arch Oral Biol. 2009 Mar;54(3):251-7. Epub 2009 Jan 14. Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, or CHRNA2, respectively) of nAChR [neuronal nicotinic (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. |
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| 20106947 | Chen RJ, Ho YS, Guo HR, Wang YJ: Long-term Nicotine Exposure-Induced Chemoresistance is Mediated by Activation of Stat3 and Downregulation of ERK1/2 via nAChR and beta-AR in Human Bladder Cancer Cells. J Pharmacol Exp Ther. 2009 Nov;331(2):547-54. Epub 2009 Jul 30. Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of ERK1/2 activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors. |
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| 19640784 | Swayne OB, Teo JT, Greenwood RJ, Rothwell JC: The facilitatory effects of intermittent theta burst stimulation on corticospinal excitability are enhanced by nicotine. Acta Pharmacol Sin. 2009 Jun;30(6):788-94. In animal models, agonists of nicotinic acetylcholine receptors have been shown to modulate or induce LTP; we thus sought to test whether nicotine may modulate the effects of iTBS on corticospinal excitability in humans. |
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| 20153739 | Hunter RG, Bloss EB, McCarthy KJ, McEwen BS: Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids. Am J Respir Crit Care Med. 2009 Jun 15;179(12):1141-50. Epub 2009 Jan 16. The alpha7 subunit of the nicotinic acetylcholine receptor (NAchRalpha7) is one of the principal brain receptors for nicotine and is thought to be a mediator of nicotine's pro-cognitive effects. |
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