| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | aldicarb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17222583 | Xu S, Wu A, Chen H, Xie Y, Xu Y, Zhang L, Li J, Zhang D: Production of a novel recombinant Drosophila melanogaster acetylcholinesterase for detection of organophosphate and insecticide residues. Biomol Eng. 2007 Jun;24(2):253-61. Epub 2006 Dec 22. The bimolecular rate constants of R-DmAChE to dichlorvos, aldicarb and carbaryl were ranging from three to six times higher than of native DmAChE. |
4(0,0,0,4) | Details |
| 7447699 | Cambon C, Declume C, Derache R: Foetal and maternal rat brain acetylcholinesterase: isoenzymes changes following insecticidal derivatives poisoning. Arch Toxicol. 1980 Oct;45(4):257-62. Pregnant rats (18th day) were orally given insecticidal carbamates with anticholinesterasic properties: 50 mg/kg carbaryl, 0.1 mg/kg aldicarb, 2.5 mg/kg carbofuran and 20 mg/kg pirimicarb. |
3(0,0,0,3) | Details |
| 8343987 | Gupta RC, Dettbarn WD: Role of carboxylesterases in the prevention and potentiation of N-methylcarbamate toxicity. Chem Biol Interact. 1993 Jun;87(1-3):295-303. Pretreatment of rats with iso-OMPA one hour prior to each of the N-methylcarbamate insecticides, carbofuran, propoxur, or aldicarb, potentiated the toxicity of these carbamates threefold. None of these compounds alone in the dosage used produced toxic signs; however, carboxylesterase (CarbE) activity in a variety of organs including brain, muscle, liver, and plasma was significantly reduced, while acetylcholinesterase (AChE) activity was unchanged. |
3(0,0,0,3) | Details |
| 7498734 | Nguyen M, Alfonso A, Johnson CD, Rand JB: Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics. 1995 Jun;140(2):527-35. |
3(0,0,0,3) | Details |
| 18631301 | Williams RL, Mihlan GJ, Tobia AJ: Modeling cholinesterase activity for human dietary risk assessment of insecticides. Risk Anal. 2008 Aug;28(4):1069-79. Epub 2008 Jul 9. This article demonstrates statistical models to quantify the interaction between a insecticide and acetylcholinesterase. Repeated measurements were taken prior to exposure and at 1, 2, 4, 6, 8, and 21 hours after exposure to the aldicarb. |
3(0,0,0,3) | Details |
| 16163484 | Suprun E, Evtugyn G, Budnikov H, Ricci F, Moscone D, Palleschi G: Acetylcholinesterase sensor based on screen-printed carbon electrode modified with prussian blue. Anal Bioanal Chem. 2005 Oct;383(4):597-604. Epub 2005 Oct 19. The ChE/PB sensor makes it possible to detect Aldicarb, Paraoxon and Parathion-Methyl with limits of detection 30, 10 and 5 ppb, respectively (incubation 10 min). |
2(0,0,0,2) | Details |
| 14709383 | Kok FN, Hasirci V: Determination of binary pesticide mixtures by an acetylcholinesterase- oxidase biosensor. Biosens Bioelectron. 2004 Feb 15;19(7):661-5. Enzyme immobilized membrane was used in the detection of anti-cholinesterase activity of aldicarb (AS), carbofuran (CF) and carbaryl (CL), as well as two mixtures, (AS+CF) and (AS+CL). |
2(0,0,0,2) | Details |
| 10696779 | Perkins EJ Jr, Schlenk D: In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity. Toxicol Sci. 2000 Feb;53(2):308-15. |
276(3,4,4,6) | Details |
| 20345797 | Sabino BD, Torraca TG, Moura CM, Rozenbaum HF, de Castro Faria MV: Development of a Simple and Low-Cost Enzymatic Methodology for Quantitative Analysis of Carbamates in Meat Samples of Forensic Interest. J Forensic Sci. 2010 Mar 15. Foods contaminated with a granulated material similar to Temik (a commercial pesticide formulation containing the insecticide aldicarb) are often involved in accidental ingestion, suicides, and homicides in Brazil. This technique is based on the inhibition of a stable preparation of the enzyme acetylcholinesterase, and it is specially adapted for forensic purposes. |
2(0,0,0,2) | Details |
| 3244345 | Farage-Elawar M: Toxicity of aldicarb in young chicks. Neurotoxicol Teratol. 1988 Nov-Dec;10(6):549-54. Brain acetylcholinesterase (AChE) and neurotoxic esterase (NTE) were measured at three times during the one week of treatment, and again on days 1, 3, 6, 10, 20, 30 and 40 after the last dose. |
2(0,0,0,2) | Details |
| 3304999 | Risher JF, Mink FL, Stara JF: The toxicologic effects of the insecticide aldicarb in mammals: a review. Environ Health Perspect. 1987 Jun;72:267-81. However, unlike the relatively irreversible anticholinesterase activity of the organophosphate pesticides, the carbamylation process which produces the anti-AChE action is quickly reversible. |
1(0,0,0,1) | Details |
| 9568379 | Singh AK, Spassova D: Effects of hexamethonium, phenothiazines, and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Jan;119(1):97-105. |
201(2,3,3,11) | Details |
| 9772213 | El-Alfy A, Schlenk D: Potential mechanisms of the enhancement of aldicarb toxicity to Japanese medaka, Oryzias latipes, at high salinity. Toxicol Appl Pharmacol. 1998 Sep;152(1):175-83. Aldicarb sulfoxide was 40 times more potent than aldicarb in inhibiting muscle AChE in Japanese medaka. |
193(2,3,3,3) | Details |
| 2033303 | Ahmed YM: Kinetic study on inhibition of earthworm acetylcholinesterase by insecticides. J Egypt Soc Parasitol. 1991 Apr;21(1):283-92. The inhibition progress of the AChE by aldicarb was relatively rapid more than the other two tested inhibitors: carbofuran and methomyl. |
115(1,2,2,5) | Details |
| 9216867 | Kallander DB, Fisher SW, Lydy MJ: Recovery following pulsed exposure to organophosphorus and insecticides in the midge, Chironomus riparius. Arch Environ Contam Toxicol. 1997 Jul;33(1):29-33. The importance of recovery following pulsed and continuous exposure was determined by measuring the acute toxicity of two organophosphorus (parathion and malathion) and four (aldicarb, carbaryl, carbofuran and propoxur) insecticides. Acetylcholinesterase activity in midges given two 1-h pulses of carbaryl separated by 24 h in clean water showed reactivation to control levels between the two exposures. |
1(0,0,0,1) | Details |
| 11521840 | El-Alfy AT, Grisle S, Schlenk D: Characterization of salinity-enhanced toxicity of aldicarb to Japanese medaka: sexual and developmental differences. Environ Toxicol Chem. 2001 Sep;20(9):2093-8. A time-course study was conducted in which muscle acetylcholinesterase (AChE) inhibition was monitored after exposure to aldicarb. |
113(1,2,2,3) | Details |
| 10871426 | Parker ML, Goldstein MI: Differential toxicities of organophosphate and insecticides in the nestling European starling (Sturnus vulgaris). Arch Environ Contam Toxicol. 2000 Aug;39(2):233-42. Methyl paraoxon and aldicarb had a higher affinity for plasma AChE than for BChE or CaE. |
83(1,1,1,3) | Details |
| 19762223 | Upadhyay S, Rao GR, Sharma MK, Bhattacharya BK, Rao VK, Vijayaraghavan R: Immobilization of acetylcholineesterase- oxidase on a gold-platinum bimetallic nanoparticles modified glassy carbon electrode for the sensitive detection of organophosphate pesticides, carbamates and nerve agents. Biosens Bioelectron. 2009 Dec 15;25(4):832-8. Epub 2009 Aug 31. Paraoxon ethyl, sarin, and aldicarb could be detected up to 150-200nM, 40-50nM, and 40-60 microM respectively at 30-40% inhibition level of AChE enzyme and followed linearity in wide range concentration. |
82(1,1,1,2) | Details |
| 11131904 | Katsoudas E, Abdelmesseh HH: Enzyme inhibition and enzyme-linked immunosorbent assay methods for pesticide residue analysis in fresh produce. J Food Prot. 2000 Dec;63(12):1758-60. An acetylcholinesterase inhibition method was employed for detection of 21 pesticides in bananas, peaches, strawberries, and tomatoes. The detection levels ranged from 0.1 ppm for carbofuran and 3-hydroxycarbofuran to 6 ppm for promecarb and aldicarb sulfoxide. |
1(0,0,0,1) | Details |
| 12417477 | Paz-y-Mino C, Bustamante G, Sanchez ME, Leone PE: Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ Health Perspect. 2002 Nov;110(11):1077-80. This study included 41 individuals occupationally exposed to 27 pesticides, some of which are restricted in many countries and are classified as extremely toxic by the World Health Organization; among these are aldicarb and fenamiphos. Levels of erythrocyte acetylcholinesterase were also determined as a complementary metabolic study. |
1(0,0,0,1) | Details |
| 12553575 | Winter MD, McPherson MJ, Atkinson HJ: Neuronal uptake of pesticides disrupts chemosensory cells of nematodes. Parasitology. 2002 Dec;125(Pt 6):561-5. Low doses of the acetylcholinesterase-inhibiting nematicides disrupt chemoreception in plant-parasitic nematodes. The widely used nematicide aldicarb disrupts the chemoreceptive response of H. glycines with 50% inhibition at very low concentrations (ca 1 pM), some 10 (-6)-fold lower than required to affect locomotion. |
1(0,0,0,1) | Details |
| 9469857 | Moore MT, Huggett DB, Gillespie WB Jr, Rodgers JH Jr, Cooper CM: Comparative Toxicity of Chlordane, Chlorpyrifos, and Aldicarb to Four Aquatic Testing Organisms. Arch Environ Contam Toxicol. 1998 Feb;34(2):152-7. Aqueous 48-h toxicity tests were performed to contrast responses of Daphnia magna Straus, Hyalella azteca Saussure, Chironomus tentans Fabricius, and Pimephales promelas Rafinesque to acetylcholinesterase-inhibiting insecticides: chlorpyrifos, aldicarb, and chlordane. |
81(1,1,1,1) | Details |
| 10330685 | Perkins EJ, el-Alfy A, Schlenk D: In vitro sulfoxidation of aldicarb by hepatic microsomes of channel catfish, Ictalurus punctatus. Toxicol Sci. 1999 Mar;48(1):67-73. In addition, the acetylcholinesterase inhibitory potencies of aldicarb and its sulfoxide and sulfone derivatives were determined. |
81(1,1,1,1) | Details |
| 12954868 | Bany IA, Dong MQ, Koelle MR: Genetic and cellular basis for inhibition of Caenorhabditis elegans egg-laying behavior. J Neurosci. 2003 Sep 3;23(22):8060-9. In addition, increasing synaptic by reducing acetylcholinesterase activity, with either mutations or the inhibitor aldicarb, decreased egg laying. |
81(1,1,1,1) | Details |
| 15081274 | Vidair CA: Age dependence of organophosphate and neurotoxicity in the postnatal rat: extrapolation to the human. Toxicol Appl Pharmacol. 2004 Apr 15;196(2):287-302. Because these compounds probably exert their effects through the inhibition of acetylcholinesterase (AChE), the above question can be narrowed to whether the cholinesterase inhibition and neurotoxicity they produce is age-dependent, both in terms of the effects produced and potency. Four pesticides were tested in rat pups in their third postnatal week: aldicarb, chlorpyrifos, malathion, and methamidophos. |
1(0,0,0,1) | Details |
| 7737038 | Baron RL: A insecticide: a case study of aldicarb. . Environ Health Perspect. 1994 Dec;102 Suppl 11:23-7. Included in these discussions is a brief description of the toxicological end point upon which regulatory decisions have been based, namely acetylcholinesterase depression. |
1(0,0,0,1) | Details |
| 494273 | Cambon C, Declume C, Derache R: Effect of the insecticidal derivatives (carbofuran, pirimicarb, aldicarb) on the activity of acetylcholinesterase in tissues from pregnant rats and fetuses. Toxicol Appl Pharmacol. 1979 Jun 30;49(2):203-8. |
81(1,1,1,1) | Details |
| 11881978 | Palumbo G, Bacchi S, Coppolino MF, Pantaleoni GC: Neurochemical and behavioural effects of chronic aldicarb administration in rats. Pharmacol Toxicol. 2001 Nov;89(5):249-54. The locomotor and explorative activities were reduced, and aldicarb significantly decreased brain AChE activity while an increase was found in the passive avoidance and water-maze performance. |
62(0,2,2,2) | Details |
| 2380482 | Farage-Elawar M: Effects of in ovo injection of carbamates on chick embryo hatchability, esterase enzyme activity and locomotion of chicks. J Appl Toxicol. 1990 Jun;10(3):197-201. Carbaryl and aldicarb, two pesticides used extensively throughout the United States, are known to act as acetylcholinesterase inhibitors. |
62(0,2,2,2) | Details |
| 406567 | Schmid ER, Damboritz W, Markl P: [Radiometric determination of 11 pesticides in the nanogram and subnanongram ranges by means of cholinesterase inhibition]. Nahrung. 1977;21(4):311-7. This method for determining carbamates is based on the inhibiting action of these substances on acetylcholinesterase activity. The limit of detection for aldicarb, baygon, benomyl, bux, carbaryl, CIPC, matacil, phenmedipham and promecarb lies in the picogram range; that for barban and methomyl, in the nanogram range. |
1(0,0,0,1) | Details |
| 224645 | Sterri SH, Rognerud B, Fiskum SE, Lyngaas S: Effect of toxogonin and P2S on the toxicity of carbamates and organophosphorus compounds. Acta Pharmacol Toxicol. 1979 Jul;45(1):9-15. Toxogonin (80 mg/kg intraperitoneally) given 15 min. prior to the administration of organophosphorus insecticides dimethoate, malathion, parathion and azinphos-methyl, organophosphorus warfare agents soman and tabun, or carbamates physostigmine, pyridostigmine and aldicarb, reduced the toxicity in mice of these agents by increasing their LD50 dose 1.5-3 fold. The acetylcholinesterase activity in erythrocytes, cerebrum and diaphragm of surviving mice 20 hours after organophosphate intoxication was similar both in toxogonin and P2S treated animals and untreated animals. |
1(0,0,0,1) | Details |
| 14644616 | Smulders CJ, Bueters TJ, Van Kleef RG, Vijverberg HP: Selective effects of pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol Appl Pharmacol. 2003 Dec 1;193(2):139-46. Conversely, the potency order of these carbamates to inhibit rat brain acetylcholinesterase is bendiocarb > propoxur, aldicarb > carbaryl > EPTC, fenoxycarb with IC50 values ranging from 1 microM for bendiocarb to 17 microM for carbaryl and > mM for EPTC and fenoxycarb. |
34(0,1,1,4) | Details |
| 3822252 | Bakry NM, Sherby SM, Eldefrawi AT, Eldefrawi ME: Oxadiazolidinones: irreversible inhibition of cholinesterases and effects on acetylcholine receptors. Neurotoxicology. 1986 Fall;7(3):1-10. Aldicarb, a anticholinesterase, which protected Torpedo AChE against irreversible phosphorylation by DFP, also protected it against irreversible inhibition by DBOX and MPOX. |
34(0,1,1,4) | Details |
| 12485777 | Ciucu AA, Negulescu C, Baldwin RP: Detection of pesticides using an amperometric biosensor based on ferophthalocyanine chemically modified carbon paste electrode and immobilized bienzymatic system. Biosens Bioelectron. 2003 Mar;18(2-3):303-10. The method is based on a ferophthalocyanine chemically modified carbon paste electrode coupled with acetylcholinesterase and oxidase co-immobilized onto the surface of a dialysis membrane. |
1(0,0,0,1) | Details |
| 9585096 | Mortensen SR, Hooper MJ, Padilla S: Rat brain acetylcholinesterase activity: developmental profile and maturational sensitivity to and organophosphorus inhibitors. Toxicology. 1998 Jan 16;125(1):13-9. IC50s (the concentration of compound that inhibits 50% of the AChE activity in 30 min at 26 degrees C) defined concomitantly for postnatal day 4 and adult brain AChE using either aldicarb, carbaryl, chlorpyrifos-oxon or malaoxon were virtually identical at both ages with average IC50 values being: aldicarb = 2.4 microM, carbaryl = 1.7 microM, chlorpyrifos-oxon = 4.9 nM and malaoxon = 140 nM. |
34(0,1,1,4) | Details |
| 17216925 | Osman MY, Sharaf IA, Mohamed AS, Osman HM: Effect of the "aldicarb" on acetyl cholinesterase extracted from whole and different parts of rat brain (in vitro and in vivo studies). J Egypt Public Health Assoc. 2000;75(3-4):301-21. Inhibition of AChE in the different parts of the brain in vitro by aldicarb was of the competitive type, with different enzyme inhibitor dissociation constants (Ki). |
33(0,1,1,3) | Details |
| 3603322 | Parks P, Lipman J, Eidelman J: toxicity. S Afr Med J. 1987 Aug 1;72(3):222. The type of poisoning which inhibits acetylcholinesterase (AChE) most often encountered in an intensive care unit is that of organophosphates (OP). |
1(0,0,0,1) | Details |
| 17723768 | Arduini F, Ricci F, Tuta CS, Moscone D, Amine A, Palleschi G: Detection of carbamic and organophosphorous pesticides in water samples using a cholinesterase biosensor based on Prussian Blue-modified screen-printed electrode. Anal Chim Acta. 2006 Nov 24;580(2):155-62. Epub 2006 Jul 29. AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). |
32(0,1,1,2) | Details |
| 19031285 | Caldas ED, Rebelo FM, Heliodoro VO, Magalhaes AF, Rebelo RM: Poisonings with pesticides in the Federal District of Brazil. Clin Toxicol. 2008 Dec;46(10):1058-63. One hundred ninety-four cases involved chumbinho, an illegal rodenticide known to contain acetylcholinesterase inhibitor insecticides, mainly aldicarb. |
32(0,1,1,2) | Details |
| 17128266 | Sieburth D, Madison JM, Kaplan JM: PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007 Jan;10(1):49-57. Epub 2006 Nov 26. Mutants lacking PCK-1 activity had delayed paralysis induced by the acetylcholinesterase inhibitor aldicarb, whereas mutants with increased PKC-1 activity had more rapid aldicarb-induced paralysis. |
31(0,1,1,1) | Details |
| 16256972 | Chang PA, Wu YJ, Li W, Leng XF: Effect of esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem Biol Interact. 2006 Jan 5;159(1):65-72. Epub 2005 Oct 27. In the present investigation, the effects of carbamates at sublethal concentration on neurite outgrowth and cytoskeleton as well as activities of acetylcholinesterase (AChE) and neuropathy target esterase (NTE) in differentiating human SK-N-SH neuroblastoma cells were studied. The results showed that 50 microM of either aldicarb or carbaryl significantly decreased neurite length in the -induced differentiation of the neuroblastoma cells, compared to cells treated with vehicle. |
1(0,0,0,1) | Details |
| 19290026 | Wang DY, Wang Y: HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans. Neurosci Bull. 2009 Apr;25(2):75-86. METHODS: To evaluate the functions of HLB-1 in regulating the organization and function of neuromuscular junctions, effects of hlb-1 mutation on the synaptic structures were revealed by uncovering the expression patterns of SNB-1::GFP and UNC-49::GFP, and pharmacologic assays with aldicarb and levamisole were also used to test the synaptic functions. The mutant animals exhibited severe defects in locomotion behaviors and altered responses to an inhibitor of acetylcholinesterase and a cholinergic agonist, indicating the altered presynaptic and postsynaptic functions. |
1(0,0,0,1) | Details |
| 17487159 | Mahoney TR, Luo S, Nonet ML: Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay. Nat Protoc. 2006;1(4):1772-7. This protocol monitors the sensitivity of C. elegans to the paralyzing affects of an acetylcholinesterase inhibitor, aldicarb. |
31(0,1,1,1) | Details |
| 18043066 | Metz LB, Dasgupta N, Liu C, Hunt SJ, Crowder CM: An evolutionarily conserved presynaptic protein is required for isoflurane sensitivity in Caenorhabditis elegans. Anesthesiology. 2007 Dec;107(6):971-82. Sensitivity to the acetylcholinesterase inhibitor aldicarb was used as an assay for the global level of C. elegans neurotransmitter release. |
31(0,1,1,1) | Details |
| 14499607 | Grisoni K, Gieseler K, Mariol MC, Martin E, Carre-Pierrat M, Moulder G, Barstead R, Segalat L: The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin. J Mol Biol. 2003 Oct 3;332(5):1037-46. We report here the molecular and functional characterization of the Caenorhabditis elegans gene stn-1 (F30A10.8), which encodes a syntrophin with homology to vertebrate alpha and beta-syntrophins. stn-1 is expressed in neurons and in muscles of C.elegans. stn-1 mutants resemble dystrophin (dys-1) and dystrobrevin (dyb-1) mutants: they are hyperactive, bend their heads when they move forward, tend to hypercontract, and are hypersensitive to the acetylcholinesterase inhibitor aldicarb. |
31(0,1,1,1) | Details |
| 9334382 | Nonet ML, Staunton JE, Kilgard MP, Fergestad T, Hartwieg E, Horvitz HR, Jorgensen EM, Meyer BJ: Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J Neurosci. 1997 Nov 1;17(21):8061-73. Furthermore, rab-3 animals were resistant to the acetylcholinesterase inhibitor aldicarb, suggesting that cholinergic transmission was generally depressed. |
31(0,1,1,1) | Details |
| 2048762 | Hong R: Effects of environmental toxins on lymphocyte function: studies in rhesus and man. Ann Allergy. 1991 Jun;66(6):474-80. In humans, exposure to the acetylcholinesterase inhibitor, Aldicarb, was received through contaminated well water. |
31(0,1,1,1) | Details |
| 11029035 | Pilon M, Peng XR, Spence AM, Plasterk RH, Dosch HM: The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Mol Biol Cell. 2000 Oct;11(10):3277-88. A deletion mutant was isolated and found to exhibit resistance to the drug aldicarb (an inhibitor of acetylcholinesterase), suggesting defective neurotransmitter secretion in the mutant. A deletion mutant was isolated and found to exhibit resistance to the drug aldicarb (an inhibitor of acetylcholinesterase), suggesting defective neurotransmitter secretion in the mutant. |
1(0,0,0,1) | Details |
| 15822765 | Mendes CA, Mendes GE, Cipullo JP, Burdmann EA: Acute intoxication due to ingestion of vegetables contaminated with aldicarb. Clin Toxicol. 2005;43(2):117-8. All three developed signs and symptoms of acetylcholinesterase inhibition and all recovered a few hours after the ingestion. |
1(0,0,0,1) | Details |
| 9933302 | Bessou C, Giugia JB, Franks CJ, Holden-Dye L, Segalat L: Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission. Neurogenetics. 1998 Dec;2(1):61-72. Finally, the dys-1 mutants are hypersensitive to and to the acetylcholinesterase inhibitor aldicarb, suggesting that dys-1 mutations affect cholinergic transmission. |
31(0,1,1,1) | Details |
| 10677040 | Nurrish S, Segalat L, Kaplan JM: inhibition of synaptic transmission: Galpha (0) decreases the abundance of UNC-13 at release sites. Neuron. 1999 Sep;24(1):231-42. Release of from motor neurons was assayed by measuring the sensitivity of intact animals to the acetylcholinesterase inhibitor aldicarb. |
31(0,1,1,1) | Details |
| 9614171 | Saifee O, Wei L, Nonet ML: The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol Biol Cell. 1998 Jun;9(6):1235-52. Less severe viable unc-64 mutants exhibit a variety of behavioral defects and show strong resistance to the acetylcholinesterase inhibitor aldicarb. |
31(0,1,1,1) | Details |
| 10445493 | Covaci A, Manirakiza P, Coucke V, Beckers R, Jorens PG, Schepens P: A case of aldicarb poisoning: a possible murder attempt. J Anal Toxicol. 1999 Jul-Aug;23(4):290-3. Because of the reversibility of inhibition of acetylcholinesterase, the patients recovered after treatment with atropine and toxogonin. |
1(0,0,0,1) | Details |
| 15378568 | Reuveny H, Cohen E: Evaluation of mechanisms of azinphos-methyl resistance in the codling moth Cydia pomonella (L.). Arch Insect Biochem Physiol. 2004 Oct;57(2):92-100. In comparison to acetylcholinesterase (AChE) from susceptible adult codling moth, the enzyme of insects resistant to azinphos-methyl has low affinities (higher K (m) values) to the substrates acetylthiocholine (ATCh) and propionylthiocholine. Of the three carbamates examined, only carbaryl was inhibitory at the mM range while pirimicarb and aldicarb were inactive. |
1(0,0,0,1) | Details |
| 9412487 | Nonet ML, Saifee O, Zhao H, Rand JB, Wei L: Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. J Neurosci. 1998 Jan 1;18(1):70-80. The viable mutants are resistant to the acetylcholinesterase inhibitor aldicarb, indicating that cholinergic transmission is impaired. |
31(0,1,1,1) | Details |
| 18279315 | Ghila L, Gomez M: The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission. Eur J Neurosci. 2008 Feb;27(3):621-30. Deletion mutations in lnp-1 result in increased resistance to aldicarb, an acetylcholinesterase inhibitor, and in locomotor defects. |
31(0,1,1,1) | Details |
| 19797046 | Locke CJ, Kautu BB, Berry KP, Lee SK, Caldwell KA, Caldwell GA: Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics. 2009 Dec;183(4):1357-72. Epub 2009 Sep 21. Rac mutants also exhibited hypersensitivity to an acetylcholinesterase inhibitor, aldicarb, uncovering deficiencies in inhibitory neurotransmission. |
31(0,1,1,1) | Details |
| 14979094 | Costa C, Catania S, Silvari V: [Genotoxicity and activation of organophosphate and pesticides by cytochrome P450 2D6]. G Ital Med Lav Ergon. 2003 Jul-Sep;25 Suppl(3):81-2. The role of the polymorphic cytochrome P450 (CYP) 2D6 isoform in catalysing the oxidative biotransformation of the organophosphate pesticide chlorpyriphos and the aldicarb into structures that inhibit cholinesterase and induce genotoxicity has been investigated in microsomal fraction, using quinine as a specific chemical inhibitor of CYP 2D6. |
0(0,0,0,0) | Details |
| 19066504 | Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G: Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants. J Vis Exp. 2008 Aug 18;(18). pii: 837. doi: 10.3791/837. In this video, we describe how two complementary neural stimulants, an acetylcholinesterase inhibitor, called aldicarb, and a (GABA) receptor antagonist, called pentylenetetrazole (PTZ), may be employed to specifically characterize signaling at C. elegans neuromuscular junctions (NMJs) and facilitate our understanding of antagonistic neural circuits. |
31(0,1,1,1) | Details |
| 19283090 | Opperman CH, Chang S: Effects of Aldicarb and Fenamiphos on Acetycholinesterase and Motility of Caenorhabditis elegans. J Nematol. 1991 Jan;23(1):20-7. The ability of Caenorhabditis elegans to recover from exposure to high doses of aldicarb and fenamiphos was examined at the organismal and biochemical levels by determination of movement and acetylcholinesterase activity. |
13(0,0,2,3) | Details |
| 11959475 | Kok FN, Bozoglu F, Hasirci V: Construction of an acetylcholinesterase- oxidase biosensor for aldicarb determination. Biosens Bioelectron. 2002 Jun;17(6-7):531-9. |
12(0,0,2,2) | Details |
| 4078930 | DePass LR, Weaver EV, Mirro EJ: Aldicarb sulfoxide/aldicarb sulfone mixture in drinking water of rats: effects on growth and acetylcholinesterase activity. J Toxicol Environ Health. 1985;16(2):163-72. |
6(0,0,1,1) | Details |
| 2061181 | Kerr LA, Pringle JK, Rohrbach BW, Edwards WC, Offutt JE: Aldicarb toxicosis in a dairy herd. J Am Vet Med Assoc. 1991 May 1;198(9):1636-9. |
0(0,0,0,0) | Details |
| 17603106 | Mullen GP, Mathews EA, Vu MH, Hunter JW, Frisby DL, Duke A, Grundahl K, Osborne JD, Crowell JA, Rand JB: transport and de novo synthesis support biosynthesis in Caenorhabditis elegans cholinergic neurons. Genetics. 2007 Sep;177(1):195-204. Epub 2007 Jul 1. We found that CHO-1 is expressed in most, but not all cholinergic neurons in C. elegans. cho-1 null mutants are viable and exhibit mild deficits in cholinergic behavior; they are slightly resistant to the acetylcholinesterase inhibitor aldicarb, and they exhibit reduced swimming rates in liquid. cho-1 mutants also fail to sustain swimming behavior; over a 33-min time course, cho-1 mutants slow down or stop swimming, whereas wild-type animals sustain the initial rate of swimming over the duration of the experiment. |
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| 8134223 | Lifshitz M, Rotenberg M, Sofer S, Tamiri T, Shahak E, Almog S: poisoning and oxime treatment in children: a clinical and laboratory study. Pediatrics. 1994 Apr;93(4):652-5. The poisoning agents in all cases were positively identified as methomyl or aldicarb by gas chromatography-mass spectrometry. (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a (aldicarb or methomyl). |
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| 1685431 | Noel GR, Mayasich SO: Partial characterization of soluble esterase from Heterodera glycines and inhibition by aldicarb and phenamiphos. Comp Biochem Physiol C. 1991;99(3):537-40. The data demonstrated that aldicarb and phenamiphos were active against esterases other than acetylcholinesterase. |
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| 16563591 | Caldas ED, Boon PE, Tressou J: Probabilistic assessment of the cumulative acute exposure to organophosphorus and insecticides in the Brazilian diet. Toxicology. 2006 May 1;222(1-2):132-42. Epub 2006 Mar 6. In the present study, the cumulative exposure of 25 acetylcholinesterase (AChE) inhibiting pesticides through the consumption of nine fruits and vegetables by the Brazilian population was assessed. Monocrotophos and triazophos, in addition to aldicarb, had the highest calculated RPF in any scenario. |
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