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imidacloprid

Identification (Source:EPA,EU)

ID	1457
Name	imidacloprid
CAS	138261-41-3
IUPAC
Inchi	InChI=1/C9H10ClN5O2/c10-8-2-1-7(5-12-8)6-14-4-3-11-9(14)13-15(16)17/h1-2,5H,3-4,6H2,(H,11,13)/f/h11H/b13-9+
CIPAC	582
EPA Code	129099
Formula	C9H10ClN5O2
SMILES	[O-][N+](=O)NC/1=N/CCN\1Cc2cnc(Cl)cc2
Status	Approved

Classification

Mode of Action	Systemic with contact and stomach action. Acetylcholine receptor (nAChR) agonist.
Pesticide Type	Insecticide, Veterinary treatment
Chemical Group	Neonicotinoid
Classification	nitroguanidine nicotinoid insecticides pyridylmethylamine nicotinoid insecticides

Properties (Source:PubChem)

Molecular Weight	255.66
Physical State	Colourless to cream crystalline powder depending on purity
AlogP	2.962
H-Bond Donor	1
H-Bond Acceptor	5
Surface Area	239.08
Polar Surface Area	86.34

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	10 mg l-1
Algae	Acute	72 hour	EC50, growth	> 10 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.046 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	85 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	1.8 mg l-1
Birds	Acute		LD50	31 mg kg-1
Earthworms	Acute	14 day	LD50	10.7 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	0.178 mg kg-1
Fish	Chronic	21 day	NOEC	9.02 mg l-1
Fish	Acute	96 hour	LC50	211 mg l-1
Honeybees	Acute	48 hour	LD50	0.0037 μg bee-1
Mammals	Acute oral		LD50	131 mg kg-1
Mammals	Short term dietary		NOEL	> 120 ppm diet
Mammals	Short term dietary		NOEL	> 13 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.055 mg l-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	> 0.0027 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	0.61

Related targets

Target Name	RScore (About this table)
acetylcholine receptor (protein family or complex)	2583(23,40,58,143)	Details
aldehyde oxidase	199(2,3,3,9)	Details
Acetylcholinesterase	183(2,2,4,13)	Details
hemoglobin (protein family or complex)	163(2,2,2,3)	Details
GABA receptor (protein family or complex)	149(1,3,3,9)	Details
cytochrome P450 (protein family or complex)	136(1,2,4,16)	Details
CYP3A4	93(1,1,2,8)	Details
NNO2	81(1,1,1,1)	Details
Koc	38(0,1,2,3)	Details
ha 1	37(0,1,2,2)	Details
glial fibrillary acidic protein	19(0,0,3,4)	Details
C18	16(0,0,2,6)	Details
glutathione S transferase	15(0,0,2,5)	Details
F11	13(0,0,2,3)	Details
thymoma	13(0,0,2,3)	Details
muscles	9(0,0,1,4)	Details
cytochrome P450 monooxygenase	9(0,0,1,4)	Details
HSP27	8(0,0,1,3)	Details

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