| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9139240 | Hinz V, Grewig S, Schmidt BH: Metrifonate and dichlorvos: effects of a single oral administration on cholinesterase activity in rat brain and blood. Neurochem Res. 1996 Mar;21(3):339-45. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.) induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and plasma. |
220(2,3,7,10) | Details |
| 9139239 | Hinz VC, Grewig S, Schmidt BH: Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos. Neurochem Res. 1996 Mar;21(3):331-7. |
193(2,3,3,3) | Details |
| 19371524 | Kose A, Gunay N, Yildirim C, Tarakcioglu M, Sari I, Demiryurek AT: Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime. Am J Emerg Med. 2009 Feb;27(2):169-75. Serum cholinesterase levels were suppressed with dichlorvos, and these reductions were inhibited with atropine and/or pralidoxime pretreatment. |
82(1,1,1,2) | Details |
| 18788997 | Taylor JT, Davis E, Dabisch P, Horsmon M, Li M, Mioduszewski R: Alterations in autonomic function in the guinea pig eye following exposure to dichlorvos vapor. J Ocul Pharmacol Ther. 2008 Oct;24(5):473-9. The present study investigated the effect of the organophosphate, dichlorvos (DDVP), on ocular function and cholinesterase activity in guinea pigs, using a single-animal-head-only vapor exposure system. |
82(1,1,1,2) | Details |
| 1609493 | Abdul Awal M: The influence of single topical application of dichlorvos on blood esterases and toxicity in male calves. Vet Hum Toxicol. 1992 Jun;34(3):229-31. Dichlorvos at all concentrations significantly inhibited erythrocyte cholinesterase (25-75%), plasma cholinesterase (30-85%), and serum carboxylesterase (15-51%) activities in male calves. |
162(2,2,2,2) | Details |
| 16293993 | Al-Jobory MM, Mohammad FK: Validation of an electrometric blood cholinesterase measurement in goats. J Vet Sci. 2005 Dec;6(4):299-303. The organophosphorus insecticides dichlorvos and diazinon at 0.5-4 microM and the insecticide carbaryl at 5-20 microM in the reaction mixture significantly inhibited plasma (13.7-85.5%) and erythrocyte (16.4-71.9%) cholinesterases in vitro in a concentration-dependent manner. |
87(1,1,1,7) | Details |
| 12676073 | Xiong YQ, Zeng FD: Effect of neferine on toxicodynamics of dichlorvos for inhibiting rabbit cholinesterase. Acta Pharmacol Sin. 2003 Apr;24(4):332-6. |
162(2,2,2,2) | Details |
| 2731661 | Casale GP, Bavari S, Connolly JJ: Inhibition of human serum complement activity by diisopropylfluorophosphate and selected anticholinesterase insecticides. Fundam Appl Toxicol. 1989 Apr;12(3):460-8. Since the widely used anticholinesterase insecticides inhibit serine esterases, the present study evaluated potencies of carbaryl, carbofuran, dichlorvos, and paraoxon to inhibit C' activities of a panel of normal human sera. |
83(1,1,1,3) | Details |
| 12143930 | Varo I, Navarro JC, Amat F, Guilhermino L: Characterisation of cholinesterases and evaluation of the inhibitory potential of chlorpyrifos and dichlorvos to Artemia salina and Artemia parthenogenetica. Chemosphere. 2002 Aug;48(6):563-9. |
82(1,1,1,2) | Details |
| 3113033 | Nistiarova A, Nistiar F, Bajgar J: [Use of sheep erythrocytes and plasma for the determination of neuroparalytic substances in vitro]. Vet Med. 1987 Jun;32(6):365-9. Dichlorvos administered at the rate of 94.64 ng per litre induced 50% inhibition of acetylcholinesterase in the erythrocytes; administration of dichlorvos at the rate of 243.82 ng per litre caused a 50% inhibition of butyrylcholinesterase in the plasma. |
82(1,1,1,2) | Details |
| 16036766 | Petroianu GA, Schmitt A, Arafat K, Hasan MY: Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride. Int J Toxicol. 2005 Mar-Apr;24(2):79-86. |
86(1,1,1,6) | Details |
| 9931232 | Sturm A, Hansen P: Altered cholinesterase and monooxygenase levels in Daphnia magna and Chironomus riparius exposed to environmental pollutants. Ecotoxicol Environ Saf. 1999 Jan;42(1):9-15. Parathion, dichlorvos, and aldicarb caused dose-related inhibition of cholinesterase (ChE) in 24-h bioassays with both species. |
83(1,1,1,3) | Details |
| 7344415 | Reiner E: Esterases in schistosomes: reaction with substrates and inhibitors. . Acta Pharmacol Toxicol. 1981;49 Suppl 5:72-8. Dichlorvos (0,0-dimethyl-2,2-dichlorovinyl is a phosphorylating inhibitor; the rate constants of inhibition of cholinesterases from schistosomes are in the order of 10 (5) M-1 min.-1. |
83(1,1,1,3) | Details |
| 7286188 | Kutsenko SA, Savateev NV: [Cerebral catecholamines in acute rat poisoning with dimethoxydichlorovinyl Farmakol Toksikol. 1981 May-Jun;44(3):334-8. Fluorescent histochemistry was used in experiments on rats to demonstrate that 30 minutes after administration of the anticholinesterase insecticide dimethoxydichlorvinyl (DDVPh) in a dose of 10 mg/kg there were changes in the catecholamine content in the brain structures. |
1(0,0,0,1) | Details |
| 6790136 | Lutz-Ostertag Y, Bruel MT: [Embryotoxic and teratogenic action of dichlorvos (organophosphate insecticide) on the development of the quail embryo]. C R Seances Acad Sci III. 1981 May 18;292(18):1051-4. The embryos surviving beyond the 5th day were affected with multiple malformations associated to those ascribed to an anticholinesterase action: lordosis, scoliosis... |
1(0,0,0,1) | Details |
| 18368617 | Taylor JT, Davis E, Dabisch P, Horsmon M, Matson K, Crouse C, Mioduszewski R: Acute toxic effects of inhaled dichlorvos vapor on respiratory mechanics and blood cholinesterase activity in guinea pigs. Inhal Toxicol. 2008 Mar;20(5):465-72. Using a modified noninvasive volume-displacement plethysmography system, we investigated the effects of inhaled dichlorvos (2,2-dimethyl-dichlorovinyl or DDVP) vapor on the respiratory mechanics and blood cholinesterase activity of guinea pigs. |
38(0,1,2,3) | Details |
| 6098064 | Nistiar F, Hrusovsky J, Mojzis J, Mizik P: [Distribution of dichlorvos in the rat and the effect of clinoptilolite on poisoning]. Vet Med. 1984 Nov;29(11):689-98. The objective of the trials was to examine the distribution of dichlorvos in the body of a rat on the basis of tissue cholinesterase inhibition. |
38(0,1,2,3) | Details |
| 12190811 | Sener EB, Ustun E, Kocamanoglu S, Tur A: Prolonged apnea following succinylcholine administration in undiagnosed acute organophosphate poisoning. Acta Anaesthesiol Scand. 2002 Sep;46(8):1046-8. Organophosphates (OP) are irreversibly bound to cholinesterase, causing deactivation of acetylcholinesterase. |
3(0,0,0,3) | Details |
| 7605915 | Mori F, Lai CC, Fusi F, Giacobini E: Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. . Neuroreport. 1995 Mar 7;6(4):633-6. |
3(0,0,0,3) | Details |
| 7469957 | Purshottam T, Kaveeshwar U: Effect of on regeneration of dichlorovos-inhibited plasma cholinesterase activity in vitro. Aviat Space Environ Med. 1980 Oct;51(10):1134-8. |
3(0,0,0,3) | Details |
| 2153864 | Casebolt DB, Leary SL, Undeutsch L: Effects of dichlorvos treatment on mouse reproduction. Lab Anim Sci. 1990 Jan;40(1):65-7. All exposure levels resulted in decreased plasma cholinesterase concentrations in treated mice for up to 10 days following the completion of exposure. |
1(0,0,0,1) | Details |
| 8083479 | Kobayashi H, Sato I, Akatsu Y, Fujii S, Suzuki T, Matsusaka N, Yuyama A: Effects of single or repeated administration of a propoxur, and an organophosphate, DDVP, on jejunal cholinergic activities and contractile responses in rats. J Appl Toxicol. 1994 May-Jun;14(3):185-90. In summary, propoxur and DDVP showed similar effects mainly through their anticholinesterase properties in the case of single injection, but DDVP had similar effects to those of oxotremorine and propoxur had similar effects to those of atropine in the case of repeated injection. Wistar rats were injected once or repeatedly for 10 days with dichlorvos (DDVP, 5 mg kg-1), propoxur (10 mg kg-1), oxotremorine (0.1 mg kg-1) or atropine (5 mg kg-1). |
1(0,0,0,1) | Details |
| 8359835 | Purshottam T, Kaveeshwar U: Comparative efficacy of exogenous acetylcholinesterase administration on soman and dichlorvos toxicity in rats. Indian J Exp Biol. 1993 Apr;31(4):365-8. Cholinesterase (ChE) activity in the blood serum of rats was elevated to 15, 25, and 45 times by the sc administration of 1000, 2000 and 3000 electric eel acetylcholinesterase (AChE) units respectively. |
1(0,0,0,1) | Details |
| 1276991 | Ecobichon DJ: Species differences in the reactivation of organophosphate-inhibited plasma esterases by diacetylmonoxime. Can J Physiol Pharmacol. 1976 Apr;54(2):86-92. In vitro, the DAM-catalyzed reactivation of plasma AliE and cholinesterases (psi ChE) of rat, rabbit and guinea pig inhibited by 10-5 M diisopropylphosphorofluoridate (DFP) and O,O-dimethyl-2,2-dichlorovinyl (DDVP) was investigated. |
1(0,0,0,1) | Details |
| 10414781 | Desi I, Nagymajtenyi L: Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Toxicol Lett. 1999 Jun 30;107(1-3):55-64. The analyzed functional parameters proved to be sensitive biomarkers of the exposure as they were changed by the lower doses, while the brain cholinesterase activity was considerably inhibited only in the groups given the highest dose. |
1(0,0,0,1) | Details |
| 8768721 | van der Staay FJ, Hinz VC, Schmidt BH: Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats. J Pharmacol Exp Ther. 1996 Aug;278(2):697-708. |
62(0,2,2,2) | Details |
| 2301824 | Khan AA, Coppock RW, Schuler MM, Lillie LE: Effects of dichlorvos on blood cholinesterase activities of cattle. Am J Vet Res. 1990 Jan;51(1):79-82. Inhibitory effects of dichlorvos (2,2-dichlorovinyl dimethyl DDVP) [corrected] on erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (ChE) activities of steers were characterized after treatments in vitro and in vivo (cutaneous application). |
37(0,1,2,2) | Details |
| 12558160 | Sanchez-Hernandez JC: Evaluating reptile exposure to cholinesterase-inhibiting agrochemicals by serum butyrylcholinesterase activity. Environ Toxicol Chem. 2003 Feb;22(2):296-301. In vitro assays showed that 10 (-4) M -2- methochloride (2-PAM) reactivated dichlorvos- or paraoxon-inhibited BChE activity within a 60-min incubation period. |
3(0,0,0,3) | Details |
| 8624119 | Giacobini E, Mori F, Lai CC: The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex. Ann N Y Acad Sci. 1996 Jan 17;777:393-8. |
3(0,0,0,3) | Details |
| 12389909 | Sanchez-Hernandez JC, Sanchez BM: Lizard cholinesterases as biomarkers of pesticide exposure: enzymological characterization. Environ Toxicol Chem. 2002 Nov;21(11):2319-25. Serum was incubated with different doses of the organophosphorus (OP) compounds dichlorvos and paraoxon and subsequently incubated in the presence of two concentrations of 2-PAM (2 x 10 (-2) or 2 x 10 (-4) M). |
3(0,0,0,3) | Details |
| 3669600 | DiGiacomo RF, Brodie SJ, Giddens WE Jr, Van Hoosier GL Jr: Dichlorvos toxicity in the white-footed mouse (Peromyscus leucopus). Lab Anim Sci. 1987 Aug;37(4):471-3. Mean serum cholinesterase in P. leucopus exposed to 3 and 6 g of DDVP was 0.35 and 0.21 U/ml as compared to 3.13 U/ml in unexposed mice. |
3(0,0,0,3) | Details |
| 9711194 | Cavaliere MJ, Puga FR, Calore EE, Calore NM, Pelegrino JR, da Rosa AR, Weg R: Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds. J Toxicol Clin Toxicol. 1998;36(4):295-300. CONCLUSIONS: Oxime reduced diaphragmatic muscle necrosis in experimental organophosphate intoxication, despite little effect on plasma cholinesterase. DESIGN: Adult male Wistar rats were given oral organophosphate compounds dissolved in formal: dichlorvos, isofenphos, metamidophos, and diazinon. |
1(0,0,0,1) | Details |
| 473212 | Reiner E, Plestina R: Regeneration of cholinesterase activities in humans and rats after inhibition by O,O-dimethyl-2,2-dichlorovinyl Toxicol Appl Pharmacol. 1979 Jul;49(3):451-4. |
1(0,0,0,1) | Details |
| 2815094 | Mohammad FK, al-Kassim NA, Abdul-Latif AR: Effect of on organophosphorus insecticide toxicity in mice. Toxicology. 1989 Sep;58(1):91-5. Male mice were treated orally with the organophosphorus insecticides fenamiphos and dichlorvos at 10 and 150 mg/kg, respectively. The insecticides produced signs of toxicosis characteristic of cholinesterase inhibition, and induced death in all treated mice. |
1(0,0,0,1) | Details |
| 17722737 | Raheja G, Gill KD: Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain. Toxicol Ind Health. 2007 Feb;23(1):25-37. Activity of the synthesizing enzyme of ie, choline acetyltransferase, was found to be significantly increased and the activity of hydrolyzing enzyme, acetyl cholinesterase (AChE), was inhibited in all the three brain regions studied. |
1(0,0,0,1) | Details |
| 1190924 | Modak AT, Stavinoha WB, Weintraub ST: Dichlorvos and the cholinergic system: effects on cholinesterase and and contents of rat tissues. Arch Int Pharmacodyn Ther. 1975 Oct;217(2):293-301. The inhibition of cholinesterase by 50 mg/kg/5 ml, p.o., dichlorvos and subsequent recovery of enzyme activity was uniform in all brain regions studied. |
37(0,1,2,2) | Details |
| 16129533 | MacGregor JA, Plunkett LM, Youngren SH, Manley A, Plunkett JB, Starr TB: Humans appear no more sensitive than laboratory animals to the inhibition of red blood cell cholinesterase by dichlorvos. Regul Toxicol Pharmacol. 2005 Nov;43(2):150-67. Epub 2005 Aug 29. Inhibition of red blood cell (RBC) cholinesterase is a consistent and sensitive indicator of exposure to dichlorvos (DDVP). |
33(0,1,1,3) | Details |
| 18639316 | Frasco MF, Fournier D, Carvalho F, Guilhermino L: Does mercury interact with the inhibitory effect of dichlorvos on Palaemon serratus (Crustacea: Decapoda) cholinesterase?. Sci Total Environ. 2008 Oct 1;404(1):88-93. Epub 2008 Jul 17. |
32(0,1,1,2) | Details |
| 3206954 | Menzikova OV: [The cholinesterase properties of Daphnia magna] . Zh Evol Biokhim Fiziol. 1988 Jul-Aug;24(4):596-8. |
3(0,0,0,3) | Details |
| 12629810 | Skopichev VG, Prozorovskii VB, Medvedeva SV: [Participation of a distant cholinergic mechanism in the response of the vascular bed to intoxication by organophosphorus inhibitors of cholinesterase]. Morfologiia. 2000;118(4):66-9. |
3(0,0,0,3) | Details |
| 11742736 | Andreou VG, Clonis YD: A portable fiber-optic pesticide biosensor based on immobilized cholinesterase and sol-gel entrapped bromcresol purple for in-field use. Biosens Bioelectron. 2002 Jan;17(1-2):61-9. A fiber-optic biosensor for the detection and determination of the pesticides carbaryl and dichlorvos was developed. |
2(0,0,0,2) | Details |
| 534330 | Badiugin IS, Titova NN, Khamitova RIa, Makarov NIa: [Clinical aspects of domestic poisonings and the pathogenesis of intoxication from anticholinesterase organophosphorus compounds] Voen Med Zh. 1979 Nov;(11):37-40. |
1(0,0,0,1) | Details |
| 9591287 | Papp A, Gyorgyi K, Nagymajtenyi L, Desi I: Effects of different types of anticholinesterase agents on in vivo hippocampal population spikes in rats. Neurobiology. 1997;5(4):495-8. |
1(0,0,0,1) | Details |
| 7344403 | Bloom A: Studies of the mode of action of metrifonate and DDVP in schistosomes - cholinesterase activity and the hepatic shift. Acta Pharmacol Toxicol. 1981;49 Suppl 5:109-13. |
1(0,0,0,1) | Details |
| 19949736 | Kang EJ, Seok SJ, Lee KH, Gil HW, Yang JO, Lee EY, Hong SY: Factors for determining survival in acute organophosphate poisoning. Korean J Intern Med. 2009 Dec;24(4):362-7. Epub 2009 Nov 27. The mortality was 0% for dichlorvos, malathion, chlorpyrifos and profenofos. We investigated patient survival according to initial parameters, including the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum cholinesterase level, and hemoperfusion and evaluated the mortality according to organophosphate types. |
1(0,0,0,1) | Details |
| 4631366 | Ecobichon DJ, Comeau AM: Pseudocholinesterases of mammalian plasma: physicochemical properties and organophosphate inhibition in eleven species. Toxicol Appl Pharmacol. 1973 Jan;24(1):92-100. |
1(0,0,0,1) | Details |
| 6535521 | Martinez-Zedillo G, Gonzalez-Barranco D, Rebolledo-Camacho P, Lara-Nunez MA: Kinetic aspects of Taenia solium metacestode cholinesterases and their inhibition with DDVP and neostigmine. Arch Invest Med. 1984 Oct-Dec;15(4):349-61. |
1(0,0,0,1) | Details |
| 653747 | Michalek H, Stavinoha WB: Effect of chlorpromazine pre-treatment on the inhibition of total cholinesterases and butyrylcholinesterase in brain of rats poisoned by physostigmine or dichlorvos. Toxicology. 1978 Mar;9(3):205-18. |
31(0,1,1,1) | Details |
| 7218377 | Kobayashi H, Yuyama A, Imajo S, Matsusaka N: Effects of acute and chronic administration of DDVP (dichlorvos) on distribution of brain in rats. J Toxicol Sci. 1980 Nov;5(4):311-9. DDVP (dichlorvos), an irreversible cholinesterase (ChE) inhibitor, was administered acutely and chronically to rats in order to investigate effects on the distribution of brain |
31(0,1,1,1) | Details |
| 1227901 | Kagan IuS, Kokshareva NV, Sasinovich LM, Krivenchuk VE: [Experimental data on a new cholinesterase reactivator from the group of thiohydroximic esters]. Farmakol Toksikol. 1975 May-Jun;38(3):294-8. |
3(0,0,0,3) | Details |
| 15979224 | Okamura A, Kamijima M, Shibata E, Ohtani K, Takagi K, Ueyama J, Watanabe Y, Omura M, Wang H, Ichihara G, Kondo T, Nakajima T: A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats. Toxicology. 2005 Sep 15;213(1-2):129-37. After that period, erythrocyte cholinesterase (ChE) activities decreased dose-dependently, showing 44-55% inhibition among the treated groups. |
2(0,0,0,2) | Details |
| 2264271 | Raina R, Srivastava AK, Malik JK: The influence of repeated oral administration of dichlorvos on circulating esterases in buffalo calves (Bubalus bubalis). Vet Hum Toxicol. 1990 Dec;32(6):577-9. Maximal inhibition of plasma cholinesterase (87-94%) and serum carboxylesterase (51-67%) was observed on the 28th day. |
1(0,0,0,1) | Details |
| 72085 | Bradway DE, Shafik TM, Lores EM: Comparison of cholinesterase activity, residue levels, and urinary metabolite excretion of rats exposed to organophosphorus pesticides. J Agric Food Chem. 1977 Nov-Dec;25(6):1353-8. |
1(0,0,0,1) | Details |
| 2767176 | Fraser PJ, Duncan G, Tomlinson J: Effect of a cholinesterase inhibitor on salmonid lens: a possible cause for the increased incidence of cataract in salmon Salmo salar (L.). Exp Eye Res. 1989 Aug;49(2):293-8. |
1(0,0,0,1) | Details |
| 7290176 | Wirthgen B, Raffke W: [Residues of dichlorvos (DDVP) in sausages and bacon following placement of Mutox strips in sales rooms of butchers' shops]. Nahrung. 1981;25(8):789-93. After extraction from the samples, Dichlorvos was determined thin-layer chromatographically using cholinesterase inhibition. |
31(0,1,1,1) | Details |
| 16449251 | Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE: Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicol Sci. 2006 May;91(1):166-72. Epub 2006 Jan 31. In an overview, inhibition of 28 serine hydrolases (including lipases) by eight OPs (chlorpyrifos oxon, diazoxon, paraoxon, dichlorvos, and four nonpesticides) showed that brain acetylcholinesterase is usually less sensitive than butyrylcholinesterase, liver esterase, cholesterol esterase, and KIAA1363. |
31(0,1,1,1) | Details |
| 7059232 | Purshottam T, Kaveeshwar U: Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos. Arch Environ Health. 1982 Jan-Feb;37(1):53-8. |
2(0,0,0,2) | Details |
| 16598855 | Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P: Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. Biochem Biophys Res Commun. 2006 Apr 14;342(3):973-8. We used mouse recombinant wild-type acetylcholinesterase (AChE; EC 3.1.1.7), butyrylcholinesterase (BChE; EC 3.1.1.8), and AChE mutants with mutations (Y337A, F295L, F297I, Y72N, Y124Q, and W286A) that resemble residues found at structurally equivalent positions in BChE, to find the basis for divergence between AChE and BChE in following reactions: reversible inhibition by two oximes, progressive inhibition by the organophosphorus compound DDVP, and oxime-assisted reactivation of the phosphorylated enzymes. |
2(0,0,0,2) | Details |
| 1711162 | Soininen H, Unni L, Shillcutt S: Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain. Neurochem Res. 1990 Dec;15(12):1185-90. Despite high brain ChE inhibition induced by metrifonate (MTF), dichlorvos (DDVP) or naled no changes in brain (NA), (DA) or occurred due to treatment with the study drugs in the acute study. |
2(0,0,0,2) | Details |
| 8424827 | Kaltner H, Andrae S, Wittmann J: Activity of cholinesterases in the Japanese quail embryo. Biochem Pharmacol. 1993 Jan 7;45(1):87-92. |
2(0,0,0,2) | Details |
| 7184787 | Nordgren I: Quantitation of metrifonate and dichlorvos in blood and tissues by gas chromatography-mass spectrometry. Fundam Appl Toxicol. 1981 Mar-Apr;1(2):230-7. The results were compared to erythrocyte and plasma cholinesterase determinations. |
2(0,0,0,2) | Details |
| 10340119 | Skopichev VG, Prozorovskii VB: [The distant effects of --links in the pathogenesis of poisoning by cholinesterase inhibitors]. Eksp Klin Farmakol. 1999 Mar-Apr;62(2):10-1. |
1(0,0,0,1) | Details |
| 82575 | Desi I, Varga L, Farkas I: Studies on the immunosuppressive effect of organochlorine and organophosphoric pesticides in subacute experiments. J Hyg Epidemiol Microbiol Immunol. 1978;22(1):115-22. Inihbition of cholinesterase activity confirmed the immunological findings. |
1(0,0,0,1) | Details |
| 423703 | Bell JU, Van Petten GR, Taylor PJ, Aiken MJ: The inhibition and reactivation of human maternal and fetal plasma cholinesterase following exposure to the organophosphate, dichlorvos. Life Sci. 1979 Jan 15;24(3):247-54. |
31(0,1,1,1) | Details |
| 1900819 | Chan PC, Huff J, Haseman JK, Alison R, Prejean JD: Carcinogenesis studies of dichlorvos in Fischer rats and B6C3F1 mice. Jpn J Cancer Res. 1991 Feb;82(2):157-64. Dichlorvos (dichlorovinyl dimethyl ester) is a cholinesterase inhibitor used widely as a contact and stomach insecticide for control of internal and external parasites. |
31(0,1,1,1) | Details |
| 19504058 | Gunay N, Kekec Z, Demiryurek S, Kose A, Namiduru ES, Gunay NE, Sari I, Demiryurek AT: Cardiac effects of magnesium sulfate pretreatment on acute dichlorvos-induced organophosphate poisoning: an experimental study in rats. Biol Trace Elem Res. 2010 Feb;133(2):227-35. Epub 2009 Jun 6. Serum cholinesterase levels were markedly depressed with dichlorvos, and further suppressed markedly with magnesium sulfate pretreatment. |
31(0,1,1,1) | Details |
| 9080632 | Yamashita M, Yamashita M, Tanaka J, Ando Y: Human mortality in organophosphate poisonings. Vet Hum Toxicol. 1997 Apr;39(2):84-5. Fenitrothion, malathion, dichlorvos, trichlorfon and fenitrothion/malathion were the most frequent chemicals involved. About 3/4 of the severely serum cholinesterase-depressed cases needed ventilators. |
2(0,0,0,2) | Details |
| 235931 | Reiner E, Krauthacker B, Simeon V, Skrinjaric-Spoljar M: Mechanism of inhibition in vitro of mammalian acetylcholinesterase and cholinesterase in solutions of 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethyl phosphonate (Trichlorphon). Biochem Pharmacol. 1975 Mar 15;24(6):717-22. |
1(0,0,0,1) | Details |
| 15525694 | Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3. The classical laboratory tests for exposure to organophosphorus toxicants (OP) are inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in blood. In vitro experiments with human plasma showed that chlorpyrifos oxon, echothiophate, malaoxon, paraoxon, methyl paraoxon, diazoxon, diisopropylfluorophosphate, and dichlorvos competed with FP- for binding to human albumin. |
1(0,0,0,1) | Details |
| 10365643 | Dingemanse J, Halabi A, Kleinbloesem CH, Heinig R, Blume H: Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor metrifonate in patients with renal impairment. Ther Drug Monit. 1999 Jun;21(3):310-6. Blood and urine samples were collected for 24 hours and concentrations of metrifonate and its metabolites dichlorvos, dichloroacetic acid, and M3 were determined. Inhibition of acetylcholinesterase activity in erythrocytes and butyrylcholinesterase in plasma were also measured. |
1(0,0,0,1) | Details |
| 9265850 | Martin RJ: Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34. Dichlorvos and haloxon are organophosphorus cholinesterase antagonists. |
31(0,1,1,1) | Details |
| 3421541 | Khan AA, Coppock RW, Schuler MM, Lillie LE: In vitro and in vivo effects of dichlorvos on blood cholinesterase activities of cattle. Am J Vet Res. 1988 Jul;49(7):1184-7. |
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| 18433895 | Varo I, Amat F, Navarro JC: Acute toxicity of dichlorvos to Aphanius iberus (Cuvier & Valenciennes, 1846) and its anti-cholinesterase effects on this species. Aquat Toxicol. 2008 Jun 2;88(1):53-61. Epub 2008 Mar 14. |
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| 8068758 | Plumlee KH, Richardson ER, Gardner IA, Galey FD: Effect of time and storage temperature on cholinesterase activity in blood from normal and organophosphorus insecticide-treated horses. J Vet Diagn Invest. 1994 Apr;6(2):247-9. The cholinesterase activities significantly increased (P < 0.05) in the stored blood from the dichlorvos-treated horses after 1 week when the blood was refrigerated and by 24 hours when the blood was stored at room temperature or incubated. |
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| 20229498 | Tacal O, Lockridge O: Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry. J Appl Toxicol. 2010 Mar 12. |
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| 1439591 | Kassa J: [The therapeutic effect of diazepam in dichlorvos poisoning] . Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1992;35(1):59-72. In order to study the influence of diazepam on both cholinergistic and non-cholinergistic (stressogenic) effects of phosphororganic insecticide dichlorovos, both the activity of cholinesterase in selected organs and blood as well as biochemical markers of stress (plasma tyrosine aminotransferase activity in the liver) have been applied. |
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| 17705652 | Rodriguez-Castellanos L, Sanchez-Hernandez JC: Chemical reactivation and aging kinetics of organophosphorus-inhibited cholinesterases from two earthworm species. Environ Toxicol Chem. 2007 Sep;26(9):1992-2000. Chemical reactivation kinetics followed an exponential rise to a maximum of 70 to 80% of normal enzyme activity when ChEs were inhibited with methyl paraoxon or dichlorvos and up to 60% for the chlorpyrifos-inhibited ChE of E. fetida. |
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| 7344416 | Nordgren I, Bengtsson E, Holmstedt B, Pettersson BM: Levels of metrifonate and dichlorvos in plasma and erythrocytes during treatment of schistosomiasis with Bilarcil. Acta Pharmacol Toxicol. 1981;49 Suppl 5:79-86. Cholinesterase activity in plasma reaches zero levels within 15 min. and remains inhibited for more than eight hours. |
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| 15888665 | Quistad GB, Klintenberg R, Casida JE: Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Toxicol Sci. 2005 Aug;86(2):291-9. Epub 2005 May 11. The most potent in vitro inhibitors for human erythrocyte and mouse brain APH are DFP (IC (50) 11-17 nM), chlorpyrifos oxon (IC (50) 21-71 nM), dichlorvos (IC (50) 230-560 nM), naled (IC (50) 370-870 nM), and their analogs with modified alkyl substituents. (3) H-diisopropyl fluorophosphate is a potent inhibitor of mouse blood and brain APH in vivo (ED (50) 0.09-0.2 mg/kg and 0.02-0.03 mg/l for ip and vapor exposure, respectively). Mouse blood and brain APH and blood butyrylcholinesterase (BChE) are of similar sensitivity to DFP in vitro and in vivo (ip and vapor exposure), but APH inhibition is much more persistent in vivo (still > 80% inhibition after 4 days). |
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| 16020401 | Cankayali I, Demirag K, Eris O, Ersoz B, Moral AR: The effects of on oxidative stress in organophosphate poisoning model. Adv Ther. 2005 Mar-Apr;22(2):107-16. Organophosphate compounds act by irreversible inhibition of cholinesterase. Invasive hemodynamic monitoring was begun and all rats were injected with 70 mg/kg of dichlorvos (DDVP) intraperitoneally. |
1(0,0,0,1) | Details |
| 2339420 | Silveira CL, Eldefrawi AT, Eldefrawi ME: Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases. Toxicol Appl Pharmacol. 1990 May;103(3):474-81. There was poor correlation between the potencies of the OPs in reversibly inhibiting [3H] CD binding, and their anticholinesterase activities and toxicities. Other OP insecticides had lower potencies, inhibiting less than 50% of 5 nM [3H] CD binding by 1 microM of EPN, coumaphos, dioxathion, dichlorvos, or chlorpyriphos. |
1(0,0,0,1) | Details |
| 1664807 | Kosmachev AB, Filippov VN, Kosmacheva IM, Khobotova ZI, Kuleshov VI: [The possible role of presynaptic effects in realizing the protective action of M-cholinolytics in dimethyl dichlorovinyl poisoning]. Farmakol Toksikol. 1991 Jul-Aug;54(4):67-9. It is supposed that the removal of the presynaptic suppression of release due to the anticholinesterase substance action deteriorates the prognosis of the course of DDVF intoxication. |
1(0,0,0,1) | Details |
| 1855619 | Takahashi H, Kojima T, Ikeda T, Tsuda S, Shirasu Y: Differences in the mode of lethality produced through intravenous and oral administration of organophosphorus insecticides in rats. Fundam Appl Toxicol. 1991 Apr;16(3):459-68. This study was undertaken to investigate the possibility that mechanisms other than cholinesterase (ChE) inhibition account for the acute toxicity of organophosphorus insecticide. Both the P = O type insecticide (direct ChE inhibitors: chlorfenvinphos and dichlorvos) and the P = S type insecticide (indirect ChE inhibitors: diazinon and fenthion) were employed. |
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| 18796381 | Mohammad FK, Al-Badrany YM, Al-Jobory MM: Acute toxicity and cholinesterase inhibition in chicks dosed orally with organophosphate insecticides. Arh Hig Rada Toksikol. 2008 Sep;59(3):145-51. Acute toxic effects of three commonly used insecticidal preparations of the organophosphates chlorpyrifos, diazinon, and dichlorvos were examined in mixed breed broiler chicks, and cholinesterase activity in plasma and brain were measured. |
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| 12660363 | Dekundy A, Kaminski RM, Turski WA: Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice. Toxicol Sci. 2003 Apr;72(2):289-95. Mice were administered anticholinesterase pesticides dichlorvos (DDVP) or methomyl (MET). |
9(0,0,1,4) | Details |
| 17098105 | Brahmi N, Mokline A, Kouraichi N, Ghorbel H, Blel Y, Thabet H, Hedhili A, Amamou M: Prognostic value of human erythrocyte acetyl cholinesterase in acute organophosphate poisoning. Am J Emerg Med. 2006 Nov;24(7):822-7. Acute organophosphate poisoning (OPP) such as dichlorvos may be monitored by the measurement of the erythrocyte acetyl cholinesterase (EAChE) and the serum cholinesterase (SChE) activities. |
9(0,0,1,4) | Details |
| 3703907 | Roney PL Jr, Costa LG, Murphy SD: Conditioned taste aversion induced by organophosphate compounds in rats. Pharmacol Biochem Behav. 1986 Mar;24(3):737-42. Three organophosphate compounds, dichlorvos, parathion and diisopropylfluorophosphate were tested as an unconditioned stimulus in the conditioned taste aversion (CTA) test. Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition. |
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| 1697627 | Yoshikawa H, Yoshida M, Hara I: Electroretinographic changes induced by organophosphorus pesticides in rats. J Toxicol Sci. 1990 May;15(2):87-95. Male Wistar rats were intraperitoneally injected with fenthion, chlorpyrifos, fenitrothion, dichlorvos or chlorfenvinphos at doses of 0.01 mmol/kg and/or 0.05 mmol/kg. The electroretinogram (ERG) was recorded at 5 hours and 2 days after the administration, and brain and retinochoroid cholinesterase (ChE) activities was assayed at 3 days after the injections. |
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| 14704117 | Peng A, Meng FQ, Sun LF, Ji ZS, Li YH: Therapeutic efficacy of charcoal hemoperfusion in patients with acute severe dichlorvos poisoning. Acta Pharmacol Sin. 2004 Jan;25(1):15-21. HP could accelerate the recovery of suppressed cholinesterase activity. |
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| 236606 | Fernandez G, Diaz Gomez MI, Castro JA: Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics: analysis of its postulated role in synergizing organophosphate toxicity. Toxicol Appl Pharmacol. 1975 Feb;31(2):179-90. |
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| 18775593 | Laguerre C, Sanchez-Hernandez JC, Kohler HR, Triebskorn R, Capowiez Y, Rault M, Mazzia C: B-type esterases in the snail Xeropicta derbentina: an enzymological analysis to evaluate their use as biomarkers of pesticide exposure. Environ Pollut. 2009 Jan;157(1):199-207. Epub 2008 Sep 4. Specific cholinesterase and carboxylesterase activities were mainly obtained with acetylthiocholine (K (m)=77.2 mM; V (max)=38.2 mU/mg protein) and 1-naphthyl (K (m)=222 mM, V (max)=1095 mU/mg protein) substrates, respectively. Acetylcholinesterase activity was concentration-dependently inhibited by chlorpyrifos-oxon, dichlorvos, carbaryl and carbofuran (IC50=1.35x10 (-5)-3.80x10 (-8) M). |
1(0,0,0,1) | Details |
| 597376 | Ehrich M, Cohen SD: DDVP (dichlorvos) detoxification by binding and interactions with DDT, dieldrin, and malaoxon. J Toxicol Environ Health. 1977 Oct;3(3):491-500. Similar DDVP pretreatment potentiated the anticholinesterase action of malaoxon (10 mg/kg, ip). |
1(0,0,0,1) | Details |
| 6147281 | Ryhanen R, Herranen J, Korhonen K, Penttila I, Polvilampi M, Puhakainen E: Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits. Int J Biochem. 1984;16(6):687-90. The activities of serum pseudocholinesterase, cholesterol acyltransferase (LCAT) and gamma-glutamyltransferase in rabbits were investigated before and after dichlorvos administration in vivo. |
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| 744539 | Maslinska D, Zalewska Z: Effect of dichlorvos, administered to the pregnant rabbits, on the colinesterases activity in the progeny. Folia Histochem Cytochem. 1978;16(4):335-41. The influence of dichlorvos on the cholinesterases activity during ontogenic development was investigated in rabbits. |
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| 10975133 | Mason HJ: The recovery of plasma cholinesterase and erythrocyte acetylcholinesterase activity in workers after over-exposure to dichlorvos. Occup Med. 2000 Jul;50(5):343-7. |
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| 1852719 | Abdi YA, Villen T: Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood. Pharmacol Toxicol. 1991 Feb;68(2):137-9. Cholinesterases were also determined in blood haemolyzed with water. |
2(0,0,0,2) | Details |
| 10582355 | Moriya F, Hashimoto Y: Comparative studies on tissue distributions of organophosphorus, and organochlorine pesticides in decedents intoxicated with these chemicals. J Forensic Sci. 1999 Nov;44(6):1131-5. This paper describes the tissue distributions of dichlorvos, an organophosphate, chlorpyrifos-methyl, an organophosphorothioate, methomyl, a and endrin, an organochlorine, in three individuals (Cases 1-3) who died after ingesting insecticidal preparations containing these chemicals. The serum cholinesterase activity was 3 IU/L/37 degrees C. |
2(0,0,0,2) | Details |
| 3761745 | Dube SN, Ghosh AK, Jeevarathinam K, Kumar D, Das Gupta S, Pant BP, Batra BS, Jaiswal DK: Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats. Jpn J Pharmacol. 1986 Jul;41(3):267-71. Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. |
1(0,0,0,1) | Details |
| 887198 | Zalewska Z, Rakowska I, Matraszek G, sitkiewicz D: Effect of dichlorvos on some enzyme activities of the rat brain during postnatal development. Neuropatol Pol. 1977 Apr-May;15(2):255-62. Cholinesterases. |
1(0,0,0,1) | Details |
| 653724 | Boyer AC: Factors which affect the in vitro inhibition of human plasma cholinesterase. Toxicol Appl Pharmacol. 1978 Mar;43(3):475-83. |
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| 7713347 | Ehrich M, Jortner BS, Padilla S: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam Appl Toxicol. 1995 Jan;24(1):94-101. Inhibition of neuropathy target esterase (NTE, neurotoxic esterase) and acetylcholinesterase (AChE) activities was compared in brain and spinal cords of adult While Leghorn hens and adult male Long Evan rats 4-48 hr after administration of triortho-tolyl (TOTP po, 50-500 mg/kg to hens; 300-1000 mg/kg to rats), phenyl saligenin (PSP im 0.1-2.5 mg/kg to hens; 5-24 mg/kg to rats), mipafox (3-30 mg/kg ip to hens and rats), diisopropyl phosphorofluoridate (DFP sc, 0.25-1.0 mg/kg to hens; 1-3 mg/kg to rats), dichlorvos (5-60 mg/kg ip to hens; 600-2000 mg/kg to rats), and carbaryl (300-560 mg/kg ip to hens; 30-170 mg/kg to rats). |
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| 7724838 | Mennear JH: Dichlorvos carcinogenicity: an assessment of the weight of experimental evidence. Regul Toxicol Pharmacol. 1994 Dec;20(3 Pt 1):354-61. EPA has published its intent to revoke the food additive registration of this cholinesterase-inhibiting insecticide. |
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| 6533340 | Yamanaka S, Nishimura M: [Effects of organophosphorus compounds and PAM on cholinesterase activity in rat tissues] Nippon Eiseigaku Zasshi. 1984 Dec;39(5):795-806. |
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| 7444165 | Sonawane BR, Baksi SN: Altered thyroid hormone status and dichlorvos toxicity in rats. Res Commun Chem Pathol Pharmacol. 1980 Nov;30(2):369-72. Hyperthyroid females were more susceptible than males to dichlorvos challenge even with similar decrease in serum cholinesterase activity. |
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| 6857660 | Casale GP, Cohen SD, DiCapua RA: The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice. Toxicol Appl Pharmacol. 1983 Apr;68(2):198-205. The present study evaluated the relationship between the anticholinesterase action of parathion, malathion, and dichlorvos (DDVP) and their effects on the primary humoral response to SRC. |
7(0,0,1,2) | Details |
| 7344402 | Slomka MB, Hine CH: Clinical pharmacology of dichlorvos. . Acta Pharmacol Toxicol. 1981;49 Suppl 5:105-8. The cholinesterase activity depressions following single doses were dose related. |
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| 3738227 | Lekeux P, Kyavu A, Clercx C, Ansay M: Pulmonary function changes induced by experimental dichlorvos toxicosis in calves. Res Vet Sci. 1986 May;40(3):318-21. From one minute after dosage, all animals showed severe respiratory distress, excitation, weakness, muscle fasciculation and cholinesterase inhibition. |
2(0,0,0,2) | Details |
| 11246494 | Chuiko GM: Comparative study of acetylcholinesterase and butyrylcholinesterase in brain and serum of several freshwater fish: specific activities and in vitro inhibition by DDVP, an organophosphorus pesticide. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Dec;127(3):233-42. |
2(0,0,0,2) | Details |
| 6298988 | Cordoba D, Cadavid S, Angulo D, Ramos I: Organophosphate poisoning: modifications in acid base equilibrium and use of sodium bicarbonate as an aid in the treatment of toxicity in dogs. Vet Hum Toxicol. 1983 Feb;25(1):1-3. We monitored blood pH, arterial gases, and cholinesterase activity before and during the intoxication and found acidosis. |
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| 8240025 | Reiner E, Simeon V, Simaga S, Cizl S, Jelicic D, Sumanovic V, Batinic D: A field-test for detecting organophosphorus compounds in water. Arh Hig Rada Toksikol. 1993 Jun;44(2):159-62. The test is based on the inhibition of cholinesterase. The detection limit for the organophosphorus pesticide dichlorvos is 50 micrograms/L. |
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| 8680570 | Skopichev VG, Sokolova IO: [The epithelial reaction of the gastrointestinal tract in dog salmon fry to exposure to an organophosphorus cholinesterase inhibitor]. Morfologiia. 1994 Jul-Dec;107(7-12):30-8. |
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| 8274696 | Zabrodskii PF: [The mechanisms of the immunotropic effects of organophosphorus compounds] . Biull Eksp Biol Med. 1993 Aug;116(8):181-3. The effects of acute poisoning with anticholinesterase insecticide dimethyldichlorvinylphosphate (DDVP) in doses 0.25; 0.5 and 1.0 LD 50, immobilisation stress (6-hour), (100 mg/kg) and --A (5 mg/kg) on the basic immune responses were investigated in experiments on CBA mice. |
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| 9004458 | Sakaguchi K, Nagayama M, Masaoka T, Nishimura A, Kageyama K, Shirai M, Akahori F: Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs. Vet Hum Toxicol. 1997 Feb;39(1):1-5. |
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| 3672530 | Pauluhn J, Machemer L, Kimmerle G: Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct 30;46(2):177-90. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the propoxur. |
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| 7115940 | Trinus FP, Braver-Chernobul'skaia BS, Luik AI: [Noncholinesterase component in the molecular mechanism of action of the cholinesterase reactivator dipyroxime]. Biull Eksp Biol Med. 1982 Jun;93(6):66-8. |
2(0,0,0,2) | Details |
| 89824 | Hazelwood JC, Stefan GE, Bowen JM: Motor unit irritability in Beagles Before and after exposure to cholinesterase inhibitors. Am J Vet Res. 1979 Jun;40(6):852-6. Electromyographic (EMG) examinations were performed on Beagles before and for 7 days after oral administration of one of the following organophosphate (OP) compounds; ronnel (55.0 or 110.0 mg/kg), dichlorvos (29.7, 59.4, or 148.5 mg/kg), or cythioate (24.8 or 33.0 mg/kg). |
2(0,0,0,2) | Details |
| 612329 | Seawright AA, Costigan P: Some toxicity aspects of dichlorvos flea collars in cats. Aust Vet J. 1977 Nov;53(11):509-14. Whole blood cholinesterase was reduced within the first week of application of the collar and remained below pretreatment levels for 5 to 8 weeks before returning to normal presumably as the insecticide concentration in the resin was progressively reduced. |
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| 2340983 | Ikeda T, Kojima T, Yoshida M, Takahashi H, Tsuda S, Shirasu Y: Pretreatment of rats with an organophosphorus insecticide, chlorfenvinphos, protects against subsequent challenge with the same compound. Fundam Appl Toxicol. 1990 Apr;14(3):560-7. The CVP pretreatment did not appreciably change the toxicities of the cholinergic agonists, carbachol and oxotremorine, but significantly increased the toxicity of another organophosphate, dichlorvos. Twenty-four hours after oral administration of CVP (15 mg/kg), the second dose (CVP 30 mg/kg, po) was less effective in inhibiting cholinesterase activities of the brain, erythrocyte, and plasma compared with naive rats treated with the same dose. |
1(0,0,0,1) | Details |
| 5520490 | Natoff IL: Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors. Eur J Toxicol. 1970 Nov-Dec;3(6):363-7. |
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| 2086312 | Schop RN, Hardy MH, Goldberg MT: Comparison of the activity of topically applied pesticides and the herbicide 2,4-D in two short-term in vivo assays of genotoxicity in the mouse. Fundam Appl Toxicol. 1990 Nov;15(4):666-75. Aminocarb and chlordane induced a dose-dependent increase in the frequency of NA, while there was an observed increase in NA incidence at only the highest doses of dichlorvos (DDVP), 4,4'-DDT (DDT), and 2,4-dichlorophenoxyacetic acid (2,4-D). Serum cholinesterase levels were reduced to 70 +/- 4.7% of the DMSO control level with DDVP, 57 +/- 8.2% with aminocarb, and 60.3 +/- 4.8% with fenitrothion, indicating some systemic activity with these topically applied agents. |
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| 8784247 | Bassant MH, Jazat-Poindessous F, Lamour Y: Effects of metrifonate, a cholinesterase inhibitor, on local cerebral utilization in young and aged rats. J Cereb Blood Flow Metab. 1996 Sep;16(5):1014-25. The effects of the centrally acting anti-cholinesterase metrifonate (MFT) and its metabolite dichlorvos (2,2-dichlorovinyl dimethyl DDVP) on local cerebral utilization (LCGU) have been studied in 3- and 27-month-old rats, using the autoradiographic [14C] deoxyglucose technique. |
82(1,1,1,2) | Details |
| 20223382 | Gunay N, Kose B, Demiryurek S, Ceylan NO, Sari I, Demiryurek AT: Protective effects of Y-27632 on acute dichlorvos poisoning in rats. Am J Emerg Med. 2010 Mar;28(3):268-74. Epub 2010 Jan 28. Serum cholinesterase activities were suppressed with dichlorvos, and these reductions were inhibited with Y-27632 pretreatment. |
82(1,1,1,2) | Details |
| 3666870 | Naidu KA, Viswanatha S, Krishnakumari MK: Cardiotoxic effects of dichlorvos (DDVP) in albino rats. Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):19-24. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. |
82(1,1,1,2) | Details |
| 8351788 | Harlin KS, Dellinger JA: Retina, brain and blood cholinesterase levels in cats treated with oral dichlorvos. Vet Hum Toxicol. 1993 Jun;35(3):201-3. |
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| 6524963 | Purshottam T, Srivastava RK: Effect of high-fat and high-protein diets on toxicity of parathion and dichlorvos. Arch Environ Health. 1984 Nov-Dec;39(6):425-30. A lower dose of parathion (7.5 mg/kg) and dichlorvos (20 mg/kg) was employed in another set of experiments to compare the spontaneous regeneration of plasma and red blood cell (RBC) cholinesterase (ChE) activity at 2 hr, 1 day, 3 days, and 5 days after administration of parathion or dichlorvos. |
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| 856330 | Kokshareva NV, Kovtun SD, Kagan IuS, Miziukova IG, Medvedev BM: [Effect of a new cholinesterase reactivator, diethixime, on the central nervous system]. Biull Eksp Biol Med. 1977 Jan;83(1):29-32. |
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| 8231460 | Moriearty PL, Thornton SL, Becker RE: Transdermal patch delivery of acetylcholinesterase inhibitors. . Methods Find Exp Clin Pharmacol. 1993 Jul-Aug;15(6):407-12. Transdermal delivery of cholinesterase inhibitors (ChEI) for treatment of dementia would have advantages associated with continuous dosing and enhanced compliance, but feasibility depends on achieving desired levels of central nervous system enzyme inhibition. |
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| 3202059 | Buchmann K, Mellergaard S: Histochemical demonstration of the inhibitory effect of Nuvan and Neguvon on cholinesterase activity in Pseudodactylogyrus anguillae (Monogenea). Acta Vet Scand. 1988;29(1):51-5. |
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| 2593091 | Audegond L, Catez D, Foulhoux P, Fournex R, Le Rumeur C, L'Hotellier M, Stepniewski JP: [Potentiation of deltamethrin toxicity by organophosphorus insecticides] . J Toxicol Clin Exp. 1989 May-Jun;9(3):163-76. It was demonstrated that some of them (azinphos, dichlorvos, dimethoate, fenitrothion, omethoate) induce an increase of toxicity of deltamethrin. Cholinesterase inhibitors of the group are ineffective. |
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| 6380243 | Gyrd-Hansen N, Kraul I: Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs. Acta Vet Scand. 1984;25(1):86-95. |
1(0,0,0,1) | Details |
| 1564112 | Unni LK, Hannant ME, Becker RE: High-performance liquid chromatographic method using ultraviolet detection for measuring metrifonate and dichlorvos levels in human plasma. J Chromatogr. 1992 Jan 3;573(1):99-103. We report high-performance liquid chromatographic methods using ultraviolet detection, developed for the first time in our laboratory with sensitivity to detect clinically significant concentrations of metrifonate (MTF), an experimental drug for Alzheimer disease, and its active anticholinesterase metabolite, dichlorvos (DDVP). |
81(1,1,1,1) | Details |
| 4859365 | Carter MK, Maddux B: Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases. Toxicol Appl Pharmacol. 1974 Feb;27(2):456-63. |
81(1,1,1,1) | Details |
| 4244722 | Wagner JE, Johnson DR: Toxicity of dichlorvos for laboratory mice--LD50 and effect on serum cholinesterase. Lab Anim Care. 1970 Feb;20(1):45-7. |
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| 16302752 | Longobardi F, Solfrizzo M, Compagnone D, Del Carlo M, Visconti A: Use of electrochemical biosensor and gas chromatography for determination of dichlorvos in wheat. J Agric Food Chem. 2005 Nov 30;53(24):9389-94. Dichlorvos, an organophosphorus anticholinesterase pesticide, was extracted from wheat with hexane, and the filtered extract was directly analyzed by gas chromatography with - flame detection (NPD). |
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| 3627083 | Dellinger JA, McKiernan BC, Koritz GD, Richardson BC: Latent dichlorvos neurotoxicity detected by vagal tone monitoring in dogs. Neurotoxicol Teratol. 1987 May-Jun;9(3):197-201. Plasma and erythrocyte cholinesterase (ChE) was monitored prior to, 90 min, and 180 min post-ingestion. 2-PAM (20 mg/kg IV) and atropine sulfate (0.022 mg/kg IM) were administered 90 min after the dichlorvos to paired treated and control dogs. |
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| 3371194 | Moody SB, Terp DK: Dystonic reaction possibly induced by cholinesterase inhibitor insecticides. Drug Intell Clin Pharm. 1988 Apr;22(4):311-2. |
2(0,0,0,2) | Details |
| 17698511 | Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O: Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci. 2007 Nov;100(1):136-45. Epub 2007 Aug 13. Our work utilized matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry to study the aging mechanism of human BChE inhibited by dichlorvos, echothiophate, diisopropylfluorophosphate (DFP), isomalathion, soman, sarin, cyclohexyl sarin, VX, and VR. |
2(0,0,0,2) | Details |
| 17150236 | Mehl A, Schanke TM, Torvik A, Fonnum F: The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):128-35. Epub 2006 Nov 1. The hypoplasia may be caused by trichlorfon itself or by its metabolite dichlorvos. There was a significant reduction in choline esterase, choline acetyltransferase and decarboxylase activities in the cerebellum. |
1(0,0,0,1) | Details |
| 4656609 | Bueding E, Liu CL, Rogers SH: Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes. Br J Pharmacol. 1972 Nov;46(3):480-7. |
81(1,1,1,1) | Details |
| 8051989 | Unni LK, Womack C, Hannant ME, Becker RE: Pharmacokinetics and pharmacodynamics of metrifonate in humans. Methods Find Exp Clin Pharmacol. 1994 May;16(4):285-9. We studied the pharmacokinetics and pharmacodynamics [red blood cell (RBC) cholinesterase (ChE) inhibition] of metrifonate (MTF) and its active anti-ChE metabolite, dichlorvos (DDVP) in Alzheimer's disease (AD) patients and normal controls after oral MTF. |
81(1,1,1,1) | Details |
| 5545548 | Ward FP, Glicksberg CL: Effects of dichlorvos on blood cholinesterase activity in dogs. J Am Vet Med Assoc. 1971 Feb 15;158(4):457-61. |
6(0,0,1,1) | Details |
| 4766839 | Rauws AG, van Logten MJ: The influence of dichlorvos from strips or sprays on cholinesterase activity in chicken. Toxicology. 1973 Mar;1(1):29-41. |
6(0,0,1,1) | Details |
| 4390485 | Natoff IL: The pharmacology of the cholinoceptor in muscle preparations of Ascaris lumbricoides var. suum. Br J Pharmacol. 1969 Sep;37(1):251-7. and barium ions stimulated the tissue, while the anti-cholinesterases, dichlorvos and eserine, increased the resting tension of the preparation and potentiated the responses to acetylcholine.5. |
6(0,0,1,1) | Details |
| 3247000 | Nagymajtenyi L, Desi I, Lorencz R: Neurophysiological markers as early signs of organophosphate neurotoxicity. Neurotoxicol Teratol. 1988 Sep-Oct;10(5):429-34. The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. Cholinesterase activity was measured in blood, brain and other organs. |
2(0,0,0,2) | Details |
| 1236842 | Bell TG, Farrell RK, Padgett GA, Leendertsen LW: Ataxia, depression, and dermatitis associated with the use of dichlorvos-impregnated collars in the laboratory cat. J Am Vet Med Assoc. 1975 Oct 1;167(7):579-86. Whole blood cholinesterase (ChE) activity was significantly (P smaller than 0.001) reduced in all cats and cervical dermatitis occurred in 37 (74%) of them. |
1(0,0,0,1) | Details |
| 5093191 | Reiff B, Lambert SM, Natoff IL: Inhibition of brain cholinesterase by organophosphorus compounds in rats. Arch Int Pharmacodyn Ther. 1971 Jul;192(1):48-60. |
1(0,0,0,1) | Details |
| 2364259 | Raina R, Srivastava AK, Malik JK: Effects of repeated topical application of dichlorvos on blood enzymes and its toxicity in buffalo calves (Bubalus bubalis). Br Vet J. 1990 May-Jun;146(3):264-9. Daily spraying of dichlorvos at both concentrations inactivated erythrocyte cholinesterase (ChE) (15-21%), plasma ChE (17-20%) and serum carboxylesterase (5-10%) within 3 days. |
81(1,1,1,1) | Details |
| 968905 | Cohen SD, Ehrich M: Cholinesterase and carboxylesterase inhibition by dichlorvos and interactions with malathion and triorthotolyl Toxicol Appl Pharmacol. 1976 Jul;37(1):39-48. |
81(1,1,1,1) | Details |
| 1949606 | Raina R, Malik JK: The therapeutic effects of monoxime and atropine in severe dichlorvos intoxication in buffalo calves. Vet Res Commun. 1991;15(4):319-25. Treatment with monoxime plus atropine 30 min after oral administration of dichlorvos (160 mg/kg) eliminated the apparent toxic signs within 10-15 min, completely prevented lethality, and reversed the dichlorvos-induced alterations in the concentrations of serum carboxylesterase, total plasma proteins, blood and plasma cholinesterase within 2, 4, 12 and 168 h, respectively. |
6(0,0,1,1) | Details |
| 16105447 | Zhu QH, Huang JX, Lin Z: [Therapeutic efficacy of N6-cyclopentyladenosine against acute dichlorvos poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Apr;23(2):94-6. Toxic signs and survival rate were recorded and cholinesterase (ChE) activities and concentrations in whole blood were determined in treatment group with CPA and non-treatment group after dichlorvos was given to rats by gastrogavage. |
6(0,0,1,1) | Details |
| 8349949 | Casale GP, Vennerstrom JL, Bavari S, Wang TL: Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected and organophosphate insecticides and congeners of carbaryl. Immunopharmacol Immunotoxicol. 1993 Mar-Jun;15(2-3):199-215. The anticholinesterase (antiCHE) insecticides, a large family of pesticides used extensively throughout the world, inhibit serine hydrolases by carbamylating or phosphorylating a serine residue at the catalytic site. The order of potency for T cell inhibition was carbaryl = dichlorvos > methiocarb > carbofuran > paraoxon > mevinphos > aldicarb = monocrotophos. |
1(0,0,0,1) | Details |
| 4209143 | Smith RL: The estimation of serum cholinesterase in the presence of anti-cholinesterase insecticides. Clin Chim Acta. 1974 May 17;52(3):315-9. |
1(0,0,0,1) | Details |
| 17188317 | Kobayashi H, Suzuki T, Sakamoto M, Hashimoto W, Kashiwada K, Sato I, Akahori F, Satoh T: Brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):151-61. Epub 2006 Nov 11. |
1(0,0,0,1) | Details |
| 7338954 | Nishio A, Uyeki EM: Induction of sister chromatid exchanges in Chinese hamster ovary cells by organophosphate insecticides and their analogs. J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):939-46. Induction of sister chromatid exchanges (SCEs) in cultures of Chinese hamster ovary cells by 10 anticholinesterase organophosphate insecticides was investigated. The insecticides were two phosphates (dichlorvos and dicrotophos), four -containing organophosphates (malathion, parathion, leptophos, and diazinon), and four analogs of the latter (malaoxon, paraoxon, leptophosoxon, and diazoxon). |
1(0,0,0,1) | Details |
| 8585661 | Sarasola P, McKellar QA: Pharmacokinetics of bacampicillin in equids. Am J Vet Res. 1995 Nov;56(11):1486-92. Plasma pseudocholinesterase and erythrocyte acetylcholinesterase activities were reduced to < 5% of reference (predichlorvos) values after dichlorvos administration. |
81(1,1,1,1) | Details |
| 898205 | Boyer AC, Brown LJ, Slomka MB, Hine CH: Inhibition of human plasma cholinesterase by ingested dichlorvos: effect of formulation vehicle. Toxicol Appl Pharmacol. 1977 Aug;41(2):389-94. |
81(1,1,1,1) | Details |
| 7009035 | Reuber MD: Carcinogenicity of dichlorvos. . Clin Toxicol. 1981 Jan;18(1):47-84. The predominant mode of toxicity of dichlorvos is inhibition of cholinesterase. |
81(1,1,1,1) | Details |
| 12828128 | Lucic A, Bradamante V, Radic B, Peraica M, Domijan AM, Fuchs R, Stavljenic-Rukavina A: The effect of dichlorvos treatment on butyrylcholinesterase activity and lipid metabolism in rats. Arh Hig Rada Toksikol. 2002 Dec;53(4):275-81. |
68(0,2,2,8) | Details |
| 4779070 | Bossen F, Karlog O, Rasmussen F: [The cholinesterase activity in red blood cells and blood plasma after oral intake of Atgard vet. (dichlorvos) in pigs (author's transl)] Nord Vet Med. 1973 Nov;25(11):584-7. |
6(0,0,1,1) | Details |
| 16193528 | Petroianu GA, Hasan MY, Arafat K, Nurulain SM, Schmitt A: Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. J Appl Toxicol. 2005 Nov-Dec;25(6):562-7. The purpose of the study was to quantify in vitro the extent that TIA conferred protection, using paraoxon (POX) as an inhibitor, and to compare the results with existing data obtained using TIA as a protective agent against dichlorvos (DDVP). |
5(0,0,0,5) | Details |
| 7351088 | Eriksson H, Faijersson Y: A reliable way of estimating cholinesterases from whole blood in the presence of anti-cholinesterases. Clin Chim Acta. 1980 Jan 15;100(2):165-71. |
5(0,0,0,5) | Details |
| 3215484 | Ryhanen R, Honkakoski P, Harri M, Ylitalo P, Hanninen O: Effect of the cold environment on organophosphate toxicity and inhibition of cholinesterase activity. Gen Pharmacol. 1988;19(5):741-5. |
4(0,0,0,4) | Details |
| 2836970 | Desi I, Nagymajtenyi L: Neurotoxicologic investigations of the pesticide dichlorvos (DDVP). Toxicology. 1988 Apr;49(1):141-8. |
0(0,0,0,0) | Details |
| 4620807 | Mori T: [Effects of anti-cholinesterase insecticides and antidotes on the salivary glands and salivation of animals (author's transl)] Shikwa Gakuho. 1974 Dec;74(12):1846-59. |
1(0,0,0,1) | Details |
| 18970436 | Shi M, Xu J, Zhang S, Liu B, Kong J: A mediator-free screen-printed amperometric biosensor for screening of organophosphorus pesticides with flow-injection analysis (FIA) system. Talanta. 2006 Feb 15;68(4):1089-95. Epub 2005 Aug 16. A mediator-free amperometric biosensor for screening organophosphorus pesticides (OPs) in flow-injection analysis (FIA) system based on anticholinesterase activity of OPs to immobilized acetylcholinesterase enzyme (AChE) has been developed. A wide linear inhibition response for dichlorvos, typical OP, is observed in the range of 0.1-80muM, corresponding to 7.91-84.94% inhibition for AChE. |
1(0,0,0,1) | Details |
| 446594 | Hasan M, Maitra SC, Ali SF: Organophosphate pesticide DDVP-induced alterations in the rat cerebellum and spinal cord -- an electron microscopic study. Exp Pathol. 1979;17(2):88-94. DDVP is an organophosphate pesticide whose neurotoxicity, in the form of cholinesterase inhbition, is well-known. |
1(0,0,0,1) | Details |
| 9397501 | Mohammad FK, Faris GA, al-Kassim NA: A modified electrometric method for measurement of erythrocyte acetylcholinesterase activity in sheep. Vet Hum Toxicol. 1997 Dec;39(6):337-9. The method was used to demonstrate in vitro inhibition of sheep EChE activity by the organophosphorus and insecticides dichlorvos and methomyl, respectively. |
0(0,0,0,0) | Details |
| 4004835 | Ellinger C: Enzyme activities after in vitro and in vivo application of dichlorvos. . Biomed Biochim Acta. 1985;44(2):311-6. |
0(0,0,0,0) | Details |
| 4809600 | Bello TR, Amborski GF, Torbert BJ: Effects of organic anthelmintics on blood cholinesterase values in horses and ponies. Am J Vet Res. 1974 Jan;35(1):73-8. |
1(0,0,0,1) | Details |
| 8939014 | Shimizu K, Shiono H, Fukushima T, Sasaki M, Akutsu H, Sakata M: Tissue distribution of DDVP after fatal ingestion. Forensic Sci Int. 1996 Nov 11;83(1):61-6. Tissue distribution of dichlorvos (DDVP) was determined in a case of fatal ingestion using a rapid and simple gas chromatographic (GC) assay. |
0(0,0,0,0) | Details |
| 17157343 | Dekundy A, Kaminski RM, Zielinska E, Turski WA: antagonists exert distinct effects in experimental organophosphate or poisoning in mice. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):114-21. Epub 2006 Nov 6. In the present study, the effects of dizocilpine (MK-801, 1 mg/kg) or 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP, 10 mg/kg), alone or combined with muscarinic antagonist atropine (1.8 mg/kg), on convulsant and lethal properties of an OP pesticide dichlorvos or a drug physostigmine, were studied in mice. |
0(0,0,0,0) | Details |
| 7234436 | Pachecka J, Grzadkowska K, Gajewski K: The activity of plasma phosphatases in rats treated with single doses of dichlorvos and trichlorphon. Acta Physiol Pol. 1980 Sep-Oct;31(5):555-9. |
0(0,0,0,0) | Details |
| 7337287 | Hsu WH: Drug interactions of levamisole with pyrantel and dichlorvos in pigs. Am J Vet Res. 1981 Nov;42(11):1912-4. |
0(0,0,0,0) | Details |
| 8065512 | Mehl A, Schanke TM, Johnsen BA, Fonnum F: The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochem Res. 1994 May;19(5):569-74. The organophosphates trichlorfon, dichlorvos, dimethoate, soman, triortho-cresyl (TOCP), and the diethoxy-analogue of trichlorfon (O,O-diethyl 2,2,2-trichloro-1-hydroxyethylphosphonate, ethyl-trichlorfon), were administered to guinea pigs between day 42 and 46 of gestation. |
0(0,0,0,0) | Details |
| 6623514 | Das YT, Taskar PK, Brown HD, Chattopadhyay SK: Exposure of professional pest control operator to dichlorvos (DDVP) and residue on house structures. Toxicol Lett. 1983 Jun;17(1-2):95-9. |
0(0,0,0,0) | Details |
| 363095 | Holmstedt B, Nordgren I, Sandoz M, Sundwall A: Metrifonate. Arch Toxicol. 1978 Oct 13;41(1):3-29. This organophosphorus compound is unique in that it has been claimed not to be a direct acting cholinesterase inhibitor but being transformed nonenzymatically into an active component dichlorvos, 2, 2-dichlorovinyl dimethyl (DDVP). |
0(0,0,0,0) | Details |
| 989297 | Blair D, Dix KM, Hunt PF, Thorpe E, Stevenson DE, Walker AI: Dichlorvos -- a 2-year inhalation carcinogenesis study in rats. Arch Toxicol. 1976 Aug 18;35(4):281-94. |
0(0,0,0,0) | Details |