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niclosamide

Identification (Source:EPA,EU)

ID	1671
Name	niclosamide
CAS	50-65-7
IUPAC	2′,5-dichloro-4′-nitrosalicylanilide
Inchi	InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
CIPAC	599
EPA Code
Formula	C13H8Cl2N2O4
SMILES	c1(C(Nc2c(cc([N+](=O)[O-])cc2)Cl)=O)c(ccc(c1)Cl)O
Status	Not Available

Classification

Mode of Action	Respiratory & stomach action. Acts by uncoupling oxidative phosphorylation in the tapeworm
Pesticide Type	Fungicide, Molluscide, Nematicide, Veterinary treatment
Chemical Group	Chloronitrophenol
Classification	Molluscicides

Properties (Source:PubChem)

Molecular Weight	327.12
Physical State	Yellow-grey coloured crystalline solid
AlogP	3.595
H-Bond Donor	2
H-Bond Acceptor	4
Surface Area	290.52
Polar Surface Area	95.15

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	5.0 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.2 mg l-1
Birds	Acute		LD50	> 2000 mg kg-1
Fish	Acute	96 hour	LC50	0.34 mg l-1
Mammals	Acute oral		LD50	> 5000 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	1.6 mg l-1
	Bio-concentration factor		BCF	250
	Bio-concentration factor		CT50	ND days

Related targets

Target Name	RScore (About this table)
SARS	181(2,2,3,16)	Details
CYP2C9	166(2,2,2,6)	Details
IkappaBalpha	82(1,1,1,2)	Details
CBF1	82(1,1,1,2)	Details
IkappaB kinase	81(1,1,1,1)	Details
TAK1	81(1,1,1,1)	Details
beta catenin	81(1,1,1,1)	Details
transferrin	81(1,1,1,1)	Details
CYP1A2	35(0,1,1,5)	Details
beta 2 adrenergic receptor	31(0,1,1,1)	Details
Dishevelled 2	31(0,1,1,1)	Details
demethylase	31(0,1,1,1)	Details
muscles	19(0,0,3,4)	Details

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