| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3113432 | Sinclair P, Lambrecht R, Sinclair J: Evidence for cytochrome P450-mediated oxidation of uroporphyrinogen by cell-free liver extracts from chick embryos treated with 3-methylcholanthrene. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1324-9. Direct involvement of cytochrome P450 was demonstrated by inhibition of the oxidation by CO, piperonyl butoxide and specific antisera to the methylcholanthrene-induced cytochrome P450. 2,4,2',4'-tetrachlorobiphenyl was inactive in the oxidation. |
83(1,1,1,3) | Details |
| 3083808 | Scott JG, Georghiou GP: The biochemical genetics of permethrin resistance in the Learn-PyR strain of house fly. Biochem Genet. 1986 Feb;24(1-2):25-37. Permethrin resistance factors on chromosome 1 consisted of a piperonyl butoxide (PB)-suppressible mechanism correlated with increased levels of cytochromes P-450 and b5; on chromosome 2, a PB-suppressible mechanism associated with elevated amounts of cytochrome P-450; on chromosome 3, decreased cuticular penetration, kdr, and increased amounts of P-450 reductase activity; and on chromosome 5, a largely PB-suppressible mechanism correlated with elevated levels of cytochrome P-450 and P-450 reductase activity. |
82(1,1,1,2) | Details |
| 12382064 | Mori T, Kondo R: Oxidation of dibenzo- p-dioxin, dibenzofuran, biphenyl, and diphenyl ether by the white-rot fungus Phlebia lindtneri. Appl Microbiol Biotechnol. 2002 Oct;60(1-2):200-5. Epub 2002 Aug 13. Significant inhibition of the degradation of DD and DF was observed in incubation with the cytochrome P-450 monooxygenase inhibitors 1-aminobenzotriazole and piperonyl butoxide. |
32(0,1,1,2) | Details |
| 3087137 | Brittebo EB, Darnerud PO, Larsson J, Svanberg O, Brandt I: O-dealkylation of phenacetin in the olfactory rosette in rainbow trout (Salmo gairdneri). Acta Pharmacol Toxicol. 1986 Apr;58(4):259-64. Addition of the cytochrome P-450 inhibitors 9-hydroxyellipticine and piperonyl butoxide significantly decreased the formation of 14CO2 from (14C-ethyl)-phenacetin in olfactory rosettes. |
32(0,1,1,2) | Details |
| 2983324 | Luini AG, Axelrod J: Inhibitors of the cytochrome P-450 enzymes block the secretagogue-induced release of corticotropin in mouse pituitary tumor cells. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1012-4. Blockers of the cytochrome P-450 epoxygenase, such as SKF 525A and piperonyl butoxide, compounds that have different molecular structures, also suppressed secretagogue-induced ACTH release. |
32(0,1,1,2) | Details |
| 2173718 | Bysani GK, Kennedy TP, Ky N, Rao NV, Blaze CA, Hoidal JR: Role of cytochrome P-450 in reperfusion injury of the rabbit lung. . J Clin Invest. 1990 Nov;86(5):1434-41. The P-450 inhibitors 8-methoxypsoralen, piperonyl butoxide, and cimetidine markedly decreased lung edema from transvascular fluid flux. |
4(0,0,0,4) | Details |
| 3741469 | Okine LK, Gram TE: In vitro studies on the metabolism and covalent binding of [14C] 1,1-dichloroethylene by mouse liver, kidney and lung. Biochem Pharmacol. 1986 Aug 15;35(16):2789-95. Covalent binding was - and cytochrome P-450-dependent. Omission of heat inactivation of microsomes, addition of SKF-525A, piperonyl butoxide or (GSH), all inhibited (40-90%) covalent binding of radiolabel to liver and lung microsomes. |
4(0,0,0,4) | Details |
| 2818619 | Kramer RA: Cytochrome P-450-dependent formation of alkylating metabolites of the 2-chloroethylnitrosoureas MeCCNU and CCNU. Biochem Pharmacol. 1989 Oct 1;38(19):3185-92. Additional studies with inhibitors such as piperonyl butoxide and with the inducers 3-methylcholanthrene and phenobarbital were consistent with this view. |
2(0,0,0,2) | Details |
| 12174045 | Coleman NV, Spain JC, Duxbury T: Evidence that RDX biodegradation by Rhodococcus strain DN22 is plasmid-borne and involves a cytochrome p-450. J Appl Microbiol. 2002;93(3):463-72. production from RDX was inhibited by piperonyl butoxide, n-octylamine and and inducible by pyrrolidine, and atrazine. |
2(0,0,0,2) | Details |
| 19161459 | Virkel G, Lifschitz A, Sallovitz J, Ballent M, Scarcella S, Lanusse C: Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep. J Vet Pharmacol Ther. 2009 Feb;32(1):79-86. |
2(0,0,0,2) | Details |
| 19125173 | Pasay C, Arlian L, Morgan M, Gunning R, Rossiter L, Holt D, Walton S, Beckham S, McCarthy J: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides. PLoS Negl Trop Dis. 2009;3(1):e354. Epub 2009 Jan 6. METHODOLOGY/PRINCIPAL FINDINGS: To determine the role of metabolic degradation as a mechanism for acaricide resistance in scabies mites, PBO (piperonyl butoxide), DEF (S,S,S-tributyl phosphorotrithioate) and DEM (diethyl were first tested for synergistic activity with permethrin in a bioassay of mite killing. Then, to investigate the relative role of specific metabolic pathways inhibited by these synergists, enzyme assays were developed to measure esterase, glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cytochrome P450) activity in mite extracts. |
1(0,0,0,1) | Details |
| 4154538 | Franklin MR: The enzymic formation of methylenedioxyphenyl derivative exhibiting an -like spectrum with reduced cytochrome P-450 in hepatic microsomes. Xenobiotica. 1971 Nov;1(6):581-91. |
1(0,0,0,1) | Details |
| 708156 | Waddell WJ, Marlowe C: Inhibition by of the accumulation of -14C in bronchial epithelium of mice. Arch Int Pharmacodyn Ther. 1978 Aug;234(2):294-307. Pretreatment with NaHCO3, NH4Cl, SKF 525A, piperonyl butoxide, phenobarbital or prior to the administration of [methyl-14C] was studied. |
0(0,0,0,0) | Details |
| 16289043 | Parker RS, McCormick CC: Selective accumulation of in Drosophila is associated with cytochrome P450 -omega-hydroxylase activity but not alpha-tocopherol transfer protein. Biochem Biophys Res Commun. 2005 Dec 23;338(3):1537-41. Epub 2005 Nov 2. Inclusion in the diet of piperonyl butoxide (PBO), an insect cytochrome P450 inhibitor and inhibitor of -omega-hydroxylase activity, greatly elevated tissue levels of but not |
0(0,0,0,0) | Details |
| 2764708 | Catinot R, Hoellinger H, Sonnier M, Do-Cao-Thang, Pichon J, Nguyen-Hoang-Nam: In vitro covalent binding of the pyrethroids cismethrin, cypermethrin and deltamethrin to rat liver homogenate and microsomes. Arch Toxicol. 1989;63(3):214-20. With microsomes, inhibition of cytochrome P-450 and mixed function oxidases by and piperonyl butoxide reduced the covalent binding so far as to be nearly absent. |
82(1,1,1,2) | Details |
| 8494497 | Frater Y, Brady A, Lock EA, De Matteis F: Formation of N-methyl in chemically-induced protoporphyria. Arch Toxicol. 1993;67(3):179-85. Two inhibitors of liver cytochrome P450, compound SKF 525-A and piperonyl butoxide, when given before ATMP, afforded protection against ATMP-induced porphyria and production of N-methyl suggesting a role of cytochrome P450 in the induction of the metabolic disorder. |
82(1,1,1,2) | Details |
| 19691325 | Keum YS, Lee YH, Kim JH: Metabolism of methoxychlor by Cunninghamella elegans ATCC36112. J Agric Food Chem. 2009 Sep 9;57(17):7931-7. Piperonyl butoxide and chlorpyrifos strongly inhibit the degradation of methoxychlor and concomitant accumulation of metabolites, indicating cytochrome P450 mediated metabolism. |
82(1,1,1,2) | Details |
| 3388433 | Smith AC, Roberts SM, Berman LM, Harbison RD, James RC: Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat. Toxicology. 1988 Jun;50(1):95-105. The metabolism of halothane was determined in both hyperthyroid 3 mg/kg per day, for 6 days) and euthyroid rats and in animals pre-treated with the cytochrome P-450 inhibitor piperonyl butoxide (75-100 mg/kg, i.p.). |
31(0,1,1,1) | Details |
| 10826201 | Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71. Including the synergists piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, or S,S,S-tributylphosphorotrithioate, an esterase inhibitor, in the methiocarb bioassays partially suppressed resistance in the most resistant populations. |
31(0,1,1,1) | Details |
| 19062071 | Marco-Urrea E, Perez-Trujillo M, Vicent T, Caminal G: Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of by Trametes versicolor. Chemosphere. 2009 Feb;74(6):765-72. Epub 2008 Dec 4. However, our in vivo studies using the cytochrome P450 inhibitors 1-aminobenzotriazole and piperonyl butoxide suggested that the cytochrome P450 system may be involved in the first step of CLOFI and CARBA oxidation by T. versicolor. |
31(0,1,1,1) | Details |
| 8498088 | Canivenc-Lavier MC, Brunold C, Siess MH, Suschetet M: Evidence for tangeretin O-demethylation by rat and human liver microsomes. . Xenobiotica. 1993 Mar;23(3):259-66. Tangeretin, a polymethoxylated was studied as a substrate for cytochrome P450-catalysed demethylation reactions by rat and human liver microsomes. The reaction was inhibited by CO, piperonyl butoxide, 7,8-benzoflavone, propyl aminobenzothiazole and 3. |
4(0,0,0,4) | Details |
| 2888625 | Young RA, Mehendale HM: Effect of cytochrome P-450 and flavin-containing monooxygenase modifying factors on the in vitro metabolism of amiodarone by rat and rabbit. Drug Metab Dispos. 1987 Jul-Aug;15(4):511-7. The classic P-450 inhibitors, piperonyl butoxide, SKF 525A, n-octylamine, and CO provided a significant reduction in the in vitro formation of DEA by microsomes from induced animals. |
4(0,0,0,4) | Details |
| 8847486 | Hildebrandt E, Albanesi JP, Falck JR, Campbell WB: Regulation of influx and catecholamine secretion in chromaffin cells by a cytochrome P450 metabolite of J Lipid Res. 1995 Dec;36(12):2599-608. Ketoconazole (10 microM), (20 microM), and piperonyl butoxide (50 microM) inhibited carbachol-dependent catecholamine secretion by 44%, 83%, and 100%, respectively; -dependent secretion by 25%, 60%, and 81%, and secretion induced by 59 mM KCl depolarization by 25%, 55%, and 89%. |
4(0,0,0,4) | Details |
| 1465429 | Frank MR, Fogleman JC: Involvement of cytochrome P450 in host-plant utilization by Sonoran Desert Drosophila. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11998-2002. To test whether P450s are involved in the detoxication of cactus allelochemicals, several experiments were done. (i) The effect of a specific P450 inhibitor, piperonyl butoxide, on larval survival through eclosion on each cactus substrate was investigated. (ii) In vitro metabolism of cactus alkaloids was determined for each Drosophila species. |
3(0,0,0,3) | Details |
| 8291265 | Yang W, Jiang T, Acosta D, Davis PJ: Microbial models of mammalian metabolism: involvement of cytochrome P450 in the N-demethylation of N-methylcarbazole by Cunninghamella echinulata. Xenobiotica. 1993 Sep;23(9):973-82. a classical P450 inhibitor, markedly inhibited the formation of NHMC, as did 1-Benzylimidazole, piperonyl butoxide and SKF-525A inhibited the formation of both NHMC and 3-OH-NHMC, while beta-naphthoflavone (5,6-benzoflavone) induced their formation. 3. |
2(0,0,0,2) | Details |
| 17014948 | Muguruma M, Nishimura J, Jin M, Kashida Y, Moto M, Takahashi M, Yokouchi Y, Mitsumori K: Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice. Toxicology. 2006 Dec 7;228(2-3):178-87. Epub 2006 Sep 1. In the microarray analysis, the expression of oxidative and metabolic stress-related genes--cytochrome P450 (Cyp) 1A1, Cyp2A5 (week 1 only), Cyp2B9, Cyp2B10, and -cytochrome P450 oxidoreductase (Por) was over-expressed in mice given PBO at weeks 1 and 4. |
1(0,0,0,1) | Details |
| 8294621 | Hemingway J, Dunbar SJ, Monro AG, Small GJ: Pyrethroid resistance in German cockroaches (Dictyoptera: Blattelidae): resistance levels and underlying mechanisms. J Econ Entomol. 1993 Dec;86(6):1631-8. Possible resistance mechanisms detected in these populations included elevated levels of cytochrome P450, general esterase and glutathione S-transferase, and nerve insensitivity (kdr-type resistance). Resistance was synergized by piperonyl butoxide in some strains. |
1(0,0,0,1) | Details |
| 8967773 | Masaphy S, Henis Y, Levanon D: -enhanced biotransformation of atrazine by the white rot fungus Pleurotus pulmonarius and its correlation with oxidation activity. Appl Environ Microbiol. 1996 Oct;62(10):3587-93. Lipid peroxidation, oxygenase and peroxidase activities, and the cytochrome P-450 concentration increased. Antioxidants, mainly nordihydroguaiaretic acid, which inhibits lipoxygenase, peroxidase, and P-450 activities, and piperonyl butoxide, which inhibits P-450 activity, inhibited atrazine transformation by the mycelium. |
1(0,0,0,1) | Details |
| 10985040 | Valles SM, Oi FM, Wagner T, Brenner RJ: Toxicity and in vitro metabolism of t-permethrin in eastern subterranean termite (Isoptera: Rhinotermitidae). J Econ Entomol. 2000 Aug;93(4):1259-64. The synergists piperonyl butoxide and S,S,S-tributylphosphorotrithioate increased t-permethrin toxicity four- and threefold (at the LC50) in the UF and ARS colonies, respectively. |
0(0,0,0,0) | Details |
| 6435605 | Sinclair PR, Bement WJ, Bonkovsky HL, Sinclair JF: Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Biochem J. 1984 Sep 15;222(3):737-48. Use of inhibitors of the P-450 and P-448 isoenzymes (SKF-525A, piperonyl butoxide and ellipticine) supported the concept that only the P-448 isoenzyme is involved in the inhibition of the decarboxylase by the halogenated biphenyls. |
0(0,0,0,0) | Details |
| 11594702 | Hong SK, Anestis DK, Valentovic MA, Ball JG, Brown PI, Rankin GO: Gender differences in the potentiation of N-(3,5-dichlorophenyl) succinimide metabolite nephrotoxicity by phenobarbital. J Toxicol Environ Health A. 2001 Oct 12;64(3):241-56. In a separate experiment, male Fischer 344 rats were pretreated with piperonyl butoxide (PIBX, 1360 mg/kg) or the PIBX vehicle. 2-NDHSA (0.1 mmol/kg) or vehicle was administered (ip) 30 min after PIBX, and renal function was monitored for 24 h. |
0(0,0,0,0) | Details |
| 20025819 | Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I: Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole. Parasitology. 2009 Dec 22:1-10. The cytochrome P450 (CYP P450) system was inhibited using piperonyl butoxide (PB). |
82(1,1,1,2) | Details |
| 6814016 | Fisher CW, Mayer RT: Characterization of house fly microsomal mixed function oxidases: inhibition by juvenile hormone i and piperonyl butoxide. Toxicology. 1982;24(1):15-31. The microsomal mixed function oxidase system of the house fly (Musca domestica [L.]) was characterized with respect to N-demethylation of p-chloromethylaniline, O-demethylation of methoxyresorufin, epoxidation of aldrin and the formation of a metabolite-cytochrome P-450 complex during oxidation of piperonyl butoxide (PB). |
82(1,1,1,2) | Details |
| 3432735 | Mizutani T, Nomura H, Nakanishi K, Fujita S: Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice. Res Commun Chem Pathol Pharmacol. 1987 Oct;58(1):75-83. Treatments of mice with the cytochrome P-450 enzyme inhibitors, SKF-525A, piperonyl butoxide, and carbon disulfide (CS2), prevented or markedly alleviated the hepatotoxicity of pulegone. |
31(0,1,1,1) | Details |
| 8866343 | Benchaoui HA, McKellar QA: Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications. J Pharm Pharmacol. 1996 Jul;48(7):753-9. The effect of the cytochrome P450 inhibitor, piperonyl butoxide on the pharmacokinetics and anthelmintic efficacy of the benzimidazole compound fenbendazole was studied in sheep and goats. |
31(0,1,1,1) | Details |
| 1426026 | Basile AS, Paul IA, de Costa B: Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors. Eur J Pharmacol. 1992 Sep 1;227(1):95-8. Furthermore, proadifen and piperonyl butoxide inhibited [3H](+)-pentazocine and [3H] DTG binding with low potency. |
3(0,0,0,3) | Details |
| 7945437 | Bonnin A, de Miguel R, Fernandez-Ruiz JJ, Cebeira M, Ramos JA: Possible role of the cytochrome P450-linked monooxygenase system in preventing delta 9-tetrahydrocannabinol-induced stimulation of tuberoinfundibular dopaminergic activity in female rats. Biochem Pharmacol. 1994 Oct 7;48(7):1387-92. However, the administration of THC to -replaced ovariectomized rats that had been pretreated with two separately administered inhibitors of cytochrome P450, piperonyl butoxide or significantly increased content in the medial basal hypothalamus, with no changes in the other parameters. |
3(0,0,0,3) | Details |
| 3718476 | Sinclair JF, Zaitlin LM, Smith EL, Howell SK, Bonkovsky HL, Sinclair PR: Induction of synthase by two- to five-carbon in cultured chick-embryo hepatocytes. Biochem J. 1986 Mar 1;234(2):405-11. Relationship to induction of cytochrome P-450.. |
3(0,0,0,3) | Details |
| 10141 | Hinson JA, Mitchell JR: N-Hydroxylation of phenacetin by hamster liver microsomes. . Drug Metab Dispos. 1976 Sep-Oct;4(5):430-5. The reaction, which requires and is inhibited by a / atmosphere, indicating that it is catalyzed by a cytochrome P-450-dependent mixed-function oxidase. |
1(0,0,0,1) | Details |
| 3664363 | Forkert PG, Hofley M, Racz WJ: Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes. Can J Physiol Pharmacol. 1987 Jul;65(7):1496-9. Piperonyl butoxide caused significant decreases in covalent binding to lung and liver microsomes; SKF 525-A significantly inhibited binding to liver microsomes but had no effect on lung microsomes. The results demonstrate that reactive metabolites of 1,1-DCE can be formed by lung and liver microsomes, and suggest the involvement of cytochrome P-450 isozymes in the lung and liver injury induced by the halocarbon. |
1(0,0,0,1) | Details |
| 1570637 | Madhu C, Klaassen CD: Bromobenzene- excretion into bile reflects toxic activation of bromobenzene in rats. Toxicol Lett. 1992 Apr;60(2):227-36. In order to test this hypothesis, the effect of chemicals known to alter the toxicity and biotransformation of BB (i.e., cytochrome P-450 inducers and inhibitors) on the biliary excretion of BB-GSH was studied in rats. Inhibitors of P-450, such as SKF 525-A and piperonyl butoxide which are known to decrease the activation and hepatotoxicity of BB, also decreased the biliary excretion of BB-GSH. |
1(0,0,0,1) | Details |
| 7062265 | Kuo CH, Rush GF, Hook JB: Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases. J Pharmacol Exp Ther. 1982 Mar;220(3):547-51. Renal cortical accumulation of phenobarbital in rats was also inhibited by piperonyl butoxide. |
0(0,0,0,0) | Details |
| 497524 | Borys HK, Ingall GB, Karler R: Development of tolerance to the prolongation of hexobarbitone sleeping time caused by cannabidiol. Br J Pharmacol. 1979 Sep;67(1):93-101. 1 The effects of acute and subacute cannabidiol (CBD) administration on hexobarbitone sleeping time and on some constituents of the hepatic microsomal drug-metabolizing system were assessed in the mouse.2 Acutely administered CBD prolonged sleeping time; but with subacute treatment, tolerance to the effect rapidly developed.3 Brain hexobarbitone concentration upon awakening was unchanged by either acute or subacute CBD treatment, which suggests that neither the prolongation of sleeping time nor the tolerance is the result of a change in sensitivity of the central nervous system to the barbiturate.4 Acute CBD treatment increased the half-time of hexobarbitone in the brain, which returned toward normal with the development of tolerance.5 Acutely, CBD caused a 30% decrease in hepatic cytochrome P-450 level; with tolerance, the cytochrome concentration returned to normal.6 The evidence suggests that the CBD-induced prolongation of barbiturate sleeping time and the tolerance to this effect are the result of changes in the rate of drug metabolism, which are related to changes in the amount of cytochrome P-450.7 The effects of CBD on the hepatic microsomal drug-metabolizing enzyme system are different from those attributed to SKF 525-A and piperonyl butoxide because the cannabinoid does not decrease cytochrome P-450 quantitatively by complex formation, it does not produce a recovery overshoot in the cytochrome concentration and, finally, it does not cause an induction of the hexobarbitone-metabolizing enzymes. |
0(0,0,0,0) | Details |
| 3672539 | Chakrabarti SK, Tuchweber B: Effects of various pretreatments on the acute nephrotoxic potential of styrene in Fischer-344 rats. Toxicology. 1987 Nov;46(3):343-56. Groups of rats were pretreated with either 3-methylcholanthrene (15 mg/kg, i.p., 3 days), or phenobarbital (80 mg/kg, i.p., 3 days), or SKF525-A (50 mg/kg, i.p., 1 h), or piperonyl butoxide (300 mg/kg, i.p., 2 h), or diethylmaleate (400 mg/kg, i.p., 90 min) prior to an i.p. administration of styrene (0, 0.6 and 0.9 g/kg) in corn oil. |
0(0,0,0,0) | Details |
| 10445162 | Song H, Lang CA, Chen TS: The role of in -induced nephrotoxicity in the mouse. Drug Chem Toxicol. 1999 Aug;22(3):529-44. Piperonyl butoxide, an inhibitor of cytochrome P-450 enzymes, enhanced nephrotoxicity and renal depletion but not GSH depletion. |
0(0,0,0,0) | Details |
| 8980035 | Karoly ED, Rose RL, Thompson DM, Hodgson E, Rock GC, Roe RM: Monooxygenase, Esterase, and Glutathione Transferase Activity Associated with Azinphosmethyl Resistance in the Tufted Apple Bud Moth, Platynota idaeusalis. Pestic Biochem Physiol. 1996 Jun;55(2):109-21. Piperonyl butoxide failed to synergize azinphosmethyl toxicity. |
0(0,0,0,0) | Details |
| 2219115 | Roberts SA, Price VF, Jollow DJ: structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide. Toxicol Appl Pharmacol. 1990 Sep 1;105(2):195-208. In addition, 3HAA produced only a modest depletion of hepatic suggesting the lack of a threshold. 3-Methylcholanthrene pretreatment increased and pretreatment with and piperonyl butoxide decreased the hepatic covalent binding of 3HAA, indicating the involvement of cytochrome P450 in the formation of the 3HAA reactive metabolite. |
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| 17598550 | Sims SR, Appel AG: Linear ethoxylates: insecticidal and synergistic effects on German cockroaches (Blattodea: Blattellidae) and other insects. J Econ Entomol. 2007 Jun;100(3):871-9. The insecticidal activity of Tomadol 23-1 was synergized by coapplication with a sublethal amount of piperonyl butoxide, indicating the involvement of cytochrome P450 microsomal monooxygenases in insect metabolism of AEO surfactants. |
31(0,1,1,1) | Details |
| 8023339 | Miller AC, Dwyer LD, Auerbach CE, Miley FB, Dinsdale D, Malkinson AM: Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain. Toxicology. 1994 May 31;90(1-2):141-59. Studies with the cytochrome P450 inhibitor, piperonyl butoxide, indicated that metabolism of BHT was required for both its acute and chronic effects. |
31(0,1,1,1) | Details |
| 702322 | Nelson SD, Mitchell JR, Snodgrass WR, Timbrell JA: Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine. J Pharmacol Exp Ther. 1978 Sep;206(3):574-85. Phenobarbital, an inducer of a class of hepatic microsomal cytochrome P-450 enzymes, greatly potentiated the necrosis, whereas inhibitors of these microsomal enzymes such as piperonyl butoxide and alpha-naphthylisothiocyanate, prevented the necrosis. |
31(0,1,1,1) | Details |
| 20333538 | Ning D, Wang H, Ding C, Lu H: Novel evidence of cytochrome P450-catalyzed oxidation of phenanthrene in Phanerochaete chrysosporium under ligninolytic conditions. Biodegradation. 2010 Mar 24. Piperonyl butoxide, a P450 inhibitor which had no effect on peroxidase activity, significantly inhibited phenanthrene degradation and the trans-9,10-dihydrodiol formation in both intact cultures and microsomal fractions. |
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| 12144699 | Brandt A, Scharf M, Pedra JH, Holmes G, Dean A, Kreitman M, Pittendrigh BR: Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst (2) DDT locus. Insect Mol Biol. 2002 Aug;11(4):337-41. |
3(0,0,0,3) | Details |
| 4147720 | Potter WZ, Davis DC, Mitchell JR, Jollow DJ, Gillette JR, Brodie BB: -induced hepatic necrosis. 3. J Pharmacol Exp Ther. 1973 Oct;187(1):203-10. Cytochrome P-450-mediated covalent binding in vitro. |
1(0,0,0,1) | Details |
| 3327440 | Bonkovsky HL, Sinclair PR, Bement WJ, Lambrecht RW, Sinclair JF: Role of cytochrome P-450 in porphyria caused by halogenated aromatic compounds. Ann N Y Acad Sci. 1987;514:96-112. |
1(0,0,0,1) | Details |
| 5008936 | Philpot RM, Hodgson E: The production and modification of cytochrome P-450 difference spectra by in vivo administration of methylenedioxyphenyl compounds. Chem Biol Interact. 1972 Feb;4(3):185-94. |
1(0,0,0,1) | Details |
| 3036125 | Galbraith RA, Jellinck PH: - causes prolonged inhibition of synthesis by rat liver microsomes. Biochem Biophys Res Commun. 1987 May 29;145(1):376-83. A single injection of - (CoPP), which produces a marked and sustained decline in hepatic cytochrome P450 content, reduced the ability of male rat liver microsomes to form estrogens to about 30% of control values within 1 day, as measured by the release of 3H2O from [2-3H] Two days after treatment, the apparent Km of 2-hydroxylase for was increased, but other inhibitors of cytochrome P450 function (SKF-525A or piperonyl butoxide) failed to affect the enzyme. |
1(0,0,0,1) | Details |
| 9455675 | Ishida K, Ikegami H, Doi K: Enhanced nephrotoxicity of in -induced hypertriglyceridemic rats: contribution of oxidation and deacetylation of to an enhancement of nephrotoxicity. Exp Toxicol Pathol. 1997 Dec;49(5):313-9. Fischer-344 rats, which are susceptible to nephrotoxicity, have two toxic metabolic pathways involving cytochrome P450-dependent oxidation of to N-- imine (NAPQI) and P450-independent deacetylation of APAP to p-aminophenol (PAP). In the non-pretreated rats, the inhibition of oxidation by the MFO inhibitor, piperonyl butoxide, and deacetylation by carboxyesterase inhibitor, bis (p-nitrophenyl) did not alter -induced renal lesions. |
1(0,0,0,1) | Details |
| 7184943 | Kluwe WM, Herrmann-Kluwe CL, Hook JB: Inhibition of mixed-function oxidase activities in vitro and in vivo: comparisons between kidney and liver. J Appl Toxicol. 1982 Oct;2(5):226-30. The concentration-dependent abilities of SKF 525-A, (MET), piperonyl butoxide (PB), allyl-isopropylacetamide (AIA) and alpha-naphthoflavone (7,8-benzoflavone; ANF) to inhibit the activities of p-chloro-N-methylaniline-N-demethylase (PCNMA) and aryl hydrocarbon hydroxylase (AHH) in vitro were determined in microsomal and postmitochondrial supernatant (PMS) fractions of homogenates prepared from kidneys and livers of rats and mice. The differences in sensitivity of renal and hepatic AHH and PCNMA activities to the inhibitors may have been due to organ-specific differences in the affinities of the inhibitors for interaction with the active site (s) on cytochrome P-450. |
1(0,0,0,1) | Details |
| 2339415 | Chambers JE, Chambers HW: Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats. Toxicol Appl Pharmacol. 1990 May;103(3):420-9. The effects of pretreatment with cytochrome P450 inducers and inhibitors were also investigated. Although pretreatment with piperonyl butoxide did not affect the rate of acetylcholinesterase inhibition, it slowed hepatic and plasma aliesterase inhibition following parathion administration, presumably from inhibition of the parathion activation pathway. |
1(0,0,0,1) | Details |
| 8980024 | Thomas JD, Ottea JA, Boethel DJ, Ibrahim S: Factors Influencing Pyrethroid Resistance in a Permethrin-Selected Strain of the Soybean Looper, Pseudoplusia includens (Walker). Pestic Biochem Physiol. 1996 May;55(1):1-9. Cytochrome P450 monooxgenase activity toward p-nitroanisole was measured in larvae of three strains of soybean looper, Pseudoplusia includens (Walker), including a laboratory susceptible (S) strain, a resistant (R) strain selected for several generations with permethrin, and a nonselected (NS) strain from the same field collections as the R strain. Piperonyl butoxide (PB) significantly increased the toxicity of each insecticide tested in the R and NS strains. |
1(0,0,0,1) | Details |
| 2841540 | Chakraborty C, Davis DL, Dey SK: Characteristics of -2/4-hydroxylase in pig blastocysts: inhibition by steroidal and nonsteroidal agents. J Steroid Biochem. 1988 Aug;31(2):231-5. Although alpha-naphthoflavone and aminoglutethimide did not affect E-2/4-H activity in vitro, inhibition by CO (95% CO + 5% O2), SKF-525A, piperonyl butoxide, and antibody to cytochrome P-450 reductase provides evidence for the involvement of cytochrome P-450 in E-2/4-H activity in pig blastocysts. |
0(0,0,0,0) | Details |
| 3377819 | Thompson D, Moldeus P: Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes. Biochem Pharmacol. 1988 Jun 1;37(11):2201-7. Their toxicity appeared to be independent of their metabolism to reactive intermediates since inhibitors of cytochrome P-450 SKF 525-A and piperonyl butoxide) had no effect on the cytotoxicity and was also without protective effect. |
0(0,0,0,0) | Details |
| 8620577 | McCord A, Boyle SP, Knowler JT, Burnett AK, Craft JA: Metabolism of benz [alpha] anthracene by human bone marrow in vitro. Chem Biol Interact. 1996 Jan 5;99(1-3):29-40. Two general cytochrome P450 inhibitors, and piperonyl butoxide, blocked the formation of metabolites but the cyclooxygenase inhibitor, indomethacin had no effect. |
0(0,0,0,0) | Details |
| 15776405 | Ninsin KD, Tanaka T: Synergism and stability of acetamiprid resistance in a laboratory colony of Plutella xylostella. Pest Manag Sci. 2005 Aug;61(8):723-7. The involvement of metabolic enzymes in the resistance of a laboratory colony of diamondback moth, Plutella xylostella (L), to the neonicotinoid insecticide acetamiprid was determined with the synergists piperonyl butoxide (PBO), which suppresses the activity of cytochrome P-450 monooxygenases, and S,S,S-tributyl phosphorotrithioate (DEF), an inhibitor of esterases, using the leaf-dipping method. |
81(1,1,1,1) | Details |
| 2338648 | Thomassen D, Slattery JT, Nelson SD: Menthofuran-dependent and independent aspects of pulegone hepatotoxicity: roles of J Pharmacol Exp Ther. 1990 May;253(2):567-72. The -depleting effect of pulegone was compromised following inhibition of cytochrome P-450 by piperonyl butoxide. |
81(1,1,1,1) | Details |
| 2050025 | Plopper CG, Chang AM, Pang A, Buckpitt AR: Use of microdissected airways to define metabolism and cytotoxicity in murine bronchiolar epithelium. Exp Lung Res. 1991 Mar-Apr;17(2):197-212. Pre-incubation of the explants with piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, prevented naphthalene-induced cytotoxicity. |
31(0,1,1,1) | Details |
| 7091806 | Hatch RC, Jain AV, Weiss R, Clark JD: Toxicologic study of carboxyatractyloside (active principle in cocklebur-- strumarium) in rats treated with enzyme inducers and inhibitors and precursor and depletor. Am J Vet Res. 1982 Jan;43(1):111-6. Male rats (10 rats/group) were treated with phenobarbital (PB), phenylbutazone (PBZ), stanozolol (3 inducers of cytochrome P450-dependent enzymes), piperonyl butoxide (PBO; a P450 inhibitor), cobaltous (CoCl2; an inhibitor of hemoprotein synthesis), 5,6-benzoflavone (BNF; an inducer of cytochrome P448 dependent enzymes), [CYS; a (GSH) precursor], or ethyl (EM; a GSH depletor). |
31(0,1,1,1) | Details |
| 19800097 | Mori T, Nakamura K, Kondo R: Fungal hydroxylation of polychlorinated naphthalenes with migration by wood rotting fungi. Chemosphere. 2009 Nov;77(9):1230-5. Epub 2009 Oct 1. Significant inhibition of the degradation of DCNs and formation of their metabolic products was observed in incubation with the cytochrome P-450 monooxygenase inhibitor piperonyl butoxide. |
31(0,1,1,1) | Details |
| 1283232 | Dahlstrom-King L, Couture J, Plaa GL: Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis. Toxicol Lett. 1992 Dec;63(3):243-52. In the present study, the possible role of cytochrome P-450 in the ketone potentiation phenomenon was investigated. Phenobarbital, 3-methylcholanthrene, chlordecone or mirex were used as inducers, and SKF 525-A, piperonyl butoxide, or cobaltous as inhibitors of monooxygenase activity. |
3(0,0,0,3) | Details |
| 3977942 | Dahl AR, Brezinski DA: Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. Biochem Pharmacol. 1985 Mar 1;34(5):631-6. |
3(0,0,0,3) | Details |
| 9929512 | Cable EE, Isom HC: Metabolism of 3,5,5-trimethylhexanoyl-ferrocene by rat liver: release of iron from 3,5,5-trimethylhexanoyl-ferrocene by a microsomal, phenobarbital-inducible cytochrome P-450. Drug Metab Dispos. 1999 Feb;27(2):255-60. The TMH-ferrocenase activity is heat labile, requires a physiologic temperature, is induced by phenobarbital, and is inhibited by and piperonyl butoxide but not by dicoumarol. |
2(0,0,0,2) | Details |
| 3802408 | Furlong BB, Weaver RP, Goldstein JA: Covalent binding to DNA and mutagenicity of 2,4-diaminotoluene metabolites produced by isolated hepatocytes and 9000 g supernatant from Fischer 344 rats. Carcinogenesis. 1987 Feb;8(2):247-51. However, treatment of hepatocytes in vitro with or piperonyl butoxide, two general inhibitors of P-450 enzymes, inhibited the binding of 2,4-DAT to DNA by approximately 80-85%. Both cytochrome P-450 and sulfation appear to be involved in the activation. |
1(0,0,0,1) | Details |
| 6872100 | Imamura T, Hasegawa L, Gandy J, Fukuto TR: Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats. Chem Biol Interact. 1983 Jul 1;45(1):53-64. Pretreatment with phenobarbital, piperonyl butoxide (2 h), SKF 525-A, or small multiple doses of OOS protected against the OOS-induced elevated level of bronchopulmonary lavage LDH, and the other signs of delayed toxicity including morphological alteration of Clara cells. These studies support the view that OOS-induced delayed toxicity is mediated by the cytochrome P-450 dependent metabolism of OOS, and the lung may be the major target organ of delayed toxicity produced by OOS. |
1(0,0,0,1) | Details |
| 18615616 | Boonsuepsakul S, Luepromchai E, Rongnoparut P: Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system. Arch Insect Biochem Physiol. 2008 Sep;69(1):13-21. We previously isolated the cytochrome P450 CYP6AA3 from deltamethrin-selected resistant strain of Anopheles minimus mosquito, a major malaria vector in Thailand. Deltamethrin degradation and formation of metabolites were -dependent and inhibited by piperonyl butoxide. |
1(0,0,0,1) | Details |
| 3081009 | Buckpitt AR, Bahnson LS, Franklin RB: Comparison of the and -dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis. Biochem Pharmacol. 1986 Feb 15;35(4):645-50. These studies suggest that the major enzymes involved in the metabolic activation of naphthalene or 2-methylnaphthalene in vitro are the cytochrome P-450 monooxygenases and that cooxidative metabolism by the prostaglandin synthetases appears to play little role in the formation of reactive metabolites in vitro. Naphthalene- but not 2-methylnaphthalene-induced pulmonary bronchiolar injury is blocked by prior administration of the cytochrome P-450 monooxygenase inhibitor piperonyl butoxide, thus suggesting that metabolism by enzymes other than the P-450 monooxygenase inhibitor piperonyl butoxide, thus suggesting that metabolism by enzymes other than the P-450 monooxygenases may be important in 2-methylnaphthalene-induced lung injury. |
1(0,0,0,1) | Details |
| 2047567 | Mizutani T, Satoh K, Nomura H, Nakanishi K: Hepatotoxicity of in mice depleted of by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol. 1991 Feb;71(2):219-30. Drug metabolism inhibitors such as carbon disulfide, methoxsalen, and piperonyl butoxide prevented or significantly reduced the hepatotoxic effect of given in combination with BSO. These results suggest that is activated by a cytochrome-P-450-dependent metabolic reaction and that the liver injury is caused by inadequate rates of detoxification of the resulting metabolite in mice depleted of hepatic GSH by BSO treatment. |
1(0,0,0,1) | Details |
| 4062959 | Sinha BK, Strong J, Gibson NW, Kalyanaraman B: Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem Pharmacol. 1985 Nov 1;34(21):3845-52. The formation of the amine metabolite was not inhibited by SKF-525A, or piperonyl butoxide, indicating that the cytochrome P-450 was not involved in this reduction. |
0(0,0,0,0) | Details |
| 11886776 | Tsagkarakou A, Pasteur N, Cuany A, Chevillon C, Navajas M: Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Insect Biochem Mol Biol. 2002 Apr;32(4):417-24. It is shown that S,S,S-tributyl phosphorotrithioate, a synergist that inhibits esterases and glutathione S-transferases, and piperonyl butoxide, a synergist that inhibits cytochrome P450 mediated monooxygenases, did not affect the level of methyl-parathion or methomyl resistance in RLAB and that resistance ratios to both insecticides did not change significantly in the presence of either synergist. |
0(0,0,0,0) | Details |
| 1965745 | Ishiyama H, Ogino K, Shimomura Y, Kanbe T, Hobara T: Hepatotoxicity of diethyldithiocarbamate in rats. Pharmacol Toxicol. 1990 Nov;67(5):426-30. Desferrioxamine (a chelator of iron) and piperonyl butoxide (an inhibitor of cytochrome P-450) prevented DDC-induced increases of both ALT and TBARS, but GSH did not, DDC hepatotoxicity was not changed by phenobarbital induction. |
0(0,0,0,0) | Details |
| 4049387 | Ravindranath V, Boyd MR: Metabolic activation of 2-methylfuran by rat microsomal systems. Toxicol Appl Pharmacol. 1985 May;78(3):370-6. The microsomal metabolism of 2-MF was inducible by pretreatment of rats with phenobarbital and was inhibited by piperonyl butoxide and N-octyl which indicates that the metabolism of 2-MF may be mediated by cytochrome P-450. |
81(1,1,1,1) | Details |
| 15448939 | Teramoto H, Tanaka H, Wariishi H: Degradation of by the lignin-degrading basidiomycete Phanerochaete chrysosporium. Appl Microbiol Biotechnol. 2004 Dec;66(3):312-7. The formation of 1,2-dimethoxy-4-nitrobenzene was effectively inhibited by exogenously added piperonyl butoxide, a cytochrome P450 inhibitor, suggesting that cytochrome P450 is involved in the hydroxylation reaction. |
81(1,1,1,1) | Details |
| 8086032 | Radin NS: Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase. Mol Chem Neuropathol. 1994 Feb-Apr;21(2-3):111-27. PDMP was found to be oxidized by cytochrome P-450, but this process could be blocked in vivo with piperonyl butoxide or cimetidine. |
81(1,1,1,1) | Details |
| 19399609 | Brausch JM, Smith PN: Development of resistance to cyfluthrin and naphthalene among Daphnia magna. Ecotoxicology. 2009 Jul;18(5):600-9. Epub 2009 Apr 28. When the cytochrome P450 inhibitor piperonyl butoxide was used in conjunction with cyfluthrin and naphthalene the sensitivity of resistant and control D. magna were equal, suggesting P450s were responsible for conveying resistance. |
31(0,1,1,1) | Details |
| 6827476 | Tune BM, Kuo CH, Hook JB, Hsu CY, Fravert D: Effects of piperonyl butoxide on cephalosporin nephrotoxicity in the rabbit. J Pharmacol Exp Ther. 1983 Mar;224(3):520-4. To evaluate the hypothesis that cytochrome P-450 mixed-function oxidase (MFO) activity may have a causal role in the production of cephalosporin nephrotoxicity, the effects of the MFO inhibitors cobaltous and piperonyl butoxide on the nephrotoxicity of cephaloridine in the rabbit were examined. |
31(0,1,1,1) | Details |
| 2691105 | Madyastha KM, Moorthy B: Pulegone mediated hepatotoxicity: evidence for covalent binding of R (+)-[14C] pulegone to microsomal proteins in vitro. Chem Biol Interact. 1989;72(3):325-33. Covalent binding was drastically inhibited (93%) in the presence of piperonyl butoxide. Antibodies to phenobarbital-induced cytochrome P-450 and -cytochrome P-450 reductase inhibited covalent binding to an extent of 72% and 47%, respectively. |
2(0,0,0,2) | Details |
| 7083396 | Warren DL, Brown DL Jr, Buckpitt AR: Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene. Chem Biol Interact. 1982 Jul 1;40(3):287-303. Pulmonary damage and mortality by naphthalene were increased by prior treatment with diethyl and decreased by prior treatment with piperonyl butoxide (1600 mg/kg). |
2(0,0,0,2) | Details |
| 8092926 | Jenner AM, Timbrell JA: Influence of inducers and inhibitors of cytochrome P450 on the hepatotoxicity of hydrazine in vivo. Arch Toxicol. 1994;68(6):349-57. Pretreatment with the inhibitor piperonyl butoxide increased triglyceride accumulation whereas pretreatment with the inducers phenobarbital and beta-naphthoflavone (BNF) resulted in reduced triglyceride accumulation. |
2(0,0,0,2) | Details |
| 32381 | Boyd MR, Burka LT, Wilson BJ, Sasame HA: In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes. J Pharmacol Exp Ther. 1978 Dec;207(3):677-86. The enzyme-mediated microsomal alkylation required and and was strongly inhibited by which indicated the participation of a cytochrome P-450-dependent monooxygenase. Other studies with inhibitors including pyrazole, piperonyl butoxide, SKF-525A, and cobaltous and with the inducers phenobarbital and 3-methylcholanthrene, also were consistent with this view. |
1(0,0,0,1) | Details |
| 2869902 | Christian MF, Yu SJ: Cytochrome P-450-dependent monooxygenase activity in the velvetbean caterpillar, Anticarsia gemmatalis Hubner. Comp Biochem Physiol C. 1986;83(1):23-7. Piperonyl butoxide decreased and increased the toxicity of methomyl and methyl parathion, respectively, suggesting that the monooxygenase system of velvetbean caterpillars plays a major role in the detoxification of xenobiotics. |
1(0,0,0,1) | Details |
| 6339097 | Cottrell RC, Blowers SD, Walters DG, Lake BG, Purchase R, Phillips JC, Gangolli SD: Studies of the metabolic bioactivation of n-nitrosopyrrolidine in the rat. Carcinogenesis. 1983;4(3):311-4. Both SKF 525A and piperonyl butoxide were found to be potent inhibitors of the production of 4-HB by rat liver microsomal preparations but were ineffective in the mutagenicity model with liver S-9 from either untreated or Aroclor 1254 pretreated rats. These results suggest that the bioactivation of NPYR may proceed by processes other than the cytochrome P-450 dependent route generating 4-HB and the amine oxidase catalysed route implicated in NDMA activation. |
1(0,0,0,1) | Details |
| 8995787 | Scott JG: Inhibitors of CYP6D1 in house fly microsomes. . Insect Biochem Mol Biol. 1996 Jul;26(7):645-9. CYP6D1 is a cytochrome P450 responsible for the metabolism of insecticides and other xenobiotics in the house fly (Musca domestica). CYP6D1 was strongly inhibited by xanthotoxin, chlorpyrifos, beta-naphthoflavone, piperonyl butoxide and 5-methoxypsoralen. |
1(0,0,0,1) | Details |
| 8658521 | Lessire F, Gustin P, Delaunois A, Bloden S, Nemmar A, Vargas M, Ansay M: Relationship between parathion and paraoxon toxicokinetics, lung metabolic activity, and cholinesterase inhibition in guinea pig and rabbit lungs. Toxicol Appl Pharmacol. 1996 Jun;138(2):201-10. After treatment with the cytochrome P450 inhibitor piperonyl butoxide, the above relations ceased to apply, but this treatment did not influence the kinetics of paraoxon and parathion uptake. |
0(0,0,0,0) | Details |
| 9282833 | Fang N, Rowlands JC, Casida JE: Anomalous structure-activity relationships of 13-homo-13-oxarotenoids and 13-homo-13-oxadehyrorotenoids. Chem Res Toxicol. 1997 Aug;10(8):853-8. This difference in cytotoxicity is not due to specificity at the oxidoreductase target but instead to more extensive cytochrome P450-dependent (piperonyl butoxide-sensitive) detoxification of 2 than of 1. |
0(0,0,0,0) | Details |
| 10877774 | Sutherland TD, Horne I, Lacey MJ, Harcourt RL, Russell RJ, Oakeshott JG: Enrichment of an endosulfan-degrading mixed bacterial culture. Appl Environ Microbiol. 2000 Jul;66(7):2822-8. The cytochrome P450 inhibitor, piperonyl butoxide, did not prevent endosulfan oxidation or the formation of other metabolites. |
0(0,0,0,0) | Details |
| 6107228 | Ohmiya Y, Mehendale HM: Uptake and metabolism of chlorpromazine by rat and rabbit lungs. . Drug Metab Dispos. 1980 Sep-Oct;8(5):313-8. Piperonyl butoxide was without any effect. |
0(0,0,0,0) | Details |
| 15135530 | Teramoto H, Tanaka H, Wariishi H: Fungal cytochrome P450s catalyzing hydroxylation of substituted toluenes to form their hydroxymethyl derivatives. FEMS Microbiol Lett. 2004 May 15;234(2):255-60. The fungal formation of 4-NBA was inhibited by piperonyl butoxide, a cytochrome P450 inhibitor, suggesting the involvement of cytochrome P450 in the hydroxylation of the methyl group. |
81(1,1,1,1) | Details |
| 8723729 | Lillibridge JH, Amore BM, Slattery JT, Kalhorn TF, Nelson SD, Finnell RH, Bennett GD: Protein-reactive metabolites of carbamazepine in mouse liver microsomes. . Drug Metab Dispos. 1996 May;24(5):509-14. A dependence on cytochrome P450 was shown by a requirement for and inhibition by 1-aminobenzotriazole, piperonyl butoxide, and stiripentol. |
81(1,1,1,1) | Details |
| 1412461 | Delaunois A, Gustin P, Ansay M: Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungs. Toxicol Appl Pharmacol. 1992 Oct;116(2):161-9. Piperonyl butoxide (4 x 10 (-4) M), an inhibitor of cytochrome P450, had a strong protective effect against Pth (4 x 10 (-4) M)-induced alterations of endothelium permeability (n = 5, p < 0.001). |
81(1,1,1,1) | Details |
| 12002632 | Gokbulut C, Nolan AM, McKellar QA: Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses. Res Vet Sci. 2002 Feb;72(1):11-5. Metabolism of OBZ to its metabolite in vitro was significantly inhibited by co-incubation with the cytochrome P450 inhibitor piperonyl butoxide. |
31(0,1,1,1) | Details |
| 16669866 | Virkel G, Lifschitz A, Sallovitz J, Pis A, Lanusse C: Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep. J Vet Pharmacol Ther. 2006 Jun;29(3):213-23. TCBZ sulphoxidative metabolism was also reduced (24% inhibition, P < 0.05) by the cytochrome P450 inhibitor piperonyl butoxide (PB). |
31(0,1,1,1) | Details |
| 6204422 | Becker GM, Breeze RG, Carlson JR: Autoradiographic evidence of covalent binding to pulmonary epithelial cells in the goat. Toxicology. 1984 May 14;31(2):109-21. Inclusion of either of the inhibitors of cytochrome P-450, SKF-525-A or piperonyl butoxide significantly reduced this binding to both the pneumocytes and the bronchiolar cells. |
31(0,1,1,1) | Details |
| 8387397 | Adams NH, Levi PE, Hodgson E: Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds. Chem Biol Interact. 1993 Mar;86(3):255-74. Piperonyl butoxide was the more potent inducing agent in both strains. |
2(0,0,0,2) | Details |
| 2541521 | Moorthy B, Madyastha P, Madyastha KM: Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo. Toxicology. 1989 May 15;55(3):327-37. Oral administration of pulegone (400 mg/kg) to rats once daily for five days caused significant decreases in the levels of liver microsomal cytochrome P-450 and heme. Pretreatment of rats with phenobarbital (PB) or diethylmaleate (DEM) potentiated the hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene (3-MC) or piperonyl butoxide protected from it. |
2(0,0,0,2) | Details |
| 16162970 | Brandon EF, Meijerman I, Klijn JS, den Arend D, Sparidans RW, Lazaro LL, Beijnen JH, Schellens JH: In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction. Anticancer Drugs. 2005 Oct;16(9):935-43. Potent cytotoxic activity of ET-743 after 120 h treatment was observed, which could be increased in combination with the CYP inhibitors (3A4), phenanthrene (substrate for 2E1, 3A4), piperonyl butoxide (3A), proadifen (2C9, 2E1, 3A4), ritonavir (3A4), and (2C9, 2C19). |
1(0,0,0,1) | Details |
| 11777067 | Stumpf N, Nauen R: Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae). J Econ Entomol. 2001 Dec;94(6):1577-83. The METI resistant strains AKITA and UK-99 showed 2.4- and 1.7-fold enhanced O-ethoxycoumarin O-deethylation (cytochrome P450) activity. Increased oxidative metabolism of the METI-acaricides in the resistant strains could be partially suppressed in vivo by the monooxygenase-inhibitor piperonyl butoxide. |
1(0,0,0,1) | Details |
| 10918309 | David JP, Rey D, Cuany A, Amichot M, Meyran JC: Comparative ability to detoxify alder leaf litter in field larval mosquito collections. Arch Insect Biochem Physiol. 2000 Aug;44(4):143-50. Larvae from polyphenol-rich habitats had a higher tolerance for polyphenols and higher midgut cytochrome P450 and esterase activities than larvae from polyphenol-poor habitats. Furthermore, the role of P450 enzymes in the mechanism of resistance to alder polyphenols was suggested by the synergistic effect in vivo of piperonyl butoxide in the resistant Ae. rusticus. |
1(0,0,0,1) | Details |
| 6547180 | Fouin-Fortunet H, Letteron P, Tinel M, Degott C, Flejou JF, Pessayre D: Mechanism for isaxonine hepatitis. J Pharmacol Exp Ther. 1984 Jun;229(3):851-8. In vivo, the concentrations of hepatic and were markedly decreased 2.5 hr after administration of isaxonine (4 mmol X kg-1 i.p.); this depletion of was prevented essentially by pretreatment with piperonyl butoxide. |
0(0,0,0,0) | Details |
| 1985772 | Smith RD, Kehrer JP: Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity. Cancer Res. 1991 Jan 15;51(2):542-8. Treatment with SKF 525A, piperonyl butoxide, or 1-benzylimidazole, followed by a single 200 mg/kg dose of cyclophosphamide, did not diminish pulmonary incorporation (an index of cell division after injury) or content (an indicator of fibrosis), compared to mice treated with cyclophosphamide alone. |
0(0,0,0,0) | Details |
| 1894223 | Wolf DC, Carlson GP, DeNicola DB, Carlton WW: Effects of reserpine and and depletion on 2-bromoethylamine hydrobromide-induced tubular necrosis in Swiss ICR mice. Food Chem Toxicol. 1991 Aug;29(8):565-73. Male Swiss ICR mice were subjected to water deprivation, or treated with 5% in water, dimethylsulphoxide, piperonyl butoxide, SKF-525A, phenobarbital, beta-naphthoflavone, probenecid, reserpine, diethyl buthionine sulphoximine or |
0(0,0,0,0) | Details |
| 9844132 | Baliga R, Zhang Z, Baliga M, Ueda N, Shah SV: Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicity. Kidney Int. 1998 Nov;54(5):1562-9. Piperonyl butoxide, a cytochrome P-450 inhibitor, was administered intraperitoneally (400 mg/kg body wt twice at 48-hr intervals) prior to cisplatin injection. |
78(0,2,4,8) | Details |
| 1933335 | Pai KS, Ravindranath V: Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Res. 1991 Aug 2;555(2):239-44. Other cytochrome P-450 inhibitors, namely, piperonyl butoxide and SKF 525A were found to offer protection against MPTP induced neurotoxicity in slices without affecting monoamine oxidase activity. |
36(0,1,1,6) | Details |
| 8821818 | Baliga R, Zhang Z, Baliga M, Shah SV: Evidence for cytochrome P-450 as a source of catalytic iron in myoglobinuric acute renal failure. Kidney Int. 1996 Feb;49(2):362-9. We then examined the effects of two different cytochrome P-450 inhibitors, cimetidine (with as a control) and piperonyl butoxide. |
36(0,1,1,6) | Details |
| 2344991 | Mizutani T, Ito K, Nomura H, Nakanishi K: Nephrotoxicity of thiabendazole in mice depleted of by treatment with DL-buthionine sulphoximine. Food Chem Toxicol. 1990 Mar;28(3):169-77. Treatment with three inhibitors of renal microsomal cytochrome P-450-dependent monooxygenases, piperonyl butoxide, methoxsalen and carbon disulphide, all equally prevented the nephrotoxicity of TBZ given in combination with BSO. |
31(0,1,1,1) | Details |
| 12450134 | Ochiai N, Fujimura M, Oshima M, Motoyama T, Ichiishi A, Yamada-Okabe H, Yamaguchi I: Effects of iprodione and fludioxonil on synthesis and hyphal development in Candida albicans. Biosci Biotechnol Biochem. 2002 Oct;66(10):2209-15. The antioxidant and the cytochrome P-450 inhibitor piperonyl butoxide antagonized the fungitoxicity of iprodione and fludioxonil in C. albicans. |
31(0,1,1,1) | Details |
| 7712112 | Mizutani T, Irie Y, Nakanishi K: Styrene-induced hepatotoxicity in mice depleted of . Res Commun Mol Pathol Pharmacol. 1994 Dec;86(3):361-74. Treatment with inhibitors of hepatic cytochrome P-450-dependent monooxygenases such as carbon disulfide, methoxsalen, piperonyl butoxide, and SKF-525A prevented or tended to reduce the hepatotoxic effect of styrene given in combination with BSO. |
31(0,1,1,1) | Details |
| 7191853 | Kedderis GL, Koop DR, Hollenberg PF: N-Demethylation reactions catalyzed by chloroperoxidase. J Biol Chem. 1980 Nov 10;255(21):10174-82. The peroxidase-supported N-demethylations catalyzed by chloroperoxidase, a heme protein isolated from Caldariomyces fumago, have been investigated as models for cytochrome P-450-catalyzed N-dealkylations. The chloroperoxidase-catalyzed demethylations were inhibited by inhibitors of cytochrome P-450 such as azide or n-propyl but not by SKF-525A, or piperonyl butoxide. |
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| 6198504 | Yamamoto T, Egashira T, Yamanaka Y, Yoshida T, Kuroiwa Y: Initial metabolism of gamma-hexachlorocyclohexane (gamma-HCH) by rat liver microsomes. J Pharmacobiodyn. 1983 Oct;6(10):721-8. The dehydrogenation was inhibited by SKF 525-A, CO, piperonyl butoxide, N2 and the absence of but not by These results suggest that cytochrome P-450 is involved in this reaction. |
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| 978483 | Mitchell JR, Nelson WL, Potter WZ, Sasame HA, Jollow DJ: Metabolic activation of to a chemically reactive, hepatotoxic metabolite. J Pharmacol Exp Ther. 1976 Oct;199(1):41-52. Hepatotoxic doses of 3H- or 14C- were administered to normal mice and to mice pretreated with piperonyl butoxide, alpha-naphthylisothiocyanate or phenobarbital. was shown to be metabolically activated to an arylating intermediate by a cytochrome P-450 mixed function oxidase in hepatic microsomes. |
1(0,0,0,1) | Details |
| 8079362 | Foster JR, Green T, Smith LL, Tittensor S, Wyatt I: Methylene an inhalation study to investigate toxicity in the mouse lung using morphological, biochemical and Clara cell culture techniques. Toxicology. 1994 Aug 12;91(3):221-34. Both cytochrome P-450 (CYP)- and glutathione S-transferase (GST)-dependent metabolism of MC are known to occur. Vacuolated bronchiolar cells were seen in mice exposed to 2000 and 4000 ppm MC but were not seen at lower concentrations, while addition of the CYP inhibitor, piperonyl butoxide, significantly reduced the bronchiolar cell vacuolation seen following exposure to 2000 ppm MC. |
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| 15912569 | Espinosa PJ, Contreras J, Quinto V, Gravalos C, Fernandez E, Bielza P: Metabolic mechanisms of insecticide resistance in the western flower thrips, Frankliniella occidentalis (Pergande). Pest Manag Sci. 2005 Oct;61(10):1009-15. The interactions between six insecticides (methiocarb, formetanate, acrinathrin, deltamethrin, methamidophos and endosulfan) and three potential synergists (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by topical exposure in strains selected for resistance to each insecticide, and in a susceptible strain of Frankliniella occidentalis (Pergande). These studies indicate that an enhanced detoxification, mediated by cytochrome P-450 monooxygenases, is the major mechanism imparting resistance to different insecticides in F occidentalis. |
1(0,0,0,1) | Details |
| 15154513 | Ahmad M, Hollingworth RM: Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae). Pest Manag Sci. 2004 May;60(5):465-73. These studies indicate that enhanced detoxification, often mediated by cytochrome P-450 monooxygenases, but with probable esterase and glutathione S-transferase contributions in some cases, is the major mechanism imparting resistance to different insecticides in C. rosaceana. The interactions between six insecticides (indoxacarb, cypermethrin, chlorpyrifos, azinphosmethyl, tebufenozide and chlorfenapyr) and three potential synergists, (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by dietary exposure in a multi-resistant and a susceptible strain of the obliquebanded leafroller, Choristoneura rosaceana (Harris). |
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| 6887004 | Browning MC, Tune BM: Reactivity and binding of beta-lactam antibiotics in rabbit renal cortex. J Pharmacol Exp Ther. 1983 Sep;226(3):640-4. Binding to cortical microsomes in vitro showed a similar pattern (greatest for cephaloglycin, least for benzylpenicillin); in addition, the binding in vitro of cephaloglycin was decreased by the addition of an -generating system and was not decreased by piperonyl butoxide. |
0(0,0,0,0) | Details |
| 1626124 | Mizutani T, Yoshida K, Ito K: Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of by treatment with buthionine sulfoximine. Res Commun Chem Pathol Pharmacol. 1992 Jan;75(1):29-38. In the absence of BSO, 4-methylthiazole resulted in no nephrotoxicity; inhibitors of hepatic and renal cytochrome P-450 enzymes such as methoxsalen and piperonyl butoxide prevented the nephrotoxicity of 4-methylthiazole given in combination with BSO. |
0(0,0,0,0) | Details |
| 3100285 | Marcocci C, Luini A, Santisteban P, Grollman EF: and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of and is associated with the iodination of thyroglobulin. Endocrinology. 1987 Mar;120(3):1127-33. Inhibitors of arachidonic acid metabolism via the lipoxygenase pathway, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid, and via the cytochrome P450-linked epoxygenase pathway, piperonyl butoxide and 2-diethylaminoethyl-2,2-diphenyl but not an inhibitor of the cyclooxygenase pathway, indomethacin, can inhibit TSH-, NE-, and A23187-induced I- efflux. |
0(0,0,0,0) | Details |
| 8887268 | Baliga R, Zhang Z, Shah SV: Role of cytochrome P-450 in peroxide-induced cytotoxicity to LLC-PK1 cells. Kidney Int. 1996 Oct;50(4):1118-24. A second inhibitor of cytochrome P-450, piperonyl butoxide, had a similar dose-dependent beneficial effect against peroxide-induced cell injury. |
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| 8041736 | Paller MS, Jacob HS: Cytochrome P-450 mediates tissue-damaging formation during reoxygenation of the kidney. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7002-6. When cells were pretreated with one of three cytochrome P-450 inhibitors (piperonyl butoxide, cimetidine, or ketoconazole), lethal cell injury was attenuated. |
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| 10333321 | Kotze AC: Peroxide-supported in-vitro cytochrome P450 activities in Haemonchus contortus. Int J Parasitol. 1999 Mar;29(3):389-96. Larval activity was inhibited by typical cytochrome P450 inhibitors (piperonyl butoxide, SKF-525A, chloramphenicol, n-octylamine) and was unaffected by the peroxidase inhibitor salicylhydroxamic acid. |
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| 3131971 | Lavrijsen K, Van Houdt J, Meuldermans W, Knaeps F, Hendrickx J, Lauwers W, Hurkmans R, Heykants J: Metabolism of alfentanil by isolated hepatocytes of rat and dog. Xenobiotica. 1988 Feb;18(2):183-97. The metabolism was strongly inhibited by the cytochrome P-450 inhibitors alpha-naphthoflavone and piperonyl butoxide. 3. |
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| 8593059 | Kullman SW, Matsumura F: Metabolic pathways utilized by Phanerochaete chrysosporium for degradation of the cyclodiene pesticide endosulfan. Appl Environ Microbiol. 1996 Feb;62(2):593-600. Piperonyl butoxide, a known cytochrome P-450 inhibitor, significantly inhibited the oxidation of endosulfan to endosulfan and enhanced hydrolysis of endosulfan to endosulfan diol. |
31(0,1,1,1) | Details |
| 18214888 | Rankin GO, Racine C, Sweeney A, Kraynie A, Anestis DK, Barnett JB: In vitro nephrotoxicity induced by propanil. Environ Toxicol. 2008 Aug;23(4):435-42. In IRCC pretreated with an antioxidant, cytochrome P450 (CYP) inhibitor, monooxygenase activity modulator, or cyclooxygenase inhibitor before propanil exposure (1.0 mM; 120 min), only piperonyl butoxide (0.1 mM), a CYP inhibitor, pretreatment decreased propanil cytotoxicity. |
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| 8571358 | Hodgson E, Ryu DY, Adams N, Levi PE: Biphasic responses in synergistic interactions. . Toxicology. 1995 Dec 28;105(2-3):211-6. This group of chemicals includes, in addition to synergists such as piperonyl butoxide, carcinogens such as and isosafrole and many compounds occurring naturally in foods, such as myristicin and piperine. These compounds may function as cytochrome P450 substrates, inhibitors and/or inducers. |
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| 3827936 | Ravindranath V, Boyd MR, Jerina DM: Hepatotoxicity of precocene I in rats. Biochem Pharmacol. 1987 Feb 15;36(4):441-6. Treatment of the rats with the mixed-function oxidase inhibitor piperonyl butoxide, before administration of precocene I, significantly decreased the proportion of the radiolabel bound covalently to proteins and DNA, although the total radioactivity (bound and unbound) in the liver remained the same. These results are consistent with the view that the hepatotoxicity of precocene I is due to reactive metabolites formed through cytochrome P-450 mediated metabolism of precocene I. |
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| 2818624 | Letteron P, Labbe G, Descatoire V, Degott C, Loeper J, Tinel M, Larrey D, Pessayre D: Metabolic activation of the antidepressant tianeptine. Biochem Pharmacol. 1989 Oct 1;38(19):3247-51. These results show that tianeptine is transformed in vivo by cytochrome P-450, including glucocorticoid-inducible isoenzymes, into chemically reactive metabolites that covalently bind to tissue proteins. Pretreatment of hamsters with piperonyl butoxide decreased in vivo covalent binding to liver proteins, and prevented the increase in SGPT activity after administration of tianeptine (0.5 mmol/kg i.p.). |
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| 7086669 | Griffin KA, Johnson CB, Breger RK, Franklin RB: Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice. J Pharmacol Exp Ther. 1982 Jun;221(3):517-24. |
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| 9928682 | Ratra GS, Cottrell S, Powell CJ: Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. Toxicol Sci. 1998 Nov;46(1):185-96. This study investigated the effects of modulators of cytochrome P450 (CYP) activity on the hepatotoxicity of methapyrilene and also the effect of methapyrilene on hepatic CYP. Pretreatment of male Han Wistar rats with beta-naphthoflavone, phenobarbitone, butylated hydroxytoluene, piperonyl butoxide, Aroclor 1254, or agents known to modify hepatic CYP, all afforded some degree of protection against a hepatotoxic dose of methapyrilene (150 mg/kg x 3 days p.o.), as assessed by clinical chemistry and histology. |
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| 18590597 | Van Pottelberge S, Van Leeuwen T, Nauen R, Tirry L: Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae). Bull Entomol Res. 2009 Feb;99(1):23-31. Epub 2008 Jul 1. A 23.5-fold increase in 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity suggested that metabolic resistance through elevated levels of cytochrome P450 dependent monooxygenase-activity is a possible resistance mechanism.However, synergism studies with different metabolic inhibitors revealed some contrasting resistance mechanisms between the METI-acaricides. Tebufenpyrad resistance could only be synergized after pre-treatment with the monooxygenase inhibitor piperonyl butoxide (PBO), whereas pyridaben resistance was strongly synergized both by PBO and the esterase inhibitor S,S,S-tributylphosphorotrithioate (DEF). |
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| 6148217 | Forte AJ, Wilson JM, Slattery JT, Nelson SD: The formation and toxicity of metabolites of in mice. Drug Metab Dispos. 1984 Jul-Aug;12(4):484-91. Mouse liver microsomes catalyze the oxidation of to the in an apparent cytochrome P-450-mediated reaction that is induced by phenobarbital and inhibited by piperonyl butoxide, but is surprisingly not altered by cobaltous |
0(0,0,0,0) | Details |
| 2818623 | Letteron P, Descatoire V, Tinel M, Maurel P, Labbe G, Loeper J, Larrey D, Freneaux E, Pessayre D: Metabolic activation of the antidepressant tianeptine. Biochem Pharmacol. 1989 Oct 1;38(19):3241-6. Covalent binding to hamster liver microsomes required and it was decreased in the presence of the cytochrome P-450 inhibitors, piperonyl butoxide (4 mM), and SKF 525-A (4 mM) or in the presence of the nucleophile, (1 or 4 mM). |
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| 6437140 | Darnerud PO: Chlorinated paraffins: effect of some microsomal enzyme inducers and inhibitors on the degradation of 1-14C-chlorododecanes to 14CO2 in mice. Acta Pharmacol Toxicol. 1984 Aug;55(2):110-5. Pretreatment with cytochrome P-450 inhibitors resulted in a marked decrease in the rate of 14CO2-formation, when measured as peak 14CO2-exhalation rate (PER): After piperonyl butoxide pretreatment the degradation rate of a high-chlorinated 14C-dodecane (PCDD II; 68% Cl w/w) to 14CO2 was 16% of control, and after pretreatment 40%. |
33(0,1,1,3) | Details |
| 9076527 | Kotze AC: Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda). Int J Parasitol. 1997 Jan;27(1):33-40. Different patterns of expression of activities towards the 2 substrates in various life-stages, as well as different sensitivities to piperonyl butoxide, suggested the presence of more than 1 cytochrome P450 enzyme. |
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| 12192904 | Durham EW, Siegfried BD, Scharf ME: In vivo and in vitro metabolism of fipronil by larvae of the European corn borer Ostrinia nubilalis. Pest Manag Sci. 2002 Aug;58(8):799-804. Cytochrome P450-dependent monooxygenase activity (methoxyresorufin O-demethylase) was consistently observed in midgut preparations, and formation and detection of the sulfone metabolite in the same midgut preparations was also -dependent and inhibited by piperonyl butoxide. |
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| 18579106 | Niknahad H, O'Brien PJ: Mechanism of cytotoxicity in isolated rat hepatocytes. . Chem Biol Interact. 2008 Aug 11;174(3):147-54. Epub 2008 Jun 4. Cytochrome P450 inhibitors, and piperonyl butoxide also prevented -induced cytotoxicity and lipid peroxidation. |
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| 6857672 | Gooch JW, Matsumura F: Characteristics of the hepatic monooxygenase system of the goldfish (Carassius auratus) and its induction with beta-naphthoflavone. Toxicol Appl Pharmacol. 1983 May;68(3):380-91. Enzyme activities were inhibited by and piperonyl butoxide confirming their cytochrome P-450 nature. |
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| 11133518 | Liu H, Shah SV, Baliga R: Cytochrome P-450 as a source of catalytic iron in minimal change nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2001 Jan;280(1):F88-94. |
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| 9233375 | Ryu DY, Levi PE, Hodgson E: Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse. Chem Biol Interact. 1997 Jun 6;105(1):53-63. These two cytochrome P450 genes are known to be regulated by the aromatic hydrocarbon-responsive receptor (AHR); however, it has been suggested that CYP1A2 is also induced by an AHR-independent mechanism. |
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| 3800966 | Smith AG, Francis JE, Kay SJ, Greig JB, Stewart FP: Mechanistic studies of the inhibition of hepatic uroporphyrinogen decarboxylase in C57BL/10 mice by iron-hexachlorobenzene synergism. Biochem J. 1986 Sep 15;238(3):871-8. Although, in further studies, total microsomal cytochrome P-450 content and ethoxyphenoxazone de-ethylase activity reached a peak a few days after dosing and had declined significantly at the time of maximum inhibition of the decarboxylase, additional treatment of HCB-dosed mice with a cytochrome P1-450 inducer, beta-naphthoflavone, enhanced the inhibition, whereas piperonyl butoxide, an inhibitor of cytochrome P-450, partially protected. Although, in further studies, total microsomal cytochrome P-450 content and ethoxyphenoxazone de-ethylase activity reached a peak a few days after dosing and had declined significantly at the time of maximum inhibition of the decarboxylase, additional treatment of HCB-dosed mice with a cytochrome P1-450 inducer, beta-naphthoflavone, enhanced the inhibition, whereas piperonyl butoxide, an inhibitor of cytochrome P-450, partially protected. |
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| 8765561 | Snyder MJ, Glendinning JI: Causal connection between detoxification enzyme activity and consumption of a toxic plant compound. J Comp Physiol A. 1996 Aug;179(2):255-61. For example, larval tobacco hornworms (Manduca sexta) experience a dramatic increase in cytochrome P450 activity against after ingesting We found that the increase in consumption following the induction of metabolism could be strongly inhibited by treatment with piperonyl butoxide, which by itself did not inhibit consumption. |
1(0,0,0,1) | Details |
| 4404917 | Reiner O, Athanassopoulos S, Hellmer KH, Murray RE, Uehleke H: [Formation of chloroform from carbon tetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450] Arch Toxikol. 1972;29(3):219-33. |
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| 1856614 | Shukla A, Radin NS: Metabolism of D-[3H] threo-1-phenyl-2-decanoylamino-3-morpholino- an inhibitor of synthesis, and the synergistic action of an inhibitor of microsomal monooxygenase. J Lipid Res. 1991 Apr;32(4):713-22. From these findings it appeared likely that the amine is attacked by a mixed function oxidase based on cytochrome P450. This conclusion was confirmed by showing that the tissue levels of PDMP could be greatly elevated, for a much longer time, when the mice were pretreated with piperonyl butoxide or cimetidine. |
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| 2759551 | Bonkovsky HL: Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells. Hepatology. 1989 Sep;10(3):354-64. These cultures have proven useful because (a) phenobarbital and phenobarbital-like drugs induce a common form (s) of cytochrome P-450 (P-450-phenobarbital) in these cultures; (b) 20-methylcholanthrene and certain other polycyclic hydrocarbons induce a different form (s) (P-450-methylchol-anthrene), and (c) uroporphyria can be produced rapidly by exposure to suitable chemicals. Inhibitors of P-450-phenobarbital, SKF525A and piperonyl butoxide, as well as cadmium and cycloheximide prevented the accumulation produced by glutethimide + iron, even though, except with cycloheximide, these substances further increased synthase activity. |
1(0,0,0,1) | Details |
| 2703963 | Madhu C, Gregus Z, Klaassen CD: Biliary excretion of - as an index of toxic activation of effect of chemicals that alter hepatotoxicity. J Pharmacol Exp Ther. 1989 Mar;248(3):1069-77. Several cytochrome P-450 inhibitors 8-methoxypsoralen, 2-(4,6-dichloro-biphenyloxy) ethylamine, alpha-naphthoflavone and cimetidine] decreased the biliary excretion of AA-GS, although SKF 525-A and piperonyl butoxide did not. |
33(0,1,1,3) | Details |
| 8355263 | Fuchs SYu, Spiegelman VS, Belitsky GA: The effect of the cytochrome P-450 system inducers on the development of Drosophila melanogaster. J Biochem Toxicol. 1993 Jun;8(2):83-8. The toxicity of phenobarbital was shown to be decreased by the cytochrome P-450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with --the indirect enhancer of ecdysone production in the larval prothoracic gland. |
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| 8799885 | Gosling M, Poyner DR, Smith JW: Effects of upon the volume-sensitive current in rat osteoblast-like (ROS 17/2.8) cells. J Physiol. 1996 Jun 15;493 ( Pt 3):613-23. was still effective in the presence of inhibitors of cyclo-oxygenase (indomethacin, 10 microM), lipoxygenase (nordihydroguaretic acid, 10-100 microM) and cytochrome P450 (SKF525A, 100 microM; ethoxyresorufin, 10 microM; 500 microM; piperonyl butoxide, 500 microM; cimetidine, 1 mM). |
31(0,1,1,1) | Details |
| 6732865 | Fakjian N, Buckpitt AR: Metabolism of bromobenzene to adducts in lung slices from mice treated with pneumotoxicants. Biochem Pharmacol. 1984 May 1;33(9):1479-86. Recent studies showing that the bronchiolar Clara cell and alveolar Type II cell are major loci of cytochrome P-450 monooxygenases in the lung suggested that measurement of xenobiotic metabolizing enzyme activity might provide a useful and sensitive index of injury to these cell types. The formation of bromobenzene adducts in lung slices from piperonyl butoxide-treated animals occurred at a significantly lower rate than control. |
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| 8346921 | Sinclair PR, Gorman N, Walton HS, Bement WJ, Jacobs JM, Sinclair JF: inhibition of cytochrome P450-catalyzed uroporphyrin accumulation. Arch Biochem Biophys. 1993 Aug 1;304(2):464-70. Under this condition, addition of piperonyl butoxide, a P450 inhibitor, increased ASC inhibition of URO accumulation. |
2(0,0,0,2) | Details |
| 19787435 | Ning D, Wang H, Zhuang Y: Induction of functional cytochrome P450 and its involvement in degradation of by Phanerochaete chrysosporium. Biodegradation. 2010 Apr;21(2):297-308. Epub 2009 Sep 29. The degradation by the microsomal P450 was -dependent at a specific rate of 194 +/- 14 min (-1), and significantly inhibited by piperonyl butoxide (a P450 inhibitor). |
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| 6135551 | Burley FE, Bray TM: Effect of rumen development and pre-exposure to chemicals on the activity of the mixed function oxidase system in goats. Comp Biochem Physiol C. 1983;75(1):137-40. The induction of the MFO system by phenobarbital (PB) and the inhibition of piperonyl butoxide (BT) in each age group were also determined. 2. The cytochrome P-450 contents of the liver and lung were less in the newborn than that of the weanling or mature goats. |
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| 7624891 | Valentovic MA, Lo HH, Brown PI, Rankin GO: 3,5-Dichloroaniline toxicity in Fischer 344 rats pretreated with inhibitors and inducers of cytochrome P450. Toxicol Lett. 1995 Aug;78(3):207-14. P450 activity was inhibited by pretreatment with piperonyl butoxide (PiBx) 30 min prior to injection of 3,5-DCA. |
1(0,0,0,1) | Details |
| 633075 | Allemand H, Pessayre D, Descatoire V, DeGott C, Feldmann G, Benhamou JP: Metabolic activation of trichloroethylene into a chemically reactive metabolite toxic to the liver. J Pharmacol Exp Ther. 1978 Mar;204(3):714-23. When 1 (14) C] trichloroethylene was incubated under air with hepatic microsomes and a -generating system, a radioactive material became irreversibly bound to microsomal proteins; binding was negligible when the -generating system was omitted; binding was inhibited by and by piperonyl butoxide; the amount of bound material was greater with microsomes from phenobarbital-pretreated rats and lower with microsomes from CoCl2-pretreated rats than with microsomes from nonpretreated rats. The reported results are consistent with the view that 1) trichloroethylene is metabolized by cytochrome P-450 into a chemically reactive metabolite which reacts with, and binds to, either proteins or 2) binding to proteins produces liver lesions and 3) binding to decreases the amount of reactive metabolite available for binding to proteins. |
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| 14749063 | Veignie E, Rafin C, Woisel P, Cazier F: Preliminary evidence of the role of peroxide in the degradation of benzo [a] pyrene by a non-white rot fungus Fusarium solani. Environ Pollut. 2004 May;129(1):1-4. We used either specific inhibitors of peroxidases (i.e. salicylhydroxamic acid) and of cytochrome P-450 (i.e. piperonyl butoxyde) or inhibitors of both enzymes (i.e. |
1(0,0,0,1) | Details |
| 18243470 | Rankin GO, Hong SK, Anestis DK, Ball JG, Valentovic MA: Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity. Toxicology. 2008 Mar 12;245(1-2):123-9. Epub 2007 Dec 27. The purpose of this study was to examine the ability of antioxidants, cytochrome P450 (CYP) and monooxygenase (FMO) activity modulators, indomethacin, and inhibitors of conjugate metabolism to attenuate ADCP cytotoxicity in vitro. Inhibitors of CYP piperonyl butoxide and isoniazid) and FMO activity modulators (methimazole, N-octylamine) had no effect on ADCP cytotoxicity. |
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| 10441362 | Ichinose H, Wariishi H, Tanaka H: Bioconversion of recalcitrant 4-methyldibenzothiophene to water-extractable products using lignin-degrading basidiomycete coriolus versicolor . Biotechnol Prog. 1999 Jul;15(4):706-14. Piperonyl butoxide, an inhibitor of cytochrome P450, suppressed fungal oxidation of MDBT to its oxide, MDBT-5-oxide to dioxide and to HMDBT-5-oxide, and HMDBT-5-oxide to dioxide. Piperonyl butoxide, an inhibitor of cytochrome P450, suppressed fungal oxidation of MDBT to its oxide, MDBT-5-oxide to dioxide and to HMDBT-5-oxide, and HMDBT-5-oxide to dioxide. |
1(0,0,0,1) | Details |
| 2337416 | Thompson D, Constantin-Teodosiu D, Egestad B, Mickos H, Moldeus P: Formation of conjugates during oxidation of by microsomal fractions of rat liver and lung. Biochem Pharmacol. 1990 May 15;39(10):1587-95. The microsomal reaction was dependent on and and was inhibited by cytochrome P450 inhibitors such as 2-diethylaminoethyl-2,2'-diphenylvalerate (SKF 525-A), alpha-naphthoflavone and piperonyl butoxide. |
32(0,1,1,2) | Details |
| 16325340 | Kotze AC, Dobson RJ, Chandler D: Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: potential for drug-synergism through inhibition of nematode oxidative detoxification pathways. Vet Parasitol. 2006 Mar 31;136(3-4):275-82. Epub 2005 Dec 1. The anthelmintic properties of rotenone and its activity in combination with the cytochrome P450 inhibitor piperonyl butoxide, were examined in in vitro assays with adults and larvae of Haemonchus contortus and larvae of Trichostrongylus colubriformis. |
32(0,1,1,2) | Details |
| 9465388 | Zhang L, Kasai S, Shono T: In vitro metabolism of pyriproxyfen by microsomes from susceptible and resistant housefly larvae. Arch Insect Biochem Physiol. 1998;37(3):215-24. Cytochrome P450 inhibitors, piperonyl butoxide (PB) and 2-propynyl 2,3,6-trichlorophenyl ether (PTPE), decreased the metabolic rates significantly in all three strains. |
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| 12763675 | Akkanen J, Kukkonen JV: Biotransformation and bioconcentration of pyrene in Daphnia magna. Aquat Toxicol. 2003 Jun 19;64(1):53-61. fleas (Daphnia magna) were exposed to [14C] pyrene in the presence and absence of piperonyl butoxide (PBO), a general cytochrome P450 (CYP) inhibitor, in organic carbon-free artificial freshwater (AFW, DOC <0.2 mg l (-1)) and in natural lake water (DOC=19.9 mg l (-1)) for 24 h. |
31(0,1,1,1) | Details |
| 7861152 | Sriram K, Pai KS, Ravindranath V: Protection and potentiation of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. J Neurochem. 1995 Mar;64(3):1203-8. MPP (+)-induced toxicity was abolished by pretreatment of the slices with inhibitors of monoamine oxidase (MAO; pargyline and deprenyl) or inhibitors of P450 (piperonyl butoxide or SKF-525A) or uptake blocker (GBR-12909), as measured by the activity of -DH in slices and leakage of lactate dehydrogenase from the slice into the medium. |
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| 3105541 | Labbe G, Descatoire V, Letteron P, Degott C, Tinel M, Larrey D, Carrion-Pavlov Y, Geneve J, Amouyal G, Pessayre D: The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. Biochem Pharmacol. 1987 Mar 15;36(6):907-14. Other cytochrome P-450 inhibitors (cimetidine, SKF 525-A or piperonyl butoxide) given at this low molar dose (250 mumol X kg-1) exerted no protective effect. |
2(0,0,0,2) | Details |
| 6547179 | Letteron P, Fouin-Fortunet H, Tinel M, Danan G, Belghiti J, Pessayre D: Mechanism for isaxonine hepatitis. J Pharmacol Exp Ther. 1984 Jun;229(3):845-50. Metabolic activation by mouse and human cytochrome P-450.. Incubation, under air, of [2-14C] isaxonine (1 mM) with mouse liver microsomes and an -generating system resulted in the irreversible binding of a [14C] isaxonine metabolite to microsomal proteins; binding required active microsomes, and it was inhibited by 4 mM piperonyl butoxide or by a CO-O2 (80:20) atmosphere. |
1(0,0,0,1) | Details |
| 7908050 | Kumar GN, Walle UK, Walle T: Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation. J Pharmacol Exp Ther. 1994 Mar;268(3):1160-5. The -dependency and the inhibitory effect of and piperonyl butoxide on taxol metabolism indicated the involvement of cytochrome P450 (CYP) monooxygenases. |
1(0,0,0,1) | Details |
| 12593759 | Pass GJ, McLean S: Inhibition of the microsomal metabolism of in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals. Xenobiotica. 2002 Dec;32(12):1109-26. Previously, we showed that dietary terpenes induce the cytochrome P450 enzymes (CYPs) responsible for their metabolism. |
1(0,0,0,1) | Details |
| 6709651 | Bray TM, Carlson JR, Nocerini MR: In vitro covalent binding of 3-[14C] methylindole metabolites in goat tissues. Proc Soc Exp Biol Med. 1984 May;176(1):48-53. The amount of bound radioactivity per nanomole of cytochrome P-450 was approximately 10 times higher in the lung compared to liver. Inhibitors and conjugating agents that are known to reduce the severity of 3MI-induced lung injury such as piperonyl butoxide (MFO inhibitor) and (conjugating agent) significantly decreased the in vitro binding of 3 [14C] MI. |
1(0,0,0,1) | Details |
| 4145693 | Franklin MR: Piperonyl butoxide metabolism by cytochrome P-450: factors affecting the formation and disappearance of the metabolite-cytochrome P-450 complex. Xenobiotica. 1972 Nov;2(6):517-27. |
1(0,0,0,1) | Details |
| 4018535 | Beumel GA, Levi PE, Hodgson E: Spectral interactions of piperonyl butoxide and isocyanides with purified hepatic cytochrome P-450 from uninduced mice. Gen Pharmacol. 1985;16(3):193-7. |
163(2,2,2,3) | Details |
| 7389009 | Fennell TR, Sweatman BC, Bridges JW: The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. Chem Biol Interact. 1980 Aug;31(2):189-201. The formation of cytochrome P-450 metabolite complexes with isosafrole and piperonyl butoxide in vivo in genetically 'responsive' C57 BL/10 mice and 'non-responsive' DBA/2 mice is described. |
99(1,1,4,4) | Details |
| 3030329 | Haim N, Nemec J, Roman J, Sinha BK: In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins. Biochem Pharmacol. 1987 Feb 15;36(4):527-36. The formation of DHVP-16 was cytochrome P-450-mediated as indicated by its dependence on its increased production following treatment of mice with phenobarbital, and its marked inhibition by SKF-525A and piperonyl butoxide. |
32(0,1,1,2) | Details |
| 7864625 | Kato H, Kodama O, Akatsuka T: Characterization of an inducible P450 hydroxylase involved in the rice diterpene phytoalexin biosynthetic pathway. Arch Biochem Biophys. 1995 Feb 1;316(2):707-12. This enzyme reaction was inhibited by cytochrome P450 inhibitors such as piperonyl butoxide, SKF-525A, paclobutorazole, cytochrome c, and |
32(0,1,1,2) | Details |
| 3941395 | Fouin-Fortunet H, Tinel M, Descatoire V, Letteron P, Larrey D, Geneve J, Pessayre D: Inactivation of cytochrome P-450 by the drug methoxsalen. . J Pharmacol Exp Ther. 1986 Jan;236(1):237-47. Methoxsalen (25-1000 microM) decreased cytochrome P-450 in vitro, in the presence of EDTA; this effect required and was decreased by piperonyl butoxide and was increased by phenobarbital pretreatment. |
14(0,0,2,4) | Details |
| 7104014 | James RC, Harbison RD: Hepatic and hepatotoxicity: effects of cytochrome P-450 complexing compounds SKF 525-A, L-alpha acetylmethadol (LAAM), norLAAM, and piperonyl butoxide. Biochem Pharmacol. 1982 May 15;31(10):1829-35. |
8(0,0,1,3) | Details |
| 4397161 | Philpot RM, Hodgson E: A cytochrome P-450-piperonyl butoxide spectrum similar to that produced by ethyl Life Sci II. 1971 May 8;10(9):503-12. |
6(0,0,1,1) | Details |
| 3118512 | Letteron P, Degott C, Labbe G, Larrey D, Descatoire V, Tinel M, Pessayre D: Methoxsalen decreases the metabolic activation and prevents the hepatotoxicity and nephrotoxicity of chloroform in mice. Toxicol Appl Pharmacol. 1987 Nov;91(2):266-73. The effects of methoxsalen, a potent inhibitor of cytochrome P-450, on the hepatotoxicity and nephrotoxicity of chloroform have been determined in mice. Other cytochrome P-450 inhibitors (SKF 525-A or piperonyl butoxide), given at the same molar dose (250 mumol.kg-1ip), exerted no protective effect. |
2(0,0,0,2) | Details |
| 2707734 | Loeper J, Descatoire V, Amouyal G, Letteron P, Larrey D, Pessayre D: Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man. Hepatology. 1989 May;9(5):675-8. Isaxonine and several other drugs transformed by cytochrome P-450 into reactive metabolites apparently lead to immunoallergic hepatitis in man. At 60 min, the amount of isaxonine metabolite covalently bound per mg of protein was similar in plasma membranes (0.42 nmole metabolite.mg protein-1) and in microsomes (0.38); both values were decreased by about 70% in rats pretreated with piperonyl butoxide, an inhibitor of cytochrome P-450. |
2(0,0,0,2) | Details |
| 3798451 | Mizutani T, Nomura H, Nakanishi K, Fujita S: Hepatotoxicity of butylated hydroxytoluene and its analogs in mice depleted of hepatic Toxicol Appl Pharmacol. 1987 Jan;87(1):166-76. As judged by the observation of normal serum GPT, drug metabolism inhibitors such as SKF-525A, piperonyl butoxide, and carbon disulfide prevented the hepatotoxic effect of BHT given in combination with BSO. These results suggest that BHT is activated by a cytochrome-P-450-dependent metabolic reaction and that the hepatotoxic effect is caused by inadequate rates of detoxification of the reactive metabolite in mice depleted of hepatic GSH by BSO administration. |
1(0,0,0,1) | Details |
| 11762605 | Hiratsuka N, Wariishi H, Tanaka H: Degradation of diphenyl ether herbicides by the lignin-degrading basidiomycete Coriolus versicolor. Appl Microbiol Biotechnol. 2001 Nov;57(4):563-71. Piperonyl butoxide, an inhibitor of cytochrome P450, suppressed fungal oxidation of CNP and NIP to their hydroxylated products. Piperonyl butoxide, an inhibitor of cytochrome P450, suppressed fungal oxidation of CNP and NIP to their hydroxylated products. |
1(0,0,0,1) | Details |
| 2996791 | Cook JC, Hodgson E: The induction of cytochrome P-450 by isosafrole and related methylenedioxyphenyl compounds. Chem Biol Interact. 1985 Aug-Sep;54(3):299-315. Isosafrole, piperonyl butoxide, and 5-t-butyl-1,3-benzodioxole were unable to displace 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene from either the Ah receptor or the 3-4S binding peak, in vitro. |
1(0,0,0,1) | Details |
| 11738241 | Norris RL, Seawright AA, Shaw GR, Senogles P, Eaglesham GK, Smith MJ, Chiswell RK, Moore MR: Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse. Toxicon. 2002 Apr;40(4):471-6. The role of both (GSH) and the cytochrome P450 enzyme system (P450) in the mechanism of toxicity of CYN has been previously investigated in in vitro systems. Conversely, pre-treatment with piperonyl butoxide, a P450 inhibitor, protected mice against CYN toxicity giving a survival rate of 10/10 compared with 4/10 in the control group (p < 0.05 Chi squared) and was protective at doses up to 0.8 mg/kg, suggesting activation of CYN by P450 is of primary importance in the mechanism of action. |
1(0,0,0,1) | Details |
| 10619188 | Segura P, Chavez J, Montano LM, Vargas MH, Delaunois A, Carbajal V, Gustin P: Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):699-710. The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to (10 (-8)-10 (-3) M), (10 (-8)-10 (-3) M) and substance P (10 (-10)-10 (-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). This effect was transient (5-10 min), suggesting that this bronchodilator triggered additional obstructive mechanisms. (2) Pth increased the water content in lung parenchyma samples, but not in trachea or bronchi, and augmented the respiratory secretions measured through monosaccharide content in bronchoalveolar lavage. (3) The increase in iRL was greater in female animals, probably due to a higher P450 basal activity, and completely blocked by pharmacological inhibition of P450 with piperonyl butoxide (500 mg/kg i.p.). (4) In male guinea pigs a subclinical dose of Pth (10 mg/kg i.p.) induced airway hyperresponsiveness to |
1(0,0,0,1) | Details |
| 3026315 | Sinclair PR, Bement WJ, Bonkovsky HL, Lambrecht RW, Frezza JE, Sinclair JF, Urquhart AJ, Elder GH: Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Biochem J. 1986 Jul 1;237(1):63-71. Reversal of the accumulation by piperonyl butoxide.. In a previous paper, an isoenzyme of cytochrome P-450 induced by 3-methylcholanthrene had been implicated in this process [Sinclair, Bement, Bonkovsky & Sinclair (1984) Biochem. |
1(0,0,0,1) | Details |
| 3259740 | Erickson DA, Goodrich MS, Lech JJ: The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri). Toxicol Appl Pharmacol. 1988 Jun 15;94(1):1-10. Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. |
89(1,1,2,4) | Details |
| 17514638 | Willoughby L, Batterham P, Daborn PJ: Piperonyl butoxide induces the expression of cytochrome P450 and glutathione S-transferase genes in Drosophila melanogaster. Pest Manag Sci. 2007 Aug;63(8):803-8. Piperonyl butoxide (PBO) is an insecticide synergist known to inhibit the activity of cytochrome P450 enzymes. |
88(1,1,2,3) | Details |
| 3983973 | Levi PE, Hodgson E: Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver. Toxicol Lett. 1985 Feb-Mar;24(2-3):221-8. All fraction metabolized the pesticide synergist piperonyl butoxide (PBO) to form an inhibitory cytochrome P-450-PBO-metabolite complex. |
86(1,1,1,6) | Details |
| 10562694 | Delaunois A, Florquin S, Segura P, Montano LM, Vargas MH, Gustin P: Interactions between cytochrome P-450 activities and ozone-induced modulatory effects on endothelial permeability in rabbit lungs: influence of gender. Inhal Toxicol. 1999 Nov;11(11):999-1014. Some animals were pretreated with piperonyl butoxide (PBO), a well-known inhibitor of CYP450. |
85(1,1,1,5) | Details |
| 3510749 | Hughes MF, Brock WJ, Marion LJ, Vore M: Characterization of covalent binding of N'-nitrosonornicotine in rat liver microsomes. Carcinogenesis. 1986 Jan;7(1):3-8. In vitro addition of the cytochrome P-450 inhibitors piperonyl butoxide and SKF-525A significantly decreased (p less than 0.05) -dependent binding of [14C] NNN by 27-40%. |
32(0,1,1,2) | Details |
| 2378670 | Moreland DE, Corbin FT, Novitzky WP, Parker CE, Tomer KB: Metabolism of metolachlor by a microsomal fraction isolated from grain sorghum (Sorghum bicolor) shoots. Z Naturforsch C. 1990 May;45(5):558-64. Compounds known to inhibit the activity of cytochrome P-450 monooxygenases (piperonyl butoxide, tetcyclacis, and tridiphane) also prevented formation of the metabolite. |
32(0,1,1,2) | Details |
| 9817083 | Lee PC, Marquardt M, Lech JJ: Metabolism of nonylphenol by rat and human microsomes. . Toxicol Lett. 1998 Oct 15;99(2):117-26. Product formation was dependent and inhibited by the cytochrome P450 inhibitors, piperonyl butoxide and SKF525. |
32(0,1,1,2) | Details |
| 12088537 | Fragoso DB, Guedes RN, Guedes RN, Picanco MC, Zambolim L: Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). Bull Entomol Res. 2002 Jun;92(3):203-12. Results from insecticide bioassays with synergists (diethyl piperonyl butoxide and triphenyl suggested that cytochrome P450-dependent monooxygenases may play a major role in resistance with minor involvement of esterases and glutathione S-transferases. |
6(0,0,1,1) | Details |
| 1889377 | Dalvi RR, Dalvi PS: Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats. Drug Chem Toxicol. 1991;14(1-2):219-29. An i.p. administration of rats with piperine (100 mg/kg) and piperonyl butoxide (400 mg/kg) produced a significant decrease in hepatic cytochrome P-450, and activities of benzphetamine N-demethylase, aminopyrine N-demethylase and hydroxylase 1 hr after the treatment. |
6(0,0,1,1) | Details |
| 4402004 | Philpot RM, Hodgson E: The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice. Mol Pharmacol. 1972 Mar;8(2):204-14. |
6(0,0,1,1) | Details |
| 11205302 | Liu H, Baliga R: Effect of iron chelator, scavenger and cytochrome P450 inhibitors on the cytotoxicity of cisplatin to tumor cells. Anticancer Res. 2000 Nov-Dec;20(6B):4547-50. |
2(0,0,0,2) | Details |
| 1987650 | Emeigh Hart SG, Beierschmitt WP, Bartolone JB, Wyand DS, Khairallah EA, Cohen SD: Evidence against deacetylation and for cytochrome P450-mediated activation in -induced nephrotoxicity in the CD-1 mouse. Toxicol Appl Pharmacol. 1991 Jan;107(1):1-15. |
2(0,0,0,2) | Details |
| 11377398 | Heder AF, Hirsch-Ernst KI, Bauer D, Kahl GF, Desel H: Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Biochem Pharmacol. 2001 Jul 1;62(1):71-9. |
2(0,0,0,2) | Details |
| 11233122 | Kranthi KR, Jadhav D, Wanjari R, Kranthi S, Russell D: Pyrethroid resistance and mechanisms of resistance in field strains of Helicoverpa armigera (Lepidoptera: Noctuidae). J Econ Entomol. 2001 Feb;94(1):253-63. Studies carried out through estimation of detoxification enzyme activity and synergists indicated that enhanced cytochrome p450 and esterase activities were probably important mechanisms for pyrethroid resistance in field strains. |
1(0,0,0,1) | Details |
| 11948970 | Kumar S, Thomas A, Sahgal A, Verma A, Samuel T, Pillai MK: Effect of the synergist, piperonyl butoxide, on the development of deltamethrin resistance in yellow fever mosquito, Aedes aegypti L. (Diptera: Culicidae). Arch Insect Biochem Physiol. 2002 May;50(1):1-8. The data indicate the involvement of cytochrome P450-dependent detoxification as the primary mechanism of development of resistance to deltamethrin in the larvae. |
1(0,0,0,1) | Details |
| 2383287 | Larrey D, Tinel M, Letteron P, Maurel P, Loeper J, Belghiti J, Pessayre D: Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450. Biochem Pharmacol. 1990 Aug 1;40(3):545-50. It was decreased by piperonyl butoxide (4 mM) by 81%, and SKF 525-A (4 mM) by 87%, two relatively non-specific inhibitors of cytochrome P450, and by (4 mM) by 70%, a nucleophile. |
84(1,1,1,4) | Details |
| 9215992 | Sriram K, Boyd MR, Vistica DT, Ravindranath R: In vitro neurotoxicity of the antitumor agent 9-methoxy-N2-methylellipticinium (MMEA): role of brain cytochrome P-450. Neurotoxicology. 1997;18(1):97-104. Pretreatment of slices with piperonyl butoxide and inhibitor of cytochrome P-450, also prevented the toxicity of MMEA. |
83(1,1,1,3) | Details |
| 7801330 | Mizutani T, Nakahori Y, Yamamoto K: p-Dichlorobenzene-induced hepatotoxicity in mice depleted of by treatment with buthionine sulfoximine. Toxicology. 1994 Nov-Dec;94(1-3):57-67. Treatment with inhibitors of hepatic cytochrome P-450-dependent monooxygenases, carbon disulfide, and piperonyl butoxide also prevented the hepatotoxicity. |
32(0,1,1,2) | Details |
| 12729218 | Artola-Garicano E, Sinnige TL, van Holsteijn I, Vaes WH, Hermens JL: Bioconcentration and acute toxicity of polycyclic musks in two benthic organisms (Chironomus riparius and Lumbriculus variegatus). Environ Toxicol Chem. 2003 May;22(5):1086-92. The BCFs for both chemicals increased after coexposure of the organism to the cytochrome P450 inhibitor piperonyl butoxide. |
32(0,1,1,2) | Details |
| 3814174 | Geneve J, Larrey D, Letteron P, Descatoire V, Tinel M, Amouyal G, Pessayre D: Metabolic activation of the tricyclic antidepressant amineptine--I. Biochem Pharmacol. 1987 Feb 1;36(3):323-9. Covalent binding required and molecular and was decreased when the incubation was made in the presence of inhibitors of cytochrome P-450 such as piperonyl butoxide (4 mM), SKF 525-A (4 mM) or (80:20 CO-O2 atmosphere). |
32(0,1,1,2) | Details |
| 6124393 | Levine WG, Lu AY: Role of isozymes of cytochrome P-450 in the metabolism of N,N-dimethyl-4-aminoazobenzene in the rat. Drug Metab Dispos. 1982 Mar-Apr;10(2):102-9. Position-selective metabolism was studied in response to induction by 3-methylcholanthrene (MC), phenobarbital (PB), beta-naphthoflavone (BNF), and -16 alpha-carbonitrile (PCN) as well as inhibition by SKF 525-A, alpha-naphthoflavone, and piperonyl butoxide. |
6(0,0,0,6) | Details |
| 2803241 | Ravindranath V, Ananda Theertha Varada HK: High activity of cytochrome P-450-linked aminopyrine N-demethylase in mouse brain microsomes, and associated sex-related difference. Biochem J. 1989 Aug 1;261(3):769-73. Aminopyrine N-demethylase activity in mouse brain microsomes was dependent on the presence of and and could be inhibited by piperonyl butoxide, N-octyl and |
6(0,0,0,6) | Details |
| 3711591 | Siddiqui MK, Anjum F, Mahboob M, Quadri SS: Effects of DDT and piperonyl butoxide on the metabolic alterations in pigeon (Columbia livia). J Environ Sci Health B. 1986 Apr;21(2):115-24. Effect of acute doses of technical grade of dichloro diphenyl trichloro ethane (DDT) and piperonyl butoxide (PB) on hepatic microsomal cytochrome P450 (Cyt. |
6(0,0,1,1) | Details |
| 9887680 | Stuart JJ, Ray S, Harrington BJ, Neal JJ, Beeman RW: Genetic mapping of a major locus controlling pyrethroid resistance in Tribolium castaneum (Coleoptera: Tenebrionidae). J Econ Entomol. 1998 Dec;91(6):1232-8. Piperonyl butoxide, an inhibitor of cytochrome P450-mediated oxidative metabolism, significantly increased the toxicity of deltamethrin to a strain derived from QTC279 that carries PyR-1, strain pR. Piperonyl butoxide, an inhibitor of cytochrome P450-mediated oxidative metabolism, significantly increased the toxicity of deltamethrin to a strain derived from QTC279 that carries PyR-1, strain pR. |
2(0,0,0,2) | Details |
| 10646973 | Li X, Berenbaum MR, Schuler MA: Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible cytochrome P450 cDNA from Helicoverpa zea. Insect Biochem Mol Biol. 2000 Jan;30(1):75-84. Xanthotoxin, a plant allelochemical, induces alpha-cypermethrin insecticide tolerance in Helicoverpa zea (corn earworm); inhibition of tolerance by piperonyl butoxide implicates cytochrome P450 monooxygenases (P450s) in the detoxification of this insecticide. |
1(0,0,0,1) | Details |
| 9268606 | Phillips JC, Price RJ, Cunninghame ME, Osimitz TG, Cockburn A, Gabriel KL, Preiss FJ, Butler WH, Lake BG: Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats. Fundam Appl Toxicol. 1997 Jul;38(1):64-74. PBO induced microsomal cytochrome P450 content and mixed function oxidase activities in the mouse and rat, although the effects were less marked than those produced by NaPB. |
1(0,0,0,1) | Details |
| 9397514 | Korytko PJ, Scott JG: CYP6D1 protects thoracic ganglia of houseflies from the insecticide cypermethrin. Arch Insect Biochem Physiol. 1998;37(1):57-63. CYP6D1 is a housefly cytochrome P450 known to metabolize pyrethroid insecticides. This metabolism was inhibited by piperonyl butoxide and a CYP6D1-specific antibody. |
1(0,0,0,1) | Details |
| 2493688 | Nomeir AA, Ioannou YM, Sanders JM, Matthews HB: Comparative metabolism and disposition of ethyl (urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol Appl Pharmacol. 1989 Feb;97(2):203-15. Pretreatment of rats with piperonyl butoxide or SKF 525A (cytochrome P-450 inhibitors) or tri-o-cresyl (TOCP) or paraoxon (carboxylesterase inhibitors) or methyl (competitive substrate) did not greatly alter the metabolism of EC to CO2. |
0(0,0,0,0) | Details |
| 2372869 | Ruch RJ, Fransson R, Flodstrom S, Warngard L, Klaunig JE: Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor. Carcinogenesis. 1990 Jul;11(7):1097-101. Concomitant treatment of the cells with inhibitors of cytochrome P450 monooxygenases (SKF-525A, piperonyl butoxide or did not alter the inhibition of GJIC by the cyclodienes, suggesting that cytochrome P450 metabolism was not involved in the inhibitory mechanism. |
0(0,0,0,0) | Details |
| 8386241 | Berson A, Wolf C, Chachaty C, Fisch C, Fau D, Eugene D, Loeper J, Gauthier JC, Beaune P, Pompon D, et al.: Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies. J Pharmacol Exp Ther. 1993 Apr;265(1):366-72. Covalent binding required and and was decreased by the nucleophile and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily). |
83(1,1,1,3) | Details |
| 12201364 | Huang H, Salahudeen AK: Cold induces catalytic iron release of cytochrome P-450 origin: a critical step in cold storage-induced renal injury. Am J Transplant. 2002 Aug;2(7):631-9. As microsomes are rich in iron-containing cytochrome P-450 enzymes, microsomes were cold stored with P-450 inhibitors, cimetidine and piperonyl butoxide. |
83(1,1,1,3) | Details |
| 14984704 | Kashian DR: Toxaphene detoxification and acclimation in Daphnia magna: do cytochrome P-450 enzymes play a role?. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jan;137(1):53-63. To determine if D. magna acclimate to toxaphene via P-450 pathways, chronic and acute toxicity tests were conducted with D. magna exposed to toxaphene in the presence and absence of piperonyl butoxide (PBO), an inhibitor of cytochrome P-450 enzymes. |
83(1,1,1,3) | Details |
| 10362270 | Mizutani T, Murakami M, Shirai M, Tanaka M, Nakanishi K: Metabolism-dependent hepatotoxicity of methimazole in mice depleted of J Appl Toxicol. 1999 May-Jun;19(3):193-8. Pretreatment with hepatic cytochrome P-450 monooxygenase inhibitors-- isosafrole, methoxsalen, and piperonyl butoxide-prevented or tended to suppress the hepatotoxicity induced by MMI in combination with BSO. |
32(0,1,1,2) | Details |
| 12743769 | Mori T, Kitano S, Kondo R: Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-rot fungus Phlebia lindtneri. Appl Microbiol Biotechnol. 2003 May;61(4):380-3. Epub 2003 Mar 14. Significant inhibition of the degradation of these substrates was observed when they were incubated with the cytochrome P-450 monooxygenase inhibitors 1-aminobenzotriazole and piperonyl butoxide. |
32(0,1,1,2) | Details |
| 8427011 | Monnet FP, Debonnel G, de Montigny C: The cytochromes P-450 are not involved in the modulation of the response by sigma ligands in the rat CA3 dorsal hippocampus. Synapse. 1993 Jan;13(1):30-8. For this purpose, two cytochrome P-450 inhibitors, proadifen (SKF-525A) and piperonyl butoxide (PB), have been tested in our model. |
32(0,1,1,2) | Details |
| 11455659 | Yun MS, Shim IS, Usui K: Involvement of cytochrome P-450 enzyme activity in the selectivity and safening action of pyrazosulfuron-ethyl. Pest Manag Sci. 2001 Mar;57(3):283-8. |
5(0,0,0,5) | Details |
| 3494453 | Tinel M, Belghiti J, Descatoire V, Amouyal G, Letteron P, Geneve J, Larrey D, Pessayre D: Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives. Biochem Pharmacol. 1987 Mar 15;36(6):951-5. At this low concentration, neither cimetidine nor SKF 525-A or piperonyl butoxide had any significant inhibitory effect. |
5(0,0,0,5) | Details |
| 8014883 | Fau D, Eugene D, Berson A, Letteron P, Fromenty B, Fisch C, Pessayre D: Toxicity of the antiandrogen flutamide in isolated rat hepatocytes. . J Pharmacol Exp Ther. 1994 Jun;269(3):954-62. Both covalent binding and LDH release were decreased by piperonyl butoxide (an inhibitor of cytochrome P450) and increased by dexamethasone pretreatment (which induces cytochrome P450 3A). Both covalent binding and LDH release were decreased by piperonyl butoxide (an inhibitor of cytochrome P450) and increased by dexamethasone pretreatment (which induces cytochrome P450 3A). |
4(0,0,0,4) | Details |
| 9463524 | Zhao ZS, Khan S, O'Brien PJ: The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. Chem Biol Interact. 1997 Dec 12;108(1-2):107-18. Pharmacol., 140 (1996) 411-421), probably as a result of forming metabolic intermediate complexes with cytochrome P450. These compounds, in decreasing order of antioxidant effectiveness, were sesamol, 4-t-butyl-methylenedioxybenzene, isosafrole, piperonyl butoxide and 4-bromo-methylenedioxybenzene and whereas, benzodioxole, 3,4-(methylenedioxy)-toluene and 1,2-(methylenedioxy)-4-nitrobenzene were ineffective. |
2(0,0,0,2) | Details |
| 789067 | Franklin MR: Methylenedioxyphenyl insecticide synergists as potential human health hazards. Environ Health Perspect. 1976 Apr;14:29-37. They are substrates for mixed function oxidation and, thus, compete with other xenobiotics for available enzyme, and an intermediate in their metabolism is able to bind with cytochrome P-450 to form an inactive complex which absorbs maximally at 455 nm. |
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| 3358010 | Roy D, Snodgrass WR: Phenytoin metabolic activation: role of cytochrome P-450, age, and sex in rats and mice. Res Commun Chem Pathol Pharmacol. 1988 Feb;59(2):173-90. In vitro addition of inhibitors of drug metabolism (piperonyl butoxide, alpha-naphthylisothiocyanate, cobaltous chloride, SKF-525A) all significantly decreased covalent binding. |
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| 14522597 | Hilscherova K, Blankenship AL, Nie M, Coady KK, Upham BL, Trosko JE, Giesy JP: Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Sep;136(1):29-45. Eggs were injected simultaneously with TCDD and cotreatment compounds in an attempt to prevent oxidative stress or to block cytochrome P450 activity. |
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| 3011629 | Okajima T, Hertting G: The possible involvement of cytochrome P-450 monooxygenase in AVP-induced ACTH secretion. Horm Metab Res. 1986 Apr;18(4):281-2. Inhibitors of P-450 monooxygenase, (10 mM) and piperonyl butoxide (1 mM and 10 mM) attenuated the ACTH and response to AVP. 7,8-benzoflavon (10 mM) which inhibits 3-methylchloranthrene inducible form of P-450 isoenzymes showed no inhibition of AVP-induced ACTH secretion. |
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| 6491983 | Buckpitt AR, Bahnson LS, Franklin RB: Hepatic and pulmonary microsomal metabolism of naphthalene to adducts: factors affecting the relative rates of conjugate formation. J Pharmacol Exp Ther. 1984 Nov;231(2):291-300. Addition of piperonyl butoxide or SKF 525-A to hepatic microsomal incubations markedly decreased covalent binding of naphthalene metabolites but only slightly decreased adduct formation. |
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| 6713597 | Halpin RA, Vyas KP, El-Naggar SF, Jerina DM: Metabolism and hepatotoxicity of the naturally occurring benzo [b] pyran precocene I. Chem Biol Interact. 1984 Mar;48(3):297-315. Depletion of levels in the rats with diethyl prior to precocene I treatment dramatically increased the severity of hepatic insult, whereas treatment of the rats with the mixed function oxidase inhibitor piperonyl butoxide prior to treatment with precocene I blocked hepatic damage. |
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