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diflubenzuron

Identification (Source:EPA,EU)

ID	374
Name	diflubenzuron
CAS	35367-38-5
IUPAC	1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
Inchi	InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)
CIPAC	339
EPA Code	108201
Formula	C14H9ClF2N2O2
SMILES	Clc2ccc(NC(=O)NC(=O)c1c(F)cccc1F)cc2
Status	Approved

Classification

Mode of Action	Selective, non-systemic with contact and stomach action, acts by inhibiting chitin synthesis
Pesticide Type	Insecticide
Chemical Group	Benzoylurea
Classification	benzoylphenylurea chitin synthesis inhibitors Chemosterilants chitin synthesis inhibitors

Properties (Source:PubChem)

Molecular Weight	310.68
Physical State	White crystalline solid
AlogP	3.47
H-Bond Donor	2
H-Bond Acceptor	2
Surface Area	269.69
Polar Surface Area	58.2

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	1 mg l-1
Algae	Acute	72 hour	EC50, growth	20 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.0021 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.00004 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0026 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	> 0.19 mg l-1
Birds	Short term dietary		LC50/LD50	> 1206 mg/kg bw/day
Birds	Acute		LD50	> 5000 mg kg-1
Earthworms	Acute	14 day	LD50	> 500 mg kg-1
Fish	Acute	96 hour	LC50	> 0.13 mg l-1
Fish	Chronic	21 day	NOEC	0.2 mg l-1
Honeybees	Acute	48 hour	LD50	> 25 μg bee-1
Mammals	Acute oral		LD50	> 4640 mg kg-1
	Bio-concentration factor		BCF	320
	Bio-concentration factor		CT50	0.6 days

Related targets

Target Name	RScore (About this table)
chitinase	333(2,7,8,18)	Details
NAGA	176(2,2,4,6)	Details
sulfonylurea receptor	162(2,2,2,2)	Details
P glycoprotein	122(1,2,3,7)	Details
CYP1A1	88(1,1,1,8)	Details
glutathione S transferases	88(1,1,1,8)	Details
dihydrofolate reductase	81(1,1,1,1)	Details
CYP2A	81(1,1,1,1)	Details
AKR1A1	36(0,1,1,6)	Details
Ah receptor	35(0,1,1,5)	Details
thymidine kinase	31(0,1,1,1)	Details

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