| Name | ionized calcium binding adapter molecule 1 |
|---|---|
| Synonyms | AIF 1; G1; AIF1; Allograft inflammatory factor 1; IBA 1; IBA1; IRT; IRT 1… |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12617960 | Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M, Shimada T, Mizuno Y, Urabe T: Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia. Neuroscience. 2003;117(3):531-9. At 48-72 h after MCAO, irregular round- or oval-shaped EGFP/ionized calcium-binding adapter molecule 1 (Iba 1)-positive cells increased in the transition zone, while many amoeboid-shaped or large-cell-body EGFP/Iba 1-positive cells were increased in number in the innermost area of ischemia. |
3(0,0,0,3) | Details |
| 18649403 | Malm TM, Magga J, Kuh GF, Vatanen T, Koistinaho M, Koistinaho J: Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease. Glia. 2008 Dec;56(16):1767-79. All engrafted cells expressed CD45, approximately 50% expressed Iba-1, and <0.5% of these cells expressed CD3e. |
2(0,0,0,2) | Details |
| 19374947 | White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim SO, Hise TL, Keller JN, Ingram DK, Morrison CD, Bruce-Keller AJ: Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis. 2009 Jul;35(1):3-13. Epub 2009 Apr 15. HFD was also associated with significant increases in inducible synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams. |
1(0,0,0,1) | Details |
| 16647243 | Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF: Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun. 2007 Jan;21(1):47-59. Epub 2006 May 2. The effect of inescapable shock (IS) on glial activation (MHC II, CD11b, Iba-1, and GFAP) and regulatory markers (CD200) in vivo, and microglia pro-inflammatory responses (interleukin-1beta; IL-1beta) to lipopolysaccharide (LPS) ex vivo, were assessed in rat hippocampus. |
1(0,0,0,1) | Details |
| 14988576 | Komine-Kobayashi M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T: Dual role of Fcgamma receptor in transient focal cerebral ischemia in mice. Stroke. 2004 Apr;35(4):958-63. Epub 2004 Feb 26. To clarify the function and distribution of microglia/macrophages, immunohistochemical staining and immunoblotting of ionized calcium-binding adapter molecule 1 (Iba-1), inducible synthase, and nitrotyrosine were performed. |
2(0,0,0,2) | Details |
| 18190912 | He J, Crews FT: Increased MCP-1 and microglia in various regions of the human alcoholic brain. J Vasc Res. 1998 Sep-Oct;35(5):303-9. Immunohistochemistry was further performed to visualize human microglia using ionized calcium binding adaptor protein-1 (Iba-1), and Glucose transporter-5 (GluT5). |
2(0,0,0,2) | Details |
| 18775685 | Payes AC, Zanon RG, Pierucci A, Oliveira AL: MHC class I upregulation is not sufficient to rescue neonatal alpha motoneurons after peripheral axotomy. Brain Res. 2008 Oct 31;1238:23-30. Epub 2008 Aug 23. The results were analyzed by counting Nissl stained motoneurons, immunohistochemistry (anti-synaptophysin, MHC class I, GFAP and Iba-1) and transmission electron microscopy. |
1(0,0,0,1) | Details |
| 19670441 | Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI: Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 2009 Jul;66(1):63-74. Administration of CHPG attenuated microglial-associated inflammatory responses in a dose-dependent fashion, including expression of ED1, Iba-1, Galectin-3, oxidase components, tumor necrosis factor-alpha, and inducible synthase. |
1(0,0,0,1) | Details |
| 19899982 | Wang WY, Xu GZ, Tian J, Sprecher AJ: Inhibitory effect on LPS-induced retinal microglial activation of downregulation of t-PA expression by siRNA interference. Curr Eye Res. 2009 Jun;34(6):476-84. Next, tPA expression was down-regulated by siRNA interference, the microglia transfected with tPA siRNA lentivirus or blank control lentivirus were activated with 30 ng/ml of LPS, the culture supernatant was collected 1, 3, 6, 12, and 24 hours after LPS treatment for IL-1beta and TNF-alpha ELISA assays, and the cells were collected 24 hours later for immunocytochemistry of microglia markers (OX42 and Iba-1) and quantitative real-time PCR to determine the inhibitory efficiency of t-PA siRNA. |
2(0,0,0,2) | Details |
| 20121416 | Haselkorn ML, Shellington D, Jackson E, Vagni VA, Janesko KL, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM: Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice. Brain Res. 2009 Aug 25;1286:42-52. Epub 2009 Jun 23. Iba-1 immunostaining was used to quantify microglia at 7d. |
2(0,0,0,2) | Details |
| 19486898 | Jung SH, Lee ST, Chu K, Park JE, Lee SU, Han TR, Kim M: Cell proliferation and synaptogenesis in the cerebellum after focal cerebral ischemia. Brain Res. 2009 Aug 11;1284:180-90. Epub 2009 May 30. BrdU+ cells and Iba-1+ cells were counted, and cerebellar synaptophysin immunoreactivity was quantitatively analyzed. |
2(0,0,0,2) | Details |
| 19103252 | Scorisa JM, Zanon RG, Freria CM, de Oliveira AL: Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion. Neurosci Lett. 2009 Feb 13;451(1):34-9. Epub 2008 Dec 16. A correlation between the synaptic changes and glial activation was obtained by performing immunolabeling against synaptophysin, GFAP and Iba-1. |
1(0,0,0,1) | Details |
| 17676428 | Takagi S, Hayakawa N, Kimoto H, Kato H, Araki T: Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice. J Neural Transm. 2007;114(12):1553-7. Epub 2007 Aug 6. In contrast, GFAP (glial fibrillary acidic protein) and Iba-1 protein in the striatum showed a significant increase of GFAP and Iba-1 protein levels 3 and 7 days after MPTP treatment. |
1(0,0,0,1) | Details |
| 19887747 | Moon JB, Lee CH, Park CW, Cho JH, Hwang IK, Yoo KY, Choi JH, Shin HC, Won MH: Neuronal degeneration and microglial activation in the ischemic dentate gyrus of the gerbil. J Vet Med Sci. 2009 Oct;71(10):1381-6. In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using -Jade B histofluorescence staining and immunohistochemistry for Iba-1. |
2(0,0,0,2) | Details |
| 19063869 | Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X: Neuroprotective effects of saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009 Feb 23;1256:129-37. Epub 2008 Nov 27. Acute cell death, inflammation and oxidative stress were evaluated at 24 h by studying caspase-3 activity, MDA measurement as well as Iba-1 immunochemistry in the brain. |
2(0,0,0,2) | Details |
| 16807899 | Leone C, Le Pavec G, Meme W, Porcheray F, Samah B, Dormont D, Gras G: Characterization of human monocyte-derived microglia-like cells. Glia. 2006 Aug 15;54(3):183-92. They overexpressed substance P and the binding protein Iba-1 and dimly expressed class II MHC, three characteristics of microglial cells. |
1(0,0,0,1) | Details |
| 19966940 | Rrapo E, Zhu Y, Tian J, Hou H, Smith A, Fernandez F, Tan J, Giunta B: Green Tea- reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. Am J Transl Res. 2009 Jan 1;1(1):72-9. This was accompanied by a mild reduction in activated microglia by Iba-1 staining and significant reduction in neuronal loss through apoptosis as demonstrated by MAP2 staining and Western blot analysis respectively. |
1(0,0,0,1) | Details |
| 19908141 | Chung DW, Yoo KY, Hwang IK, Kim DW, Chung JY, Lee CH, Choi JH, Choi SY, Youn HY, Lee IS, Won MH: Systemic Administration of Lipopolysaccharide Induces Cyclooxygenase-2 Immunoreactivity in Endothelium and Increases Microglia in the Mouse Hippocampus. Cell Mol Neurobiol. 2009 Nov 12. In addition, the ionized calcium-binding adapter molecule 1 (Iba-1)-immunoreactive ((+)) microglia were morphologically activated in the mouse hippocampus after LPS treatment. |
2(0,0,0,2) | Details |
| 19243075 | Lewis CA, Solomon JN, Rossi FM, Krieger C: Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX (3) CR1. Glia. 2009 Oct;57(13):1410-9. GFP+ and CX (3) CR1 (+/GFP) cells within the CNS have a variety of morphologies, including cells with an elongated appearance, weak Iba-1 immunoreactivity, and often receptor immunoreactivity, indicating that these cells are perivascular microglia. |
2(0,0,0,2) | Details |
| 17988243 | Xu H, Chen M, Manivannan A, Lois N, Forrester JV: Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008 Jan;7(1):58-68. Epub 2007 Nov 26. Confocal microscopy of retinal and choroid/RPE flat mounts demonstrated that most of the AF signals were derived from Iba-1+ perivascular and subretinal microglia. |
2(0,0,0,2) | Details |
| 18496347 | Hatashita S, Sekiguchi M, Kobayashi H, Konno S, Kikuchi S: Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats. Spine (Phila Pa 1976). 2008 May 20;33(12):1344-51. Expression of TNF-alpha and GFAP in bilateral L5 DRGs and expression of GFAP and ionized -binding adaptor molecule-1 (Iba-1) in bilateral L5 spinal dorsal horns were studied using immunohistochemistry and immunoblotting. |
1(0,0,0,1) | Details |
| 17267172 | Beggs S, Salter MW: Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Exp Neurol. 2010 Jan;221(1):231-45. Epub 2009 Nov 11. Design-based stereological techniques were combined with iba-1 immunohistochemistry to estimate the total number of microglia in the spinal dorsal horn in naive and peripheral nerve-injured adult rats. |
1(0,0,0,1) | Details |
| 19368835 | Hwang IK, Yoo KY, Yi SS, Kim IY, Hwang HS, Lee KY, Choi SM, Lee IS, Yoon YS, Kim SY, Won MH, Seong JK: Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils. Brain Res. 2009 Mar 31;1263:134-42. Epub 2009 Jan 31. In addition, tTG immunoreaction was expressed in microglia which were immunostained with Iba-1 at 4 days post-ischemia, and tTG immunoreactivity in the microglia was also highest at 5 days post-ischemia. |
1(0,0,0,1) | Details |
| 18080746 | Saxena K, Patro N, Patro I: FK506 protects neurons following peripheral nerve injury via immunosuppression. Cell Mol Neurobiol. 2007 Dec;27(8):1049-57. Epub 2007 Dec 14. The cryocut sections were used for immunohistochemistry for localizing all microglia (using anti-Iba-1) and MHC-II expressing microglia (with OX-6). |
2(0,0,0,2) | Details |
| 12202516 | Naskar R, Wissing M, Thanos S: Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Glia. 2007 Aug 15;55(11):1189-98. Activated microglia and RGCs were also identified immunocytochemically, with an antibody against ionized -binding adaptor molecule (Iba)-1 and an antibody specific to the 200-kDa subunit of the neurofilament protein, respectively. |
1(0,0,0,1) | Details |
| 17928735 | Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M: Involvement of (A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci. 2007 Oct;105(2):211-4. Epub 2007 Oct 6. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. |
1(0,0,0,1) | Details |
| 18055806 | Du J, Tran T, Fu C, Sretavan DW: Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss. J Neurotrauma. 2010 Feb 1. EphB2 was expressed by F4/80 (+), MOMA2 (+), ED1 (-) macrophage-like cells, ephrin-B2 was expressed by Iba-1 (+) microglia and GFAP (+) astrocytes, whereas EphA4 was expressed by GFAP (+) astrocytes. |
1(0,0,0,1) | Details |
| 12944523 | Babcock AA, Kuziel WA, Rivest S, Owens T: Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci. 2003 Aug 27;23(21):7922-30. In situ hybridization combined with immunohistochemistry for ionized binding adapter molecule (iba) 1 or glial fibrillary acidic protein (GFAP) identified iba1+ microglia and GFAP+ astrocytes as major sources of MCP-1/CCL2 within the lesion-reactive hippocampus. |
1(0,0,0,1) | Details |
| 16835629 | Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, Cerami A, Brines M, Leist M, Ghezzi P, Torup L: Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab. 2007 Mar;27(3):552-63. Epub 2006 Jul 12. Brain sections were stained and analyzed for Iba-1, myeloperoxidase, Tau-1, CD68 (ED1), glial fibrillary acidic protein (GFAP), -Jade B staining, and overall infarct volumes. |
1(0,0,0,1) | Details |
| 18699778 | Schulze JO, Quedenau C, Roske Y, Adam T, Schuler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Bussow K: Structural and functional characterization of human Iba proteins. FEBS J. 2008 Sep;275(18):4627-40. Epub 2008 Aug 11. Iba2 is a homolog of ionized calcium-binding adapter molecule 1 (Iba1), a 17-kDa protein that binds and cross-links filamentous actin (F-actin) and localizes to membrane ruffles and phagocytic cups. |
1(0,0,0,1) | Details |
| 17088948 | He BP, Wang JJ, Zhang X, Wu Y, Wang M, Bay BH, Chang AY: Differential reactions of microglia to brain metastasis of lung cancer. . Brain Behav Immun. 2007 Jul;21(5):624-33. Epub 2006 Dec 16. There was an obvious increase in the number of microglia labeled with ionized binding adaptor molecule 1 (Iba-1) antibody, a specific marker of microglia. |
1(0,0,0,1) | Details |
| 18585922 | Nixon K, Kim DH, Potts EN, He J, Crews FT: Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis. Neurobiol Dis. 2008 Aug;31(2):218-29. Epub 2008 May 3. These new cells expressed a microglia-specific marker, Iba-1, and survived at least 2 months. |
1(0,0,0,1) | Details |
| 18703033 | Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, Takeuchi A, Yano A, Kurozumi K, Agari T, Miyoshi Y, Kinugasa K, Date I: Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells. Brain Res. 2008 Oct 9;1234:172-82. Epub 2008 Jul 30. Iba-1-positive inflammatory cells of rats receiving adult NPCs were prominent, compared to those receiving embryonic NPCs, which might be a rationale for the differences between rats receiving adult and embryonic NPCs in the number of surviving NPCs. |
1(0,0,0,1) | Details |
| 12843240 | Martin A, Hofmann HD, Kirsch M: Glial reactivity in ciliary neurotrophic factor-deficient mice after optic nerve lesion. J Neurosci. 2003 Jul 2;23(13):5416-24. Lesion-induced upregulation of Iba-1, ICAM-1, and F4/80 in microglial cells was unaffected in CNTF-deficient animals. |
1(0,0,0,1) | Details |
| 18977160 | Wodarski R, Clark AK, Grist J, Marchand F, Malcangio M: reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. Eur J Pain. 2009 Sep;13(8):807-11. Epub 2008 Oct 31. Quantification of cell markers Iba-1 for microglia and GFAP for astrocytes revealed extensive activation of microglia in the dorsal horn of diabetic rats, whereas a reduction in the number of astrocytes could be observed. |
1(0,0,0,1) | Details |
| 20002517 | Pifarre P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A: Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. J Neurochem. 2010 Feb;112(3):807-17. Epub 2009 Nov 30. In contrast, zaprinast decreased the number of round/ameboid lectin-positive cells and the expression of the activated microglia/macrophage markers Iba-1 and CD11b indicating decreased recruitment and activation of these cells. |
1(0,0,0,1) | Details |
| 20030829 | Ryu JK, Cho T, Wang YT, McLarnon JG: Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain. J Neuroinflammation. 2009 Dec 23;6:39. Immunohistochemical analysis was carried out (7 d post-NPC transplantation, 10 d post-peptide/PBS injection) for GFP, microgliosis (Iba-1 marker), astrogliosis (GFAP marker), neuron viability (MAP-2 marker) and levels of the proinflammatory cytokine, TNF-alpha. |
1(0,0,0,1) | Details |
| 19267908 | Buhler LA, Samara R, Guzman E, Wilson CL, Krizanac-Bengez L, Janigro D, Ethell DW: Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis. BMC Neurosci. 2009 Mar 6;10:17. At the peak of EAE wild-type mice had MMP-7 immuno-reactive cells in vascular cuffs that also expressed the macrophage markers Iba-1 and Gr-1, as well as tomato lectin. |
1(0,0,0,1) | Details |
| 9789110 | Sunagawa M, Yokoshiki H, Seki T, Sperelakis N: Intracellular application of calmidazolium increases Ca2+ current through activation of protein kinase A in cultured vascular smooth muscle cells. Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2962-8. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carrier) was evoked every 15 s by a test potential to +10 mV from a holding potential of -60 mV. To test the effect of CaM on IBa, 1 microM calmidazolium (CMZ), an inhibitor of CaM, was added to the pipette solution (pCa of 6.5 or 300 nM [Ca] i). |
1(0,0,0,1) | Details |
| 19076732 | He J, Overstreet DH, Crews FT: Abstinence from moderate self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P rats. Alcohol Clin Exp Res. 2009 Jan;33(1):129-38. Epub 2008 Dec 10. Animals were then killed 4 weeks later to conduct immunohistochemical and confocal analyses using antibodies against BrdU and other phenotypic markers (NeuN for mature neurons; Iba-1 for microglia; GFAP for astrocytes; and NG (2) for oligodendrocyte progenitors). |
1(0,0,0,1) | Details |
| 10776916 | Isaksson J, Farooque M, Olsson Y: Spinal cord injury in ICAM-1-deficient mice: assessment of functional and histopathological outcome. J Neurotrauma. 2000 Apr;17(4):333-44. Luxol-stained, MAP2-, GFAP- and iba-1-immunostained cross-sectional areas were quantitated using a computerized image analysis system to investigate white matter damage, neuronal loss, astrocytic response and microglial activation respectively. |
1(0,0,0,1) | Details |
| 19582534 | Cho Y, Son HJ, Kim EM, Choi JH, Kim ST, Ji IJ, Choi DH, Joh TH, Kim YS, Hwang O: Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotox Res. 2009 Nov;16(4):361-71. Epub 2009 Jul 7. In vivo, doxycycline provided neuroprotection of the nigral DAergic neurons following MPTP treatment, as assessed by tyrosine hydroxylase immunocytochemistry and silver staining, and suppressed microglial activation and astrogliosis as assessed by Iba-1 and GFAP immunochemistry, respectively. |
1(0,0,0,1) | Details |
| 20025929 | Sakoori K, Murphy NP: Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice. Neurosci Lett. 2010 Jan 29;469(3):309-13. Epub 2009 Dec 16. Three days later, brains were immunohistochemically processed to visualize methamphetamine-induced loss of tyrosine hydroxylase (as a marker of damage to terminals), glial fibrillary acidic protein (GFAP, as a marker of astrocytes), and ionized calcium-binding adapter molecule 1 (lba-1, as a marker of microglia) in the striatum. |
1(0,0,0,1) | Details |
| 17560721 | Echeverry S, Shi XQ, Zhang J: Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain. 2008 Mar;135(1-2):37-47. Epub 2007 Jun 8. The majority of the proliferating cells were Iba-1 (+) microglia, together with some NG2 (+) oligodendrocyte progenitors, and GFAP (+) astrocytes. |
1(0,0,0,1) | Details |
| 20353427 | Uchida H, Yokoyama H, Kimoto H, Kato H, Araki T: Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. Int J Exp Pathol. 2010 Mar 26. In the present study, we investigated long-term changes in the ipsilateral substantia nigra from 1 up to 20 weeks after 90 min of transient focal cerebral ischaemia in rats, using tyrosine hydroxylase (TH), neuronal nuclei (NeuN), Iba-1, glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) immunostaining. |
1(0,0,0,1) | Details |
| 18671880 | Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, Wang F, Leung H, Matsui T, Miyoshi Y, Date I: Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons. BMC Neurosci. 2008 Aug 1;9:75. TUNEL, HEt and Iba-1 staining in vivo might demonstrate the involvement of anti-apoptotic, anti-oxidative and anti-inflammatory effects of edaravone-administration. |
1(0,0,0,1) | Details |
| 20220055 | Glybina IV, Kennedy A, Ashton P, Abrams G, Iezzi R: Intravitreous Delivery of the Corticosteroid FluocinoloneAcetonide Attenuates Retinal Degeneration in S334ter-4 Rats. Invest Ophthalmol Vis Sci. 2010 Mar 10. Microglial cell counts were obtained from retinal wholemounts labeled for Iba-1. |
1(0,0,0,1) | Details |
| 19249294 | Shapiro LA, Perez ZD, Foresti ML, Arisi GM, Ribak CE: Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus. Brain Res. 2009 Apr 17;1266:29-36. Epub 2009 Feb 26. These data showing "resting" Iba-1 labeled microglial cells in the normal adult rat dentate gyrus provide a basis for comparison with the morphology of microglial cells in disease and injury models where they are activated or phagocytotic. |
1(0,0,0,1) | Details |
| 18362111 | Sappington RM, Calkins DJ: Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3004-17. Epub 2008 Mar 24. METHODS: The authors first examined IL-6 colocalization with the microglia marker Iba-1 in the DBA/2 mouse model of glaucoma to establish relevance. |
1(0,0,0,1) | Details |
| 19837065 | Lathia JD, Chigurupati S, Thundyil J, Selvaraj PK, Mughal MR, Woodruff TM, Chan SL, Karamyan VT, Mattson MP, Arumugam TV: Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. 382. Double-label immunohistochemical analysis for beta1 integrin with neuronal (NeuN), microglial (Iba-1), astrocyte (GFAP), progenitor cell (Ng2) and blood vessel (collagen 4) markers showed that beta1 integrin expression only localized to blood vessels. |
1(0,0,0,1) | Details |
| 19410369 | Hathway GJ, Vega-Avelaira D, Moss A, Ingram R, Fitzgerald M: Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Pain. 2009 Jul;144(1-2):110-8. Epub 2009 May 1. C-fibre evoked sensitization was accompanied by significant microglial activation, shown by increased Iba-1 immunoreactivity throughout the dorsal horn at 24 and 48 h and significant upregulation of markers of microglial activation: IL-6 and Mcp-1 at 3h and Mmp3, CSF-1 and CD163 at 24 and 48 h. |
1(0,0,0,1) | Details |
| 16846658 | Wada M, Yoshimi K, Higo N, Ren YR, Mochizuki H, Mizuno Y, Kitazawa S: Statistical parametric mapping of immunopositive cell density. Neurosci Res. 2006 Sep;56(1):96-102. Epub 2006 Jul 17. As an example, we compared Iba-1 (microglial marker) positive cell densities in rats with (n=6) and without (n=6) unilateral injection of 1-methyl-4-phenylpyridinium salt (MPP+). |
1(0,0,0,1) | Details |
| 2511858 | Zhang ZH, Liu H, Zhao LH, Han XZ: [Clonal propagation of Gynostemma pentaphyllum (Thumb.) Makino in test tubes]. Zhongguo Zhong Yao Za Zhi. 1989 Jun;14(6):335-6 When the segments of shoots were grown on the 1/2MS medium supplemented with IBA 1 mg/L, roots were initiated differentiating to plantlets. |
1(0,0,0,1) | Details |
| 19070908 | Kalm M, Lannering B, Bjork-Eriksson T, Blomgren K: Irradiation-induced loss of microglia in the young brain. . J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13. The number of Iba-1-positive microglia increased 6 h after IR but had decreased 7 days later, below control levels, and this decrease was more pronounced in P9 rats. |
1(0,0,0,1) | Details |
| 18850268 | Hwang IK, Kim IY, Kim YN, Yi SS, Park IS, Min BH, Doo HK, Ahn SY, Kim YS, Lee IS, Yoon YS, Seong JK: Comparative study on high fat diet-induced 4--2E-nonenal adducts in the hippocampal CA1 region of C57BL/6N and C3H/HeN mice. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5567-81. In addition, ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactive microglia in the HD fed C57BL/6N showed hypertrophy of cytoplasm, which is the characteristics of activated microglia. |
1(0,0,0,1) | Details |
| 19608545 | Mendes-Jorge L, Ramos D, Luppo M, Llombart C, Alexandre-Pires G, Nacher V, Melgarejo V, Correia M, Navarro M, Carretero A, Tafuro S, Rodriguez-Baeza A, Esperanca-Pina JA, Bosch F, Ruberte J: Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5997-6005. Epub 2009 Jul 15. RESULTS: The macrophages analyzed constituted a small population of resident perivascular cells different from microglia, since they were Iba-1 negative. |
1(0,0,0,1) | Details |
| 19834041 | Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B, Alavi MV: Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1424-31. Epub 2009 Oct 15. Phagocytosis-dependent labeled microglial cells were identified by an Iba-1 staining. |
1(0,0,0,1) | Details |
| 16841189 | Hwang IK, Yoo KY, Kim DW, Choi SY, Kang TC, Kim YS, Won MH: Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion. Neurochem Res. 2006 Jul;31(7):957-65. Epub 2006 Jul 14. |
11(0,0,0,11) | Details |
| 18057827 | Choi JH, Lee CH, Hwang IK, Won MH, Seong JK, Yoon YS, Lee HS, Lee IS: Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region. J Vet Med Sci. 2007 Nov;69(11):1131-6. |
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| 18270819 | Hwang IK, Lee CH, Li H, Yoo KY, Choi JH, Kim DW, Kim DW, Suh HW, Won MH: Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs. Neurochem Res. 2008 Jul;33(7):1309-15. Epub 2008 Feb 13. |
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| 17823975 | Ji KA, Yang MS, Jeong HK, Min KJ, Kang SH, Jou I, Joe EH: Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain. Glia. 2007 Nov 15;55(15):1577-88. To understand contribution of microglia and blood inflammatory cells to brain inflammation, the behavior of microglia, neutrophils, and monocytes was investigated in LPS (lipopolysaccharide)-injected substantia nigra pars compacta, cortex, and hippocampus of normal and/or leukopenic rats using specific markers of neutrophils (myeloperoxidase, MPO), and microglia and monocytes (ionized binding adaptor molecule-1, Iba-1), as well as a general marker for these inflammatory cells (CD11b). |
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| 16920084 | Li ZH, Lu J, Tay SS, Wu YJ, Strong MJ, He BP: Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feature in pre-clinical development of neurodegenerative diseases. Brain Res. 2006 Oct 3;1113(1):200-9. Epub 2006 Aug 22. In addition, retardation in morphological transformation from activated to amoeboid microglia in response to sciatic nerve injury, differential expressions of some cytokines in the lumbar cord segments and induction of Iba-1 (ionized -binding adaptor molecule-1) expression in microglia were observed in NFL-/- mice. |
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| 18343932 | Zecca L, Wilms H, Geick S, Claasen JH, Brandenburg LO, Holzknecht C, Panizza ML, Zucca FA, Deuschl G, Sievers J, Lucius R: Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta Neuropathol. 2008 Jul;116(1):47-55. Epub 2008 Mar 15. After different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (SN, 1 week) were stained with Iba-1 and/or GFAP antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (TH) to monitor dopaminergic cell survival (SN group only). |
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| 19407016 | Glybina IV, Kennedy A, Ashton P, Abrams GW, Iezzi R: Photoreceptor neuroprotection in RCS rats via low-dose intravitreal sustained-delivery of fluocinolone acetonide. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4847-57. Epub 2009 Apr 30. Total microglial cell counts were made by using Iba-1 antibody labeling. |
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| 20012688 | Chung JY, Choi JH, Lee CH, Yoo KY, Won MH, Yoo DY, Kim DW, Choi SY, Youn HY, Moon SM, Hwang IK: Comparison of ionized calcium-binding adapter molecule 1-immunoreactive microglia in the spinal cord between young adult and aged dogs. Neurochem Res. 2010 Apr;35(4):620-7. |
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| 19122416 | Lee CH, Hwang IK, Lee IS, Yoo KY, Choi JH, Lee BH, Won MH: Differential immunoreactivity of microglial and astrocytic marker protein in the hippocampus of the seizure resistant and sensitive gerbils. J Vet Med Sci. 2008 Dec;70(12):1405-9. In the present study, we compared differences in ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) immunoreactivities for microglia and astrocytes, respectively, in the hippocampus of the seizure-resistant (SR) and seizure-sensitive (SS) gerbils. |
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| 18487364 | Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H: Characteristics of bone marrow-derived microglia in the normal and injured retina. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4162-8. Epub 2008 May 16. One month to 12 months after BM transplantation, eyes were analyzed histologically for the expression of EGFP and various monocyte/microglia/macrophage markers (Iba-1, F4/80, GS-1, major histocompatibility complex [MHC] class II). |
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| 17245706 | Berglof E, Af Bjerken S, Stromberg I: Glial influence on nerve fiber formation from rat ventral mesencephalic organotypic tissue cultures. J Comp Neurol. 2007 Mar 20;501(3):431-42. Vimentin-positive cells preceded migration of NG2-positive oligodendrocytes and Iba-1-positive microglia. |
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| 19913017 | Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS: HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes. Exp Neurol. 2010 Jan;221(1):107-14. Epub 2009 Oct 21. CD11b-positive microglia were increased 1 day post-challenge; Iba-1- and ED1-positive cells peaked at 7 days and 14 days. |
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| 19472050 | Kimoto H, Eto R, Abe M, Kato H, Araki T: Alterations of glial cells in the mouse hippocampus during postnatal development. Exp Neurol. 2008 Apr;210(2):349-58. Epub 2007 Dec 3. Neuronal nuclei (NeuN), Glial fibrillary acidic protein (GFAP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and ionized binding adaptor molecule 1 (Iba 1) immunoreactivity were measured in 1-, 2-, 4-, and 8-week-old mice. |
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| 19555675 | Hernstadt H, Wang S, Lim G, Mao J: Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. Cell Mol Neurobiol. 2009 Dec;29(8):1181-9. Epub . Immunohistochemistry was performed using Iba-1 (microglia), NeuN (neurons), anti-Glial Fibrillary Acidic Protein, GFAP (astrocytes) and anti-PBR (TSPO) on Days 1, 7 and 14 after CFA-induced arthritis. |
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| 18612315 | Hilton GD, Stoica BA, Byrnes KR, Faden AI: Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. J Cereb Blood Flow Metab. 2008 Nov;28(11):1845-59. Epub 2008 Jul 9. Treatment also decreased microglial activation after TBI, as reflected by reductions in ED1, galectin-3, p22 (PHOX), and Iba-1 levels, and attenuated astrogliosis, as shown by decreased accumulation of glial fibrillary acidic protein. |
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| 18538310 | Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA: A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008 Jul 11;1219:116-26. Epub 2008 May 11. Immunohistochemistry was performed using anti-ionized binding adaptor protein, Iba-1 (microglia), and anti-Glial Fibrillary Acidic Protein, GFAP (astrocytes) on day 1, 4 and 7 after surgery. |
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| 17600341 | Xu H, Chen M, Mayer EJ, Forrester JV, Dick AD: Turnover of resident retinal microglia in the normal adult mouse. Mol Med. 2006 Jul-Aug;12(7-8):161-70. Retinal microglia were identified by F4/80, CD45, and Iba-1 immunostaining. |
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| 8979516 | Nataraja K, Neelambika GK: Somatic embryogenesis and plantlet from petal cultures of pomegranate, Punica granatum L. Indian J Exp Biol. 1996 Jul;34(7):719-21. Numerous embryoids formed from friable callus on MS with 5 mg/L of IAA, IBA or developed only roots, but those formed on MS with 5 mg/L of BAP or KN developed shoots. However, callus induced on MS with IAA (1 mg/L) or IBA (1 mg/L) on subculturing in the same medium with half-strength salts and (4%) produced both roots and shoots resulting in plantlets. |
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